Journal of Holistic Integrative Pharmacy最新文献

{"title":"The impact of solvent composition, concentration, and temperature on the solubility of naproxen: A review of mono-solvent, binary, and ternary systems","authors":"Abdolhamid Khodadadi ,&nbsp;Shirin Boghrat ,&nbsp;Zahra Besharati ,&nbsp;Seyed Hossein Hashemi","doi":"10.1016/j.jhip.2025.12.004","DOIUrl":"10.1016/j.jhip.2025.12.004","url":null,"abstract":"<div><div>Solubility is a key factor affecting drug absorption and therapeutic effectiveness. Naproxen, a common anti-inflammatory medication, has poor water solubility, which limits its bioavailability. This review thoroughly explores various solvent-based approaches to overcome this issue. It discusses mono-solvent systems (acetone, chloroform, β-cyclodextrins), binary systems (ethanol, PEG, PG, deep eutectic solvents), and ternary systems that combine water with co-solvents and additives like HPβCD and L-arginine. The review also assesses advanced techniques such as supercritical CO₂ and CO₂-expanded solvents. Findings show that solvent type, hydrogen bonding ability, and molecular interactions play crucial roles in improving solubility. Ternary systems exhibit notable synergistic effects, and deep eutectic solvents present promising eco-friendly alternatives. In conclusion, careful selection and combination of solvents can significantly enhance naproxen's solubility, guiding future research toward optimizing formulations for pharmaceutical and industrial uses.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 4","pages":"Pages 427-442"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the extraction, separation, purification, detection of flavonoids from aging Citri Reticulatae Pericarpium and its beneficial effects on spleen deficiency","authors":"Leixi Ye ,&nbsp;Le Yu ,&nbsp;Hongjie Xu ,&nbsp;Kunyi Liu ,&nbsp;Yunqi Shan ,&nbsp;Quan Yang ,&nbsp;Xiaoming Sun","doi":"10.1016/j.jhip.2025.12.001","DOIUrl":"10.1016/j.jhip.2025.12.001","url":null,"abstract":"<div><div>Citri Reticulatae Pericarpium (CRP) plays beneficial effects on regulating Qi and strengthening spleen, drying dampness, and resolving phlegm in traditional Chinese medicine. This review centered on the advantageous impacts of flavonoids regarding spleen deficiency as well as their extraction, separation, and purification procedures, aiming to disclose the characteristics manifested in spleen deficiency conditions. The existing literature has not merely shed light on the therapeutic mechanisms underlying CRP flavonoids within the digestive tract, but has also highlighted their cooperative and amplifying impacts on other organs. By integrating these diverse strands of research, a more in-depth understanding of the pharmacological actions of CRP has emerged, providing a fresh theoretical framework for deciphering the scientific significance of aged CRP.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 4","pages":"Pages 415-426"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative network pharmacology and transcriptomics suggest the mechanism of Buyang Huanwu Decoction in attenuating vascular aging via AMPK signaling pathway","authors":"Xuejuan Shen ,&nbsp;Jieyong Du ,&nbsp;Xiangyu Chen ,&nbsp;Xiaodie Chen ,&nbsp;Nan Xiao ,&nbsp;Danping Huang ,&nbsp;Yubin Yang ,&nbsp;Rong Chen ,&nbsp;Zunpeng Shu ,&nbsp;Li Zhang","doi":"10.1016/j.jhip.2025.09.004","DOIUrl":"10.1016/j.jhip.2025.09.004","url":null,"abstract":"<div><h3>Objective</h3><div>Vascular aging is a critical factor in cardiovascular diseases. Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, shows potential in delaying vascular aging, yet its mechanisms remain unclear. This study aims to explore BYHWD's pharmacological mechanisms through integrative network pharmacology and transcriptomics.</div></div><div><h3>Methods</h3><div>Network pharmacology identified BYHWD targets related to aging, followed by pathway enrichment analysis. Vascular histopathology was evaluated using HE, Masson, and EVG staining. Senescence biomarkers SA-<em>β</em>-gal, advanced glycation end products (AGEs), p16, p21, and p53 were determined. Oxidative-inflammatory markers were quantified via ELISA and RT-qPCR. Transcriptomic profiling used Illumina NovaSeq. AMP-activated protein kinase (AMPK) signaling pathway analysis employed immunohistochemistry.</div></div><div><h3>Results</h3><div>Network pharmacology identified 103 key targets, including SIRT1 and AMPK, related to oxidative stress and inflammation. In the D-galactose-induced aging model rats, BYHWD treatment significantly reduced vascular media thickness by 28% in the medium-dose group, collagen deposition, and markers of senescence, such as SA-<em>β</em>-gal, AGEs, p16, p21, and p53. Transcriptomics revealed AMPK signaling pathway enrichment, and further experiments revealed that BYHWD mediates its effects involving activation of the AMPK/Sirt1/Foxo3a axis, a key regulator of vascular homeostasis.</div></div><div><h3>Conclusion</h3><div>BYHWD may attenuate vascular aging by AMPK-mediated regulation of oxidative stress and inflammation, providing a novel multi-target strategy against age-related cardiovascular diseases. The underlying molecular mechanism still needs to be further clarified.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 276-289"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrative framework for precision medication in hypertension: Applying a dialectical perspective to traditional Chinese and Western medicine","authors":"Jinliang Liu ,&nbsp;Jiena Xiao ,&nbsp;Zhongwei Lin ,&nbsp;Mingzhu Xiao","doi":"10.1016/j.jhip.2025.09.001","DOIUrl":"10.1016/j.jhip.2025.09.001","url":null,"abstract":"<div><div>Hypertension is the most common cardiovascular disease. In terms of diagnosis and treatment, Traditional Chinese Medicine (TCM) and Western medicine each have their own strengths, but also have certain limitations. Affected by the combined effects of genetic and environmental factors, the pharmacotherapy of hypertension shows significant individual differences. Therefore, how to integrate the advantages of TCM and Western medicine to achieve precision medication has become an important research topic. A single diagnostic and therapeutic model is difficult to take into account both the characteristics of TCM's \"holistic regulation\" and Western medicine's \"precision intervention\": TCM focuses on holistic syndrome differentiation and the restoration of bodily balance, yet it is relatively vague in the analysis of disease mechanisms and the identification of drug targets; Western medicine excels in targeted therapy, but often overlooks the patient's overall physiological state and the holistic progression of the disease. In the current development of precision medication, the concept of integrative pharmacy provides important support. By systematically integrating multi-source knowledge and technical means, it is committed to combining the macro-holistic perspective with micro-precision intervention, and provides a practical framework for the integration and innovation of TCM and Western medicine. Against this background, TCM takes \"holistic concept\" and \"syndrome differentiation and treatment\" as its fundamentals, and devotes itself to maintaining the dynamic balance of human body functions; Western medicine, relying on advanced tools such as genomics and proteomics, emphasizes the precise identification of etiologies and targeted therapy. The two show a dialectical unity in concepts and methods, and jointly serve the realization of the goal of individualized treatment for hypertension. With \"principle, method, prescription, and medicine\" as the logical main line, this paper systematically explores the diagnostic and therapeutic ideas and practical strategies of TCM and Western medicine for hypertension, and expounds on how to take integrative pharmacy as a bridge to incorporate the holistic thinking of TCM into the modern precision medication system, thereby providing theoretical references and practical paths for promoting the integrated diagnosis and treatment of hypertension with TCM and Western medicine and the implementation of precise drug intervention.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 290-300"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analysis establishes a causal relationship between COVID-19 and cardiometabolic diseases","authors":"Haibo Chen ,&nbsp;Lizhen Liao ,&nbsp;Zezhi Ke ,&nbsp;Xu Zhang ,&nbsp;Xiaodong Zhuang ,&nbsp;Xin Gao ,&nbsp;Litao Pan","doi":"10.1016/j.jhip.2025.08.001","DOIUrl":"10.1016/j.jhip.2025.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>The causal impacts of COVID-19 on cardiometabolic diseases remained uncertain. This study utilized the two-sample Mendelian randomization (MR) method to evaluate causal relationships between COVID-19 (susceptibility and severity) and four primary cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischemic stroke, and heart failure).</div></div><div><h3>Methods</h3><div>MR analysis was conducted using genome-wide association study (GWAS) results. Susceptibility and severity were defined as COVID-19-positive and COVID-19-hospitalization, respectively. Data from the COVID-19 Host Genetics Initiative were used for susceptibility and severity analysis. Consortium data from Spracklen CN, Nikpay, Malik R, and Neale lab were employed for type 2 diabetes, coronary heart disease, ischemic stroke, and heart failure, respectively.</div></div><div><h3>Results</h3><div>For COVID-19 susceptibility, the inverse variance weighted (IVW) method showed the odds ratio (OR) (95% confidence interval [CI], <em>P</em>-value) for type 2 diabetes was 1.719 (1.510–1.956, <em>P</em> ​= ​0.000). For COVID-19 severity, the IVW method estimate indicated that the OR (95% CI, P-value) for ischemic stroke was 1.051 (1.008–1.095, <em>P</em> ​= ​0.020). Moreover, the OR for heart failure was slightly higher in the hospitalized population than in the control population (1.001, 95% CI 1.000–1.002, <em>P</em> ​= ​0.010). The remaining results were negative.</div></div><div><h3>Conclusion</h3><div>This MR study establishes that genetically predicted COVID-19 susceptibility causally increases type 2 diabetes risk, while severe infection shows suggestive causal links with ischemic stroke and heart failure, redefining COVID-19 as an independent cardiometabolic risk factor.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 301-307"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking artemisinin's potential in polycystic ovary syndrome treatment: A call for controlled human trials","authors":"Osama Ahmad ,&nbsp;Komal Zulfiqar","doi":"10.1016/j.jhip.2025.09.009","DOIUrl":"10.1016/j.jhip.2025.09.009","url":null,"abstract":"","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 322-323"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization, characterization, hypoglycemic and antioxidant activity studies of ultrasonic-assisted deep eutectic solvent extraction of polysaccharides from Perilla frutescens","authors":"Jiajian Tang,&nbsp;Zilin Cong,&nbsp;Huijia Dai,&nbsp;Sigui Zhou,&nbsp;Yao Wen","doi":"10.1016/j.jhip.2025.09.008","DOIUrl":"10.1016/j.jhip.2025.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>In order to further develop and utilise <em>Perilla frutescens</em> polysaccharides, the aim of this study was to optimize process conditions for the extraction of <em>Perilla frutescens</em> polysaccharides with deep eutectic solvents (DES), to investigate their biological activities and to analyse their monosaccharide composition.</div></div><div><h3>Methods</h3><div><em>Perilla frutescens</em> polysaccharides were extracted by DES and ultrasonic extraction, and the optimal extraction process was obtained by one-way test and response surface method. The extract was collected and concentrated, alcohol precipitated, deproteinized, dialyzed, and evaporated to make a solution, which was purified by DEAE and Sephadex G-75 columns to obtain the arginal polysaccharide PFP-1.</div></div><div><h3>Results</h3><div>The polysaccharide was extracted from <em>Perilla frutescens</em> by ultrasonication with the aid of a new type of DES, and the optimal conditions for extraction were determined: the optimal DES system for extracting the polysaccharide of <em>Perilla frutescens</em> and the molar ratio was choline chloride: oxalic acid ​= ​2:1; ultrasonication temperature, power, and time were 70 ​°C, 280 ​W, and 45 ​min, respectively; and the liquid-solid ratio was 21 ​mL/g, and the extraction rate of polysaccharide was 2.44%. The molecular weight (<em>Mw</em>) of PFP-1 is approximately 11600 ​Da. Hydrolysis and derivatization of the refined polysaccharide PFP-1 followed by analytical experiments determined that the polysaccharide monosaccharides consisted of rhamnose, glucuronic acid, and glucose, with the molar ratios of 1.45: 2.82: 1.41. The antioxidant activity and hypoglycemic activity of the polysaccharide were determined to be good by free radical scavenging and enzyme inhibition experiments, and the IC₅₀ of <em>Perilla frutescens</em> polysaccharide against DPPH• was 0.117 ​mg/mL and that against <em>α</em>-amylase was 0.002 ​mg/mL.</div></div><div><h3>Conclusion</h3><div>This study can provide an experimental basis for the establishment of an industrialized production process of polysaccharides and the study of their biological activities.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 333-342"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of antidepressant like potentiality of Phyllanthus emblica on experimental rodent model of depressive disorder under the light of numerous behavioural test batteries","authors":"Md. Rafat Tahsin ,&nbsp;Arifa Sultana ,&nbsp;Fahima Aktar ,&nbsp;Nasiba Binte Bahar ,&nbsp;Md Naeem Hossain Rony ,&nbsp;Rifah Noor Chowdhury ,&nbsp;Sabiha Rahman Mim ,&nbsp;Safa H. Qahl ,&nbsp;Ishrat Jahan ,&nbsp;Md. Shah Amran","doi":"10.1016/j.jhip.2025.09.006","DOIUrl":"10.1016/j.jhip.2025.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>The unfavorable costs and effects of currently accessible antidepressant agents necessitate the development of more potent and safe alternatives, that will obviate the potential problems associated with the commercially available marketed ones. <em>Phyllanthus emblica</em>, widely known as emblic or amla, is utilized in traditional Asian medicine. In this study, the potential of <em>Phyllanthus emblica</em>'s extract as an antidepressant drug was investigated.</div></div><div><h3>Methods</h3><div>The dried and pulverized powder of fruit was extracted in 70% ethanol. Rat model was used to assess the antidepressant effect of this extract and rats were treated with 800 ​mg/kg extract for 28 days. To assess the impact of the treatment, different behavioural tests like forced swimming test, tail suspension test, open field test, elevated plus maze, light dark box test, and coat state test were conducted.</div></div><div><h3>Results</h3><div>Following the administration of <em>Phyllanthus emblica</em>'s extract, a significant decrease in immobility times was observed in the forced swimming test and tail suspension test (<em>P</em> ​&lt; ​0.05). Similarly, the intake of glucose water was increased significantly (<em>P</em> ​&lt; ​0.05) after <em>Phyllanthus emblica</em>'s extract treatment. Additionally, in all behavioural tests associated with the open field test, elevated plus maze, and light dark box test, abnormal behavioural states were significantly restored (<em>P</em> ​&lt; ​0.05) in the extract-treated group. Besides, in all behavioural tests, it has been observed that the standard drug also restored all the abnormal behavioural conditions. In silico docking revealed that compounds C_66 (stigmast-4-en-3-one) and C_43 (7-ketositosterol) exhibited the strongest binding affinity for MAO-A (−11.8 and −11.7 ​kJ/mol), surpassing the control drug Phenelzine (−6.7 ​kJ/mol), with distinct binding site residues. For hSERT, C_71 (Phyllanemblinin A, −11.4 ​kJ/mol) and C_66 (−10.8 ​kJ/mol) outperformed Fluoxetine (−8.9 ​kJ/mol), with Stigmast-4-en-3-one showing potential multi-target activity. ADME and toxicity prediction indicated low GI absorption for all candidates; C_43 showed the best drug-likeness and was predicted as non-toxic (class 6), while C_66 and C_71 were class 5, with additional nephrotoxicity and mutagenicity for C_71.</div></div><div><h3>Conclusion</h3><div>It can be inferred that the fruit extract of <em>Phyllanthus emblica</em> can efficiently reverse the disturbing psychological ailment towards a healthy status, which has the potential to be further developed into an alternative of currently accessible marketed antidepressant agents.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 343-361"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of fresh Dendrobium officinale against gastric ulcer by regulating Keap1-Nrf2 signaling pathway","authors":"Shuidi Zhang ,&nbsp;Bei Gui ,&nbsp;Zijun Wu ,&nbsp;Yuanjun Wei ,&nbsp;Hong Deng ,&nbsp;Kunping Li ,&nbsp;Caie Guo ,&nbsp;Yanfen Chen","doi":"10.1016/j.jhip.2025.09.007","DOIUrl":"10.1016/j.jhip.2025.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to systematically investigate the gastroprotective effects and underlying mechanisms of fresh <em>Dendrobium officinale</em> granules (FDG), a clinically convenient formulation of fresh <em>Dendrobium officinale</em> (<em>D. officinale</em>).</div></div><div><h3>Methods</h3><div>For the convenience of clinical use, fresh <em>D. officinale</em> was prepared into granules. The active ingredients of FDG were detected by HPLC. The gastroprotective efficacy of FDG was investigated in mice with alcoholic, indometacin, and reserpine gastric ulcer models, and in rats with acetic acid chronic gastric ulcers. The ulcer index, histopathology of gastric mucosa, and the levels of nitric oxide (NO), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) were measured. Network pharmacology method was used to predict the potential mechanism of FDG. Lastly, the expression levels of Keap1, Nrf2, and HO-1 were assessed by qRT-PCR and Western blot methods.</div></div><div><h3>Results</h3><div>HPLC result showed that the four active ingredients of FDG were vicenin-2, isoschaftoside, schaftoside, and 6-C-xylosyl-8-C-glucosylapigenin. FDG exerted significant effects against acute and chronic gastric ulcers in a dose-dependent manner. The network pharmacology analysis predicted the potential mechanism on oxidative stress and its related pathways. FDG remarkably increased SOD, NO, and CAT levels and lowered MDA levels in various gastric ulcer models, indicating it could enhance the antioxidant capacity to prevent gastric ulcers. FDG obviously down-regulated Keap1 expression and up-regulated Nrf2 and HO-1 expression.</div></div><div><h3>Conclusion</h3><div>This study proved the gastroprotective efficacy ​of fresh <em>D. officinale</em>, and its mechanism may be related to the antioxidation activity and the regulation of Keap1-Nrf2 signaling pathway.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 362-372"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holistic insights of 6D printing in healthcare","authors":"Jatin Tekawade,&nbsp;Rohan Barse,&nbsp;Vijay Jagtap","doi":"10.1016/j.jhip.2025.09.003","DOIUrl":"10.1016/j.jhip.2025.09.003","url":null,"abstract":"<div><div>Additive manufacturing has recently demonstrated significant progress in healthcare. Six-dimensional (6D) printing is an emerging field that holds great promise through the rapid, layer-by-layer creation of complex objects capable of changing over time in response to external stimuli, resulting in dynamic and adaptable products. 6D printing represents a superimposition of 4D and 5D printing, combining the stimuli-responsiveness of 4D printing with the structural robustness of 5D printing. It uniquely enables autonomous, adaptive drug delivery systems by utilizing smart materials such as shape-memory alloys, responsive polymers, and hydrogels that react to environmental triggers. This review explores the evolution, mechanisms, significance, and innovations of 6D printing, which has made notable strides toward patient-centered medical approaches. Future developments in 6D printing may involve the use of material panels that adapt to stimuli varying over time under physiological conditions, offering new possibilities for advanced medical applications and solutions.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 263-275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}