Journal of Cellular Immunotherapy最新文献_第8页

The SNP rs3746444 within mir-499a is associated with breast cancer risk in Iranian population mir-499a中的SNP rs3746444与伊朗人群乳腺癌风险相关

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/j.jocit.2016.08.003

Shahrzad Kabirizadeh , Mansoureh Azadeh , Mahboubeh Mirhosseini , Kamran Ghaedi , Hamzeh Mesrian Tanha

{"title":"The SNP rs3746444 within mir-499a is associated with breast cancer risk in Iranian population","authors":"Shahrzad Kabirizadeh , Mansoureh Azadeh , Mahboubeh Mirhosseini , Kamran Ghaedi , Hamzeh Mesrian Tanha","doi":"10.1016/j.jocit.2016.08.003","DOIUrl":"10.1016/j.jocit.2016.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>Our study aimed to evaluate the possible association between hsa-mir-499a (rs3746444 A>G) polymorphism and susceptibility to breast cancer in an Isfahanian population.</p></div><div><h3>Materials & methods</h3><p>In this case–control study we enrolled 91 healthy subjects and patients with breast cancer. Allele-specific primer PCR was applied for genotyping the SNP.</p></div><div><h3>Results</h3><p>Our study showed that the hsa-mir-499a rs3746444 G allele increased the risk of breast cancer regarding to allele frequency differences (OR: 1.922; 95% CI: 1.064–3.470; p = 0.02952) and Armitage's trend test (OR: 1.722; p = 0.04732) in comparison with the A allele. In addition, an in silico attempt to find functional consequences of A>G substation suggested that the G allele may decrease hsa-mir-499a stability based on calculated free energy differences between A and G alleles.</p></div><div><h3>Conclusion</h3><p>Our findings illustrated that the mir-499a rs3746444 G polymorphism is associated with higher risk of developing breast cancer in Isfahanian population.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"2 2","pages":"Pages 95-97"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2016.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81552031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Chimeric antigen receptor (CAR) T cell therapy for malignant cancers: Summary and perspective 嵌合抗原受体(CAR) T细胞治疗恶性肿瘤:综述与展望

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/j.jocit.2016.08.001

Aaron J. Smith, John Oertle, Dan Warren, Dino Prato

引用次数: 50

Chimeric antigen receptor (CAR) T cell therapy for malignant cancers: Summary and perspective 嵌合抗原受体(CAR) T细胞治疗恶性肿瘤:综述与展望

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/J.JOCIT.2016.08.001

Aaron Smith, John Oertle, Dan Warren, D. Prato

引用次数: 50

Dendritic cells used in anti-HIV immunotherapy showed different modulation in anti-HIV genes expression: New concept for the improvement of patients' selection criteria 用于抗hiv免疫治疗的树突状细胞在抗hiv基因表达上表现出不同的调节作用:提高患者选择标准的新概念

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/j.jocit.2016.03.002

Alessandra Pontillo , Edione C. Reis , Lais T. da Silva , Alberto J.S. Duarte , Sergio Crovella , Telma M. Oshiro

{"title":"Dendritic cells used in anti-HIV immunotherapy showed different modulation in anti-HIV genes expression: New concept for the improvement of patients' selection criteria","authors":"Alessandra Pontillo , Edione C. Reis , Lais T. da Silva , Alberto J.S. Duarte , Sergio Crovella , Telma M. Oshiro","doi":"10.1016/j.jocit.2016.03.002","DOIUrl":"10.1016/j.jocit.2016.03.002","url":null,"abstract":"<div><h3>Objective</h3><p>As the host's genetics influences immune response to HIV-1 and progression to AIDS, similar genetic factors could affect response to immunotherapy. Differential genes expression was evaluated in clinical trial, aimed at identifying a potential predictive marker for DC quality and, finally, for therapy responsiveness.</p></div><div><h3>Methods and Results</h3><p>DC used for immunotherapy revealed a clear difference of anti-HIV genes signature, so we classified DC into two groups (A-DC and B-DC). In A-DC a limited number of genes, including inflammasome-related genes (<em>IL1B, IL18</em>), were modulated during monocytes-to-DC differentiation. A larger subset of anti-HIV genes (restriction factors, co-factors, apoptotic factors) was modulated in B-DC. This more “activated/exhausted” expression profile of B-DC apparently resulted from a more activated monocyte precursor.</p></div><div><h3>Conclusions</h3><p>These results suggest that the actual selection of HIV<sup>+</sup> individual for immunotherapy, based on clinical features, did not ensure the same DC product, and that less “activated/exhausted” DC could positively affect the outcome of immunotherapy.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"2 2","pages":"Pages 85-94"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2016.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78382988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Local elevation of CCL22: A new trend in immunotherapy (skin model) 局部CCL22升高:免疫治疗的新趋势(皮肤模型)

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/j.jocit.2015.12.001

Omer Yahia Elhussein Mohamed , Altayeb Elazomi , Malik Suliman Mohamed , Fathi B. Abdalla

引用次数: 3

Bilateral occult breast carcinoma presenting as bilateral axillary mass: An unusual presentation 双侧隐匿性乳腺癌表现为双侧腋窝肿块:一种不寻常的表现

Journal of Cellular Immunotherapy Pub Date : 2016-11-01 DOI: 10.1016/j.jocit.2016.05.001

Kafil Akhtar, Murad Ahmad, Asim Israr Khan, Rana K. Sherwani

引用次数: 1

Phagocytic activity of neutrophil is induced by granulocyte colony stimulating factor and interleukin-15 in leukemic animal model 粒细胞集落刺激因子和白细胞介素-15在白血病动物模型中诱导中性粒细胞的吞噬活性

Journal of Cellular Immunotherapy Pub Date : 2016-03-01 DOI: 10.1016/J.JOCIT.2016.01.002

Bhaskar Bhattacharjee, A. Singha, D. Maiti

引用次数: 2

A new wave: Introducing the Journal of Cellular Immunotherapy 新浪潮:《细胞免疫疗法》杂志的介绍

Journal of Cellular Immunotherapy Pub Date : 2016-03-01 DOI: 10.1016/j.jocit.2016.03.001

Xuetao Cao M.D., Ph.D. (Editor-in-Chief), Hu Chen M.D., Ph.D. (Editor-in-Chief)

引用次数: 1

Phagocytic activity of neutrophil is induced by granulocyte colony stimulating factor and interleukin-15 in leukemic animal model 粒细胞集落刺激因子和白细胞介素-15在白血病动物模型中诱导中性粒细胞的吞噬活性

Journal of Cellular Immunotherapy Pub Date : 2016-03-01 DOI: 10.1016/j.jocit.2016.01.002

Bhaskar Bhattacharjee, Ashish Kumar Singha, Debasish Maiti

{"title":"Phagocytic activity of neutrophil is induced by granulocyte colony stimulating factor and interleukin-15 in leukemic animal model","authors":"Bhaskar Bhattacharjee, Ashish Kumar Singha, Debasish Maiti","doi":"10.1016/j.jocit.2016.01.002","DOIUrl":"https://doi.org/10.1016/j.jocit.2016.01.002","url":null,"abstract":"<div><p>In leukemia, secondary infection is common and after chemotherapy the number of normal active neutrophil reduced significantly. Therefore, to avoid side effects of chemotherapy and to induce neutrophil activity and number, in this study, we have treated with G-CSF plus IL-15 in combination to N–N′ Ethylnitrosourea (ENU) induced leukemia in BALB/c mice. After 5 months of ENU treatment in 3–4 weeks old mice at 80 mg/kg body weight, leukemia was confirmed by histology of blood smear co-treatment started with cytokines for 5 days. The <em>in vitro</em> phagocytosis activity of neutrophil from spleen was assayed using Dalton's lymphoma ascites as target cell. Using real time polymerase chain reaction (RT-PCR), Toll like receptor 4 (TLR4) and toll like receptor 9 (TLR9) expression of neutrophil was also measured. Our data suggests that G-CSF plus IL-15 induce the phagocytic activity of neutrophil. TLR4 and TLR9 expression was induced in neutrophil after treatment with cytokines together which was significantly reduced in leukemia. In conclusion, G-CSF plus IL-15 has potential role as therapeutic immunomodulators for neutrophil activity in leukemia.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"2 1","pages":"Pages 52-57"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2016.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91719545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The LALF32-51 peptide as component of HPV therapeutic vaccine circumvents the alum-mediated inhibition of IL-12 and promotes a Th1 response LALF32-51肽作为HPV治疗性疫苗的组成部分绕过铝介导的IL-12抑制并促进Th1反应

Journal of Cellular Immunotherapy Pub Date : 2016-03-01 DOI: 10.1016/j.jocit.2015.01.001

Milaid Granadillo , Alain B. Alfonso , Maribel G. Vallespi , Aileen Batte , Yordanka Soria , Enma Brown , Miladys Limonta , Yayrí C. Prieto , Laura Varas , Isis Torrens

{"title":"The LALF32-51 peptide as component of HPV therapeutic vaccine circumvents the alum-mediated inhibition of IL-12 and promotes a Th1 response","authors":"Milaid Granadillo , Alain B. Alfonso , Maribel G. Vallespi , Aileen Batte , Yordanka Soria , Enma Brown , Miladys Limonta , Yayrí C. Prieto , Laura Varas , Isis Torrens","doi":"10.1016/j.jocit.2015.01.001","DOIUrl":"https://doi.org/10.1016/j.jocit.2015.01.001","url":null,"abstract":"<div><p>Aluminum-containing adjuvants (alum) continue to be the most widely used adjuvants. It is common knowledge that these adjuvants predominantly induce humoral immunity, but some reports also describe their role combined with IL-12 in the induction of a Th1 immune response. In this study we want to investigate if alum could be an adjuvant to be used as a component of a therapeutic vaccine that require the generation of cell-mediated immunity. To demonstrate this concept we selected the human papillomavirus (HPV) 16-transformed mouse TC-1 cells as model and the fusion protein LALF<sub>32-51</sub>-E7 as antigen. Our results suggest that LALF<sub>32-51</sub>-E7 combined with aluminum hydroxide adjuvant promotes a Th1 immune response and consequently an anti-tumor response in the TC-1 tumor model. These results could have important application in future clinical trials in women with low grade squamous intraepithelial neoplasia.</p></div>","PeriodicalId":100761,"journal":{"name":"Journal of Cellular Immunotherapy","volume":"2 1","pages":"Pages 44-51"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jocit.2015.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91719547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5