Journal of Dermatological Science Supplement最新文献

{"title":"The concepts of the new criteria for Yusho poisoning","authors":"Shoji Tokunaga ,&nbsp;Takao Iida ,&nbsp;Masutaka Furue ,&nbsp;on behalf of the Study Group for Yusho","doi":"10.1016/j.descs.2005.03.012","DOIUrl":"10.1016/j.descs.2005.03.012","url":null,"abstract":"<div><h3>Background:</h3><p><span>The current diagnostic criteria for Yusho poisoning do not include dioxin levels, although one of the subgroups of dioxins, </span>polychlorinated dibenzofurans, was shown to contribute the most to the total toxic equivalent quantity in the blood of Yusho patients.</p></div><div><h3>Objective:</h3><p>To propose new diagnostic criteria for Yusho using blood dioxin levels.</p></div><div><h3>Subjects and methods:</h3><p>Participants of the nationwide health examination for Yusho in 2001 and 2002, and randomly selected residents of Fukuoka City, Japan, were included in this study. A multiplicative model was applied to blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) level with age and sex as explanatory variables. A logistic regression model including 2,3,4,7,8-PeCDF level, age and sex was also used.</p></div><div><h3>Results:</h3><p>Three criteria are proposed based on different approaches: 2,3,4,7,8-PeCDF level adjusted for age and sex (criterion 1), its one-tailed upper prediction limit (criterion 2), and the estimated probability of being a Yusho patient (criterion 3). By applying these three criteria to potential victims who had not been diagnosed as having Yusho according to the current diagnostic criteria, the same people were identified as Yusho sufferers. Criterion 1 with an upper 99 percentile of age- and sex-adjusted 2,3,4,7,8-PeCDF level of controls as a cut-off was determined, from a practical perspective, to be superior to the other criteria.</p></div>","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"1 1","pages":"Pages S95-S104"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.descs.2005.03.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78984196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Yusho","authors":"Masutaka Furue ,&nbsp;Takeshi Uenotsuchi ,&nbsp;Kazunori Urabe ,&nbsp;Takehiko Ishikawa ,&nbsp;Masao Kuwabara ,&nbsp;Study Group for Yusho","doi":"10.1016/j.descs.2005.03.002","DOIUrl":"10.1016/j.descs.2005.03.002","url":null,"abstract":"<div><h3>Background:</h3><p><span>Yusho is a type of food poisoning from rice bran oil contaminated with polychlorinated biphenyls (PCBs) and various dioxins such as </span>polychlorinated dibenzofurans<span> (PCDFs). The victims of Yusho suffered from dermatological manifestations (acneform eruptions, comedones, etc.) in association with systemic, ophthalmological, and mucosal symptoms.</span></p></div><div><h3>Objective:</h3><p>To analyze the relationship between the concentrations of dioxins/PCBs and the subjective/objective complaints of patients with Yusho.</p></div><div><h3>Methods:</h3><p>We recently started to measure the blood levels of dioxins in the annual medical check-up of Yusho patients. In addition, we reviewed the clinical and epidemiological findings elucidated over the past 36 years by the Study Group for Yusho.</p></div><div><h3>Results and conclusion:</h3><p>High amounts of PCBs and PCDFs are still present in a number of patients with Yusho. The majority of laboratory findings, except for triglyceride concentration, were within normal limits throughout the clinical course. However, the patients still suffered from various mucocutaneous and subjective symptoms, and these symptoms were correlated to the blood levels of polychlorinated congeners. The development of therapeutic interventions is warranted in the near future.</p></div>","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"1 1","pages":"Pages S3-S10"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.descs.2005.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82005125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucosa and dental findings in Yusho","authors":"I. Hashiguchi, A. Akamine","doi":"10.1016/J.DESCS.2005.03.010","DOIUrl":"https://doi.org/10.1016/J.DESCS.2005.03.010","url":null,"abstract":"","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85080132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete blood cell counts and blood chemistry in Yusho","authors":"Toshiro Yoshimura ,&nbsp;Jiro Nakano ,&nbsp;Minoru Okita ,&nbsp;Yasuki Kikuchi ,&nbsp;Takashi Kitamura ,&nbsp;Takehiko Ishikawa","doi":"10.1016/j.descs.2005.03.008","DOIUrl":"10.1016/j.descs.2005.03.008","url":null,"abstract":"<div><h3>Background:</h3><p>Because of their lipophilic nature, polychlorinated biphenyls (PCBs) bioaccumulate in the food chain and their residues have been detected in foods. Consequently, they accumulate readily in the human body. Reports suggest that PCB blood levels remain constant or increase. Little, however, is known about the long-term hazardous effects of PCBs and dioxins on human health. Yusho is a type of food poisoning caused by PCBs and dioxins that contaminated rice bran oil. We analyzed blood samples of the Yusho patients from 1986 to 2002, and studied changes in blood cell counts, blood chemistry and tumor markers.</p></div><div><h3>Participants and methods:</h3><p>A population of 1041 patients was divided into patient and control groups based on the diagnostic criteria established for Yusho and participant's blood polychlorinated quarterphenyl (PCQ) levels. In total, 1666 blood and 1652 urine samples from 374 patients in the patient group (PCQ levels<!--> <!-->=<!--> <!-->0.1<!--> <!-->ppb), and 373 blood and 302 urine samples from 151 people in the control group (PCQ levels<!--> <!-->&lt;<!--> <!-->0.02<!--> <!-->ppb) were analyzed. Blood levels of PCBs, PCQs, polychlorinated dibenzo-<em>p</em><span><span>-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) were determined, and we analyzed their correlation with the data of complete blood cell counts, blood chemistry and </span>urinalysis.</span></p></div><div><h3>Results and conclusion:</h3><p><span>Blood analyses, blood chemistry and urine values in Yusho patients were not significantly different from those in the control group 34 years after the Yusho incident. PCBs, PCQs or PCDFs may, however, affect hematogenesis, serum potassium, serum phosphorus, protein metabolism and </span>creatine kinase<span> metabolism because these parameters had slight but significant correlations with the levels of PCBs, PCQs or PCDFs. Exposure to PCBs and the related organochlorine compounds should be avoided.</span></p></div>","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"1 1","pages":"Pages S45-S55"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.descs.2005.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79199966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavior and toxic effects of PCBs and PCDFs in Yusho patients for 35 years","authors":"Yoshito Masuda,&nbsp;on behalf of the Study Group for Yusho","doi":"10.1016/j.descs.2005.03.003","DOIUrl":"10.1016/j.descs.2005.03.003","url":null,"abstract":"<div><h3>Background:</h3><p><span>Yusho<span> polychlorinated biphenyl (PCB) poisoning occurred in northern Kyushu in 1968, and the patients have been suffering from various symptoms for 35 years. From the epidemiological survey of 141 Yusho patients in Fukuoka, the total amounts of PCBs, polychlorinated dibenzofurans (PCDFs) and the toxic equivalent quantity (TEQ) ingested by each patient were calculated to be 633, 3.4 and 0.62</span></span> <!-->mg, respectively.</p></div><div><h3>Objectives:</h3><p>The purpose of this paper is to review the behavior and toxic effects of these polychlorinated congeners in Yusho patients.</p></div><div><h3>Results and conclusions:</h3><p>From the follow-up data of three Yu-cheng patients and five Yusho patients, fat-based concentrations of TEQ and PCBs in the Yusho patients were estimated to have decreased from 40<!--> <!-->ppb and 75<!--> <!-->ppm, respectively, in 1969, to 0.6<!--> <!-->ppb and 2.3<!--> <span>ppm, respectively, in 1999. Estimated median half-lives of three PCDFs and six PCBs were 3.0 and 4.6 years, respectively, in the first 15 years after the incident, and 5.4 and 14.6 years, respectively, in the following 15 years. Patients have recovered gradually from the typical Yusho symptoms of acneform eruptions, dermal pigmentation<span> and increased eye discharge<span>. However, enzyme- and/or hormone-mediated signs of high serum triglyceride<span>, high serum thyroxine, immunoglobulin disorder, etc. remain persistent for more than 30 years.</span></span></span></span></p></div>","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"1 1","pages":"Pages S11-S20"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.descs.2005.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89385540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood chemistry, alpha-fetoprotein and hepatitis B surface antigen in Yusho","authors":"H. Tsuji, Yasuo Ito","doi":"10.1016/J.DESCS.2005.03.005","DOIUrl":"https://doi.org/10.1016/J.DESCS.2005.03.005","url":null,"abstract":"","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79819992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dioxins on stress-responsive systems and their relevance to toxicity","authors":"Takumi Ishida ,&nbsp;Miho Hori ,&nbsp;Yuji Ishii ,&nbsp;Kazuta Oguri ,&nbsp;Hideyuki Yamada ,&nbsp;on behalf of the Study Group for Yusho","doi":"10.1016/j.descs.2005.03.011","DOIUrl":"10.1016/j.descs.2005.03.011","url":null,"abstract":"<div><h3>Background:</h3><p>Dioxins and related compounds, exemplified by 2,3,7,8-tetrachlorodibenzo-<em>p</em><span>-dioxin, are recognized as widespread, persistent and highly toxic environmental pollutants. Although numerous studies have been performed to clarify the mechanisms governing dioxin toxicity, these are not yet fully understood because of their complexity. In 1968, subacute poisoning by polychlorinated biphenyls, called ‘Yusho’, occurred in the southwest part of Japan. Although many of the Yusho patients appear to be free from any of the symptoms produced by the pollutant at present, they remain at high risk of dioxin toxicity because of the high concentrations present in the body. To date, no effective method for combating this toxicity has been developed.</span></p></div><div><h3>Objective:</h3><p>In this review, we summarize dioxin toxicity by focusing on the quenching systems of reactive oxygen species and chaperone proteins. In addition, the possibility of the development of protective and therapeutic treatments for dioxin toxicity is discussed.</p></div>","PeriodicalId":100772,"journal":{"name":"Journal of Dermatological Science Supplement","volume":"1 1","pages":"Pages S105-S112"},"PeriodicalIF":0.0,"publicationDate":"2005-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.descs.2005.03.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82324285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}