International Journal of Medical Microbiology Supplements最新文献_第2页

Safety and immunogenicity of FSME-IMMUN® “new” vs. Encepur® in adults FSME-IMMUN®“new”与Encepur®在成人中的安全性和免疫原性

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80022-6

引用次数: 0

TBE booster immunization in adults — first experience with a new tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer 成人流行性脑炎加强免疫——首次接种不含蛋白质来源稳定剂的新型蜱传脑炎(TBE)疫苗

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80024-X

Olaf Zent , Tino F. Schwarz , Annelie Plentz , Angelika Banzhoff , Wolfgang Jilg

{"title":"TBE booster immunization in adults — first experience with a new tick-borne encephalitis (TBE) vaccine, free of protein-derived stabilizer","authors":"Olaf Zent , Tino F. Schwarz , Annelie Plentz , Angelika Banzhoff , Wolfgang Jilg","doi":"10.1016/S1433-1128(04)80024-X","DOIUrl":"10.1016/S1433-1128(04)80024-X","url":null,"abstract":"<div><p>A total of 222 adult subjects, all of whom received primary immunization according to the rapid immunization schedule in a preceding clinical trial with either a new (i.e. polygeline free) or formerly licensed (i.e. polygeline containing) TBE vaccine were invited for extension studies. The subjects received the first booster immunization with the new TBE vaccine at 12 to 18 months after primary immunization. Subsequently, a total of 191 of the 222 subjects could be enrolled in a serological follow-up one year after the booster immunization. Neutralizing TBE antibody titers were determined prior to, 21 days after and approximately 12 months after booster immunization. Prior to first booster immunization, TBE antibodies (GMTs) had remained on a high level and were far above the detection limit of the neutralization test used. All subjects of the per protocol population who were primarily immunized with the new TBE vaccine formulation and all but one subject of the control group were still seropositive prior to the booster. All subjects showed a sharp increase of TBE antibodies following the booster immunization. Within the 12 months follow-up period, neutralizing TBE antibody titers remained on a high level. The booster vaccination was well tolerated by the subjects. Only very few febrile reactions (<1%) none higher than 38.5°C were reported. No serious or unexpected adverse events related to vaccination were reported. These successful results in terms of both immunogenicity and safety indicate that TBE vaccination with this new TBE vaccine can be used safely in adults. A long lasting immunity can be concluded from the strong immune response following the booster immunization.</p></div>","PeriodicalId":100707,"journal":{"name":"International Journal of Medical Microbiology Supplements","volume":"293 ","pages":"Pages 134-138"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1433-1128(04)80024-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24522106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Message of greetings 问候短信

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80002-0

Dr. Carola Reimann (Member of the Deutscher Bundestag)

引用次数: 1

Geographical and seasonal variation in detecting Borrelia burgdorferi sensu lato in rodents of North East Austria 奥地利东北部啮齿动物勃氏疏螺旋体检测的地理和季节变化

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80019-6

引用次数: 0

Decreasing tick-borne disease risk in the US by intervening in the natural cycle: lessons from the woods thus far 通过干预自然周期来降低美国蜱传疾病的风险:迄今为止森林的教训

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80026-3

引用次数: 0

Test systems for tick repellents 驱蜱剂测试系统

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80037-8

Hans Dautel

引用次数: 50

State-of-the-art serological techniques for detection of antibodies against tick-borne encephalitis virus 检测蜱传脑炎病毒抗体的最新血清学技术

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80028-7

Karen Sonnenberg , Matthias Niedrig , Katja Steinhagen , Edda Rohwäder , Wolfgang Meyer , Wolfgang Schlumberger , Ewald Müller-Kunert , Winfried Stöcker

引用次数: 20

Evidence that climate change has caused ‘emergence’ of tick-borne diseases in Europe? 气候变化导致欧洲“出现”蜱传疾病的证据?

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80004-4

Sarah E. Randolph

{"title":"Evidence that climate change has caused ‘emergence’ of tick-borne diseases in Europe?","authors":"Sarah E. Randolph","doi":"10.1016/S1433-1128(04)80004-4","DOIUrl":"10.1016/S1433-1128(04)80004-4","url":null,"abstract":"<div><p>Even though tick-borne disease systems are highly susceptible to climatic influences, climate change to date is not necessarily the cause of the marked increased incidence of a variety of tick-borne diseases in many parts of Europe over the past two decades. To test for causality, rather than coincidence, we need to examine whether the right sorts of climate change have occurred at the right time and in the right places to account for the observed heterogeneous temporal and spatial patterns of tick-borne disease ‘emergence’. Tick-borne encephalitis (TBE) incidence, for example, showed a 3-fold step increase from 1983 to 1986 in Sweden, doubled in 1993 in the Czech Republic, increased even more dramatically in the same year in Lithuania and Poland, but declined markedly in 1997 in Hungary, Croatia and Slovenia. Within each country, TBE incidence has changed to different degrees in different regions. Because other tick-borne diseases, notably Lyme borreliosis, has commonly ‘emerged’ in parallel with TBE, we should first examine climate variables predicted to have a general effect on tick abundance, which has indeed increased in the past decade. These include temperature and moisture stress, which have seasonally differential impacts. Monthly mean records for 1960–2000 from the UK Climate Research Unit's interpolated global climate surface reveal that mean spring, spring-autumn and winter temperatures have all increased gradually over the past 40 years, but apparently most sharply in the late 1980s, when moisture stress also increased. These climate data do not reveal any obvious differences between sites where TBE did or did not ‘emerge’, and in Sweden increases in TBE pre-dated the onset of warmer springs and winters. If recorded climate changes cannot yet satisfactorily explain the temporal and spatial patterns of tick-borne disease change in Europe, the impact of biotic factors, such as increases in deer abundance and changing habitat structure, and of socio-political changes following the end of communist rule, demand more detailed quantitative analyses.</p></div>","PeriodicalId":100707,"journal":{"name":"International Journal of Medical Microbiology Supplements","volume":"293 ","pages":"Pages 5-15"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1433-1128(04)80004-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24522222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 191

Global climate change and the emergence/re-emergence of infectious diseases 全球气候变化和传染病的出现/再次出现

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80005-6

Roland Zell

引用次数: 135

A tick-borne encephalitis ceiling in Central Europe has moved upwards during the last 30 years: Possible impact of global warming? 在过去的30年里，中欧的蜱传脑炎上限已经上升:可能是全球变暖的影响?

International Journal of Medical Microbiology Supplements Pub Date : 2004-04-01 DOI: 10.1016/S1433-1128(04)80008-1

Petr Zeman , Cestmir Beneš

{"title":"A tick-borne encephalitis ceiling in Central Europe has moved upwards during the last 30 years: Possible impact of global warming?","authors":"Petr Zeman , Cestmir Beneš","doi":"10.1016/S1433-1128(04)80008-1","DOIUrl":"10.1016/S1433-1128(04)80008-1","url":null,"abstract":"<div><p>The geographic/temporal pattern of cases of tick-borne encephalitis (TBE) registered in the Czech Republic since 1970 was analysed to verify the surmise of a global warming effect. Using a geographic information system, over 8,700 notified places of infection were pinpointed on a map and overlaid with a digital elevation model to estimate the vertical distribution of the cases. Series of yearly disease ceilings (assessed alternatively as the respective maximum altitude or mean altitudes of the upper 5 or 10 cases) were tested against the null hypothesis of random elevation course and analysed for correlation with concomitant factors (yearly TBE incidence rate, mean yearly temperature, population density of small rodents and roe deer). Statistical tests proved that the TBE ceiling has gradually moved upwards in the course of the last three decades. The average rate of ascension within this period was approx. 5.4 ± 1.7 m yearly, which corresponds well with concurrent mean temperature rising of approx. 0.036 ± 0.007°C yearly, and the vertical temperature gradient of 0.0065 ± 0.0004°C m<sup>−1</sup>. The TBE-ceiling estimates significantly correlated with TBE-incidence data and the mean yearly temperature recorded 1–2 years earlier. Although TBE incidence correlated with rodent population density that was observed 1–2 years earlier, the TBE ceiling does not seem to be influenced by rodent population dynamics nor did the population dynamics correlate with mean yearly temperatures. TBE incidence as well as mean altitudes of the upper 10 cases also correlated with official data on harvested roe deer. Overall, the fluctuations of TBE incidence and TBE ceiling proved to be synchronous processes that correspond with temperature changes. Although the dependence of TBE on temperature is not a direct one and various factors could be involved, an impact of climate warming on the vertical disease distribution in Central Europe is evident.</p></div>","PeriodicalId":100707,"journal":{"name":"International Journal of Medical Microbiology Supplements","volume":"293 ","pages":"Pages 48-54"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1433-1128(04)80008-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24522226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81