Journal of Holistic Integrative Pharmacy最新文献

{"title":"Pharmacological underlying mechanisms of the anticancer effect of licorice: Bioinformatics and experimental verification","authors":"Mengqi Liu ,&nbsp;Lingping Fu ,&nbsp;Hao Fu ,&nbsp;Yu Chen ,&nbsp;Mengxia Wu ,&nbsp;Hanchun Liu","doi":"10.1016/j.jhip.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.jhip.2024.04.006","url":null,"abstract":"<div><h3>Purpose</h3><p>Cancer is the second leading cause of human mortality and has rapidly become a major global issue. According to traditional Chinese medicine (TCM) theory, the primary pathogenesis of cancer is the deficiency of \"vital Qi\". Licorice (Gancao in Chinese, GC) one of the oldest and the most frequently used herbs for tonifying Qi, is commonly integrated with other Chinese medicines to treat cancer in TCM clinical practice. GC extract, or its chemical components, are often utilized in cancer treatment. However, the molecular mechanisms underlying GC's therapeutic effects on cancer remain unclear. Our current study aimed to elucidate these mechanisms from the perspective of network pharmacology and experimental validation.</p></div><div><h3>Methods</h3><p>We employed network pharmacology and bioinformatics to explore the anti-cancer mechanism, crucial targets, and kernel ingredients of GC. The significant targets and key ingredients (quercetin, glycyrrhetinic acid, and glucyrin) were substantiated using the Cancer Genome Atlas (TCGA) and Cell Counting Kit-8 (CCK-8) viability assay, respectively.</p></div><div><h3>Results</h3><p>Our findings identified eight critical targets and key ingredients (quercetin, glycyrrhetinic acid, glucyrin) and suggested that GC's anti-cancer effects are primarily associated with modulation of the immune system, signal transduction, cell cycle, and gene expression. The efficacy of quercetin, glycyrrhetinic acid, glucyrin against Human A549 lung cancer cells was confirmed.</p></div><div><h3>Conclusion</h3><p>This study comprehensively elucidates the mechanisms through which GC addresses cancer, leveraging network pharmacology and experimental validation. These insights contribute to identifying principal compounds and developing innovative drugs for cancer therapy.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 1","pages":"Pages 45-55"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000219/pdfft?md5=3d1a92d2f359aeb92fc3bb5a4cde7208&pid=1-s2.0-S2707368824000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140947423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic evaluation of isosorbide mononitrate sustained-release capsules for the treatment of angina pectoris","authors":"Yuhang Liu ,&nbsp;Jienan Zheng ,&nbsp;Yeyou Xu ,&nbsp;Shuli Zhang ,&nbsp;Yueyun Li ,&nbsp;Hui Zhang","doi":"10.1016/j.jhip.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.jhip.2024.04.003","url":null,"abstract":"<div><h3>Objective</h3><p>Systematically evaluate the efficacy of (1) isosorbide mononitrate sustained-release capsules combined with conventional therapy and (2) conventional therapy alone in the treatment of angina pectoris and analyze their economic value to provide evidence and a reference for clinical medication and decision-making.</p></div><div><h3>Methods</h3><p>Randomized controlled trials on the efficacy of isosorbide mononitrate sustained-release capsules combined with conventional therapy and conventional therapy in the treatment of angina pectoris were searched and abstracted from major Chinese and English literature databases from August 26, 2003 to August 26, 2023, to calculate the rate of improvement in clinical symptoms using isosorbide mononitrate sustained-release capsules combined with conventional therapy (observation group) and using conventional therapy alone (control group). Review Manager 5.4 software was used for meta-analysis, and an economic evaluation was performed using cost-effectiveness analysis (CEA).</p></div><div><h3>Results</h3><p>The effectiveness rates for clinical symptom improvement were 95% in the observation group and 78% in the control group. According to the meta-analysis results, the efficiency of clinical symptom improvement in the observation group, which received the combination therapy with isosorbide mononitrate sustained-release capsules, was significantly better than that of the control group (OR ​= ​3.38, 95% CI: 2.28 to 4.99, <em>P</em> ​&lt; ​0.001). The CEA indicated an incremental cost-effectiveness ratio of 434.12 yuan, and the sensitivity analysis results demonstrated that the evaluation outcomes were stable, suggesting a robust foundation for the study's conclusions.</p></div><div><h3>Conclusions</h3><p>Compared with conventional therapy alone, isosorbide mononitrate sustained-release capsules combined with traditional treatment have good efficacy and safety in the treatment of angina pectoris and have certain economic advantages.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 1","pages":"Pages 56-62"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000189/pdfft?md5=bdf6519fe9293a110c942eacc49acc18&pid=1-s2.0-S2707368824000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140952202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danhong injection alleviates OGD-induced blood-brain barrier injury via VEGFR2/PI3K/AKT pathway based on network pharmacology and experimental evidence","authors":"Yutong Zhang ,&nbsp;Meixia Xie ,&nbsp;Jiayin Liang ,&nbsp;Li Li ,&nbsp;Shumei Wang ,&nbsp;Minghua Xian","doi":"10.1016/j.jhip.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.jhip.2024.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>Previous studies have shown that Danhong injection (DHI) has a protective effect on the blood-brain barrier (BBB) function after ischemic stroke. However, the role of DHI in protecting the integrity of the BBB after ischemic stroke through endothelial cells is still unclear. The purpose of this study is to explore the role and mechanism of DHI in protecting BBB by interfering with endothelial cells.</p></div><div><h3>Methods</h3><p>We used network pharmacology technology to determine the potential pathways and mechanisms of DHI in treating ischemic stroke through endothelial cells. On account of the network pharmacology results, we assessed the effects of DHI in oxygen-glucose deprivation (OGD) model of mouse brain-derived endothelial (bEnd.3) cells via MTT, and validated the molecular mechanisms of DHI improving BBB injury through Western blot.</p></div><div><h3>Results</h3><p>Network pharmacology analysis suggested that DHI may regulate the PI3K/AKT signaling pathway of endothelial cells in the treatment of ischemic stroke. Cellular experiments showed that DHI stimulates endothelial cell migration and reduces OGD-induced BBB damage via VEGFR2/PI3K/AKT pathway.</p></div><div><h3>Conclusion</h3><p>Network pharmacology analysis and cellular experiments have shown that DHI alleviated the BBB damage by activating the VEGFR2/PI3K/AKT signaling pathway on endothelial cells.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 1","pages":"Pages 10-18"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000165/pdfft?md5=acdc42b921cd0790171af8d8ea952319&pid=1-s2.0-S2707368824000165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140622257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Analysis of clinical drug use and construction of pharmacy service model for children with Kawasaki disease based on integration concept” [J Holist Integr Pharm (2023) 133–139]","authors":"Huashen He ,&nbsp;Yingyao Luo ,&nbsp;Binghong Yu ,&nbsp;Yingqiang Lai ,&nbsp;Jinkun Zheng ,&nbsp;Junfeng Ban","doi":"10.1016/j.jhip.2024.03.001","DOIUrl":"https://doi.org/10.1016/j.jhip.2024.03.001","url":null,"abstract":"","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 1","pages":"Page 1"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000141/pdfft?md5=362f95fa5f20ee7f1e6e361de8152970&pid=1-s2.0-S2707368824000141-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140343732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostic studies on three species of Spermacoce","authors":"Shan Fan,&nbsp;Wenfeng Weng,&nbsp;Shengguo Ji","doi":"10.1016/j.jhip.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.jhip.2024.03.002","url":null,"abstract":"<div><p>To provide a scientific basis for identification of <em>Spermacoce</em> species, including <em>Spermacoce remota</em> Lamarck, <em>Spermacoce exilis</em> (L. O. Williams) C. D. Adams, and <em>Spermacoce alata</em> Aubl., the current study was carried out for pharmacognostical parameters. Roots, stems, and leaves of plants were collected for pharmacognostical studies involving source identification, microscopic evaluation, character observation, phytochemical screening, ultraviolet spectrum and molecular pharmacognosy analysis. <em>S. remota</em>, <em>S. alata</em>, and <em>S. exilis</em> belong to the same genus, and the morphology of the plants was similar. Powder microscopy showed the presence of fibers, needle crystal bundles, spiral vessels, and near spherical pollen grains in all the plants. Phytochemical investigation demonstrated that <em>S. remota</em>, <em>S. alata</em>, and <em>S. exilis</em> all contained glycosides, proteins and volatile oils. In addition, the extracts of <em>S. alata</em> and <em>S. exilis</em> revealed the presence of flavonoids and tannins. In this study, the ITS sequence of <em>S. exilis</em> was found for the first time which had been submitted to NCBI to obtain the GenBank registration number. The results of neighbor-joining phylogenetic tree showed that <em>S. exilis</em>, <em>S. remota</em> and <em>S. alata</em> could be distinguished accurately. The study will be beneficial to the identification, resource conservation and quality control of <em>Spermacoce</em> species.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 1","pages":"Pages 2-9"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000153/pdfft?md5=d847d7f26f0deb88024f245cd579201b&pid=1-s2.0-S2707368824000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140345107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining single-cell RNA sequencing data and network pharmacology to explore the mechanism of action of Dayuan Yin in the treatment of acute lung injury","authors":"Lei Zhang,&nbsp;Wei Zhu,&nbsp;Zepeng Zhang,&nbsp;Yu Huang","doi":"10.1016/j.jhip.2024.01.002","DOIUrl":"10.1016/j.jhip.2024.01.002","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to analyze the usefulness of combined single-cell RNA sequencing data and network pharmacology in understanding the molecular regulation mechanism of Dayuan Yin (DYY) in acute lung injury (ALI).</div></div><div><h3>Methods</h3><div>The single-cell ALI dataset GSE224938 was acquired from the Gene Expression Database and cellular heterogeneity was examined using the Seurat software package. Differential expression analysis was conducted using the R software to identify genes with significant expression differences. The active constituents and therapeutic targets of DYY were acquired from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. Subsequently, the protein-protein interaction (PPI) networks, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) were employed to analyze the key targets. A visual network depicting the interaction between compounds, targets, and pathways was constructed, and the CytoNCA plug-in was utilized to identify core targets. The active component-core target relationship was validated using MOE, AutoDockTools, AutoDockVina, and other software. Finally, a preliminary experiment was conducted using the lipopolysaccharide-induced acute lung injury (ALI) rat model.</div></div><div><h3>Results</h3><div>In total, 5243 significantly differentially expressed genes were identified in ALI, and 260 genes were identified as DYY targets. Then, 81 target genes were identified at the intersection between drugs and diseases. The identified core target genes included PIK3R1, IL-1β, IL-6, ICAM1, and CCL2. GO analysis was mainly involved in cellular inflammatory response, dual regulation of cell apoptosis, and coordinated migration. KEGG analysis showed enrichment in inflammatory pathways. The major active components were well connected with IL-1β. DYY could significantly reduce the phosphorylation expression of PI3K, Akt, and NF-κBp65 in the lung tissue of ALI rats, and regulated the activation of related inflammatory cells.</div></div><div><h3>Conclusions</h3><div>We successfully screened the potential active ingredients of DYY for the treatment of ALI. In addition, in vivo experiments preliminarily verified the predictions of network pharmacology, showing that DYY can inhibit the PI3K/Akt/NF−КВ signaling pathway, reduce cytokine release and regulate the number of inflammatory cells, providing an alternative for ALI treatment.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"4 4","pages":"Pages 259-271"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in the regulation of secondary metabolism in medicinal plants by MYB transcription factors","authors":"Xi Huang ,&nbsp;Quan Yang ,&nbsp;Hongyang Gao","doi":"10.1016/j.jhip.2024.01.006","DOIUrl":"10.1016/j.jhip.2024.01.006","url":null,"abstract":"<div><div>MYB transcription factors (MYB TFs)are one of the largest families of transcription factors in plants, which are widely involved in various fields of plant growth and development, and play an important regulatory role in the biosynthesis of plant secondary metabolites. Most of the current studies on MYB transcription factors have focused on agricultural crops, and fewer studies have been conducted on medicinal plants. Therefore, this study reviews the research progress of plant MYB transcription factors in secondary metabolism of medicinal plants, which provides ideas and methods for better utilisation and development of medicinal plants.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"4 4","pages":"Pages 287-292"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamins strategies for psoriasis: An update on current scientific evidence","authors":"Suyash Agnihotri ,&nbsp;Jasleen Kaur ,&nbsp;Priya Masand ,&nbsp;Anurag ,&nbsp;Vipan Kumar Parihar ,&nbsp;Alok Sharma","doi":"10.1016/j.jhip.2024.01.005","DOIUrl":"10.1016/j.jhip.2024.01.005","url":null,"abstract":"<div><div>Psoriasis is an aggressive chronic skin disorder that requires various therapies such as topical, oral, and occasionally, subcutaneous, or intravenous. In contrast, vitamins have more significant evidence in alteration to first-line therapies in the treatment of psoriasis. Vitamins such as fat-soluble and water-soluble supplements act as a secondary treatment that is given to reduce possible adverse effects from systematic medication, increase patient compliance, and consider affordable treatment costs. Here, the comparative study was conducted based on the data search from Pub Med, Google Scholar, Willy Library, etc., for both fat and water-soluble vitamins in psoriasis treatment first time. The present review summarizes the role of fat-soluble vitamins (A, D, E) and water-soluble vitamins (B₂, B₆, B₁₂, and C) based therapies in psoriasis treatment and result highlights the efficiency of oral supplementation of vitamins in psoriasis and systematic inflammation. Further, clinical studies along with <em>in-vitro</em> and <em>in vivo</em> based investigations have been compiled in this review, which shows that vitamins effectively can manage psoriasis. Additionally, the present review consists of chemical identification of both fat and water-soluble vitamins by High Performance Liquid Chromatography. The role of vitamins therapies in psoriasis management is promising and can be further to give in new horizon for improving the treatment efficacy. This review could provide an insight into vitamins emerging therapy in the treatments of psoriasis.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"4 4","pages":"Pages 299-309"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying candidate drugs based on transcriptional landscape associated with triple-negative breast cancer","authors":"Yuqin Lin ,&nbsp;Yanghong Zhu ,&nbsp;Xiang Li ,&nbsp;Qi Chen ,&nbsp;Guoyu Wu","doi":"10.1016/j.jhip.2023.12.001","DOIUrl":"10.1016/j.jhip.2023.12.001","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) is a special type of breast cancer in which ER, PR and HER2 are all negative, characterized by high malignancy, strong invasiveness, and high recurrence rate. It is critical to develop novel drugs for improved therapies for triple-negative breast cancers. Here, we unveiled the transcriptional landscape associated with triple-negative breast cancer and identified candidate drugs using a comprehensive connectivity map. The candidate components could induce reverse expressions of the TNBC gene expression signature and trigger transcriptional reprogramming with a positive impact on modulating chemoresistance and the survival probability of breast cancer patients. Our study also provided an example of drug discovery using <em>in silico</em> drug screening followed by further validations, illustrating an effective computational drug discovery strategy.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"4 4","pages":"Pages 318-324"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic effects of Zingiberis Rhizoma Preparatum (Pao-Jiang) against DSS-induced ulcerative colitis in mice by metabolomics-guided analysis","authors":"Jianliang Geng ,&nbsp;Chen Chen ,&nbsp;Dabo Pan ,&nbsp;Qiuhong Wang","doi":"10.1016/j.jhip.2024.01.001","DOIUrl":"10.1016/j.jhip.2024.01.001","url":null,"abstract":"<div><div>Zingiberis Rhizoma Recens (Sheng-Jiang) is a kind of edible and medicinal plant resource in China. Both Zingiberis Rhizoma Recens and its dried form, Zingiberis Rhizome (Gan-Jiang), have been widely used in traditional Chinese medicine prescriptions for the treatment of digestive disease. Based on traditional Chinese medicine (TCM) theory, the heat-processed product of Zingiberis Rhizome, Zingiberis Rhizoma Preparatum (Pao-Jiang) is more effective in arresting bleeding and alleviating pain, which is suitable for relieving the classic symptoms of ulcerative colitis (UC), a chronic relapsing idiopathic inflammation of the gastrointestinal tract. In present study, the pharmacological evaluation combined with metabolomics-guided analysis were applied to explore the intestinal protective effects and mechanism of Pao-Jiang on dextran sulfate sodium (DSS)-induced colitis mouse model. The pathological and biochemical tests showed that the water and alcohol extracts of Gan-Jiang and Pao-Jiang could reduce the disease activity index (DAI) and colon tissue damage, inhibit the secretion of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and leukocyte-mediated interleukin-1β and 6 (IL-1β and IL-6), and alleviate abnormal histopathological changes of UC mice in various degrees. The alcohol extracts of Pao-Jiang showed relatively better effects. Untargeted and targeted metabolomic profiling revealed that the alcohol extracts of Pao-Jiang can significantly reverse the UC induced metabolic perturbations, especially focuses on bile acids metabolism, eicosanoids and phospholipids metabolism. Furthermore, comparative chemical profiling and molecular docking analysis indicated that the contents of shogaols and gingerdiones in Pao-Jiang increased after heating processing and may contribute to the regulatory effects of bile acid synthesis and transport by interacting with CYP7A1, BSEP and IBABP, and promote the anti-inflammatory effects. This study expands our knowledge about potential function of Gan-Jiang and Pao-Jiang, and are of significance for providing insights into the scientific connotation of traditional Chinese medicine processing methods.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"4 4","pages":"Pages 272-280"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143291709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}