Journal of Holistic Integrative Pharmacy最新文献

{"title":"Enlightenment of EU Herbal Medicinal Products regulation on the registration of Traditional Chinese Medicines in the Guangdong-Hong Kong-Macao Greater Bay Area","authors":"Ran Xiong ,&nbsp;Hui Zhang ,&nbsp;Yueyun Li ,&nbsp;Guihao Zeng ,&nbsp;Yonghui Liu ,&nbsp;Yeyou Xu","doi":"10.1016/j.jhip.2024.11.005","DOIUrl":"10.1016/j.jhip.2024.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study analyzes the European Union's (EU's) regulatory practices of Herbal Medicinal Products (HMPs), aiming to provide implications for Traditional Chinese Medicines (TCMs) registration process within the Guangdong-Hong Kong-Macao Greater Bay Area (GBA).</div></div><div><h3>Methods</h3><div>This paper conducts a comparative analysis of the regulatory agencies, legal frameworks, registration classifications, market authorization procedures, and the number of applications and approvals for both HMPs in the EU and TCMs in the GBA, thereby identifying the distinctive regulatory features across these regions.</div></div><div><h3>Results</h3><div>Our study finds that the EU has established a scientific, efficient, and harmonized regulation system for HMPs, whereas the registration of TCMs in the GBA is characterized by complexity and jurisdictional disparities in requirements and procedures. Drawing on the EU's advanced regulatory practices, the study offers recommendations to enhance the mutual recognition and accessibility of TCMs within the GBA.</div></div><div><h3>Conclusion</h3><div>This study offers a comprehensive understanding of the EU's HMPs regulation and the GBA's TCMs registration, contributing to the synergistic development of TCMs in the GBA.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 4","pages":"Pages 344-353"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the mechanism of Lingbao Huxin Dan in the treatment of bradycardia based on atrioventricular node electrical signal conduction","authors":"Jing Zhang ,&nbsp;Guobin Zheng ,&nbsp;Shangjing Liu ,&nbsp;Yaodong Miao ,&nbsp;Shu Yang ,&nbsp;Sheng Li ,&nbsp;Zhihui Yang ,&nbsp;Danping Zhuo ,&nbsp;Rui Guo ,&nbsp;Yang Guo ,&nbsp;Rongjiang Shao ,&nbsp;Yunqing Hua ,&nbsp;Chuanrui Ma","doi":"10.1016/j.jhip.2024.12.003","DOIUrl":"10.1016/j.jhip.2024.12.003","url":null,"abstract":"<div><h3>Background</h3><div>Prolonged bradycardia leads to inadequate pumping of the heart, causing myocardial ischemia, which in turn affects cardiac function. Depending on its clinical features, improving the AV node conduction block may be an important tool to inhibit the progression of the disease. Lingbao Huxin Dan, which consists of several traditional Chinese medicines, is used for conditions similar to bradycardia and may be a potential therapeutic agent for bradycardia. In this experiment, we investigated its therapeutic significance and possible therapeutic targets for sinus bradycardia.</div></div><div><h3>Methods</h3><div>The bradycardia model of SD rats was prepared by using acetylcholine, propranolol, and verapamil respectively, and treated with Lingbao Huxin Dan for 3 weeks. At the end of treatment, the rats' ECG was recorded using a PV-LOOP heart rate recorder. The hearts and serum samples were collected to detect heart rate and related gene expression which were screened through network pharmacology analysis, as well as to evaluate the effect of Lingbao Huxin Dan on ion channels in the cardiac conduction system.</div></div><div><h3>Results</h3><div>Lingbao Huxin Dan improved the heart rate in the bradycardia model of SD rats and inhibited AV node conduction block by targeting ion channel proteins in the cardiac conduction system. The underlying molecular mechanism may be the activation of the β-adrenergic receptor-dependent cAMP/PKA signaling pathway targeted to enhance the expression of the pacing channel HCN4. In addition, Lingbao Huxin Dan prevented the deterioration of bradycardia by promoting the production of the oxygen radical scavenger SOD and inhibiting the upregulation of LDH due to cardiomyocyte damage.</div></div><div><h3>Conclusions</h3><div>Our study proved that Lingbao Huxin Dan alleviated bradycardia by downregulating CX45 and enhancing the expression of HCN4, ADRβ1, and TRPM7 to shorten the atrioventricular node induction period and improve sinoatrial node signaling. In addition, Lingbao Huxin Dan relieved myocardial injury induced by bradycardia by reducing the level of oxygen free radicals in the cardiac microenvironment.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 4","pages":"Pages 333-343"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network pharmacology-based study on the mechanism of Yiwei Decoction in chronic atrophic gastritis and experimental assessment","authors":"Zepeng Zhang ,&nbsp;Ju Liu ,&nbsp;Yi Wang ,&nbsp;Xiwen Li ,&nbsp;Manman Guo ,&nbsp;Menglei Ding ,&nbsp;Tongtong Zhu ,&nbsp;Lei Zhang","doi":"10.1016/j.jhip.2024.11.004","DOIUrl":"10.1016/j.jhip.2024.11.004","url":null,"abstract":"<div><h3>Objective</h3><div>Yiwei Decoction (YWD) is an ancient TCM formula with historical use in treating chronic atrophic gastritis (CAG). However, its pharmacodynamic mechanisms remain poorly understood. This study aims to study the effect of YWD on CAG through network pharmacology and experimental verification.</div></div><div><h3>Methods</h3><div>UPLC/MS and the SwissADME database were employed to identify active compounds in YWD. YWD targets were screened by SwissTargetPrediction databases, CAG targets were screened by databases, and the two were intersected for PPI network analysis. The target prediction was performed by GO and KEGG analysis. H₂O₂-induced injury models were established in zebrafish and GES-1 ​cells, which were subsequently treated with varying doses of YWD. Oxidative stress indicators and apoptosis and inflammation levels in zebrafish and GES-1 ​cells were assessed using fluorescence microscopy, flow cytometry, and microplate reader assays. The binding capabilities of the core components and core targets were examined using molecular docking. Q-PCR and Western blot were employed to analyze the expression levels of Nrf2, Keap1, and HO-1, respectively.</div></div><div><h3>Results</h3><div>Forty-nine compounds were identified from YWD. Network pharmacological analysis suggested that YWD may treat CAG by modulating redox-related signaling pathways, inhibiting apoptosis, and reducing inflammation. Subsequent <em>in vitro</em> and <em>in vivo</em> experiments validated these predictions. YWD effectively mitigated H₂O₂-induced oxidative stress in zebrafish and GES-1 ​cells, suppressing ROS and decreasing apoptosis. YWD reduced inflammation in gastric epithelial cells. Molecular docking results suggested that methylophiopogonanone A and imperatorin may play a key role in the treatment of YWD. Mechanistically, YWD activated the Nrf2 signaling pathway, downregulated Keap1 expression, and upregulated HO-1 and Bcl2 expression.</div></div><div><h3>Conclusion</h3><div>YWD could improve oxidative stress indicators, inhibiting cell apoptosis, reducing inflammation, and its molecular mechanism of the CAG treatment may be through the Keap1/Nrf2/HO-1 pathways, and to promote the body's antioxidant system.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 4","pages":"Pages 277-290"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143174792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary metabolites from the cold-seep-derived fungus Penicillium sp. SCSIO 41425 and their free radical scavenging activity","authors":"Yi Chen ,&nbsp;Ying Liu ,&nbsp;Jianglian She ,&nbsp;Mengjing Cong ,&nbsp;Junfeng Wang ,&nbsp;Lalith Jayasinghe ,&nbsp;Yonghong Liu ,&nbsp;Xuefeng Zhou","doi":"10.1016/j.jhip.2024.10.002","DOIUrl":"10.1016/j.jhip.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>To study the chemical compositions from <em>Penicillium</em> sp. SCSIO 41425 and explore their DPPH radical scavenging activity.</div></div><div><h3>Methods</h3><div>Ethyl acetate extract of <em>Penicillium</em> sp. SCSIO 41425 was separated and purified by silica gel, Ostade-cylsilane (ODS), semi-preparative HPLC, and thin layer chromatography, and their structures were determined by spectroscopic analysis and comparison with the reported literatures.</div></div><div><h3>Results</h3><div>A total of 18 compounds were isolated from <em>Penicillium</em> sp. SCSIO 41425, including one new compound, (2′<em>R</em>,3′<em>R</em>)-4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol (<strong>1</strong>) and seventeen known compounds (<strong>2</strong>–<strong>18</strong>). Their structures were elucidated by detailed NMR and ECD calculations. Compounds <strong>4</strong> and <strong>5</strong> exhibited potent DPPH radical scavenging activity, with EC₅₀ values of 8.42 and 6.62 ​μg/mL, which were stronger than the positive control ascorbic acid (EC₅₀, 11.22 ​μg/mL).</div></div><div><h3>Conclusion</h3><div>This study expands the natural product library of marine cold-seep-derived fungus and provides marine-derived drug source molecules for potent antioxidants.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 4","pages":"Pages 257-261"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The versatility of apigenin: Especially as a chemopreventive agent for cancer","authors":"Om Prakash ,&nbsp;Amit Kumar ,&nbsp;Salil Tiwari,&nbsp;Priyanka Bajpai","doi":"10.1016/j.jhip.2024.10.001","DOIUrl":"10.1016/j.jhip.2024.10.001","url":null,"abstract":"<div><div>Apigenin, a naturally occurring flavonoid found in fruits and vegetables, has received substantial attention due to its various pharmacological effects, particularly in cancer therapy. This review delves deeply into apigenin's phytochemical properties and pharmacological activity, with a particular emphasis on its potential as a targeted cancer therapy. We conducted an exhaustive literature study to investigate the molecular processes underlying apigenin's anticancer actions, such as its ability to induce apoptosis, block angiogenesis, and decrease metastasis. We also examine its synergistic effects with conventional chemotherapy drugs and its potential as an adjuvant therapy. Furthermore, the paper discusses current advances in nanoparticle-based delivery systems that improve the bioavailability and efficacy of apigenin in cancer treatment. This detailed investigation aims to provide insights into apigenin's therapeutic capabilities and future possibilities in targeted cancer treatment.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 4","pages":"Pages 249-256"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in application of alginate gel as tumor drug delivery carrier, for tumor localization and 3D tumor cell model","authors":"Lili Huang ,&nbsp;Yicong Lei ,&nbsp;Yucheng Chen ,&nbsp;Xin Hu ,&nbsp;Chengyu Huang ,&nbsp;Huaqing Lin","doi":"10.1016/j.jhip.2024.08.003","DOIUrl":"10.1016/j.jhip.2024.08.003","url":null,"abstract":"<div><p>As one of the hot materials in biomedical research, alginate gel shows great potential in tumor therapy with its unique physical and chemical properties. In order to better meet the complex needs of cancer treatment, alginate brine gel composite system has come into being. This system not only inherits many advantages of single alginate brine gel, but also significantly improves the mechanical properties of the material through compounding, and effectively overcomes the limitations of application. These composites have been applied to drug delivery carriers, tumor targeting systems and three-dimensional tumor cell models in various forms, showing a wide range of application prospects. This paper aims to review the basic structure and properties of alginate gel and analyze the research progress of alginate gel composite systems in the field of cancer in recent years, to provide a valuable reference for the further expansion of the application of this material in tumor therapy.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 3","pages":"Pages 174-184"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S270736882400044X/pdfft?md5=f29f11a86eb718a899081ba88a8a3df2&pid=1-s2.0-S270736882400044X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise therapy: Anti-tumor and improving chemotherapy efficacy","authors":"Zhongyu Wang ,&nbsp;Zongming Wang ,&nbsp;Huitong Chen ,&nbsp;Siyuan Li ,&nbsp;Junhua Yang ,&nbsp;Yuxin Ma ,&nbsp;Chang Zhou ,&nbsp;Xiaobao Jin ,&nbsp;Jing Liu ,&nbsp;Xin Wang","doi":"10.1016/j.jhip.2024.09.001","DOIUrl":"10.1016/j.jhip.2024.09.001","url":null,"abstract":"<div><p>The extant research evidence indicates that sensible exercise has a beneficial impact on the prevention and treatment of cancer. This paper presents a comprehensive literature review of the field of sports oncology. Its objective is to synthesize and analyze the impact of exercise training on cancer, as well as to elucidate the mechanisms through which exercise affects cancer progression. Additionally, it offers valuable insights for advancing fundamental and clinical research in sports oncology. Firstly, this paper provides a summary of the relationship between exercise and various aspects of tumor progression, including tumor size, weight, metastasis, tumor vascularity, myokine production, immune response, and the efficacy of cancer chemotherapy. Secondly, due to the diversity of tumor properties, we also explore the fact that the specificity of exercise prescription should be tailored to the different tumor types and patient profiles. Furthermore, we discuss the importance of considering individual differences when determining the type of exercise, intensity, intervention, and duration of exercise. Finally, this paper emphasizes the necessity of evaluating the interaction between exercise and conventional or novel immunotherapies and pharmacodynamics in future preclinical studies.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 3","pages":"Pages 185-194"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000463/pdfft?md5=1c425ff73e1b4b3311bda377509f1338&pid=1-s2.0-S2707368824000463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The research advance on the theory of Chinese medicine-exterior-interior correlation between the Lung and Large Intestine in the treatment of chronic cough","authors":"Meng Yuan ,&nbsp;Hongyuan Chen ,&nbsp;Wen Rui","doi":"10.1016/j.jhip.2024.09.004","DOIUrl":"10.1016/j.jhip.2024.09.004","url":null,"abstract":"<div><p>Coughing as the main symptom of a chronic cough is a persistent respiratory disease that poses a substantial challenge to Western medicine and traditional Chinese medicine (TCM). The Large Intestine and Lung are intimately related, impacting each other's pathology and physiology, according to TCM theory. This complex interaction emphasizes how crucial it is to treat both organs at the same time while treating cough to support gut health. This viewpoint is further supported by current research, which demonstrates the connections between the Large Intestine and the Lung through a variety of pathways, including neurological pathways, mucosal immune system modulation, gas exchange dynamics, and microbiota composition. To clarify the mechanisms and practical applications of treating chronic cough by concurrently targeting the Lung and Intestine in TCM, this paper merges ideas from TCM theory and empirical research in Western medicine. This provides insightful information for efficiently managing chronic cough.</p></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 3","pages":"Pages 195-204"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000499/pdfft?md5=289fa59ec45c85a0aeb3b087762f597e&pid=1-s2.0-S2707368824000499-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and risk control study of antibody preparation based on CiteSpace","authors":"Chanyuan Chen ,&nbsp;Rong Wang ,&nbsp;Yuanxuan Cai ,&nbsp;Yuhang Zhao ,&nbsp;Zherui Chen ,&nbsp;Ke Li ,&nbsp;Li Zhao ,&nbsp;Rui Huang ,&nbsp;Nooruldeen Riyadh Ibrahim ,&nbsp;Xiaofang Shangguan","doi":"10.1016/j.jhip.2024.08.002","DOIUrl":"10.1016/j.jhip.2024.08.002","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the hotspots, patterns, and distribution of research on the safety and risk of antibody preparations in the past 20 years. It also seeks to summarize the current status and trends of research on the safety and risk control of antibody preparations.</div></div><div><h3>Methods</h3><div>Taking “antibody preparation”, “safety” and “risk” as keywords, relevant articles were searched in the databases Web of Science. CiteSpace was utilized to analyze the annual number of publications, countries, authors, institutions, highly cited literature and keywords of the screened literature, and the relevant maps were drawn and the results were analyzed.</div></div><div><h3>Results</h3><div>A total of 1693 articles were included. The annual number of publications in the field of antibody preparation safety has shown stable growth followed by a rapid increase between 2002 and 2022. Among the countries, the United States accounted for 36.7% of the total publications, ranking first in the world. Large foreign pharmaceutical companies, research institutions, comprehensive university and their affiliated hospitals were the most high-yield institutions. Current hot topics in the field of antibody preparation safety research include “ADC”, “monoclonal antibody”, “anti-tumor activity”, “immunotherapy”, etc.</div></div><div><h3>Conclusion</h3><div>Over the past 20 years, research on antibody formulations has garnered increasing attention both domestically and internationally, with a focus mainly on efficacy and safety. There has been relatively little research on risk control. In the future, more in-depth research is needed on the mechanisms of adverse reactions in antibody formulations to provide more effective strategies for risk control.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 3","pages":"Pages 215-222"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000438/pdfft?md5=dbd847feccf183fe426029fd67f3c531&pid=1-s2.0-S2707368824000438-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling","authors":"Xing Chang ,&nbsp;Meng Cheng ,&nbsp;Ying Li ,&nbsp;Xiuteng Zhou","doi":"10.1016/j.jhip.2024.08.004","DOIUrl":"10.1016/j.jhip.2024.08.004","url":null,"abstract":"<div><div>Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties and the main active component isolated from the rhizome of <em>Pueraria lobata</em>. PUE exhibits a good anti-atherosclerotic pharmacological effect, but there are few studies on the mechanism of its protective effect on endothelial cells. This study found that PUE could regulate to some extent the mitochondrial function of human umbilical vein endothelial cells (HUVECs) and reduce or inhibit lipopolysaccharide-induced inflammatory reactions and oxidative stress injury in HUVECs. Furthermore, the protective effect of PUE on HUVECs was closely related to the SIRT-1 signaling pathway. PUE increased the level of mitophagy and the activity of mitochondrial antioxidant enzymes by increasing SIRT-1 expression, reducing excessive production of ROS, and inhibiting expression of inflammatory factors and oxidative stress injury. Therefore, PUE may improve mitochondrial respiratory function and energy metabolism and increase the activity of HUVECs in the inflammatory state.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"5 3","pages":"Pages 205-214"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2707368824000451/pdfft?md5=32ba5f3ca37031f4c62e8b1d9b7d5c7d&pid=1-s2.0-S2707368824000451-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}