Journal of Liver Transplantation最新文献

{"title":"Challenges in deceased organ transplantation in Pakistan: The final heroic act of a modern-day hero","authors":"Zubia Afzal , Abdul Rehman Gull","doi":"10.1016/j.liver.2024.100220","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100220","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100220"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000217/pdfft?md5=1ac5bef39f226bf8fca9ce963a96aba2&pid=1-s2.0-S2666967624000217-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140347310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak systolic velocity at arterial Doppler ultrasound in pediatric liver transplantation: A predictor of acute severe complications","authors":"Ana Coma ,&nbsp;Maria Victoria Fasano ,&nbsp;Alba Anton-Jimenez ,&nbsp;Jose Andres Molino ,&nbsp;Jesus Quintero ,&nbsp;Maria Margaret Mercadal-Hally ,&nbsp;Mercedes Perez ,&nbsp;Juan Ortega ,&nbsp;Jose Miguel Escudero-Fernandez ,&nbsp;Ernest Hidalgo ,&nbsp;Ramon Charco","doi":"10.1016/j.liver.2024.100218","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100218","url":null,"abstract":"<div><p>The diagnosis of arterial complications in children after Liver Transplantation (LT) urges prompt diagnosis and treatment. This study aims to determine whether hepatic artery Doppler Ultrasound (DUS) parameters can predict arterial complications in the immediate period after LT in children.</p><p>A retrospective review of the pediatric liver database at our tertiary-care pediatric hospital was performed. The study included 70 pediatric patients who underwent a liver transplantation from 2016 to 2021. Clinical, laboratory and Doppler findings were recorded daily the first 5 days after transplantation, with special attention given to post-anastomotic Peak Systolic Velocity (PSV) and Resistive Index (RI).</p><p>Patients with hepatic artery complications, including acute thrombosis and stenosis, had lower PSV values after surgery compared to the group with non-complications, with a statistical significance (&lt; 0.001). Receiver operating characteristic (ROC) curve analysis determined an optimal cut-off value of PSV less than 29 cm/s the 2nd day after LT, 25.2 cm/s the 3rd day, 28.5 cm/s the 4th day and 29.4 cm/s the 5th day, to discriminate children with and without hepatic arterial complications. Notably, these cut-off values are lower than those proposed in adults.</p><p>Optimal PSV cutt-off values in children in the immediate period after LT are presented. Knowledge of these cutt-off values improves the interpretation of DUS measurements and thereby, may help to accurately guide the clinical management.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000199/pdfft?md5=b0b504b7f877ad0272187a56db35fab6&pid=1-s2.0-S2666967624000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140347068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential bone marrow and combined liver-kidney transplantations for a non-amyloid light chain deposition disease: A unique case report with a complete remission at 6 years","authors":"Carolina R D Carmo ,&nbsp;Madalina Uzunov ,&nbsp;Nadia Arzouk ,&nbsp;Frederic Charlotte ,&nbsp;Magali Colombat ,&nbsp;Pascal Lebray","doi":"10.1016/j.liver.2024.100219","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100219","url":null,"abstract":"<div><p>Light Chain Deposition Disease (LCDD) is a rare monoclonal gammopathy characterized by deposition of light chains along the basement membranes of various organs, leading to progressive dysfunction (1,2). It has histological features that differ from amyloidosis and is most often characterized by the overproduction of kappa light chains (2). The kidney is usually the most affected organ and is responsible for the initial clinical manifestations, whereas liver dysfunction is less common and generally less severe than kidney involvement (1,3). We present a case of LCDD in a patient with renal dysfunction associated with secondary sclerosing cholangitis (SSC) and severe liver and kidney involvement, efficiently treated with autologous stem cell transplantation followed by double liver-kidney transplantation.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100219"},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000205/pdfft?md5=3f38ee5f3beb9fefcfaab667b14b0f90&pid=1-s2.0-S2666967624000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140344056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.liver.2024.100217","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100217","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000187/pdfft?md5=02d4281e9d3936ef6a0c876ce962b74a&pid=1-s2.0-S2666967624000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140321202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital diseases with multi-organ expression as an indication for liver transplantation in children during the first years of life: Integrative approach to improve the outcomes","authors":"Marina Moguilevitch,&nbsp;Ingrid Fitz-james","doi":"10.1016/j.liver.2024.100216","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100216","url":null,"abstract":"<div><p>Pediatric liver transplantation has evolved since the first transplant was performed by Dr. Starzl more than 50 years ago. Innovations in surgical techniques, immunosuppression, and infection control have significantly improved patient outcomes, graft survival, and quality of life. However, further progress depends not only on the discovery of new treatment option but should rely upon the identification of the factors in the perioperative care which contribute to successful outcomes and guide our decision-making process.</p><p>Indications for pediatric liver transplantation can be divided into three major groups: cholestatic liver conditions, liver based metabolic disorders, and others represented by acute liver failure of different etiologies, tumors, inherited autoimmune diseases, and multiple infectious causes.</p><p>Many of these conditions manifest themselves with multi organ pathologic expression, requiring earlier interventions to treat acute liver failure or chronic cholestasis leading to failure to thrive. Containment of patient pathology and maintenance of optimal neurologic and extra-hepatic visceral organ function is paramount during the pre - transplant period.</p><p>Multidisciplinary management of comorbid conditions in complex pediatric liver transplant candidates during the perioperative period with the emphases on optimization and patient selection has never been summarized in the literature. Thant is why this review focuses on a comprehensive, multidisciplinary preoperative evaluation of pediatric patients in whom progressive liver disfunction manifests early in life and eventually requires liver transplantation. We will address multi-organ system involvement, preoperative optimization in anticipation of the complexity of intraoperative care, as well as short- and long-term postoperative management.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000175/pdfft?md5=fb2348a21ad25fe272d50c01e1849aa6&pid=1-s2.0-S2666967624000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Subdural hematomas must remain a can't-miss diagnosis in patients who have undergone orthotopic liver transplantation with no history of trauma","authors":"Pranvera Sulejmani ,&nbsp;Morgan Sturgis ,&nbsp;Nathalie Sela","doi":"10.1016/j.liver.2024.100215","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100215","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000163/pdfft?md5=ab53591d76228ca2bf0152a19c336083&pid=1-s2.0-S2666967624000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor-specific antibodies and their impact on antibody-mediated rejection post-liver transplantation: A comprehensive review","authors":"Henry Sutanto ,&nbsp;Ummi Maimunah ,&nbsp;Deasy Fetarayani","doi":"10.1016/j.liver.2024.100214","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100214","url":null,"abstract":"<div><p>Antibody-mediated rejection (AMR) following liver transplantation is a significant clinical challenge, with donor-specific antibodies (DSAs) playing a pivotal role. Understanding the mechanisms and impact of DSAs is crucial for improving transplant outcomes and patient care. This review provides an in-depth analysis of the pathogenesis, diagnosis, and management of AMR in liver transplantation, focusing on the role of DSAs. AMR in liver transplants, though less common than in other organ transplants, presents unique diagnostic and therapeutic challenges. The review explores the latest diagnostic criteria, including serum DSAs, C4d staining, and liver biopsy findings. It delves into the pathogenesis of AMR, emphasizing the role of both preformed and de novo DSAs in causing graft injury and rejection. The review also discusses current therapeutic strategies, such as the use of immunosuppressants, plasmapheresis, intravenous immunoglobulin, and proteasome inhibitors, highlighting their efficacy and limitations. Furthermore, it examines the unique aspects of liver immunology that contribute to the organ's relative resistance to DSA-mediated injury. Emerging research, particularly on gene expression changes in renal allografts during simultaneous liver-kidney transplantation, is also discussed, offering insights into future directions. This review is instrumental for clinicians and researchers in understanding the complexities of AMR in liver transplantation and in developing more effective management strategies.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100214"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000151/pdfft?md5=53c1d35afbc728736fa6b921a12cb87e&pid=1-s2.0-S2666967624000151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming traditional barriers in living donor liver transplant","authors":"Reed T. Jenkins ,&nbsp;Al-Faraaz Kassam ,&nbsp;David J. Farhat ,&nbsp;Manuj M. Shah ,&nbsp;Damon Cooney ,&nbsp;Francis Tinney ,&nbsp;Ramy El-Diwany ,&nbsp;Shane E. Ottmann ,&nbsp;Andrew M. Cameron ,&nbsp;Ahmet Gurakar ,&nbsp;Russell N. Wesson ,&nbsp;Elizabeth King ,&nbsp;Benjamin Philosophe","doi":"10.1016/j.liver.2024.100212","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100212","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000138/pdfft?md5=4b404fd04ca6cc2c6d69447f60eb5993&pid=1-s2.0-S2666967624000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nivolumab as a bridge to liver transplantation in advanced hepatocellular carcinoma","authors":"Julie Sullivan,&nbsp;Steven Stanek,&nbsp;Richard Kalman","doi":"10.1016/j.liver.2024.100213","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100213","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696762400014X/pdfft?md5=fb588bef7752b98ff65590fc4063ad61&pid=1-s2.0-S266696762400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Sirolimus Immunosuppression on Cardiovascular Outcomes in Liver Transplantation","authors":"Ho Jason ,&nbsp;Breslin Zachary ,&nbsp;Lally Lauren ,&nbsp;Halegoua-DeMarzio Dina ,&nbsp;Tholey Danielle","doi":"10.1016/j.liver.2024.100211","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100211","url":null,"abstract":"<div><h3>Introduction</h3><p>Non-alcoholic steatohepatitis (NASH) is a rising cause of liver transplantation and is linked to higher rates of cardiovascular complications. The aim of this study was to evaluate the risk of post-transplant cardiac events in patients with NASH that were exposed to sirolimus (SRL) vs. calcineurin-inhibitor (CNI) immunosuppression.</p></div><div><h3>Methods</h3><p>We retrospectively reviewed all adult liver transplant recipients at our institution between 2002 and 2020. Subjects were grouped based on immunosuppressive regimen. We also analyzed the subgroup of patients with NASH as the primary indication for transplant, as well as a non-NASH subpopulation. The primary outcome measure was risk of major adverse cardiovascular events (MACE) post-transplant. Comparisons between groups were conducted with chi-squared tests. Univariate Cox regression and multivariate time-dependent Cox regression models were used to analyze the relationship between immunosuppression and MACE risk.</p></div><div><h3>Results</h3><p>803 liver transplant patients met criteria for study inclusion. Of these, 169 patients had NASH as their primary indication for liver transplant. 18 % of the study population received SRL immunosuppression post-transplant, and the remainder received only CNI immunosuppression. Post-transplant MACE occurred in 32.65 % of patients on SRL compared to 10.27 % in patients on CNI immunosuppression (<em>p</em> =&lt; 0.001). Without taking development of post-transplant CKD into account, our study showed a significantly higher risk of MACE with SRL immunosuppression in both the non-NASH cohort (HR 1.67, <em>p</em> = 0.036) and the NASH cohort (HR 2.48, <em>p</em> = 0.037. However, when accounting for post-transplant CKD, our analysis of the Non-NASH and NASH cohorts did not show a significantly greater risk of post-transplant MACE with SRL compared to CNI immunosuppression.</p></div><div><h3>Conclusions</h3><p>Our analysis shows that in both the NASH and non-NASH cohorts, liver transplant patients on sirolimus did not have a significantly higher risk of developing cardiovascular disease after transplant compared to immunosuppression with calcineurin inhibitors.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100211"},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000126/pdfft?md5=abc66d3a3bb07f5ce8bb95f336ea1beb&pid=1-s2.0-S2666967624000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}