Chemosensors最新文献_第6页

A Biomimetic Chip with Dendrimer-Encapsulated Platinum Nanoparticles for Enhanced Electrochemiluminescence Detection of Cardiac Troponin I 树突包裹铂纳米粒子仿生芯片增强心肌肌钙蛋白I的电化学发光检测

3区工程技术

Chemosensors Pub Date : 2024-10-16 DOI: 10.3390/chemosensors12100214

Hui Yun, Weijun Kong, Weiliang Shu, Zhiting Peng, Fengshan Shen, Mingyang Jiang, Zhen Xu, Tianzhun Wu, Wenhua Zhou, Xue‐Feng Yu

{"title":"A Biomimetic Chip with Dendrimer-Encapsulated Platinum Nanoparticles for Enhanced Electrochemiluminescence Detection of Cardiac Troponin I","authors":"Hui Yun, Weijun Kong, Weiliang Shu, Zhiting Peng, Fengshan Shen, Mingyang Jiang, Zhen Xu, Tianzhun Wu, Wenhua Zhou, Xue‐Feng Yu","doi":"10.3390/chemosensors12100214","DOIUrl":"https://doi.org/10.3390/chemosensors12100214","url":null,"abstract":"The measurement of cardiac troponin I (cTnI) is of vital importance for the early diagnosis of acute myocardial infarction. In this study, an enhanced electrochemiluminescent immunoassay for the highly sensitive and precise determination of cTnI was reported. A biomimetic chip with nepenthes peristome surface microstructures to achieve single-layer microbead arrays and integrated microelectrode arrays (MEAs) for ECL detection was microfabricated. Ru@SiO2 nanoparticles were prepared as signal amplificators labeling immunomagnetic beads. Dendrimer-encapsulated platinum nanoparticles (Pt DENs) were electrochemically modified on ITO MEAs. The resulting Pt DEN-modified ITO MEAs preserved good optical transparency and exhibited an approximately 20-fold ECL signal amplification compared to that obtained from bare ITO. The method made full use of the biomimetic chip with Pt DENs to develop single-layer immunomagnetic bead arrays with increasingly catalyzed electrochemical oxidation of the [Ru(bpy)3]2+–TPA system. Consequently, a limit of detection calculated as 0.38 pg/mL (S/N = 3) was obtained with excellent selectivity, demonstrating significant potential for the detection of cTnI in clinical diagnostics.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 10","pages":"214-214"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications 基于氨基mofs （MIL-125， UiO-66和MIL-101）的纸基分析装置作为荧光生物检测应用的平台

3区工程技术

Chemosensors Pub Date : 2024-10-11 DOI: 10.3390/chemosensors12100208

Sofía V. Piguillem, Germán E. Gómez, Gonzalo Tortella, Amedea B. Seabra, Matías Regiart, Germán A. Messina, Martín A. Fernández‐Baldo

{"title":"Paper-Based Analytical Devices Based on Amino-MOFs (MIL-125, UiO-66, and MIL-101) as Platforms towards Fluorescence Biodetection Applications","authors":"Sofía V. Piguillem, Germán E. Gómez, Gonzalo Tortella, Amedea B. Seabra, Matías Regiart, Germán A. Messina, Martín A. Fernández‐Baldo","doi":"10.3390/chemosensors12100208","DOIUrl":"https://doi.org/10.3390/chemosensors12100208","url":null,"abstract":"In this study, we designed three promising platforms based on metal–organic frameworks (MOFs) to develop paper-based analytical devices (PADs) for biosensing applications. PADs have become increasingly popular in field sensing in recent years due to their portability, low cost, simplicity, efficiency, fast detection capability, excellent sensitivity, and selectivity. In addition, MOFs are excellent choices for developing highly sensitive and selective sensors due their versatility for functionalizing, structural stability, and capability to adsorb and desorb specific molecules by reversible interactions. These materials also offer the possibility to modify their structure and properties, making them highly versatile and adaptable to different environments and sensing needs. In this research, we synthesized and characterized three different amino-functionalized MOFs: UiO-66-NH2 (Zr), MIL-125-NH2 (Ti), and MIL-101-NH2 (Fe). These MOFs were used to fabricate PADs capable of sensitive and portable monitoring of alkaline phosphatase (ALP) enzyme activity by laser-induced fluorescence (LIF). Overall, amino-derivated MOF platforms demonstrate significant potential for integration into biosensor PADs, offering key properties that enhance their performance and applicability in analytical chemistry and diagnostics.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 10","pages":"208-208"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/10/208/pdf?version=1728646320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Zinc Oxide Nanorod-Based Electrochemical Aptasensor for the Detection of Tumor Markers in Saliva 基于氧化锌纳米棒的唾液肿瘤标记物电化学适配体传感器的研究

3区工程技术

Chemosensors Pub Date : 2024-10-02 DOI: 10.3390/chemosensors12100203

Junrong Li, Yihao Ding, Yuxuan Shi, Zhiying Liu, Jun Lin, Rui Cao, Miaomiao Wang, Yushuo Tan, Xiaolin Zong, Zhan Qu, Liping Du, Chunsheng Wu

{"title":"A Zinc Oxide Nanorod-Based Electrochemical Aptasensor for the Detection of Tumor Markers in Saliva","authors":"Junrong Li, Yihao Ding, Yuxuan Shi, Zhiying Liu, Jun Lin, Rui Cao, Miaomiao Wang, Yushuo Tan, Xiaolin Zong, Zhan Qu, Liping Du, Chunsheng Wu","doi":"10.3390/chemosensors12100203","DOIUrl":"https://doi.org/10.3390/chemosensors12100203","url":null,"abstract":"Biosensors have emerged as a promising tool for the early detection of oral squamous cell carcinoma (OSCC) due to their rapid, sensitive, and specific detection of cancer biomarkers. Saliva is a non-invasive and easy-to-obtain biofluid that contains various biomarkers of OSCC, including the carcinoembryonic antigen (CEA). In this study, an electrochemical aptasensor for the detection of CEA in saliva has been developed towards the diagnosis and early screening of OSCC. This aptasensor utilized a CEA-sensitive aptamer as sensitive elements. A fluorine-doped Tin Oxide (FTO) chip with a surface modification of a zinc oxide nanorod was employed as a transducer. Electrochemical measurements were carried out to detect the responsive signals originating from the specific binding between aptamers and CEAs. The measurement results indicated that this aptasensor was responsive to different concentrations of CEA ranging from 1 ng/mL to 80 ng/mL in a linear relationship. The limit of detection (LOD) was 0.75 ng/mL. This aptasensor also showed very good specificity and regenerative capability. Stability testing over a 12-day period showed excellent performance of this aptasensor. All the results demonstrated that this aptasensor has great potential to be used for the detection of CEA in the saliva of OSCC patients. This aptasensor provides a promising method for the rapid detection of CEA with convenience, which has great potential to be used as a new method for clinical diagnoses and early screening of OSCC.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 10","pages":"203-203"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/10/203/pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An Integration of UPLC-Q-TOF-MS, GC-MS, Electronic Nose, Electronic Tongue, and Molecular Docking for the Study of the Chemical Properties and Flavor Profiles of Moringa oleifera Leaves 综合UPLC-Q-TOF-MS、GC-MS、电子鼻、电子舌和分子对接技术研究辣木叶的化学性质和风味特征

3区工程技术

Chemosensors Pub Date : 2024-09-23 DOI: 10.3390/chemosensors12090199

Mingxiao Zhang, Mengjia Guo, Na Chen, Zhuqian Tang, Junjie Xiang, Lixin Yang, Guohua Wang, Bin Yang, Hua Li

{"title":"An Integration of UPLC-Q-TOF-MS, GC-MS, Electronic Nose, Electronic Tongue, and Molecular Docking for the Study of the Chemical Properties and Flavor Profiles of Moringa oleifera Leaves","authors":"Mingxiao Zhang, Mengjia Guo, Na Chen, Zhuqian Tang, Junjie Xiang, Lixin Yang, Guohua Wang, Bin Yang, Hua Li","doi":"10.3390/chemosensors12090199","DOIUrl":"https://doi.org/10.3390/chemosensors12090199","url":null,"abstract":"Moringa oleifera leaves (MOLs) have gained significant attention due to their nutritional and biological activity. Therefore, this study aimed to examine its flavor characteristics and underlying compositions. In this study, we used ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), gas chromatography-mass spectrometry (GC-MS), electronic nose, electronic tongue, and molecular docking to comprehensively investigate the chemical properties and flavor profiles of MOLs. UPLC-Q-TOF-MS and GC-MS were instrumental in identifying the 20 non-volatile and 19 volatile constituents of MOLs, respectively. The electronic nose and electronic tongue systems provided an objective evaluation of the sweet, bitter, and spicy attributes and flavor characteristics of MOLs. Concurrently, molecular docking was employed to elucidate the material basis of flavor profiles. It revealed that glucosinolates and flavonoids are probably the key components for the bitter taste of MOLs. The sweet taste may be attributed to glucosinolates and flavonoids. The spicy scent appears to be linked to the presence of glucosinolates and alkaloids. The integration of these techniques confers a thorough understanding of the chemical composition and sensory properties of MOLs. These findings have significant implications for innovative applications in the food industry as well as pharmaceuticals and agriculture sectors; furthermore, they contribute towards enhancing the perception of Moringa oleifera as a valuable natural resource.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 9","pages":"199-199"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/9/199/pdf?version=1727158779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Efficient and Sensitive Detection of Serum Dopamine Based on a MOF-199/Ag@Au Composite SERS Sensing Structure 基于MOF-199/Ag@Au复合SERS传感结构的高效灵敏血清多巴胺检测

3区工程技术

Chemosensors Pub Date : 2024-09-13 DOI: 10.3390/chemosensors12090187

Yuyu Peng, Chunyan Wang, Gen Li, Jianguo Cui, Yina Jiang, Xiwang Li, Zhengjie Wang, Xiaofeng Zhou

{"title":"The Efficient and Sensitive Detection of Serum Dopamine Based on a MOF-199/Ag@Au Composite SERS Sensing Structure","authors":"Yuyu Peng, Chunyan Wang, Gen Li, Jianguo Cui, Yina Jiang, Xiwang Li, Zhengjie Wang, Xiaofeng Zhou","doi":"10.3390/chemosensors12090187","DOIUrl":"https://doi.org/10.3390/chemosensors12090187","url":null,"abstract":"In this study, a MOF-199/Ag@Au SERS sensing structure was successfully synthesized by combining metal–organic frameworks (MOFs) with surface-enhanced Raman scattering (SERS) technology for the efficient detection of dopamine (DA), a biomarker for neurological diseases, in serum. Using electrochemical methods, a copper-based MOF (MOF-199) was synthesized in situ on copper substrates and further deposited with silver nanoparticles (AgNPs). Subsequently, gold nanoshells were encapsulated around these silver cores by in situ chemical deposition. This preparation process is simple, controllable, and inexpensive. Furthermore, a novel Azo reaction-based DA SERS method was proposed to detect 1 pM DA, which represents an improvement in sensitivity by two orders of magnitude compared to previous unlabeled SERS detection methods and by four orders of magnitude compared to another SERS approach proposed in this work. There was an excellent linear relationship (R2 = 0.976) between the SERS signal at 1140 cm−1 and the DA concentration (0.001 M~1 pM). The results indicate that the MOF-199/Ag@Au sensor structure can successfully achieve both the qualitative and quantitative detection of DA in serum, thus providing a robust technical basis for the application of SERS technology in the field of clinical neurological disease screening.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 9","pages":"187-187"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/9/187/pdf?version=1726210487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

A Novel Colorimetric Biosensor for the Detection of Catalase-Positive Staphylococcus aureus Based on an Onion-like Carbon Nanozyme 基于洋葱样碳纳米酶的新型过氧化氢酶阳性金黄色葡萄球菌比色生物传感器的研究

3区工程技术

Chemosensors Pub Date : 2024-09-02 DOI: 10.3390/chemosensors12090176

Yining Fan, Guanyue Gao, Jinfang Zhi

{"title":"A Novel Colorimetric Biosensor for the Detection of Catalase-Positive Staphylococcus aureus Based on an Onion-like Carbon Nanozyme","authors":"Yining Fan, Guanyue Gao, Jinfang Zhi","doi":"10.3390/chemosensors12090176","DOIUrl":"https://doi.org/10.3390/chemosensors12090176","url":null,"abstract":"Staphylococcus aureus is one of the leading causes of skin and soft tissue infections, and it is even life-threatening if it enters the bloodstream, lung or heart. In the present work, we proposed a novel colorimetric biosensor for the detection of S. aureus through hydrogen peroxide consumption. An onion-like carbon nanozyme with high peroxidase-like activity was prepared, which competed with the endogenous catalase of S. aureus in consuming hydrogen peroxide. This reaction was further characterized by the colorimetric reaction of 3,3′,5,5′-tetramethylbenzidine. The results showed that our approach allowed for the simple and rapid determination of S. aureus, with a linear range of 2 × 104 to 2 × 107 CFU/mL. Moreover, our method displayed good selectivity, with Bacillus subtilis and Escherichia coli showing negligible responses at the concentration of 2 × 105 CFU/mL. The application of the as-prepared biosensor to analyze S. aureus in real water samples yielded recovery rates ranging from 95% to 112%, with relative standard deviations less than 7%. The method demonstrated good accuracy and specificity, which offers a novel approach for the simple and selective detection of S. aureus.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 9","pages":"176-176"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/9/176/pdf?version=1725285744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Water-Soluble Photoluminescent Ag Nanoclusters Stabilized by Amphiphilic Copolymers as Nanoprobe for Hypochlorite Detection 两亲性共聚物稳定的水溶性光致发光银纳米团簇作为次氯酸盐检测的纳米探针

3区工程技术

Chemosensors Pub Date : 2024-08-17 DOI: 10.3390/chemosensors12080166

Xiangfang Lin, Qinhui Dong, Ya-Lin Chang, Shusheng Zhang, Pengfei Shi

{"title":"Water-Soluble Photoluminescent Ag Nanoclusters Stabilized by Amphiphilic Copolymers as Nanoprobe for Hypochlorite Detection","authors":"Xiangfang Lin, Qinhui Dong, Ya-Lin Chang, Shusheng Zhang, Pengfei Shi","doi":"10.3390/chemosensors12080166","DOIUrl":"https://doi.org/10.3390/chemosensors12080166","url":null,"abstract":"Luminescent Ag nanoclusters (Ag NCs) are a promising probe material for sensing and bioimaging applications. However, the intrinsic obstacle of poor water stability and photostability greatly restrict their practical application in biological systems. Herein, we report the intracellular hypochlorite (ClO−) detection with amphiphilic copolymer-modified luminescent Ag NCs with good biocompatibility and photostability. The Ag NCs were synthesized by using chemically inert hydrophobic ligands and then modified with an amphiphilic (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(poly(ethylene glycol))-2000]) (DSPE-PEG-2000) and sodium dodecyl sulfonate (SDS) for phase transfer. It was found that the approach of the removal of organic solvents during the phase transfer has remarkable influences on the properties of the Ag NCs, including their size, luminescence property, and aqueous stability. Furthermore, the silver core of Ag NCs could be oxidatively damaged by ClO−, thereby causing photoluminescence (PL) quenching. The ClO−-induced PL quenching was specific over the other common reactive oxygen species (ROS) as well as some common interferences. Finally, they have been successfully applied as a fluorescent nanoprobe for detecting exogenous and endogenous ClO− in living cells.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 8","pages":"166-166"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/8/166/pdf?version=1724148302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Integrated Application of Risk Management Techniques in Developing an Analysis Method for Traditional Chinese Medicine: A Case Study of a Percolation Solution for Xiaochaihu Capsules 风险管理技术在中药分析方法开发中的综合应用——以小柴胡胶囊渗滤液为例

3区工程技术

Chemosensors Pub Date : 2024-08-12 DOI: 10.3390/chemosensors12080161

Mintong Zhao, Yanni Tai, Gelin Wu, Feng Ding, Haibin Qu, Xingchu Gong

{"title":"Integrated Application of Risk Management Techniques in Developing an Analysis Method for Traditional Chinese Medicine: A Case Study of a Percolation Solution for Xiaochaihu Capsules","authors":"Mintong Zhao, Yanni Tai, Gelin Wu, Feng Ding, Haibin Qu, Xingchu Gong","doi":"10.3390/chemosensors12080161","DOIUrl":"https://doi.org/10.3390/chemosensors12080161","url":null,"abstract":"Risk management should run through the entire process of method development, utilization, and maintenance. Based on the analytical quality by design (AQbD) concept, various integrated risk management techniques were used in this study to develop an analysis method for the percolation solution of Xiaochaihu capsules. During the development of the analysis method, risk assessment was conducted using an Ishikawa diagram and failure mode effects analysis, followed by method optimization using experimental design. The probability of nonconformance calculated via an exhaustive Monte Carlo method quantitatively characterized the risk magnitude of method parameter failures, leading to the establishment of a operable design region method based on risk magnitude. Validation experiments and robustness tests of the data were utilized for model refinement and initial risk review. Methodological validation of the developed method was performed, and control strategies for the analysis method were presented through a decision tree. Stability experiments demonstrated that the samples remained stable at 4 °C for 24 h. The average recovery rate fell between 98.8% and 105%, with relative standard deviations ranging from 2.73% to 4.48%. The results showed that the established analysis method exhibited robustness. This analysis method can simultaneously determine the contents of uridine, adenine, 5-hydroxymethylfurfural, and guanosine. This method can also be employed for process control during percolation. This study integrated various risk management techniques to develop and maintain the analysis method, and this approach can potentially be extended to other analytical methods.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 8","pages":"161-161"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/8/161/pdf?version=1723467319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Investigating the Mechanism Underlying Umami Substance Detection in Taste Sensors by Using 1H-NMR Analysis 用1H-NMR分析研究味觉传感器中鲜味物质检测的机制

3区工程技术

Chemosensors Pub Date : 2024-08-01 DOI: 10.3390/chemosensors12080146

Wenhao Yuan, Haruna Ide, Zeyu Zhao, M. Koshi, Shunsuke Kimura, Toshiro Matsui, Kiyoshi Toko

{"title":"Investigating the Mechanism Underlying Umami Substance Detection in Taste Sensors by Using 1H-NMR Analysis","authors":"Wenhao Yuan, Haruna Ide, Zeyu Zhao, M. Koshi, Shunsuke Kimura, Toshiro Matsui, Kiyoshi Toko","doi":"10.3390/chemosensors12080146","DOIUrl":"https://doi.org/10.3390/chemosensors12080146","url":null,"abstract":"Previous studies have reported the development of a taste sensor using a surface modification approach to evaluate umami taste, specifically substances like monosodium L-glutamate (MSG) and monosodium L-aspartate. The sensor was modified with 2,6-dihydroxyterephthalic acid (2,6-DHTA). However, the mechanism underlying umami substance detection in the 2,6-DHTA- treated sensor remains unidentified, as does whether the specific detection is due to an intermolecular interaction between the modifier and the analyte. In this study, 1H-NMR measurements were conducted for a variety of modifiers and analytes in terms of structures, along with taste sensor measurements. By comparing the 1H-NMR spectra and the results of the taste sensor, we suggested that both modifiers and analytes need to meet certain molecular structure conditions to produce intermolecular interactions. The modifier needs to possess intramolecular H-bonds and have carboxyl groups in the para position of the benzene ring, i.e., two carboxyl groups. In conclusion, we validated that the response mechanism of the taste sensor for umami substance measurement proposed in previous studies is reasonable and predicted the binding form of 2,6-DHTA and MSG.","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 8","pages":"146-146"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.mdpi.com/2227-9040/12/8/146/pdf?version=1722492253","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Diagnostic Case Study for Manufacturing Gas-Phase Chemical Sensors. 制造气相化学传感器的诊断案例研究。

IF 3.7 3区工程技术

Chemosensors Pub Date : 2024-08-01 Epub Date: 2024-08-07 DOI: 10.3390/chemosensors12080155

Raquel Pimentel Contreras, Dylan T Koch, Patrick Gibson, Mitchell M McCartney, Bradley S Chew, Pranay Chakraborty, Daniel A Chevy, Reid Honeycutt, Joseph Haun, Thomas Griffin, Tristan L Hicks, Cristina E Davis

{"title":"A Diagnostic Case Study for Manufacturing Gas-Phase Chemical Sensors.","authors":"Raquel Pimentel Contreras, Dylan T Koch, Patrick Gibson, Mitchell M McCartney, Bradley S Chew, Pranay Chakraborty, Daniel A Chevy, Reid Honeycutt, Joseph Haun, Thomas Griffin, Tristan L Hicks, Cristina E Davis","doi":"10.3390/chemosensors12080155","DOIUrl":"10.3390/chemosensors12080155","url":null,"abstract":"<p><p>In this work, we describe the design, manufacturing development and refinement of a chemical detection platform designed to identify specific odorants in the natural gas industry. As the demand for reliable and sensitive volatile organic compound (VOC) detection systems grows, our project aimed to construct multiple prototypes to enhance detection capabilities and provide portable detection platforms. Throughout the development process across nominally identical and duplicate instruments, various failure modes were encountered, which provided insight into the design and manufacturing challenges present when designing such platforms. We conducted a post-hoc root cause analysis for each failure mode, leading to a series of design modifications and solutions. This paper details these design and manufacturing challenges, the analytical methods used to diagnose and address them, and the resulting improvements in system performance. In the end, a debugging flow chart is presented to aid future researchers in solving possible issues that could be encountered. Our findings show the complexities of bespoke chemical sensor design for unique applications and highlight the critical importance of iterative testing and problem-solving in the development of industrial detection technologies. Achieving consistency across devices is essential for optimizing device-to-device efficiency. The work presented is the first step towards ensuring uniform performance across a production run of chemically sensitive devices. In the future a universal device calibration model will be implemented, eliminating the need to collect data from each individual device.</p>","PeriodicalId":10057,"journal":{"name":"Chemosensors","volume":"12 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0