Journal of Liver Transplantation最新文献

{"title":"Single organ transplant for transposition of the great arteries","authors":"Tripti Gupta , Kayla Buttafuoco , Kara Siegrist , Kelly Mishra , Benjamin Byrd , Frank Fish , Angela Weingarten , Benjamin Frischhertz , Roman Perri , Martin Montenovo , Jonathan Menachem","doi":"10.1016/j.liver.2025.100273","DOIUrl":"10.1016/j.liver.2025.100273","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tacrolimus-induced psychosis in liver transplant recipients: A systematic review of all published cases","authors":"Pooja Belur ,&nbsp;Komal Dani ,&nbsp;Stephanie H. Cho","doi":"10.1016/j.liver.2025.100265","DOIUrl":"10.1016/j.liver.2025.100265","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review aims to better characterize the clinical patterns, potential protective and risk factors, prognosis, and management of tacrolimus-induced psychosis in liver transplant recipients.</div></div><div><h3>Method</h3><div>We reviewed all published cases of severe psychiatric complications associated with tacrolimus in liver transplant recipients from 1998 to 2024. In total, 17 case reports, 1 case-control study, 3 retrospective studies, and 2 prospective studies were identified.</div></div><div><h3>Results</h3><div>Tacrolimus-induced psychosis presented with a wide range of symptoms, including tremor, speech difficulties, seizures, delusions, and paranoia. Of the 17 case reports, only 10 documented symptoms aligning with a clinical, DSM-based definition of psychosis. Affected patients varied in age, and a significant proportion had no prior psychiatric history. Symptom onset after tacrolimus initiation varied, though 15 of 17 cases developed psychosis within the first 6 months of treatment. Of these cases, 13 saw resolution of symptoms within one month of stopping tacrolimus. We differentiated cases by a strict, DSM-based definition of psychosis versus a broader categorization. The 10 cases fitting the classic definition showed a higher rate of symptom resolution within the first month.</div></div><div><h3>Conclusion</h3><div>Presentation of tacrolimus-induced psychosis varied considerably across reviewed studies, with rapid resolution upon drug discontinuation in most cases. However, a standardized approach to balancing risks of drug withdrawal against the need for immunosuppression remains absent. This review underscores the need for standardized diagnostic criteria.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100265"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental hepatocellular carcinoma in explanted livers: Prevalence, prognosis and features","authors":"Emilie Kerstens ,&nbsp;Samuele Iesari ,&nbsp;Eliano Bonaccorsi ,&nbsp;Laurent Coubeau ,&nbsp;Géraldine Dahlqvist ,&nbsp;Coralie Hamoir ,&nbsp;Olga Ciccarelli ,&nbsp;Bénédicte Delire","doi":"10.1016/j.liver.2025.100264","DOIUrl":"10.1016/j.liver.2025.100264","url":null,"abstract":"<div><h3>Background and aims</h3><div>Incidental hepatocellular carcinoma (iHCC) on cirrhotic liver specimens is not rare. The aim of this study was to evaluate prevalence and outcomes of liver transplant recipients (LTRs) with iHCC. We compared this group to cirrhotic patients who underwent liver transplantation (LT) for previously known hepatocellular carcinoma (pkHCC) or tumor-free end-stage liver disease (ESLD).</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 268 cirrhotic patients who underwent LT at our center between 2010 and 2020<em>.</em> Patient selection was made according to the indication for LT and histopathological analyses of surgical specimens (tumor-free ESLD, hepatocellular carcinoma (HCC)). Results were compared using Fisher's exact or Mann-Whitney U tests as appropriate. We used the Kaplan-Meier method to analyze the rate of death and log-rank tests to compare survival curves.</div></div><div><h3>Results</h3><div>The prevalence of iHCC was 12 %. Alcohol-related liver disease was more frequent in iHCC LTRs than in the other groups (<em>p</em> = 0.046). iHCC patients spent more time on the waiting list than patients with tumor-free ESLD cirrhosis (Ci) (12.2 months vs. 3.5 months; <em>p</em> = 0.04). Five-year overall survival of iHCC LTRs was significantly reduced compared to the survival of Ci LTRs (44 % vs. 87 %, <em>p</em> = 0.028).</div></div><div><h3>Conclusions</h3><div>The prevalence of iHCC within LT candidates is significant. iHCC LTRs show a lower survival rate than Ci LTRs, but a reduced rate of tumor recurrence compared to pkHCC LTRs. HCC screening protocol of ESLD LT candidates might include a larger use of high-resolution imaging techniques and iHCC LTRs should be approached as pkHCC LTRs with regards to postoperative imaging follow-up.</div></div><div><h3>Summary</h3><div>Prevalence of incidental hepatocellular carcinoma is considerable among LT candidates. These patients have a lower survival rate than recipients with tumor-free ESLD cirrhosis. Optimizing screening methods for hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation could improve their prognosis.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100264"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of bridge therapy for hepatocellular carcinoma in patients submitted to liver transplantation: A Brazilian multicenter study","authors":"Julia Fadini Margon ,&nbsp;Aline Lopes Chagas ,&nbsp;Angelo A. Mattos ,&nbsp;Márcio A. Diniz ,&nbsp;Guilherme E.G. Felga ,&nbsp;Ilka F.S.F. Boin ,&nbsp;Renato Ferreira da Silva ,&nbsp;José Huygens Parente Garcia ,&nbsp;Agnaldo Soares Lima ,&nbsp;Rita C.M.A. da Silva ,&nbsp;Paulo Everton Garcia Costa ,&nbsp;Maria Lúcia Zanotelli ,&nbsp;Júlio Cezar Uili Coelho ,&nbsp;André L.C. Watanabe ,&nbsp;Débora Raquel Terrabuio ,&nbsp;Paulo Roberto Reichert ,&nbsp;Paulo Lisboa Bittencourt ,&nbsp;Leila M.M. Beltrão Pereira ,&nbsp;Luiz Augusto Carneiro-D'Albuquerque ,&nbsp;Flair José Carrilho","doi":"10.1016/j.liver.2025.100258","DOIUrl":"10.1016/j.liver.2025.100258","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Hepatocellular carcinoma (HCC) is a main indication for liver transplantation (LT). Bridge therapy (BT) is recommended when waiting time on transplant list is longer than 6 months to prevent dropout. However, the prognostic role of locoregional treatment in post-LT outcomes needs to be better defined. Our aims were to evaluate the impact of BT on post-LT overall survival (OS) and recurrence-free survival (RFS) among LT recipients with HCC.</div></div><div><h3>Materials and Methods</h3><div>Multicenter retrospective cohort study in HCC patients submitted to LT with clinical and radiological data analysis. Clinical features, BT and tumor response according to mRECIST were analyzed. Post-LT OS and RFS according to this were compared.</div></div><div><h3>Results</h3><div>1,119 patients were included. Waiting time on transplant list was longer than 6 months in 49 % of patients and 67 % underwent BT. Transarterial-chemoembolization/embolization were the most common treatments performed (80 %). According to mRECIST, 37 % showed complete response (CR), 38 % partial response (PR), 12 % stable disease (SD) and 13 % progressive disease (PD). The OS was 63 % in 5y in a mean follow-up of 28 months. Post-LT tumor recurrence was 8 %. There were no differences in RFS or OS among patients who underwent or not BT. However, patients who achieved CR had a higher RFS compared to PR, SD or PD (<em>p</em> = 0.019) and the objective response to treatment was an independent predictor of lower recurrence risk.</div></div><div><h3>Conclusions</h3><div>In a large multicentric cohort of LT recipients we observed that patients that achieved CR after BT presented lower risk of post-LT tumor recurrence.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual hypothermic oxygenated machine perfusion (DHOPE) improves extended allocation graft function in liver transplantation","authors":"J Arend,&nbsp;A Bollensdorf,&nbsp;F Stelter,&nbsp;M Rahimli,&nbsp;RS Croner,&nbsp;M Franz","doi":"10.1016/j.liver.2025.100271","DOIUrl":"10.1016/j.liver.2025.100271","url":null,"abstract":"<div><h3>Background</h3><div>Patients with end-stage liver disease or liver tumours can only be treated curatively with liver transplantation (LTx). The glaring organ shortage and the increasing allocation of marginal donor organs is an international challenge. These organs can be accepted and transplanted with good results through preconditioning using machine perfusion (MP). This makes it possible to shorten the waiting list time and thus reduce the dropout rate from the waiting list, especially for patients with hepatocellular carcinoma.</div></div><div><h3>Materials and Methods</h3><div>The Magdeburg Liver Surgery Register/ Study was screened for the last 132 liver transplant patients. Of these, 18 were transplanted with Dual Hypothermic Oxygenated Machine (DHOPE) perfusion and 114 without (non-MP). Recipient demographic, perioperative and follow-up data were retrospectively collected and analysed. Donor data and risk factors were evaluated.</div></div><div><h3>Results</h3><div>The mean recipient age with DHOPE was 57.4 years vs. non-MP 55.9 years. The mean donor age was higher in the DHOPE Group (64.5 vs. 58.3 years, <em>p</em> = 0.073). The mean DHOPE time was 371.0 (57–945) minutes. The DHOPE reduced the cold ischemic time significant (7.1 vs. 8.4 h, <em>p</em> = 0.010). The Donor Risk Index was higher with DHOPE (1.903 vs. 1.889, <em>p</em> = 0.869). The rate of <em>Re</em>-LTx was 0 % vs 7.0 % with and without DHOPE (<em>p</em> = 0.299). The rate of EAD and primary non-function DHOPE vs. non-MP was 23.5 % vs. 27.8 % (<em>p</em> = 0.485) and 0.0 % vs. 5.3 % (<em>p</em> = 0.427). DHOPE significantly increased the rate of extended or rescue allocation from 26.3 % to 61.1 % (<em>p</em> = 0.003). With DHOPE, the donor age was higher (64.5 vs. 58.3 years, <em>p</em> = 0.0.073). The postoperative ICU time was significantly shorter after DHOPE (7.2 vs. 13.6 days, <em>p</em> = 0.044). The hospitalisation time after LTx was not significant, but it tended to be shorter at 28.7 vs 39.3 days (<em>p</em> = 0.097). The 1-year survival rate with and without DHOPE was 88,9 % vs. 80,3 % (<em>p</em> = 0593).</div></div><div><h3>Conclusion</h3><div>The increasing proportion of marginal donor organs requires optimisation of organ reconditioning, as is possible with Dual Hypothermic Oxygenated Machine Perfusion. Reduction of reperfusion damage leads to better postoperative graft function and thus faster convalescence. As the data show, marginal organs can be transplanted safely and with a good result using DHOPE.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial hepatic artery reperfusion for complex portal vein thrombosis in living donor liver transplantation: A case report","authors":"Takako Yamada Fujii ,&nbsp;Koichi Tanaka ,&nbsp;Takuya Kimura","doi":"10.1016/j.liver.2025.100276","DOIUrl":"10.1016/j.liver.2025.100276","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100276"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of living donor liver transplant in elevated body mass index over a decade in the United States","authors":"Marie L Jacobs ,&nbsp;Matthew Byrne ,&nbsp;Xueya Cai ,&nbsp;Shan Gao ,&nbsp;John Martens ,&nbsp;Luis I Ruffolo ,&nbsp;Ana Paula Cupertino ,&nbsp;Karen Pineda-Solis","doi":"10.1016/j.liver.2025.100274","DOIUrl":"10.1016/j.liver.2025.100274","url":null,"abstract":"<div><h3>Introduction</h3><div>Living donor liver transplant (LDLT) is a treatment option for end stage liver disease (ESLD). This study assesses the impact of recipient BMI on LDLT outcomes.</div></div><div><h3>Methods</h3><div>The United Network for Organ Sharing (UNOS) database was reviewed for adult LDLTs between January 2010 and December 2020. Recipients were stratified by BMI: Normal: &lt; 25 kg/m²; Overweight: 25 to &lt;30 kg/m², Class 1 Obesity: 30 to &lt;35 kg/m², and Class 2/3 Obesity: ≥35 kg/m². Recipient and donor characteristics, and post-transplant graft failure and mortality were compared.</div></div><div><h3>Results</h3><div>3068 patients were included. The mean age was 53 ± 13 years. The prevalence of diabetes and MASH cirrhosis was positively correlated with higher BMI groups (<em>p</em> &lt; 0.0001 and <em>p</em> &lt; 0.0001). At 5-years, graft failure (GF) in each group was 7.7 %, 5.2 %, 4.2 %, and 3.5 %, respectively (<em>p</em> = 0.0091). At 5 years, rate of death in each group was 11.2 %, 12.5 %, 10.7 %, and 10.4 %, respectively (<em>p</em> = 0.61). After controlling for patient demographics, clinical characteristics, and donor age, weight was no longer associated with graft failure or death.</div></div><div><h3>Conclusion</h3><div>In this retrospective analysis, recipient BMI did not correlate with death, and obesity is associated with lower rates of graft failure. Obesity alone should not preclude candidacy for LDLT.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100274"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De novo shrimp allergy in an adult liver transplant recipient","authors":"Jaimie Chang,&nbsp;Aryanna Sousa,&nbsp;Steven Flamm,&nbsp;Lloyd Brown,&nbsp;Edie Chan,&nbsp;Nathalie Sela","doi":"10.1016/j.liver.2025.100269","DOIUrl":"10.1016/j.liver.2025.100269","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic liver tumor classification using UNet70 a deep learning model","authors":"Yashaswini Gowda N ,&nbsp;Manjunath R V","doi":"10.1016/j.liver.2025.100260","DOIUrl":"10.1016/j.liver.2025.100260","url":null,"abstract":"<div><div>Diagnosing liver diseases using computed tomography (CT) images can be challenging even for experienced radiologists due to the complexities involved in evaluating the liver. Accurately determining the type, size and severity of tumors is often difficult. In recent years there has been a growing need for computer-assisted imaging techniques to aid in liver disease diagnosis ultimately improving clinical outcomes which in turn improves the life span of patients by early detection of the disease and treatment. This paper presents an innovative deep learning model UNet70 for liver tumor classification where CT images are categorized as either having a tumor (hepatocellular and Metastatic) or not. Our results show that the proposed model excels in terms of accuracy, sensitivity and dice score compared to other established algorithms and demonstrates excellent adaptability across various datasets. With an accuracy of 94.58 %, dice score of 94.73 % and sensitivity of 97.50 % the model outperforms existing methods showcasing its effectiveness.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"18 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143220291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From severe acute cholangitis to aggressive intrahepatic cholangiocarcinoma: Causal or coincidental association?","authors":"Victoria Ramdour ,&nbsp;Thomas Lévi-Strauss ,&nbsp;Patrick Chevallier ,&nbsp;Delphine Ouvrier ,&nbsp;Antonio Iannelli ,&nbsp;Albert Tran ,&nbsp;Rodolphe Anty","doi":"10.1016/j.liver.2024.100250","DOIUrl":"10.1016/j.liver.2024.100250","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"17 ","pages":"Article 100250"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}