Chemosensors最新文献

{"title":"Relationship Between Sensor Sensitivity and Chemical Structure of Benzene-Carboxylic Modifiers for Umami Substance Detection","authors":"Wenhao Yuan, Sota Otsuka, Jiarui Jin, Takeshi Onodera, Rui Yatabe, Shunsuke Kimura, Kiyoshi Toko","doi":"10.3390/chemosensors13030098","DOIUrl":"https://doi.org/10.3390/chemosensors13030098","url":null,"abstract":"A 2,6-dihydroxyterephthalic acid (2,6-DHTA)-treated taste sensor exhibited sensitivity and selectivity for umami substances, as previously reported. This study aims to investigate the relationship between the sensor’s sensitivity to umami substance and the chemical structure of modifiers—specifically ortho, meta, and para substituents. The investigations focused on using structurally different modifiers to measure monosodium L-glutamate (MSG) at various concentrations. Additionally, based on the investigation of lipid and modifier conditions, a 1 mM lipid concentration was chosen for fabricating the lipid/polymer membranes used in MSG measurements, and each membrane was treated with a 0.03 wt% modifier solution. The results revealed that the sensor’s sensitivity varied depending on the modifier structures as well as the presence of an intramolecular H-bond within these modifiers, indicating the critical role of modifier structures in effectively detecting umami substance with the taste sensor.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 3","pages":"98-98"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/3/98/pdf?version=1741428530","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Tumbleweed-like MoSe2 Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid","authors":"Peizheng Shi, Ningbin Zhao, Zhuang Sun, Kaiqiang Sun, Wubo Chu, Hsu‐Sheng Tsai, Lidong Wu, Tao Cai, Yuezhong Wang, Nan Jiang, Chen Ye, Li Fu, Lixin Xu, Cheng‐Te Lin","doi":"10.3390/chemosensors13030081","DOIUrl":"https://doi.org/10.3390/chemosensors13030081","url":null,"abstract":"Uric acid (UA), the final metabolic product of purines, plays a crucial role in human health monitoring. The UA concentration in biological fluids serves as a diagnostic marker for various disorders, particularly kidney diseases, and represents a potential therapeutic target. Given the growing emphasis on preventive healthcare, developing methods for real-time UA detection has become increasingly significant. Here, we demonstrate the synthesis of novel tumbleweed-like molybdenum diselenide (MoSe2) nanostructures through a single-step hydrothermal process. The synthesized MoSe2 was subsequently hybridized with reduced graphene oxide (rGO) to construct electrodes for UA sensing. Differential pulse voltammetry (DPV) measurements revealed that the MoSe2/rGO-modified glassy carbon electrode (GCE) exhibited excellent UA detection capabilities under optimized conditions. The sensor demonstrated a remarkably low limit of detection (LOD) of 28.4 nM and maintained linearity across a wide concentration range (40 nM to 200 μM). Notably, the sensor showed high selectivity for UA detection even in the presence of common interfering species, including citric acid (CA), dopamine (DA), ascorbic acid (AA), cysteine (Cys), glucose (Glu), oxalic acid (OA), sodium ions (Na+), and potassium ions (K+). The developed sensor displayed outstanding selectivity, stability, and reproducibility characteristics. This synthetic approach offers promising opportunities for developing MoSe2-based electrochemical sensing platforms suitable for diverse bioanalytical applications.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 3","pages":"81-81"},"PeriodicalIF":0.0,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/3/81/pdf?version=1740902228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid-Gated Graphene Field Effect Transistor for High-Performance Label-Free Sensing of Polycyclic Aromatic Hydrocarbons","authors":"Cuiyun Kou, Xiaofeng Xu, Yu Bao, Zhinan Guo, Li Niu","doi":"10.3390/chemosensors13020056","DOIUrl":"https://doi.org/10.3390/chemosensors13020056","url":null,"abstract":"Polycyclic aromatic hydrocarbons (PAHs) are one of the most toxic environmental pollutants, which are very harmful to the human body. It is crucial to find convenient and effective detection methods of PAHs for preventing and controlling environmental pollution. Low-dimensional material-based field effect transistor (FET) sensors exhibit the advantages of a small size, simple structure, fast response, and high sensitivity. In this work, graphene (Gr) has been selected as the channel material for FET sensors for PAH detections. Through π-π electron stacking interactions, PAHs could be spontaneously adsorbed on the surface of the Gr and affect its electronic carrier transport behavior. Based on the relationship between the concentrations and the changes in the Dirac point of the Gr, the sensor achieved an effective response to PAHs in a broad range from 10−10 to 10−6 mol/L and a limit of detection of 10−10 mol/L was obtained, which was lower than that provided by the World Health Organization (3.46 × 10−9 mol/L), in drinking water. The results demonstrate a great application of the FET sensors in environmental analysis, and provide an important way for rapid and in situ monitoring of PAHs.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 2","pages":"56-56"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/2/56/pdf?version=1738941364","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun WO3/TiO2 Core–Shell Nanowires for Triethylamine Gas Sensing","authors":"Wenhao Li, Bo Zhang, Xiangrui Dong, Qi Lu, Hao Shen, Yi Ni, Yuechen Liu, Haitao Song","doi":"10.3390/chemosensors13020045","DOIUrl":"https://doi.org/10.3390/chemosensors13020045","url":null,"abstract":"In this work, WO3/TiO2 core–shell (C-S) nanowires (NWs) were successfully synthesized by the coaxial electrospinning method and subsequent high-temperature calcination treatment. After some microscopic structural characterizations, although the prepared WO3–TiO2 and TiO2–WO3 C-S NWs displayed quite different surface morphologies, both of the shell coatings were uniform and their typical shell thicknesses were extremely close, with mean values of 22 and 20 nm, respectively. In gas sensing tests, WO3/TiO2 C-S NWs exhibited good selectivity towards triethylamine (TEA) without significant interfering gases. Compared with bare WO3 and TiO2 NWs, WO3/TiO2 C-S NWs showed better gas sensing performance. Specifically, the optimal operating temperature and response of TiO2–WO3 C-S NWs to 100 ppm TEA were 130 °C and 106, which were reduced by 70 °C and increased by 5.73 times compared to bare WO3, respectively. Obviously, the C-S nanostructures contributed to improving the gas sensing performance of materials towards TEA. Finally, some hypothetical sensing mechanisms were proposed, which were expected to have important reference significance for the design of target products applied to TEA sensing.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 2","pages":"45-45"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Invasive Detection of Interferon-Gamma in Sweat Using a Wearable DNA Hydrogel-Based Electrochemical Sensor","authors":"Yang Dai, X. Mao, Maimaiti A. Abulaiti, Qianyu Wang, Zhihao Bai, Yifeng Ding, Shao‐Lun Zhai, Yang Pan, Yue Zhang","doi":"10.3390/chemosensors13020032","DOIUrl":"https://doi.org/10.3390/chemosensors13020032","url":null,"abstract":"Monitoring of immune factors, including interferon-gamma (IFN-γ), holds great importance for understanding immune responses and disease diagnosis. Wearable sensors enable continuous and non-invasive detection of immune markers in sweat, drawing significant attention to their potential in real-time health monitoring and personalized medicine. Among these, electrochemical sensors are particularly advantageous, due to their excellent signal responsiveness, cost-effectiveness, miniaturization, and broad applicability, making them ideal for constructing wearable sweat sensors. In this study, we present a flexible and sensitive wearable platform for the detection of IFN-γ, utilizing a DNA hydrogel with favorable loading performance and sample collection capability, and the application of mobile software achieves immediate data analysis and processing. This platform integrates three-dimensional DNA hydrogel functionalized with IFN-γ-specific aptamers for precise target recognition and efficient sweat collection. Signal amplification is achieved through target-triggered catalytic hairpin assembly (CHA), with DNA hairpins remarkably enhancing sensitivity. Ferrocene-labeled reporting strands immobilized on a screen-printed carbon electrode are displayed via CHA-mediated strand displacement, leading to a measurable reduction in electrical signals. These changes are transmitted to a custom-developed mobile application via a portable electrochemical workstation for real-time data analysis and recording. This wearable sensor platform combines the specificity of DNA aptamers, advanced signal amplification, and the convenience of mobile data processing. It offers a high-sensitivity approach to detecting low-abundance targets in sweat, paving the way for new applications in point-of-care diagnostics and wearable health monitoring.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 2","pages":"32-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/2/32/pdf?version=1737706983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-Site Detection of Ca and Mg in Surface Water Using Portable Laser-Induced Breakdown Spectroscopy","authors":"Yuanxin Wan, Shixiang Ma, Peichao Zheng, Xiande Zhao, Zhen Xing, Leizi Jiao, Hongwu Tian, Daming Dong","doi":"10.3390/chemosensors13010016","DOIUrl":"https://doi.org/10.3390/chemosensors13010016","url":null,"abstract":"Ca and Mg are key constituents in surface water that are essential nutrients and vital indicators of water hardness. Rapid on-site measurement of Ca and Mg concentrations in surface water is important. However, traditional laboratory detection methods are complex and time-consuming, and on-site detection is difficult. In this study, a portable surface water detection method was developed using laser-induced breakdown spectroscopy with a miniaturized spectrometer LIBS and a liquid jet device for sample introduction. The device enables the rapid online in situ measurement of elemental concentrations in the water. The limits of detection for the rapid on-site detection of Ca and Mg in surface water were 11.58 and 2.57 mg/L, respectively. We applied this method to assess the concentrations of Ca and Mg in authentic water samples collected from rivers and ponds. The recovery rates for Ca and Mg were 90.83–101.74% and 93.43–108.74%, respectively. This method is suitable for rapid, on-site, and highly sensitive monitoring of Ca and Mg concentrations in the environment.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 1","pages":"16-16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/1/16/pdf?version=1736864497","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-Induced Graphene-Based Gas Sensor with PEDOT:PSS/Gold–Platinum Nanocomposites for Highly Sensitive Detection of Methane","authors":"Jiaying Sun, Zhuoru Huang, Xiaojing Zhang, Hangming Xiong, Weijie Yu, Shimeng Mou, Wenwu Zhu, Hao Wan","doi":"10.3390/chemosensors13010003","DOIUrl":"https://doi.org/10.3390/chemosensors13010003","url":null,"abstract":"Methane is a common intestinal gas that has been linked to a variety of gastrointestinal disorders. In this study, we prepared a LIG-based electrochemical sensor modified with PEDOT:PSS/Au-Pt nanocomposites for high-sensitivity methane detection. LIG’s high porosity, flexibility, and excellent electrical conductivity are beneficial for electrochemical detection. The PEDOT:PSS film is electrodeposited on the electrode surface to amplify the signal further. The synergistic effect of bimetallic nanocomposites can improve the electrochemical catalytic activity and increase the specific surface area and the advantages of active sites. The experimental results show that the LIG sensor has a wide linear detection range (2–500 ppm), a low detection limit (about 0.36 ppm), high sensitivity, and good repeatability. The sensor is easy to manufacture, is low-cost, operates at room temperature, has high sensitivity, has a low detection limit, and is expected to be used for methane breath detection in the future.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"13 1","pages":"3-3"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/13/1/3/pdf?version=1735129255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Correction of Turbidity Interference on Chemical Oxygen Demand Measurements by Using Ultraviolet-Visible Spectrometry","authors":"Shihan Shan, Yanan Ji, Hanjing Deng, Zhuohui Wu, Tinglong Yang, Xiaoping Wang","doi":"10.3390/chemosensors12120247","DOIUrl":"https://doi.org/10.3390/chemosensors12120247","url":null,"abstract":"We developed a simple, rapid, and high-precision method to compensate for the turbidity interference in the measurement of water parameters using ultraviolet-visible spectrometry. By combining direct orthogonal signal correction (DOSC) with partial least squares (PLS), we corrected the full spectra (220 nm to 600 nm), significantly enhancing the accuracy of the water parameter calculations. First, DOSC was applied to filter out turbidity-related components, retaining only the spectral elements most closely associated with the target substance, without requiring a standard baseline for the turbidity effect. Then, 13 wavelengths were selected from the corrected full spectra to construct the discrete absorption spectra. Further, a PLS regression model was established based on the corrected discrete absorption spectra and their corresponding concentrations. In our experiment, this method effectively eliminated the blue shift and peak height reduction caused by turbidity, especially in shorter wavelengths, which are more sensitive to interference. Moreover, when applied to new samples, the correlation coefficients (R2) between the predicted and actual values improved from 0.5455 to 0.9997, and the root mean square error (RMSE) decreased from 12.3604 to 0.2295 after correction. Overall, the DOSC-PLS method, together with ultraviolet-visible spectrometry, posed a great potential for the precise monitoring of target water parameters in field studies.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 12","pages":"247-247"},"PeriodicalIF":0.0,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/12/247/pdf?version=1732442973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coral-like Ti3C2Tx/PANI Binary Nanocomposite Wearable Enzyme Electrochemical Biosensor for Continuous Monitoring of Human Sweat Glucose","authors":"Jinhao Wang, Lijuan Chen, Fan Chen, Xinyang Lu, X. Li, Yu Bao, Wei Wang, Dongxue Han, Li Niu","doi":"10.3390/chemosensors12110222","DOIUrl":"https://doi.org/10.3390/chemosensors12110222","url":null,"abstract":"With the continuous advancement of contemporary medical technology, an increasing number of individuals are inclined towards self-monitoring their physiological health information, specifically focusing on monitoring blood glucose levels. However, as an emerging flexible sensing technique, continuous and non-invasive monitoring of glucose in sweat offers a promising alternative to conventional invasive blood tests for measuring blood glucose levels, reducing the risk of infection associated with blood testing. In this study, we fabricated a flexible and wearable electrochemical enzyme sensor based on a two-dimensional Ti3C2Tx MXene nanosheets and coral-like polyaniline (PANI) binary nanocomposite (denoted as Ti3C2Tx/PANI) for continuous, non-invasive, real-time monitoring of sweat glucose. The exceptional conductivity of Ti3C2Tx MXene nanosheets, in conjunction with the mutual doping effect facilitated by coral-like PANI, significantly enhances electrical conductivity and specific surface areas of Ti3C2Tx/PANI. Consequently, the fabricated sensor exhibits remarkable sensitivity (25.16 μA·mM−1·cm−2), a low detection limit of glucose (26 μM), and an extensive detection range (0.05 mM ~ 1.0 mM) in sweat. Due to the dense coral-like structure of Ti3C2Tx/PANI binary nanocomposite, a larger effective area is obtained to offer more active sites for enzyme immobilization and enhancing enzymatic catalytic activity. Moreover, the sensor demonstrates exceptional mechanical performance, enabling a 60° bend in practical applications, thus satisfying the rigorous demands of human sweat detection applications. The results obtained from continuous 60 min in vitro monitoring of sweat glucose levels demonstrate a robust correlation with the data of blood glucose levels collected by a commercial glucose meter. Furthermore, the fabricated Ti3C2Tx/PANI/GOx sensor demonstrated agreement with HPLC findings regarding the actual concentration of added glucose. This study presents an efficient and practical approach for the development of a highly reliable MXene glucose biosensor, enabling stable and long-term monitoring of glucose levels in human sweat.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 11","pages":"222-222"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/11/222/pdf?version=1729857759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast Determination and Source Apportionment of Eight Polycyclic Aromatic Hydrocarbons in PM10 Using the Chemometric-Assisted HPLC-DAD Method","authors":"Ting Hu, Yitao Xia, You Wang, Lin Li, Rong An, Ling Xu, Xiang-Dong Qing","doi":"10.3390/chemosensors12100220","DOIUrl":"https://doi.org/10.3390/chemosensors12100220","url":null,"abstract":"Polycyclic aromatic hydrocarbons (PAHs) are a group of organic compounds that are both toxic and hazardous to human health and ecological systems. In recent work, a novel analytical strategy based on the chemometric-assisted HPLC-DAD method was proposed for the quantification and source apportionment of eight PAHs in PM10 samples. Compared to traditional chromatographic methods, this approach does not require the purification of complex PM10 samples. Instead, it utilizes a mathematical separation method to extract analytes’ profiles from overlapping chromatographic peaks, enabling precise quantification of PAHs in PM10. Firstly, 40 PM10 samples collected in Loudi city during two sampling periods were used for analysis. Subsequently, the second-order calibration method based on alternating trilinear decomposition (ATLD) was employed to handle the three-way HPLC-DAD data. Finally, the pollution sources of PAHs were analyzed by the feature component analysis method according to the obtained relative concentration matrix. For the validation model, the average recoveries of eight PAHs were between (88.8 ± 7.6)% and (105.6 ± 7.5)%, and the root-mean-square errors of prediction ranged from 0.03 μg mL−1 to 0.47 μg mL−1. The obtained limits of quantification for eight PAHs were in the range of 0.0050 μg mL−1 to 0.079 μg mL−1. For actual PM10 samples, results of the feature component analysis indicated that the main source of PAHs in PM10 may be traffic emissions and coal combustion. In summary, the proposed method provided a new and rapid analysis method for the accurate determination and source apportionment of PAHs in atmospheric aerosols.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 10","pages":"220-220"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/10/220/pdf?version=1729247047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}