Cephalalgia最新文献

{"title":"Reply to: interpreting discordant negative-control outcomes in the cerebrovascular safety assessment of CGRP monoclonal antibodies.","authors":"Bradley Ong, Sedat Gül","doi":"10.1177/03331024261493112","DOIUrl":"https://doi.org/10.1177/03331024261493112","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 10","pages":"3331024261493112"},"PeriodicalIF":5.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting discordant negative-control outcomes in the cerebrovascular safety assessment of CGRP monoclonal antibodies.","authors":"Xiangrong Xin, Fang Hao","doi":"10.1177/03331024261493119","DOIUrl":"https://doi.org/10.1177/03331024261493119","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 10","pages":"3331024261493119"},"PeriodicalIF":5.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Optimized diagnostic criteria for burning mouth syndrome should remain clinically grounded.","authors":"Mohamed El-Rubaiy, Thomas List, Anna Truedsson, Jean-Paul Goulet, Peter Svensson, Per Alstergren","doi":"10.1177/03331024261493168","DOIUrl":"https://doi.org/10.1177/03331024261493168","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 10","pages":"3331024261493168"},"PeriodicalIF":5.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in the interstitial microenvironment across headache phases and clinical phenotypes in migraine: A multimodal diffusion MRI study.","authors":"Roberta Messina, Ilaria Cetta, Elisabetta Pagani, Edoardo Ratto, Federica Genovese, Alessandro Visentini, Bruno Colombo, Maria Assunta Rocca, Massimo Filippi","doi":"10.1177/03331024261470368","DOIUrl":"https://doi.org/10.1177/03331024261470368","url":null,"abstract":"<p><p>AimProcesses related to glymphatic function and fluid exchange may contribute to migraine pathophysiology. We used multimodal diffusion MRI to investigate perivascular diffusivity and the interstitial microenvironment in migraine and to assess differences across migraine phases and clinical phenotypes.MethodsWe enrolled 120 migraine participants and 52 healthy controls (HC) who underwent 3 T MRI. Participants were classified as episodic migraine (EM, n = 93) or chronic migraine with medication-overuse headache (CM-MOH, n = 25), and by headache status as migraine with headache (MwH, n = 25) or headache-free migraine (MwoH, n = 95). Two CM participants without MOH were excluded from phenotype analyses. Diffusion-derived metrics included diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) and neurite orientation dispersion and density imaging-derived white matter intracellular (IVF) and extracellular volume fractions (EVF). Group comparisons and correlations were assessed using <i>p</i>_{Bonferroni-corrected} < 0.05. Voxel-wise IVF and EVF analyses were performed using tract-based spatial statistics with threshold-free cluster enhancement (<i>p</i>_{FWE-corrected} < 0.05).ResultsNo DTI-ALPS differences were observed between migraine and HC or across subgroups. No significant IVF or EVF differences emerged between the migraine group and HC, between EM and HC, or between EM and CM-MOH. In contrast, CM-MOH participants showed reduced EVF and increased IVF versus HC (<i>p</i>_FWE<i>-corrected</i> < 0.05). Similar alterations were observed in MwH versus HC and MwoH (<i>p_{FWE-corrected}</i> < 0.05). Changes involved the corpus callosum, anterior thalamic radiation, cingulum, and optic radiations. No significant associations with clinical variables emerged, except a weak association between longer disease duration and lower EVF (r = -0.3, <i>p_{Bonferroni-corrected}</i>=0.04).ConclusionsMultimodal diffusion MRI revealed subgroup-specific differences in compartmental volume fractions, with reduced EVF and increased IVF, in individuals with migraine. These findings suggest possible alterations in the interstitial microenvironment that vary with headache phase and disease burden, rather than representing a stable trait. Whether such compartmental shifts influence interstitial transport or glymphatic-related processes remains speculative and warrants further investigation.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 10","pages":"3331024261470368"},"PeriodicalIF":5.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"App-based self-administered biofeedback for the prevention of episodic migraine: A randomized controlled trial.","authors":"Amalie Christine Poole, Anker Stubberud, Melanie Rae Simpson, Lise Rystad Øie, Erling Tronvik, Espen Saxhaug Kristoffersen, Marte-Helene Bjørk, Iben Cornelia Keim Larsen, Kjersti Grøtta Vetvik, Nina Bäcklund, Joakim Høgsteggen Østhus, Joan Crespi, Oda Vardenær Lunder, Andrej Netland Khanevski, Ane Bakke Øvrevik, Alexander Olsen, Mattias Linde, Øyvind Salvesen, Tore Wergeland","doi":"10.1177/03331024261480724","DOIUrl":"10.1177/03331024261480724","url":null,"abstract":"<p><p>AimTo evaluate the efficacy and safety of a fully self-administered, app-based biofeedback intervention for the prevention of episodic migraineMethodsThis open-label, randomized, waitlist-controlled multicenter trial included adults with episodic migraine assigned to 12 weeks of daily biofeedback or a waitlist control. The primary outcome was change in monthly migraine days (MMDs) from baseline to weeks 9-12. Secondary outcomes included migraine intensity, acute medication use, and migraine-specific quality of life (MSQ v2.1). Statistical analyses were performed according to the intention-to-treat principle by a statistician masked to treatment assignment.ResultsOf 1113 individuals screened, 279 participants (mean [SD] age, 41 [10] years; 92% women) were randomized to the intervention (n = 140) or waitlist control (n = 139). Baseline MMDs were 4.8 (2.4) and 4.6 (2.3) in the intervention and control groups, respectively. During weeks 9-12, the estimated reduction in MMDs was 0.9 days (95% CI, -1.4 to -0.5) in the intervention group and 0.0 days (95% CI, -0.5 to 0.4) in the control group (between-group difference, 0.9 days; 95% CI, 0.3 to 1.5; P = 0.002). Participants receiving biofeedback also showed greater improvements in MSQ v2.1 total scores (mean difference, 5.3 points; 95% CI, 2.1 to 8.6; P = 0.001). Nine device-related adverse events occurred, all with mild severity.ConclusionApp-based self-administered biofeedback was associated with a statistically significant reduction in migraine frequency and improved quality of life, with a favorable safety profile.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261480724"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new <i>telos</i> for migraine prevention: From potentiality to actuality through the IHS higher standards.","authors":"Luigi Francesco Iannone","doi":"10.1177/03331024261489742","DOIUrl":"https://doi.org/10.1177/03331024261489742","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261489742"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal 7T MRI reveals subcortical structural, functional, iron accumulation, and glymphatic abnormalities in chronic migraine.","authors":"Xinyu Wang, Jianxin Hu, Caohui Duan, Yongqin Xiong, Xiaopeng Zong, Yuhan Wu, Luhua Zhang, Xiangbing Bian, Song Wang, Haoxuan Lu, Bingbing Zhao, Zhixuan Li, Jiaxin Sun, Zhao Dong, Xin Lou","doi":"10.1177/03331024261485487","DOIUrl":"https://doi.org/10.1177/03331024261485487","url":null,"abstract":"<p><p>BackgroundExploring the pathogenesis of chronic migraine (CM) remains a formidable challenge. While 7T MRI enables precise detection of microstructural alterations in subcortical nuclei and subregions in CM, comprehensive multimodal imaging studies are few. We therefore conducted a 7T multimodal imaging study to characterize subcortical nuclei and limbic subregions within the hypothalamus, thalamus, hippocampus, and amygdala alterations associated with migraine chronification and to determine the impact of medication-overuse headache (MOH) on CM brain changes.MethodsWe performed multimodal 7T MRI in 62 healthy controls (HCs), 62 episodic migraine (EM) patients, and 62 CM patients (31 with MOH). MRI measures included volumes, functional indicators (fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo)), quantitative susceptibility mapping (QSM), and diffusion tensor imaging analysis along the perivascular space, choroid plexus volume, and basal ganglia perivascular space (PVS) metrics for glymphatic function. Group differences and associations with clinical measures were assessed.ResultsAfter false discovery rate (FDR) correction, fALFF in the accumbens area (L) and mean individual PVS volume differed significantly among the three groups (<i>q</i> < 0.05). Both EM and CM showed lower left accumbens fALFF and greater PVS volume than HCs, whereas no significant difference was detected between EM and CM. No group effects survived FDR correction for regional volume, ReHo, QSM, or other PVS metrics. No significant differences were found between CM patients with and without MOH. Left accumbens fALFF was negatively correlated with the headache duration, whereas PVS volume was positively correlated with headache duration.ConclusionsMigraine was associated with reduced spontaneous activity in the left accumbens area and increased basal ganglia PVS volume. The absence of detectable differences between EM and CM suggests that these abnormalities may represent shared migraine-related features rather than changes that increase linearly with chronification. The findings implicate altered pain-reward processing and perivascular morphology, while indicating that the transition to CM may depend on changes that static regional measures do not capture.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261485487"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered integration of bodily and visual signals in visual snow syndrome.","authors":"Sophie De Beukelaer, Insa Schlossmacher, Sarah A Aeschlimann, Antonia Klein, Andreas Szukics, Matthias Ertl, Christoph J Schankin","doi":"10.1177/03331024261480300","DOIUrl":"https://doi.org/10.1177/03331024261480300","url":null,"abstract":"<p><p>BackgroundVisual snow syndrome (VSS) is characterized by persistent visual disturbances and is considered to involve altered sensory integration and salience processing. Neuroimaging studies suggest aberrant attention and salience network integration, yet the real-time interaction between internal bodily signals and external sensory processing remains unclear.MethodsWe conducted a case-control electroencephalogram study in 18 VSS patients and 16 matched controls performing a visual oddball task with standard and deviant stimuli. Heartbeat-evoked potentials (HEP) were extracted as an index of cortical interoceptive processing and visual mismatch negativity (MMN) as a marker of exteroceptive prediction error. Trial-wise analyses and source localization assessed interoceptive-exteroceptive interactions.ResultsVSS participants exhibited altered HEP amplitudes relative to controls, together with reduced condition-dependent differentiation between standard and deviant trials. The relationship between HEP and MMN amplitudes was significantly moderated by group and associated with symptom intensity in VSS. Source analysis localized these effects to a left frontotemporal network.ConclusionsVSS is associated with altered interoceptive-exteroceptive interactions during visual perception, which may contribute to persistent visual symptoms.</p>","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261480300"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It was a common, prevalent, and disabling night <i>A corpus analysis of formulaic opening sentences in migraine research</i>.","authors":"Gal Ifergane","doi":"10.1177/03331024261489743","DOIUrl":"https://doi.org/10.1177/03331024261489743","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261489743"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Musella et al.: Engaging psychiatry in the perceptual dimension of oral dysaesthetic and perceptual disorder.","authors":"Gilad Wasserman, Ayelet Zlotogorski-Hurvitz, Iftah Biran","doi":"10.1177/03331024261479682","DOIUrl":"https://doi.org/10.1177/03331024261479682","url":null,"abstract":"","PeriodicalId":10075,"journal":{"name":"Cephalalgia","volume":"46 9","pages":"3331024261479682"},"PeriodicalIF":5.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}