Cephalalgia最新文献

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The long-term effect of work schedule, shift work disorder, insomnia and restless legs syndrome on headache among nurses: A prospective longitudinal cohort study. 作息时间、轮班工作紊乱、失眠和不安腿综合征对护士头痛的长期影响:前瞻性纵向队列研究。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2024-01-01 DOI: 10.1177/03331024231226323
Espen Saxhaug Kristoffersen, Ståle Pallesen, Siri Waage, Bjørn Bjorvatn
{"title":"The long-term effect of work schedule, shift work disorder, insomnia and restless legs syndrome on headache among nurses: A prospective longitudinal cohort study.","authors":"Espen Saxhaug Kristoffersen, Ståle Pallesen, Siri Waage, Bjørn Bjorvatn","doi":"10.1177/03331024231226323","DOIUrl":"10.1177/03331024231226323","url":null,"abstract":"<p><strong>Background: </strong>The preset study aimed to explore whether work schedules and sleep disorders predict the onset of headache.</p><p><strong>Methods: </strong>A longitudinal study was conducted with questionnaire data from 2014 (baseline) and 2017 (follow-up) on work schedule, number of night shifts, number of quick returns, insomnia, shift work disorder (SWD), restless legs syndrome (RLS) and validated headache diagnoses among 1560 Norwegian nurses. Associations were explored by multivariate regression analyses.</p><p><strong>Results: </strong>Work related factors at baseline did not predict onset of headache three years later. In the adjusted logistic regressions, insomnia at baseline predicted increased risk of new onset of migraine (odds ratio (OR) = 1.58; 95% confidence interval (CI) = 1.08-2.33), chronic headache (OR = 2.02; 95% CI = 1.04-4.66) and medication-overuse headache (OR = 3.79; 95% CI = 1.26-11.42) at follow-up. SWD at baseline predicted new onset of migraine (OR = 1.64; 95% CI = 1.07-2.50) and RLS at baseline predicted new onset of headache ≥1 day per month (OR = 1.55; 95% CI = 1.01-2.36) and migraine (OR = 1.55; 95% CI = 1.03-2.32) at follow-up. No factors predicted tension-type headache.</p><p><strong>Conclusions: </strong>Overall, work related factors did not predict the onset of headache three years later, whereas insomnia, SWD and RLS at baseline all increased the risk of future headaches.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grey matter structure within the visual networks in migraine with aura: multivariate and univariate analyses. 先兆偏头痛患者视觉网络内的灰质结构:多变量和单变量分析。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2024-01-01 DOI: 10.1177/03331024231222637
David M Niddam, Kuan-Lin Lai, Yi-Ting Hsiao, Yen-Feng Wang, Shuu-Jiun Wang
{"title":"Grey matter structure within the visual networks in migraine with aura: multivariate and univariate analyses.","authors":"David M Niddam, Kuan-Lin Lai, Yi-Ting Hsiao, Yen-Feng Wang, Shuu-Jiun Wang","doi":"10.1177/03331024231222637","DOIUrl":"10.1177/03331024231222637","url":null,"abstract":"<p><strong>Background: </strong>The visual cortex is involved in the generation of migraine aura. Voxel-based multivariate analyses applied to this region may provide complementary information about aura mechanisms relative to the commonly used mass-univariate analyses.</p><p><strong>Methods: </strong>Structural images constrained within the functional resting-state visual networks were obtained in migraine patients with (n = 50) and without (n = 50) visual aura and healthy controls (n = 50). The masked images entered a multivariate analysis in which Gaussian process classification was used to generate pairwise models. Generalizability was assessed by five-fold cross-validation and non-parametric permutation tests were used to estimate significance levels. A univariate voxel-based morphometry analysis was also performed.</p><p><strong>Results: </strong>A multivariate pattern of grey matter voxels within the ventral medial visual network contained significant information related to the diagnosis of migraine with visual aura (aura vs. healthy controls: classification accuracy = 78%, <i>p</i> < 0.001; area under the curve = 0.84, <i>p</i> < 0.001; migraine with aura vs. without aura: classification accuracy = 71%, <i>p</i> < 0.001; area under the curve = 0.73, <i>p</i> < 0.003). Furthermore, patients with visual aura exhibited increased grey matter volume in the medial occipital cortex compared to the two other groups.</p><p><strong>Conclusions: </strong>Migraine with visual aura is characterized by multivariate and univariate patterns of grey matter changes within the medial occipital cortex that have discriminative power and may reflect pathological mechanisms.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The midfacial segment pain: little known disorder in need of scientific evaluation. 面部中段疼痛:鲜为人知的疾病,需要科学评估。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2024-01-01 DOI: 10.1177/03331024231226176
Marcin Straburzyński, Adrian M Agius, Magdalena Boczarska-Jedynak, Eliza Brożek-Mądry, Karolina Dżaman, Elżbieta Gradek-Kwinta, Anna Gryglas-Dworak, Magdalena Nowaczewska, Anshul Sama, Joanna Smardz, Hoo Kee Tsang, Mieszko Więckiewicz, Marta Waliszewska-Prosół
{"title":"The midfacial segment pain: little known disorder in need of scientific evaluation.","authors":"Marcin Straburzyński, Adrian M Agius, Magdalena Boczarska-Jedynak, Eliza Brożek-Mądry, Karolina Dżaman, Elżbieta Gradek-Kwinta, Anna Gryglas-Dworak, Magdalena Nowaczewska, Anshul Sama, Joanna Smardz, Hoo Kee Tsang, Mieszko Więckiewicz, Marta Waliszewska-Prosół","doi":"10.1177/03331024231226176","DOIUrl":"10.1177/03331024231226176","url":null,"abstract":"<p><p>Despite its inclusion in the International Classification of Orofacial Pain, tension-type orofacial pain has little support in the scientific literature. However, a similar-in-phenotype orofacial pain perceived in the middle segment of the face has been described by few case series from mostly ear, nose and throat clinics. The authors of these descriptions used the term 'midfacial segment pain'. Patients had no significant sinonasal disorder in these studies, but experienced symmetrical pain perceived mostly over the maxillary and ethmoid sinuses. No aura or autonomic symptoms were present apart from mild nasal congestion or rhinorrhoea in some individuals. This description appears similar to tension-type headache, but with midfacial location. In this viewpoint, we indicate a need to fill this gap in scientific knowledge and propose a multicentre interdisciplinary study that would give a detailed description of this type of orofacial pain.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cumulative exposure to estrogen may increase the risk of migraine in women. 累积接触雌激素可能会增加女性偏头痛的风险。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2024-01-01 DOI: 10.1177/03331024231225972
Nora Stensland Bugge, Kjersti Grøtta Vetvik, Karl Bjørnar Alstadhaug, Tonje Braaten
{"title":"Cumulative exposure to estrogen may increase the risk of migraine in women.","authors":"Nora Stensland Bugge, Kjersti Grøtta Vetvik, Karl Bjørnar Alstadhaug, Tonje Braaten","doi":"10.1177/03331024231225972","DOIUrl":"10.1177/03331024231225972","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a common disorder, particularly affecting women during their reproductive years. This female preponderance has been linked to exposure to female sex hormones.</p><p><strong>Methods: </strong>We used self-reported data from women born in 1943-1965 enrolled in the Norwegian Women and Cancer Study to examine the differences between women with migraine and women without migraine in a prospective design with respect to both endogenous and exogenous female sex hormone exposure.</p><p><strong>Results: </strong>In total, 62,959 women were included in the study, of whom 24.8% reported previous migraine (n = 15,635). Using a Cox proportional hazards model, we found that higher age at menarche reduced the risk of migraine (hazards ratio (HR) = 0.96, 95% confidence interval (CI) = 0.95-0.98) and that oral contraceptive use and parity increased the risk of migraine (HR = 1.12, 95% CI = 1.06-1.18 and HR = 1.37, 95% CI = 1.29-1.46, respectively).</p><p><strong>Conclusions: </strong>Older age at menarche appears to reduce migraine risk, whereas oral contraceptive use and having children appear to increase the risk. Further research is required to investigate the causality of these associations.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139432390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephalalgia: a legacy of excellence, a vision for tomorrow. 头痛症:传承卓越,展望未来。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2024-01-01 DOI: 10.1177/03331024231223663
Simona Sacco
{"title":"<i>Cephalalgia</i>: a legacy of excellence, a vision for tomorrow.","authors":"Simona Sacco","doi":"10.1177/03331024231223663","DOIUrl":"10.1177/03331024231223663","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139085992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic lupus erythematosus mimicking retinal migraine: a case report 模仿视网膜偏头痛的系统性红斑狼疮:一份病例报告
IF 4.9 2区 医学
Cephalalgia Pub Date : 2023-12-01 DOI: 10.1177/03331024231219477
Toshiki Tezuka, Mamoru Shibata, Hironari Hanaoka, Y. Izawa, Taku Kikuchi, Kunihiko Akino, Yoko Ozawa, Masataka Saito, Yuko Kaneko, Jin Nakahara, T. Takizawa
{"title":"Systemic lupus erythematosus mimicking retinal migraine: a case report","authors":"Toshiki Tezuka, Mamoru Shibata, Hironari Hanaoka, Y. Izawa, Taku Kikuchi, Kunihiko Akino, Yoko Ozawa, Masataka Saito, Yuko Kaneko, Jin Nakahara, T. Takizawa","doi":"10.1177/03331024231219477","DOIUrl":"https://doi.org/10.1177/03331024231219477","url":null,"abstract":"Retinal migraine is a diagnosis of exclusion and is characterized by repeated episodes of transient monocular blindness associated with migraine. We report a case of systemic lupus erythematosus with acute episodes mimicking retinal migraines. A 46-year-old woman with a history of migraine with aura since her 20s and Evans syndrome presented with episodic transient monocular blindness. Retinal migraine was considered as the cause, and migraine prophylaxis initially reduced its frequency. After 5 months, the frequency increased, with chilblain-like lupus lesions on her extremities. Laboratory testing revealed lymphopenia and hypocomplementemia, fulfilling the diagnostic criteria for systemic lupus erythematosus, which may have caused Evans syndrome and transient monocular blindness, mimicking retinal migraines. After intravenous methylprednisolone and rituximab therapy, the transient monocular blindness episodes did not recur. Given the clinical presentation, systemic lupus erythematosus should be considered as a cause of transient monocular blindness and should be distinguished from retinal migraine.","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The shortcoming of using glibenclamide in exploratory clinical headache provocation studies. 在探索性临床头痛诱发研究中使用格列本脲的不足之处。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2023-12-01 DOI: 10.1177/03331024231219475
Palle Christophersen, Tino Dyhring
{"title":"The shortcoming of using glibenclamide in exploratory clinical headache provocation studies.","authors":"Palle Christophersen, Tino Dyhring","doi":"10.1177/03331024231219475","DOIUrl":"https://doi.org/10.1177/03331024231219475","url":null,"abstract":"<p><strong>Objective: </strong>Preclinical and clinical studies implicate the vascular ATP-sensitive potassium (K<sub>ATP</sub>) channel in the signaling cascades underlying headache and migraine. However, attempts to demonstrate that the K<sub>ATP</sub> channel inhibitor glibenclamide would attenuate triggered headache in healthy volunteers have proven unsuccessful. It is questionable, however, whether target engagement was achieved in these clinical studies.</p><p><strong>Methods: </strong>Literature data for human glibenclamide pharmacokinetics, plasma protein binding and functional IC<sub>50</sub> values were used to predict the K<sub>ATP</sub> receptor occupancy (RO) levels obtained after glibenclamide dosing in the published exploratory clinical headache provocation studies. RO vs. time profiles of glibenclamide were simulated for the pancreatic K<sub>ATP</sub> channel subtype Kir6.2/SUR1 and the vascular subtype Kir6.1/SUR2B.</p><p><strong>Results: </strong>At the clinical dose of 10 mg of glibenclamide used in the headache provocation studies, predicted maximal occupancy levels of up to 90% and up to 26% were found for Kir6.2/SUR1 and Kir6.1/SUR2B, respectively.</p><p><strong>Conclusions: </strong>The findings of the present study indicate that effective Kir6.1/SUR2B target engagement was not achieved in the clinical headache provocation studies using glibenclamide. Therefore, development of novel selective Kir6.1/SUR2B inhibitors, with good bioavailability and low plasma protein binding, is required to reveal the potential of K<sub>ATP</sub> channel inhibition in the treatment of migraine.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting CGRP pathways and aura: A peripheral site with a central effect. 靶向 CGRP 通路和先兆:具有中心效应的外周部位。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2023-12-01 DOI: 10.1177/03331024231212895
Mohammad Al-Mahdi Al-Karagholi
{"title":"Targeting CGRP pathways and aura: A peripheral site with a central effect.","authors":"Mohammad Al-Mahdi Al-Karagholi","doi":"10.1177/03331024231212895","DOIUrl":"https://doi.org/10.1177/03331024231212895","url":null,"abstract":"<p><p>Targeting CGRP-pathways has substantially expanded our options for treating individuals with migraine. Although the efficacy of these drugs on migraine aura is yet to be fully revealed, it seems from existing studies that CGRP antagonism reduces the number of migraine auras. The present perspective summarizes the evidence linking CGRP to the migraine aura and proposes a model by which targeting the CGRP-pathways and, thus, inhibition the interaction between C- and Aδ-trigeminal fibers might reverse a possible high cortical glutamate level leading to a reduced number of migraine auras.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138798567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Looking at Cephalalgia from the inside. 从内部看头痛症。
IF 4.9 2区 医学
Cephalalgia Pub Date : 2023-12-01 DOI: 10.1177/03331024231218381
Arne May
{"title":"Looking at <i>Cephalalgia</i> from the inside.","authors":"Arne May","doi":"10.1177/03331024231218381","DOIUrl":"10.1177/03331024231218381","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138476908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placebo and nocebo in the treatment of migraine: How much does real world effectiveness depend on contextual effects? 治疗偏头痛的安慰剂和反安慰剂:现实世界的有效性在多大程度上取决于情境效应?
IF 4.9 2区 医学
Cephalalgia Pub Date : 2023-12-01 DOI: 10.1177/03331024231218392
Hauke Basedau, Raffaele Ornello, Eleonora De Matteis, Bolortsetseg Davaasuren, Begimai Kadyrova, Doga Vuralli, Myroslav Bozhenko, Ilaha Azizova, Natia Bitsadze, Elnura Eralieva, Messoud Ashina, Dimos Mitsikostas, Francesca Puledda
{"title":"Placebo and nocebo in the treatment of migraine: How much does real world effectiveness depend on contextual effects?","authors":"Hauke Basedau, Raffaele Ornello, Eleonora De Matteis, Bolortsetseg Davaasuren, Begimai Kadyrova, Doga Vuralli, Myroslav Bozhenko, Ilaha Azizova, Natia Bitsadze, Elnura Eralieva, Messoud Ashina, Dimos Mitsikostas, Francesca Puledda","doi":"10.1177/03331024231218392","DOIUrl":"https://doi.org/10.1177/03331024231218392","url":null,"abstract":"<p><strong>Purpose: </strong>Treatments in medicine impact individuals beyond their intended effects, due to phenomena such as the placebo and nocebo effects. The placebo effect arises from the positive expectation of a treatment being beneficial, while the nocebo effect stems from the negative expectation of a treatment causing harm. Both in real-world practice and clinical trials, treatments can lead to outcomes unrelated to their intended mechanism of action, which we categorize as placebo and nocebo responses. These responses, combined with the inherent fluctuation in a condition's natural progression, regression to the mean, and random comorbidities, make up a significant part of the therapeutic experience. Particularly in pain management, placebo and nocebo effects play a substantial role. By addressing modifiable contextual factors such as patient expectations, lifestyle choices, and the therapeutic relationship, healthcare providers can enhance the effectiveness of migraine treatments, paving the way for a more comprehensive, individualized approach to patient care. We must also consider non-modifiable factors like personal experiences, beliefs, and information from social media and the internet.</p><p><strong>Conclusion: </strong>This review offers a summary of our current understanding of the placebo and nocebo effects in migraine management.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138476909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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