Cephalalgia最新文献_第10页

Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine. CGRP 诱导的人类中脑膜动脉血管扩张的性别差异，而非人类冠状动脉：对偏头痛的影响。

IF 5 2区医学

Cephalalgia Pub Date : 2024-07-01 DOI: 10.1177/03331024241254088

Tessa de Vries, Deirdre M Boucherie, Kayi Y Chan, Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Sieneke Labruijere, Saurabh Gupta, Antoon van den Bogaerdt, Arnaud Vincent, Ruben Dammers, A H Jan Danser, Antoinette MaassenVanDenBrink

{"title":"Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine.","authors":"Tessa de Vries, Deirdre M Boucherie, Kayi Y Chan, Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Sieneke Labruijere, Saurabh Gupta, Antoon van den Bogaerdt, Arnaud Vincent, Ruben Dammers, A H Jan Danser, Antoinette MaassenVanDenBrink","doi":"10.1177/03331024241254088","DOIUrl":"10.1177/03331024241254088","url":null,"abstract":"Background: Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries.Methods: CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.Results: In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups.Conclusions: Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"44 7","pages":"3331024241254088"},"PeriodicalIF":5.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimal important difference of the Migraine Disability Assessment (MIDAS): Longitudinal data from the DMKG Headache Registry. 偏头痛残疾评估（MIDAS）的最小重要差异：来自 DMKG 头痛登记处的纵向数据。

IF 5 2区医学

Cephalalgia Pub Date : 2024-07-01 Epub Date: 2024-07-21 DOI: 10.1177/03331024241261077

Ruth Ruscheweyh, Stefanie Förderreuther, Tobias Freilinger, Charly Gaul, Gudrun Goßrau, Tim Patrick Jürgens, Torsten Kraya, Lars Neeb, Victoria Ruschil, Jörg Scheidt, Thomas Dresler

{"title":"Minimal important difference of the Migraine Disability Assessment (MIDAS): Longitudinal data from the DMKG Headache Registry.","authors":"Ruth Ruscheweyh, Stefanie Förderreuther, Tobias Freilinger, Charly Gaul, Gudrun Goßrau, Tim Patrick Jürgens, Torsten Kraya, Lars Neeb, Victoria Ruschil, Jörg Scheidt, Thomas Dresler","doi":"10.1177/03331024241261077","DOIUrl":"10.1177/03331024241261077","url":null,"abstract":"Background: The Migraine Disability Assessment (MIDAS) is widely used. However, there are limited data on how much a reduction in the MIDAS score indicates a change that matters to the patient.Methods: Data from the DMKG (i.e. German Migraine and Headache Society) Headache Registry were used to determine the minimal important difference (MID) of the MIDAS, using the Patient Global Impression of Change (PGIC) as anchor and applying average change and receiver operating characteristic curve methods.Results: In total, 1218 adult migraine patients (85.6% female, 40.2 ± 12.8 years, baseline MIDAS 44.2 ± 47.4, follow-up MIDAS 36.5 ± 45.3) were included. For patients with baseline MIDAS >20 (MIDAS grade IV, n = 757), different methods using PGIC \"somewhat improved\" as anchor yielded percent change MIDs of the MIDAS between -29.4% and -33.2%. For baseline MIDAS between 6 and 20 (grades II and III, n = 334), using PGIC \"much improved\" as anchor, difference change MIDs were between -3.5 and -4.5 points.Conclusions: Based on the above results, we estimated the MID of the MIDAS at -30% for patients with a baseline MIDAS >20, and at -4 points for those with a baseline MIDAS of 6-20, for a tertiary headache care population.Trial registration: The DMKG Headache Registry is registered with the German Clinical Trials Register (DRKS 00021081).","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":" ","pages":"3331024241261077"},"PeriodicalIF":5.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headache in Sturge-Weber syndrome: A systematic review. 斯特格-韦伯综合征的头痛：系统综述。

IF 5 2区医学

Cephalalgia Pub Date : 2024-07-01 DOI: 10.1177/03331024241265881

Alessandro Ferretti, Marta Muscianese, Claudia Fanfoni, Giulia Bellone, Maurizio Mennini, Giovanni Di Nardo, Solmaz Abdolrahimzadeh, Gabriella De Marco, Alessandro Orsini, Thomas Foiadelli, Ilaria Frattale, Massimiliano Valeriani, Pasquale Parisi

{"title":"Headache in Sturge-Weber syndrome: A systematic review.","authors":"Alessandro Ferretti, Marta Muscianese, Claudia Fanfoni, Giulia Bellone, Maurizio Mennini, Giovanni Di Nardo, Solmaz Abdolrahimzadeh, Gabriella De Marco, Alessandro Orsini, Thomas Foiadelli, Ilaria Frattale, Massimiliano Valeriani, Pasquale Parisi","doi":"10.1177/03331024241265881","DOIUrl":"10.1177/03331024241265881","url":null,"abstract":"Background: Sturge-Weber syndrome (SWS) is a neurocutaneous disorder for which the neurological aspects, particularly headaches, remain poorly understood, despite significantly affecting morbidity. The present study aimed to elucidate the prevalence, characteristics and treatment strategies, as well as explore the pathogenesis of headaches, in SWS.Methods: Using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we systematically reviewed observational studies, case reports and series from eight databases (Cochrane Library, EBSCO, Embase, Medline, PubMed, Science Direct, Scopus and Web of Science), published from 1978 to 2023, to investigate the prevalence, characteristics, medication response and pathogenic theories of headaches in SWS.Results: The review analyzed 48 studies, uncovering headache prevalence between 37% and 71%. Migraine-like headache affected up to 52% of individuals. Prophylactic and acute treatments included non-steroidal anti-inflammatory drugs, triptans and antiepileptic drugs, despite the lack of established guidelines. Life-threatening headaches in SWS are uncommon, typically accompanied by other neurological symptoms. The pathogenesis of headaches in SWS is considered to involve venous congestion and neuronal hyperexcitability linked to leptomeningeal angiomas.Conclusions: Headaches occur more frequently in individuals with SWS than in the general population. Despite symptoms meeting migraine criteria, these headaches should be considered secondary to vascular conditions. Implementing acute and prophylactic treatment is advised to reduce the impact on patients' lives.","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"44 7","pages":"3331024241265881"},"PeriodicalIF":5.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced audiovisual associative pair learning in migraine without aura in adult patients: An unexpected finding. 成年无先兆偏头痛患者的视听联想对学习能力增强：意想不到的发现

IF 5 2区医学

Cephalalgia Pub Date : 2024-07-01 DOI: 10.1177/03331024241258722

Kálmán Tót, Gábor Braunitzer, Noémi Harcsa-Pintér, Ádám Kiss, Balázs Bodosi, János Tajti, Anett Csáti, Gabriella Eördegh, Attila Nagy

{"title":"Enhanced audiovisual associative pair learning in migraine without aura in adult patients: An unexpected finding.","authors":"Kálmán Tót, Gábor Braunitzer, Noémi Harcsa-Pintér, Ádám Kiss, Balázs Bodosi, János Tajti, Anett Csáti, Gabriella Eördegh, Attila Nagy","doi":"10.1177/03331024241258722","DOIUrl":"https://doi.org/10.1177/03331024241258722","url":null,"abstract":"Background: Altered sensory processing in migraine has been demonstrated by several studies in unimodal, and especially visual, tasks. While there is some limited evidence hinting at potential alterations in multisensory processing among migraine sufferers, this aspect remains relatively unexplored. This study investigated the interictal cognitive performance of migraine patients without aura compared to matched controls, focusing on associative learning, recall, and transfer abilities through the Sound-Face Test, an audiovisual test based on the principles of the Rutgers Acquired Equivalence Test.Materials and methods: The performance of 42 volunteering migraine patients was compared to the data of 42 matched controls, selected from a database of healthy volunteers who had taken the test earlier. The study aimed to compare the groups' performance in learning, recall, and the ability to transfer learned associations.Results: Migraine patients demonstrated significantly superior associative learning as compared to controls, requiring fewer trials, and making fewer errors during the acquisition phase. However, no significant differences were observed in retrieval error ratios, generalization error ratios, or reaction times between migraine patients and controls in later stages of the test.Conclusion: The results of our study support those of previous investigations, which concluded that multisensory processing exhibits a unique pattern in migraine. The specific finding that associative audiovisual pair learning is more effective in adult migraine patients than in matched controls is unexpected. If the phenomenon is not an artifact, it may be assumed to be a combined result of the hypersensitivity present in migraine and the sensory threshold-lowering effect of multisensory integration.","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"44 7","pages":"3331024241258722"},"PeriodicalIF":5.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: Evaluation of outcomes of calcitonin gene-related peptide (CGRP)-targeting therapies for acute and preventive migraine treatment based on patient sex. 更正：基于患者性别的降钙素基因相关肽（CGRP）靶向疗法对急性和预防性偏头痛治疗效果的评估。

IF 5 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241254952

引用次数: 0

Hypersensitivity to CGRP as a predictive biomarker of migraine prevention with erenumab. 对 CGRP 的超敏反应是使用艾伦单抗预防偏头痛的预测性生物标志物。

IF 5 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241258734

Haidar M Al-Khazali, Håkan Ashina, Rune Häckert Christensen, Astrid Wiggers, Kathrine Rose, Afrim Iljazi, Faisal Mohammad Amin, Messoud Ashina, Josefin Snellman, Tina Maio-Twofoot, Henrik W Schytz

{"title":"Hypersensitivity to CGRP as a predictive biomarker of migraine prevention with erenumab.","authors":"Haidar M Al-Khazali, Håkan Ashina, Rune Häckert Christensen, Astrid Wiggers, Kathrine Rose, Afrim Iljazi, Faisal Mohammad Amin, Messoud Ashina, Josefin Snellman, Tina Maio-Twofoot, Henrik W Schytz","doi":"10.1177/03331024241258734","DOIUrl":"10.1177/03331024241258734","url":null,"abstract":"Background: The present study aimed to investigate the predictive value of calcitonin gene-related peptide (CGRP)-induced migraine attacks for effectiveness to erenumab treatment in people with migraine.Methods: In total, 139 participants with migraine underwent a single experimental day involving a 20-min infusion with CGRP. Following this, the participants entered a 24-week treatment period with erenumab. The primary endpoints were the predictive value of CGRP-induced migraine attacks on the effectiveness of erenumab, defined as ≥50% reduction in monthly migraine days, or ≥ 50% reduction in either monthly migraine or monthly headache days of moderate to severe intensity.Results: Among participants with CGRP-induced migraine attacks, 60 of 99 (61%) achieved ≥50% reduction in monthly migraine days during weeks 13-24 with erenumab. Conversely, 13 of 25 (52%) where CGRP infusion did not induce a migraine achieved the same endpoint (p = 0.498). There were no significant differences between the ≥50% reduction in either monthly migraine or monthly headache days of moderate to severe intensity between CGRP-sensitive and non-sensitive participants (p = 0.625).Conclusions: Our findings suggest that the CGRP-provocation model cannot be used to predict erenumab's effectiveness. It remains uncertain whether this finding extends to other monoclonal antibodies targeting the CGRP ligand or to gepants.Trial Registration: The study was registered at ClinicalTrials.gov (NCT04592952).","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"44 6","pages":"3331024241258734"},"PeriodicalIF":5.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REPLY to Comment on Correlation between endometriosis and migraine features: Results from a prospective case-control study'': Correlation between endometriosis and migraine features is not based on a broad strokes results. REPLY to Comment on Correlation between endometriosis and migraine features：一项前瞻性病例对照研究的结果''：子宫内膜异位症与偏头痛特征之间的相关性并非基于一刀切的结果。

IF 4.9 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241254821

Caterina Exacoustos, Francesco Giuseppe Martire, Maria Albanese, Aikaterini Selntigia

引用次数: 0

Registry-based safety studies of migraine drugs in pregnancy: Acknowledging our failures. 以登记为基础的妊娠期偏头痛药物安全性研究：承认我们的失败

IF 4.9 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241262486

Alain Braillon

引用次数: 0

Visual snow syndrome or "what's in a name?" 视觉雪综合症或 "名字里有什么"？

IF 4.9 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241259359

Gordon T Plant

引用次数: 0

Onabotulinumtoxina (craniotomy scar combined with cranial suture line injections) for persistent post craniotomy headache: Case series with long-term follow-up. Onabotulinumtoxina （开颅手术疤痕联合头颅缝合线注射）治疗开颅手术后顽固性头痛：长期随访的病例系列。

IF 5 2区医学

Cephalalgia Pub Date : 2024-06-01 DOI: 10.1177/03331024241259452

Janet Leon, Todd D Rozen, Alok A Bhatt

{"title":"Onabotulinumtoxina (craniotomy scar combined with cranial suture line injections) for persistent post craniotomy headache: Case series with long-term follow-up.","authors":"Janet Leon, Todd D Rozen, Alok A Bhatt","doi":"10.1177/03331024241259452","DOIUrl":"10.1177/03331024241259452","url":null,"abstract":"Background: There is no defined preventive treatment protocol for persistent post-craniotomy headache. In several small case series and individual case reports onabotulinumtoxinA injected into the craniotomy scar has shown possible efficacy. What is lacking is long term follow-up and if focusing on the cranial suture lines along with the craniotomy scar can enhance improvement and provide more sustained benefit.Methods: Retrospective chart review with case series.Results: Four patients (three women, one man) with ICHD-3 defined persistent post craniotomy headache were treated using a novel onabotulinumtoxinA injection protocol. All the patients presented with continuous head pain of moderate to severe intensity. All had severe allodynia on the side of their craniotomy. All had significant reduction in quality of life. Our application of onabotulinumtoxinA involved injection into both the surgical scar and the transected/irritated cranial suture lines noted on neuroimaging and physical examination. With treatment all patients demonstrated significant benefit including a reduction in daily pain intensity (75%-100%), developing periods of pain freedom (2-7 days per week) and having a dramatic improvement in quality of life (close to 100% in all). The benefit was sustained for at least five years of follow-up.Conclusion: From our case series it appears that injection not only along the painful craniotomy scar but into the involved cranial suture lines provides positive efficacy and sustained improvement in patients with persistent post craniotomy headache.","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"44 6","pages":"3331024241259452"},"PeriodicalIF":5.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0