Journal of Allergy and Hypersensitivity Diseases最新文献

{"title":"Multiple hypothesis testing in allergy and hypersensitivity diseases investigation: a pedagogical perspective","authors":"Hugo Guillermou ,&nbsp;Christophe Abraham ,&nbsp;Isabella Annesi-Maesano ,&nbsp;Nicolas Molinari","doi":"10.1016/j.jahd.2024.100014","DOIUrl":"10.1016/j.jahd.2024.100014","url":null,"abstract":"<div><h3>Background</h3><div>Allergy and hypersensitivity diseases (AHD) are multifactorial diseases affecting different organs of the human body and with different level of severity. Therefore, multiple hypothesis testing is a common practice in AHD investigation. However, this increases the probability of rejecting a true null hypothesis, meaning there's no effect, the so-called risk of type 1 error or alpha risk. We present here how to control global alpha risk in the case of multiple comparisons or multitesting in AHD investigations to minimize the risk of drawing false positive conclusions.</div></div><div><h3>Methods</h3><div>Four methods for controlling global alpha risk, namely Bonferroni, Sidak, Holm–Bonferroni, and Benjamini–Hochberg, were applied to simulated and real data. Their performance was assessed through false negative, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).</div></div><div><h3>Results</h3><div>The Bonferroni method was found to be the most conservative, while the Benjamini–Hochberg method had the most power. The Holm–Bonferroni method was a compromise between statistical power and control of false positives.</div></div><div><h3>Conclusions</h3><div>Controlling global alpha risk is crucial in multiple comparisons like they are needed in AHD investigation, and different methods are available to achieve it. Researchers should choose the method that best suits their study, considering the assumptions and objectives.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-fatal food anaphylaxis: From epidemiological data to care challenges","authors":"Guillaume Pouessel ,&nbsp;Sylvie Leroy ,&nbsp;Antoine Deschildre","doi":"10.1016/j.jahd.2024.100018","DOIUrl":"10.1016/j.jahd.2024.100018","url":null,"abstract":"<div><h3>Introduction</h3><div>Near-fatal and fatal anaphylaxis induced by food is a critical event for the patient/caregivers but is also a challenge for the physician/allergist for both acute and long-term care. We aimed to describe the epidemiology of food-induced near-fatal anaphylaxis (NFA), the key factors that may impact their approach, and its management.</div></div><div><h3>Methods</h3><div>In this narrative review, we have focused on food-induced NFA moving from epidemiological data and risk factors to management using a search of PubMed online databank.</div></div><div><h3>Results</h3><div>NFA is not well-defined in the literature. Food-induced anaphylaxis mortality rate is estimated less than 0.3 deaths per million persons-years in the general population. Refractory anaphylaxis also appears to be rare (&lt; 2 % of anaphylaxis cases). Food-induced NFA are mostly observed in children but can also occur in adults, even the elderly. While most countries report peanut/tree nuts being frequently involved in NFA, seafood or milks are reported in other countries.</div><div>Prior anaphylaxis, asthma diagnosis, IgE sensitization or basophil activation tests are not good predictors of NFA whereas adolescence/young adulthood are associated with a higher risk of severe outcome. However there remain major knowledge gaps regarding risk factors of NFA, including the impact of asthma.</div><div>There is a clear room for improvement in the prevention and management of NFA to focus on: prompt adrenaline use in prehospital care, innovations regarding alternative forms of injectable adrenaline, prevention at school, therapeutic education, food allergen avoidance and adequate labelling. Some patients may benefit from immunotherapy and/or biologicals in the context of personalized care.</div></div><div><h3>Conclusion</h3><div>A collaborative research is needed to address knowledge gaps in anaphylaxis, even more for food-induced NFA. We need to go further in identifying biomarkers, pathophysiologic pathways, genetic factors that may be associated with an increased risk of NFA. Novel therapeutic options should be envisaged in these patients.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P values or not? How journals can promote better statistical reporting in exploratory research","authors":"Alessandro Marcon","doi":"10.1016/j.jahd.2024.100022","DOIUrl":"10.1016/j.jahd.2024.100022","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"3 ","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143093197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma and coagulation: A (seemingly) strange couple and its pathophysiological and clinical implications","authors":"Annalisa Castagna ,&nbsp;Gianenrico Senna ,&nbsp;Giuseppe Argentino ,&nbsp;Marco Caminati ,&nbsp;Simonetta Friso ,&nbsp;Nicola Martinelli","doi":"10.1016/j.jahd.2024.100012","DOIUrl":"10.1016/j.jahd.2024.100012","url":null,"abstract":"<div><p>Asthma is a heterogeneous disease characterized by chronic inflammation and variable airway remodeling, determining a range of clinical presentations defined by respiratory symptoms and airway involvement. Inflammation, driven by both adaptive and innate immune responses, plays a key role in the pathophysiology of asthma. Other crucial biological pathways, including the coagulation cascade, are closely and two-way entwined with inflammatory processes. Such interconnections represent the molecular bases explaining the asthma-related alterations of haemostatic balance, which are usually shifted to procoagulant states, leading to pathophysiological and clinical implications. Many different chronic inflammatory conditions have also been associated with prothrombotic diathesis and an increased risk of venous thromboembolism, but in asthma, these bidirectional interconnections appear particularly evident. A growing number of studies in the last decades have addressed the bidirectional relationship between asthma pathways and coagulation mechanisms. This narrative review summarises the molecular/biological proofs and clinical/epidemiological evidence linking asthma and coagulation. This relationship is not limited to the inflammatory-driven processes leading to procoagulant states and, therefore, to an increased risk of thrombosis in patients with asthma but it is also related to the extra-haemostatic effects of coagulation factors, which may modulate asthma pathways and even influence the development of respiratory manifestations. Consistent with the former issue, several epidemiological studies demonstrated a compelling association between asthma and an increased risk of venous thromboembolism, independent of potential confounding factors. Regarding the latter issue, it appears biologically suggestive and therapeutically intriguing that, at least in animal models, many anticoagulant drugs have been shown to reduce airway hyperresponsiveness/remodeling and improve respiratory performance in the setting of asthma. Certainly, such therapeutic approaches, whose effectiveness has yet to be fully demonstrated in humans and whose bleeding-related side effects represent a major concern about their use, remain only speculative in clinical practice and we are still very far from their hypothetical application. Anyway, a more thorough understanding of molecular mechanisms connecting asthma, allergic inflammation, coagulation, and thrombosis may allow a better knowledge of asthma pathophysiology, potentially paving the way towards innovative therapeutic approaches and leading to better strategies in the overall management of patients with asthma.</p></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100012"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000125/pdfft?md5=6e7804fd07a44d7cff30341109a849b3&pid=1-s2.0-S2950312424000125-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergy and hypersensitivity diseases in space: physiological changes, clinical aspects, and mechanisms with countermeasures","authors":"Brigitte Godard","doi":"10.1016/j.jahd.2024.100007","DOIUrl":"https://doi.org/10.1016/j.jahd.2024.100007","url":null,"abstract":"<div><p>Allergy and hypersensitivity diseases are important topics worldwide. The development of allergies in humans has become increasingly common and is expected to increase in the next future, the incidence is expected to reach 50% of the worldwide adult population. Space is not left out in this phenomenon. Having allergies requires further care, considering that astronauts spend time far away from home, working with widely diverse materials for science experiments and repairing stations. A history of atopy is checked during the selection process and can request further investigation to make sure the crew and mission will not be impacted. It is not itself a disqualifying criterion: it has to be balanced with all other parameters. Space is a very extreme environment for the body that increases the risk to develop allergy or hypersensitivity. This article focuses on the specificity of space by reviewing the very challenging and extreme environment of space: microgravity, radiation, isolation and other specificity of the International Space Station. Space-related clinical diseases, including allergies, and the mechanisms and countermeasures used in space to avoid major clinical events were also reviewed. One of the major consequences of space in the topic of allergy is the change in the immune system. If the immune system is altered, the capacity for recovery is impacted, and more critical infections can be expected in space. Further studies are needed to ensure the safety of next interplanetary travel to space. In this review new countermeasures are mentioned, they seem promising but need further research on human bodies to ensure safe travel to space.</p></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000071/pdfft?md5=b16475c850498e9d9fd2877060b07efa&pid=1-s2.0-S2950312424000071-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish allergy management: Should fish be completely avoided? The pros and cons debate","authors":"Agnes Sze-Yin Leung ,&nbsp;Naoko Fusayasu ,&nbsp;Laura Argiz Álvarez ,&nbsp;Yanjun Gu ,&nbsp;Motohiro Ebisawa ,&nbsp;Gary Wing-Kin Wong","doi":"10.1016/j.jahd.2024.100008","DOIUrl":"10.1016/j.jahd.2024.100008","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000083/pdfft?md5=d428891186f801c4c7f85e1a1ac61d23&pid=1-s2.0-S2950312424000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141406652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D deficiency may be associated with allergies in sub-Saharan Africa","authors":"Ofilia Mvoundza Ndjindji ,&nbsp;Steeve Minto’o Rogombe ,&nbsp;Amandine Mveang-Nzoghe ,&nbsp;Marielle Leboueny ,&nbsp;Ouloungou Mbina ,&nbsp;Nancy Abougono Ekogha ,&nbsp;Anicet Christel Maloupazoa Siawaya ,&nbsp;Éliane Kuissi Kamgaing ,&nbsp;Bénédicte Ndeboko ,&nbsp;Simon Ategbo ,&nbsp;Joël Fleury Djoba Siawaya","doi":"10.1016/j.jahd.2024.100011","DOIUrl":"https://doi.org/10.1016/j.jahd.2024.100011","url":null,"abstract":"<div><h3>Background</h3><p>Though the consensus is that vitamin D deficiency is associated with allergies, virtually no study investigates this association in a sub-Saharan African setting.</p></div><div><h3>Methods</h3><p>To investigate the association between vitamin D deficiency and allergies in this setting, we recruited 42 allergic patients (60% adults vs. 40% children) and 20 controls (45% adults vs. 55% children). Allergies were confirmed in symptomatic patients by measuring circulating allergens-specific IgE antibodies (Proteome Tech kits), whereas blood concentration of vitamin D was measured using the total 25-hydroxyvitamin D kit (BioMérieux).</p></div><div><h3>Results</h3><p>88% (37/42) of allergic patients had low vitamin D. Only 25% of (5/20) non-allergic controls had low serum vitamin D levels. Vitamin D insufficiency was significantly higher in allergic patients than non-allergic controls (odds ratio = 22.2; relative risk: 3.5; χ² = 24.7; <em>P</em> &lt; 0.0001). Low vitamin D serum concentration prevalence was similar in both children and adult patients (87% (13/15) vs. 85.2% (23/27) respectively). In children (odds ratio: 26; relative risk: 4.3; χ² = 11.1; p-value &lt; 0.001), like in adults (odds ratio: 72; relative risk: 3.8; χ² = 20.7; <em>P</em> &lt; 0.0001), low serum vitamin D level was significantly associated to allergies.</p></div><div><h3>Conclusion</h3><p>A strong association was found between low serum vitamin D level and allergies, suggesting that vitamin D deficiency may be linked to allergy development in sub-Saharan African settings. More extensive studies need to be done to confirm our findings.</p></div><div><h3>Key message</h3><p>The development of allergies in sub-Saharan Africa may be linked to vitamin D insufficiency.</p></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100011"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950312424000113/pdfft?md5=4f2ae8ef871f618ef3588195500e921a&pid=1-s2.0-S2950312424000113-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision medicine targeting groups of intervention in difficult-to-treat asthma","authors":"Pascal Demoly ,&nbsp;Anne-Sophie Gamez ,&nbsp;Arnaud Bourdin ,&nbsp;Davide Caimmi","doi":"10.1016/j.jahd.2024.100013","DOIUrl":"10.1016/j.jahd.2024.100013","url":null,"abstract":"<div><h3>Introduction</h3><div>Asthma is a chronic airway inflammatory disease, and its medical complexity essentially resides in the management of the difficult-to-treat and severe forms. Previous studies have focused essentially on severe asthma and endotypes. Using the concept of precision medicine, we addressed the less standardized management of difficult-to-treat asthma based upon clinical features solely.</div></div><div><h3>Objectives</h3><div>The objective of this work was to identify possible reasons for adults and children for suffering from difficult-to-treat asthma, to propose the best therapeutical and diagnostic approach.</div></div><div><h3>Material and methods</h3><div>We conducted a qualitative analysis of the medical records of 42 consecutive adult and pediatric patients suffering from difficult-to-treat asthma seen in a tertiary hospital and based on the French respiratory medicine society questionnaire for severe asthma. The study of all records was performed by two independent clinicians. In all cases, missing data were openly discussed among all coauthors until resolution was achieved.</div></div><div><h3>Results</h3><div>Our findings show that, in a real-life setting, patients with difficult-to-treat asthma may be better approached if considering one or more of the nine following groups of cointervention: metabolic comorbidities; ENT comorbidities; other comorbidities such as gastro-esophageal reflux; non-allergic environment; allergic environment linked to respiratory or food allergens; inappropriate behavior; error of diagnosis; insufficiently treated patients; and intrinsic resistance. When these groups are identified and targeted with the appropriate treatment in one patient, including their approach in the management of asthma allow reaching better control of symptoms.</div></div><div><h3>Conclusions</h3><div>Behind each group of intervention, a specific pedagogic challenge is hidden on which physicians may implement their management strategy to optimize the treatment of their patients based on their own individual characteristics.</div></div>","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"2 ","pages":"Article 100013"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142421979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE-mediated Egg Allergy in Children: Diagnosis and Management","authors":"Enrica Manca, P. Demoly, Davide Caimmi","doi":"10.1016/j.jahd.2024.100003","DOIUrl":"https://doi.org/10.1016/j.jahd.2024.100003","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unreveling determinants of severe anaphylaxis – a cluster analysis from a large national hospitalization database","authors":"L. Kase Tanno, Pham Thao Van Luong, Megane Dieval, Caroline Dunoyer, Nicolas Molinari, Isabella Annesi-Maesano, Pascal Demoly","doi":"10.1016/j.jahd.2024.100004","DOIUrl":"https://doi.org/10.1016/j.jahd.2024.100004","url":null,"abstract":"","PeriodicalId":100752,"journal":{"name":"Journal of Allergy and Hypersensitivity Diseases","volume":"62 1-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139877070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}