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Novel method for refractory tracheoesophageal fistula closure: modified polydioxanone suture mesh with fibrin glue 难治性气管食管瘘闭合术的新方法:改良聚二氧酮缝合网与纤维蛋白胶
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.012
Biswa Ranjan Patra MD, DM, Shashank Pujalwar MD, Ankita Singh MD, DM, Shubham Gupta MD, Chetan Saner MD, Sidharth Harindranath MD, DM, Akash Shukla MD, DM
{"title":"Novel method for refractory tracheoesophageal fistula closure: modified polydioxanone suture mesh with fibrin glue","authors":"Biswa Ranjan Patra MD, DM,&nbsp;Shashank Pujalwar MD,&nbsp;Ankita Singh MD, DM,&nbsp;Shubham Gupta MD,&nbsp;Chetan Saner MD,&nbsp;Sidharth Harindranath MD, DM,&nbsp;Akash Shukla MD, DM","doi":"10.1016/j.igie.2023.11.012","DOIUrl":"10.1016/j.igie.2023.11.012","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Refractory tracheoesophageal fistulas (TEFs) are difficult to treat, with high morbidity and mortality associated with surgical re-exploration. Various endoscopic modalities have offered minimally invasive therapeutic options. Tissue adhesive agents with ablation have achieved closure of TEFs with varying success. We adopted a novel method by using modified polydioxanone (PDS) suture mesh with fibrin glue in a child who had previously failed surgical correction twice as well as various endoscopic modalities.</p></div><div><h3>Methods</h3><p>A 5-year-old child with congenital TEF presented with recurrence after failing multiple surgical and endoscopic attempts at closure. An endoscopic examination revealed a fistula opening with a diameter of 7 mm that was 19 cm from the incisors. We used a modified PDS suture mesh with 3 sessions of fibrin glue application. PDS sutures 3-0 in size were used to knit the tubular mesh after inserting multiple knots. The suture mesh was then placed in the fistula and fixed with clips after ablating the edges with argon plasma coagulation. Subsequently, a double-lumen catheter was used to deliver processed components of fibrin sealant into the fistula tract to form the final fibrin clot. Two sessions of repeat ablation and fibrin glue application were done at 2-week intervals.</p></div><div><h3>Results</h3><p>Successful closure of the TEF was achieved with PDS suture mesh and 3 sessions of fibrin glue application over a total treatment duration of 8 weeks.</p></div><div><h3>Conclusions</h3><p>A modified PDS suture mesh with fibrin glue application offers an additional modality for endoscopic closure of refractory recurrent TEF. This novel technique is safe, effective, and easily adaptable.</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 5-9"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001425/pdfft?md5=de038e1bc48981178faae2265a3960de&pid=1-s2.0-S2949708623001425-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Teaching the next endoscopy teacher: a novel curriculum for senior gastroenterology fellows to improve their confidence in teaching endoscopy 教导下一位内镜教师:为高级消化内科研究员设计的新颖课程,以提高他们教授内镜的信心
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.004
Ryan Flanagan MD, MPH, Daniel Stein MD, MPH, Molly Perencevich MD, Marvin Ryou MD, Navin Kumar MD
{"title":"Teaching the next endoscopy teacher: a novel curriculum for senior gastroenterology fellows to improve their confidence in teaching endoscopy","authors":"Ryan Flanagan MD, MPH,&nbsp;Daniel Stein MD, MPH,&nbsp;Molly Perencevich MD,&nbsp;Marvin Ryou MD,&nbsp;Navin Kumar MD","doi":"10.1016/j.igie.2023.11.004","DOIUrl":"https://doi.org/10.1016/j.igie.2023.11.004","url":null,"abstract":"<div><h3>Background and aims</h3><p>Gastroenterology fellowship focuses on ensuring independent clinical competency, including proficiency with endoscopic procedures. However, there is currently no formalized training to ensure that fellows can effectively teach procedures to trainees before finishing fellowship and starting a faculty position.</p></div><div><h3>Methods</h3><p>A needs assessment survey was performed with junior faculty to understand common challenges in early career endoscopy teaching. A 1-hour endoscopy teaching workshop for fellows was designed to address identified deficiencies. Second-, third-, and fourth-year fellows participated in this workshop, followed by a 4-hour endoscopy session to practice teaching endoscopy to a first-year fellow under attending supervision. Serial surveys and a focus group were conducted to collect data on fellows’ confidence and experience with teaching endoscopy.</p></div><div><h3>Results</h3><p>All survey items related to general teaching ability and giving feedback showed improvement after the endoscopy workshop and in-person teaching session. The focus group identified impactful aspects of the curriculum, including the opportunity for senior fellows to reflect on their own procedural skills and teaching ability during the in-person endoscopy session.</p></div><div><h3>Conclusions</h3><p>An endoscopy teaching workshop followed by an in-person teaching experience is an effective method to introduce fellows to endoscopy teaching concepts and allow real-world practice in a safe learning environment. Future studies will need to assess whether this curriculum can directly improve teaching ability when fellows start their first faculty position.</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 66-71.e1"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001346/pdfft?md5=0c86ec9f5782ff606ebb4ae0bb638ccf&pid=1-s2.0-S2949708623001346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic flexible endoscope: a novel platform for diagnostic and therapeutic colonoscopy 磁性柔性内窥镜:用于结肠镜诊断和治疗的新型平台
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.011
Claire A. Landewee BS , Conchúbhair Winters MBChB , James Martin PhD , Joseph Norton PhD , Simone Calo PhD , Bruno Scaglioni PhD , Tamaryn Townley MEng , Jun Wai Kow PhD , Pietro Valdastri PhD , Venkataraman Subramanian MD, DM , Keith L. Obstein MD, MPH
{"title":"Magnetic flexible endoscope: a novel platform for diagnostic and therapeutic colonoscopy","authors":"Claire A. Landewee BS ,&nbsp;Conchúbhair Winters MBChB ,&nbsp;James Martin PhD ,&nbsp;Joseph Norton PhD ,&nbsp;Simone Calo PhD ,&nbsp;Bruno Scaglioni PhD ,&nbsp;Tamaryn Townley MEng ,&nbsp;Jun Wai Kow PhD ,&nbsp;Pietro Valdastri PhD ,&nbsp;Venkataraman Subramanian MD, DM ,&nbsp;Keith L. Obstein MD, MPH","doi":"10.1016/j.igie.2023.11.011","DOIUrl":"https://doi.org/10.1016/j.igie.2023.11.011","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001401/pdfft?md5=c126c6100ac683a3e845c2f8c935df0a&pid=1-s2.0-S2949708623001401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASGE Endoscopy Live: Management of Achalasia. A case of “anti-reflux POEM” in a patient with type II achalasia ASGE 内镜直播:贲门失弛缓症的治疗。II 型贲门失弛缓症患者的 "抗反流 POEM "病例
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.006
Stavros N. Stavropoulos MD, FASGE, Aymen Bukannan MD
{"title":"ASGE Endoscopy Live: Management of Achalasia. A case of “anti-reflux POEM” in a patient with type II achalasia","authors":"Stavros N. Stavropoulos MD, FASGE,&nbsp;Aymen Bukannan MD","doi":"10.1016/j.igie.2023.11.006","DOIUrl":"https://doi.org/10.1016/j.igie.2023.11.006","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 116-119"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294970862300136X/pdfft?md5=2095172d555a5e407cf472899c3c4896&pid=1-s2.0-S294970862300136X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doubling-down: LAMS-in-LAMS rescue of a migrated cholecystogastrostomy stent 加倍努力:LAMS 中 LAMS 挽救移位的胆囊胃管造口术支架
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.010
Stephen A. Firkins MD, Hassan Siddiki MD
{"title":"Doubling-down: LAMS-in-LAMS rescue of a migrated cholecystogastrostomy stent","authors":"Stephen A. Firkins MD,&nbsp;Hassan Siddiki MD","doi":"10.1016/j.igie.2023.11.010","DOIUrl":"https://doi.org/10.1016/j.igie.2023.11.010","url":null,"abstract":"","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 29-31"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001413/pdfft?md5=5d4219a21371b4c12cef7d1986672877&pid=1-s2.0-S2949708623001413-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dedicated endoscopy for Barrett’s esophagus randomized blinded pilot study: comparing a dedicated Barrett’s surveillance service with standard care 巴雷特食管专用内镜检查随机盲法试点研究:比较巴雷特食管专用监测服务与标准护理方法
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.003
Elizabeth Ratcliffe PhD , James Britton PhD , Richard Keld MD , Shaheen Hamdy PhD , John McLaughlin PhD , Yeng Ang MD
{"title":"Dedicated endoscopy for Barrett’s esophagus randomized blinded pilot study: comparing a dedicated Barrett’s surveillance service with standard care","authors":"Elizabeth Ratcliffe PhD ,&nbsp;James Britton PhD ,&nbsp;Richard Keld MD ,&nbsp;Shaheen Hamdy PhD ,&nbsp;John McLaughlin PhD ,&nbsp;Yeng Ang MD","doi":"10.1016/j.igie.2023.11.003","DOIUrl":"https://doi.org/10.1016/j.igie.2023.11.003","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Barrett’s esophagus endoscopic surveillance is prone to poor guideline adherence. This study was undertaken to obtain pilot data comparing standard care with a dedicated Barrett’s endoscopy service.</p></div><div><h3>Methods</h3><p>Adults with nondysplastic Barrett’s esophagus at 2 sites in the northwest of England were randomized to a dedicated service versus a nondedicated service for their routine surveillance. On the dedicated arm, 64% were male; 72% in the nondedicated arm were male. Median ages were 66 years and 63 years in the dedicated and nondedicated arms, and mean Prague circumferential length was 2 cm and 3 cm, respectively. The dedicated service was performed by endoscopists trained in Barrett’s assessment on specific sessions. Data were obtained on dysplasia detection and adherence to British Society of Gastroenterology guidelines.</p></div><div><h3>Results</h3><p>Of 111 recruited cases (80% recruitment rate), 92 underwent endoscopy (39 were correctly performed on the dedicated arm and 25 on the nondedicated arm). In the dedicated arm, 5 (13%) cases of dysplasia were found; 2 (8%) cases of dysplasia were found in the nondedicated arm. Guideline adherence was better in the dedicated arm, particularly Prague classification documentation (37 of 39 [95%] vs 20 of 25 [80%]) and Seattle protocol adherence (34 of 39 [87%] vs 15 of 25 [60%]). Post hoc analysis with χ<sup>2</sup> test showed improved Seattle protocol adherence (34 of 37 dedicated vs 15 of 24 nondedicated, <em>P</em> = .005), visible lesion documentation (37 of 38 dedicated vs 12 of 23 nondedicated, <em>P ≤</em> .001), and use of targeted biopsies (25 of 39 dedicated vs 3 of 25, nondedicated <em>P</em> ≤ .001).</p></div><div><h3>Conclusions</h3><p>This study is the first pilot randomized trial of dedicated services versus non-dedicated services for Barrett’s surveillance. It shows that the study design is feasible and informs a future powered multicenter study. (Clinical trial registration number: ISRCTN12259569.)</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 58-65"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001334/pdfft?md5=f7aa8264accf49c265238812bfeb2b16&pid=1-s2.0-S2949708623001334-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic diagnosis and treatment of a pyriform sinus-cutaneous fistula in a non-pediatric patient: thinking outside the box 一名非儿童患者梨状窦-皮肤瘘的内窥镜诊断和治疗:打破常规思维
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2024.01.005
Diogo Turiani Hourneaux de Moura MD, MSc, PhD, Post-PhD , Thadeu Rangel Fernandes MD , Alexandre Moraes Bestetti MD , Saullo Queiroz Silveira MD , Maria Luisa do Nascimento Moura MD , Pedro Henrique Loretti MD , Eduardo Guimarães Hourneaux de Moura PhD , Flavio Hojaij PhD
{"title":"Endoscopic diagnosis and treatment of a pyriform sinus-cutaneous fistula in a non-pediatric patient: thinking outside the box","authors":"Diogo Turiani Hourneaux de Moura MD, MSc, PhD, Post-PhD ,&nbsp;Thadeu Rangel Fernandes MD ,&nbsp;Alexandre Moraes Bestetti MD ,&nbsp;Saullo Queiroz Silveira MD ,&nbsp;Maria Luisa do Nascimento Moura MD ,&nbsp;Pedro Henrique Loretti MD ,&nbsp;Eduardo Guimarães Hourneaux de Moura PhD ,&nbsp;Flavio Hojaij PhD","doi":"10.1016/j.igie.2024.01.005","DOIUrl":"10.1016/j.igie.2024.01.005","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Pyriform sinus-cutaneous fistula is often observed in pediatric patients and is very rare in adults. Diagnosing this condition in adults is challenging, and contrast-enhanced CT misdiagnosis is not uncommon. Neck abscess formation secondary to this fistula is treated with surgical incision and drainage, but recurrence can occur due to the fistula. Although surgery is the most effective treatment modality, less-invasive therapies such as electrocauterization or chemocauterization may be indicated. However, treatment with these cauterization techniques has a high treatment failure rate.</p></div><div><h3>Methods</h3><p>This is the first case report of diagnosing, by EGD, a pyriform sinus fistula in an adult treated with autologous abdominal fat transplantation associated with adjunctive conventional endoscopic therapies.</p></div><div><h3>Results</h3><p>A 35-year-old woman with a history of 2 cervical abscesses was admitted due to a recurrent abscess with unknown etiology. She underwent surgical drainage with intraoperative EGD under fluoroscopic assistance, and a pyriform sinus-cutaneous fistula was diagnosed. Subsequently, fistula treatment with unprocessed autologous adipose abdominal tissue collected by lipoaspiration associated with argon plasma coagulation and endoscopic vacuum therapy were successfully performed. Immediately after the procedure, the patient no longer experienced fluid discharge through the skin. The patient had no recurrence within 10 months of follow-up.</p></div><div><h3>Conclusions</h3><p>Autologous abdominal fat transplantation may be an effective minimally invasive therapy for pyriform sinus-cutaneous fistula and has the potential to become an alternative therapy for GI fistulas. We encourage future studies to exploit the role of this therapy for GI fistulas.</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 48-52"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708624000050/pdfft?md5=d736cdd41934bd2680d6d6c319444f4c&pid=1-s2.0-S2949708624000050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of a novel ultrathin gastroscope for unsedated transnasal endoscopy in children and adults for evaluation of upper GI disorders 新型超薄胃镜在儿童和成人中用于无麻醉经鼻内镜检查以评估上消化道疾病的安全性和有效性
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.12.005
Aravind Thavamani MD , Matthew J. Ryan MD , Kristina Leinwand MD , Ramya Ramraj MD , Shauna Schroeder MD , Paul A. Menard-Katcher MD , Vrinda Bhardwaj MD , James P. Franciosi MD , Joel A. Friedlander MD , Ramy Sabe MBBCh
{"title":"Safety and efficacy of a novel ultrathin gastroscope for unsedated transnasal endoscopy in children and adults for evaluation of upper GI disorders","authors":"Aravind Thavamani MD ,&nbsp;Matthew J. Ryan MD ,&nbsp;Kristina Leinwand MD ,&nbsp;Ramya Ramraj MD ,&nbsp;Shauna Schroeder MD ,&nbsp;Paul A. Menard-Katcher MD ,&nbsp;Vrinda Bhardwaj MD ,&nbsp;James P. Franciosi MD ,&nbsp;Joel A. Friedlander MD ,&nbsp;Ramy Sabe MBBCh","doi":"10.1016/j.igie.2023.12.005","DOIUrl":"https://doi.org/10.1016/j.igie.2023.12.005","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Sedation-free transnasal endoscopy (TNE) is a valuable tool for endoscopic evaluation of the upper GI tract without the risk of general anesthesia. In pediatrics, bronchoscopes are often used for TNE, which precludes gastroduodenal evaluation. We evaluated the use of a novel ultrathin (3.5-mm) gastroscope.</p></div><div><h3>Methods</h3><p>This multicenter retrospective study involved 7 U.S. hospitals from May 2022 to July 2023. Data were collected from the electronic medical record. The primary outcome was the safety and efficacy measured by completion rate and adverse events. Secondary outcomes were procedure and encounter duration and biopsy sample adequacy.</p></div><div><h3>Results</h3><p>Fifty-three patients were recruited. Indications were eosinophilic esophagitis surveillance (n = 51) and esophageal variceal evaluation (n = 2). Mean patient age was 15.1 years (range, 6-37 years) with a male predominance (84.9%). Four procedures were unable to be completed. The procedure was successful in 92.4%, and the device success rate was 94.3%. Extent of intended accessibility was transnasal esophagoscopy in 3 patients, transnasal esophagogastroscopy in 42 patients, and transnasal EGD in 4 patients. Almost 40% underwent TNE for the first time. Biopsy samples obtained were adequate for histopathologic analyses. No significant adverse events were observed. Five patients (9.4%) experienced minimal epistaxis, gagging, and nasal pain.</p></div><div><h3>Conclusions</h3><p>Sedation-free TNE using a single-use gastroscope was well tolerated and safe in pediatric and adult age groups with a success rate similar to previous studies. User feedback noted that the single-use gastroscopes provided improved visualization, increased length, and larger working channel to allow for diagnostic EGD in an efficient ambulatory setting without general anesthesia.</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 15-19"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708623001619/pdfft?md5=fe670c190c5ce34ac1f8803853a103ed&pid=1-s2.0-S2949708623001619-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety and efficacy of diphenhydramine as an adjunct to midazolam and fentanyl use for sedation in young patients undergoing endoscopic evaluation: a single-center retrospective study 苯海拉明辅助咪达唑仑和芬太尼用于内窥镜评估年轻患者镇静的安全性和有效性:单中心回顾性研究
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2024.01.002
Danyal Imam MD , Yinglin Gao DO , Wichit Srikureja MD , Timothy Allison-Aipa PhD , Steve Serrao MD , Manish Shrestha , Nikhil R. Thiruvengadam MD , Pejman Solaimani MD
{"title":"Safety and efficacy of diphenhydramine as an adjunct to midazolam and fentanyl use for sedation in young patients undergoing endoscopic evaluation: a single-center retrospective study","authors":"Danyal Imam MD ,&nbsp;Yinglin Gao DO ,&nbsp;Wichit Srikureja MD ,&nbsp;Timothy Allison-Aipa PhD ,&nbsp;Steve Serrao MD ,&nbsp;Manish Shrestha ,&nbsp;Nikhil R. Thiruvengadam MD ,&nbsp;Pejman Solaimani MD","doi":"10.1016/j.igie.2024.01.002","DOIUrl":"10.1016/j.igie.2024.01.002","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Achieving adequate sedation may be difficult for young patients and can be associated with adverse events. Diphenhydramine (DPH) has not been studied in patients &lt;45 years of age undergoing endoscopy. The aim of this study, therefore, was to evaluate the safety and efficacy of DPH as an adjunct to fentanyl/midazolam during endoscopy in this patient population.</p></div><div><h3>Methods</h3><p>A retrospective, single-center cohort study was performed in patients aged 18 to 44 years who underwent EGD, colonoscopy, or both between 2020 and 2021. Patients who received DPH as an adjunct to fentanyl/midazolam (DPH group) were compared with those who received fentanyl/midazolam alone (non-DPH group). Outcomes included the incidence of adverse events, total facility time, total recovery time, total time to adequate sedation, and total sedation dose of midazolam and fentanyl used in both groups.</p></div><div><h3>Results</h3><p>A total of 714 patients met the inclusion criteria: DPH group (n = 375) versus non-DPH group (n = 339). There was no difference in the incidence of adverse events (<em>P</em> = .29), total facility time (<em>P</em> = .97), recovery time (<em>P</em> = .28), time to reach adequate sedation (<em>P</em> = .95), or amount of midazolam required (<em>P</em> = .53). However, the non-DPH group needed significantly more fentanyl than the DPH group (<em>P</em> = .01).</p></div><div><h3>Conclusions</h3><p>This study found that DPH as an adjunctive sedative is safe and well tolerated in patients aged &lt;45 years undergoing endoscopy and does not prolong the procedure or recovery time. Further prospective studies are needed to assess if DPH improves patient comfort, tolerance, and overall experience during endoscopic procedures.</p></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 1","pages":"Pages 104-109"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949708624000025/pdfft?md5=3682e3fc7586ce1647dfc4e95c6f5535&pid=1-s2.0-S2949708624000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histoacryl glue injection in walled-off necrosis impression on gastric wall mistaken as gastric varix: an unintended adverse event having therapeutic benefit 胃壁上的脱壁坏死印迹被误认为是胃静脉曲张而注射组胺胶:具有治疗效果的意外不良事件。
iGIE Pub Date : 2024-03-01 DOI: 10.1016/j.igie.2023.11.005
Kishalaya DM, Dipankar Mondal DM, Mousam Dey MD, Souveek Mitra DM, Srijan Mazumdar DM
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