Gastroenterología y Hepatología (English Edition)最新文献

{"title":"Genetic characteristics and extracolonic phenotypic manifestations in patients with familiar adenomatous polyposis","authors":"Víctor Argumánez ,&nbsp;Vicente Lorenzo-Zúñiga ,&nbsp;Marco Bustamante-Balén ,&nbsp;Sonia García García ,&nbsp;Isabel Terol Cháfer ,&nbsp;Silvestre Oltra ,&nbsp;Vicente Pons-Beltrán","doi":"10.1016/j.gastre.2025.502266","DOIUrl":"10.1016/j.gastre.2025.502266","url":null,"abstract":"<div><h3>Introduction</h3><div>Familial adenomatous polyposis (FAP) is a hereditary disease caused by mutations in the <em>APC</em> gene, which is also associated with extracolonic manifestations. The objective was to characterize the extracolonic manifestations in a cohort of patients with classic FAP and the possible genotype-phenotype association.</div></div><div><h3>Materials and methods</h3><div>The study design was observational and descriptive. Demographic, clinical, and genetic variables were collected based on the type of mutation (frameshift, nonsense, splicing, rearrangement, and others).</div></div><div><h3>Results</h3><div>We included 45 patients with FAP (mean age 47 years, range 21–78; 51% female), belonging to 21 families, with a median of 2 (range 0–6) manifestations per patient. Eighty percent (<em>n</em> = 36) had upper digestive tract involvement, with duodenal adenomas (73%), fundic gland polyposis (56%), and ampullary adenoma (36%) being the most frequent findings. The most common extraintestinal manifestations were desmoid tumors (16%) and papillary thyroid carcinoma (13%). Thirty eight percent of the patients presented an aggressive phenotype (Spigelman III–IV, high-grade dysplasia, invasive neoplasia, desmoid tumor, and papillary thyroid carcinoma). The most common genetic mutations were frameshift (56%), nonsense (26%), and splicing (16%), primarily located in exon 15 (50%). No significant correlation was found between the type of genetic mutation and the severity or location of phenotypic manifestations.</div></div><div><h3>Conclusions</h3><div>One-third of patients with FAP present an aggressive phenotype, without a demonstrated correlation between the type of genetic alteration and the phenotypic manifestations.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502266"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease clearance in ulcerative colitis: What is it? What does it involve? How do we translate it into Spanish?","authors":"Laura Ramos ,&nbsp;Ignacio Marín-Jiménez","doi":"10.1016/j.gastre.2025.502281","DOIUrl":"10.1016/j.gastre.2025.502281","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502281"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descriptive observational study on the use of virtual reality in patients with inflammatory bowel disease undergoing biological treatment","authors":"Raúl José Díaz Molina ,&nbsp;Carlos Comesaña Castellar ,&nbsp;Joan Crespí Rigo ,&nbsp;Catalina Radu Tomsa ,&nbsp;Patricia Quesada Bauzá ,&nbsp;Isabel Porcel Corra ,&nbsp;Pau Sendra Rumbeu ,&nbsp;Vanesa Royo Escosa ,&nbsp;María Dolores Herrera González ,&nbsp;Eva Puchol Segarra ,&nbsp;Daniel Ginard Vicens","doi":"10.1016/j.gastre.2025.502236","DOIUrl":"10.1016/j.gastre.2025.502236","url":null,"abstract":"<div><h3>Background</h3><div>Virtual reality (VR) is a neurosensory experience in which simulated spaces a person has the sensation of being able to function within them. Some patients with inflammatory bowel disease (IBD) receive intravenous biological treatments in an Adult Day Hospital (ADH) regime. VR has been used in some fields of medicine, demonstrating its usefulness in reducing negative symptoms. However, we do not have any literature showing the applicability in real clinical practice of VR in IBD.</div></div><div><h3>Methods</h3><div>Descriptive observational pilot study based on an initial cohort of 87 patients that were obtained from the ADH of the IBD Unit. Satisfaction and acceptance of VR through the use of 3D glasses and the reduction of negative symptoms during intravenous biological treatment in patients with IBD in ADH have been assessed.</div></div><div><h3>Results</h3><div>43 patients (52.4%) used VR and completed the study. In the comparative analysis of the results of the questionnaires before and after the use of VR, a statistically significant improvement was observed in the patients’ view on the ability of VR to achieve a reduction in stress (65% patients improve; <em>p</em>: 0.0021) and pain (VAS, 54% p. improve; <em>p</em> <!-->&lt;<!--> <!-->0.05) during treatment. Likewise, with the applicability of VR in other areas of medicine (53%; <em>p</em>: 0.05) and with the possibility of improving well-being during the stay in the ADH (56%; <em>p</em>: 0.0014). No side effects were reported with the use of the 3D glasses.</div></div><div><h3>Conclusions</h3><div>VR is a useful complementary tool to improve the stay of patients with IBD on ADH during intravenous treatment.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502236"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chief cell-type fundic gland neoplasm, a new entity to consider","authors":"Mariana Tavecchia Castro ,&nbsp;Joaquin Fisac Vázquez ,&nbsp;Laura Guerra Pastrián ,&nbsp;Aurora Burgos García","doi":"10.1016/j.gastre.2025.502261","DOIUrl":"10.1016/j.gastre.2025.502261","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502261"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroral endoscopic myotomy (POEM) as a treatment for pediatric achalasia: Multicenter study and first results","authors":"Carlos Leganés Villanueva ,&nbsp;Eduardo Albéniz Arbizu ,&nbsp;Ilaria Goruppi ,&nbsp;Nuria Brun Lozano ,&nbsp;Federica Bianchi ,&nbsp;Alberto Pérez Martínez ,&nbsp;Sheyla Montori Pina ,&nbsp;Ada Yessenia Molina Caballero ,&nbsp;Marianette Murzi ,&nbsp;Federico Betroletti ,&nbsp;Fermin Estremera ,&nbsp;Susana Boronat Guerrero ,&nbsp;Carlos Guarner Argente","doi":"10.1016/j.gastre.2025.502262","DOIUrl":"10.1016/j.gastre.2025.502262","url":null,"abstract":"<div><h3>Introduction</h3><div>Laparoscopic Heller miotomy of achalasia has been classically recognized as the gold standard management in children. There is increasing experience with the peroral endoscopic miotomy (POEM) approach in pediatrics, although the series published are scarce. The objective of this study was to present our experience in primary or secondary treatment of pediatric achalasia by POEM and its clinical success rate.</div></div><div><h3>Methods</h3><div>We performed a retrospective review of pediatric patients with achalasia who underwent POEM in some national centers from October 2016 to January 2023. We evaluated clinical efficacy (Eckardt score ≤3), demographic characteristics, intraoperative, preoperative and postoperative, complications, and follow-up.</div></div><div><h3>Results</h3><div>Fifteen POEM were performed in fourteen pediatric patients (aged 12–18 years) with achalasia. POEM was the first line treatment in 11 patients, but 4 (21.3%) had previous treatment: 1 (7,1%) pneumatic balloon dilation and 2 (14,2%) laparoscopic Heller myotomy and 1 (7,1%) previous POEM. The average age was 15 years (SD ± 1,9). The baseline Eckardt score was 7,5 (SD: ± 1,8), with the baseline GERD score being 6 (SD: ± 2,9). There was a Clavien-Dindo grade 2 postoperative adverse event corresponding to mild pneumonia (7,1%). The postoperative Eckardt and GERD score after 12 months of follow-up were 0.7 (SD ± 1,2) and 0,5 (SD ± 0,7). The study has a success rate greater than 93%.</div></div><div><h3>Conclusions</h3><div>POEM seems a safe and effective procedure, with a short postoperative period for treatment of pediatric achalasia.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502262"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The simplified depth-predicting score outperforms the depth-predicting score for predicting the depth of invasion in differentiated early gastric cancer patients among nonexpert endoscopists","authors":"Lulu Zeng ,&nbsp;Hui Li ,&nbsp;Tian Huang ,&nbsp;Yuting Heng ,&nbsp;Jun Liu ,&nbsp;Xiangpeng Hu","doi":"10.1016/j.gastre.2025.502265","DOIUrl":"10.1016/j.gastre.2025.502265","url":null,"abstract":"<div><h3>Aim</h3><div>Endoscopists utilize depth-predicting score (DPS) and simplified depth-predicting score (S-DPS) to predict the invasion depth of early gastric cancer based on conventional white-light endoscopic features. The effectiveness of these scores has not been fully elucidated among nonexpert endoscopists. This study aimed to compare the ability of DPS and S-DPS to predict invasion depth of differentiated early gastric cancers by nonexpert endoscopists.</div></div><div><h3>Participants and methods</h3><div>We collected subitem scores of DPS and S-DPS from 19 nonexpert endoscopists for early gastric cancer conventional white-light endoscopy images in the test dataset to predict the invasion depth of the early gastric cancer conventional white-light endoscopy images. Accuracy, specificity, overdiagnosis rate, and underdiagnosis rate were subsequently calculated using the histological invasion depth as the gold standard.</div></div><div><h3>Results</h3><div>Using 3 as the cutoff line, the overall S-DPS diagnostic accuracy for invasion depth was significantly greater than that of DPS [73.86% (69.32%, 75.00%) vs. 67.05% (62.50%, 71.59%), <em>p</em> <!-->=<!--> <!-->0.005]. The overall S-DPS overdiagnosis rate was significantly lower than that of DPS [7.58% (3.03%, 13.64%) vs. 28.79% (18.18%, 37.88%), <em>p</em> <!-->=<!--> <!-->0.000]. The overall S-DPS under-diagnosed rate was significantly higher than that of DPS [86.36% (68.18%, 90.91%) vs. 45.45% (31.82%, 59.09%), <em>p</em> <!-->=<!--> <!-->0.000]. The specificity of the S-DPS was significantly greater than that of DPS [92.42% (86.36%, 96.97%) vs. 71.21% (62.12%, 81.82%), <em>p</em> <!-->=<!--> <!-->0.000].</div></div><div><h3>Conclusion</h3><div>The diagnostic accuracy of the S-DPS was greater than that of the DPS among nonexpert endoscopists. Furthermore, S-DPS is simpler than other methods, making it more conducive to clinical application for nonexpert endoscopists.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502265"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of renal replacement therapy in improving normothermic machine perfusion of liver grafts","authors":"Jordi Vengohechea,&nbsp;Aida Vaquero-Rey,&nbsp;Constantino Fondevila,&nbsp;Amelia J. Hessheimer","doi":"10.1016/j.gastre.2025.502336","DOIUrl":"10.1016/j.gastre.2025.502336","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502336"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in management of pediatric functional dyspepsia in Spain, a descriptive study by the Working Group on Motility and Functional Gastrointestinal Disorders of SEGHNP","authors":"Miguel Ángel Carro Rodríguez ,&nbsp;Inmaculada Hidalgo Montes ,&nbsp;Carlos Ruiz Hernández ,&nbsp;César Sánchez Sánchez ,&nbsp;Andrés Bodas Pinedo","doi":"10.1016/j.gastre.2025.502279","DOIUrl":"10.1016/j.gastre.2025.502279","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502279"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tenofovir alafenamide versus entecavir in treating patients with chronic hepatitis B: A meta-analysis","authors":"Jian-Xing Luo ,&nbsp;Guo Chen ,&nbsp;Xiao-Yu Hu ,&nbsp;Chang Yu","doi":"10.1016/j.gastre.2025.502276","DOIUrl":"10.1016/j.gastre.2025.502276","url":null,"abstract":"<div><h3>Background</h3><div>The superiority between TAF and ETV remains unclear. Which is the best choice for patients with CHB? Thus, this meta-analysis aimed to evaluate the efficacy and safety of TAF and ETV for patients with CHB.</div></div><div><h3>Methods</h3><div>MEDLINE/PubMed, Cochrane Library, EMBASE, Web of Science and CNKI were searched for eligible studies from inception to January 2024 and a meta-analysis was done.</div></div><div><h3>Results</h3><div>24 trials with a total of 6753 subjects were screened. TAF significantly improved 12- and 24-week complete virological response (CVR), 12-week biochemical response (BR) and 24-week HBeAg loss, but could not improve 48- and 96-week CVR, 24-, 48- and 96-week BR, 96-week HBeAg loss, adverse events, 48-week HBsAg decline and loss, 12-, 24- and 48-week HBeAg seroconversion, 96-week HCC incidence compared to ETV. Subgroup analysis was conducted according to race, research type and switching. Different results were obtained from different subgroups.</div></div><div><h3>Conclusions</h3><div>TAF was superior to ETV at 12- and 24-week CVR, 12-week BR and 24-week HBeAg loss. Race and switching might affect the efficacy of TAF and ETV.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502276"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A targeted endoscopic band ligation technique for management of acute esophageal variceal bleeding","authors":"Gilberto Herrera-Quiñones ,&nbsp;Raúl Alberto Jiménez-Castillo ,&nbsp;Susana Isabel Scharrer ,&nbsp;Diego García-Compean ,&nbsp;Joel Omar Jaquez-Quintana ,&nbsp;Carlos Alejandro Cortez-Hernández ,&nbsp;Héctor Jesús Maldonado-Garza ,&nbsp;Andres Cardenas ,&nbsp;José Alberto González-González","doi":"10.1016/j.gastre.2025.502282","DOIUrl":"10.1016/j.gastre.2025.502282","url":null,"abstract":"<div><h3>Background/Aims</h3><div>Endoscopic band ligation (EBL) standard therapy is traditionally performed with banding from the distal esophagus upwards. However, esophageal varices (EV) with stigma of recent bleeding are not consistently banded at the first attempt. We aimed to compare conventional banding in acute variceal bleeding (AVB) vs targeted banding of EV in patients with stigma of recent bleeding (white nipple sign).</div></div><div><h3>Methods</h3><div>This case–control study included patients treated in our hospital from December 2016 to September 2019 with endoscopic signs of recent variceal bleeding. The targeted technique involves deploying the first band at the recent bleeding stigmata and then completing the procedure with standard variceal banding technique. The conventional group included patients treated with standard EBL.</div></div><div><h3>Results</h3><div>We analyzed 92 patients, 54 (58.7%) in conventional technique and 38 (41.3%) in the targeted group. Active bleeding during endoscopy occurred in 11 (20.0%) of conventional and two (6.5%) of the targeted group (<em>p</em> <!-->=<!--> <!-->0.021). Although procedure time was longer in the conventional group (24.3<!--> <!-->min SD 11.58) compared to the targeted group (21.52<!--> <!-->min SD 8.73) this difference was not significant. One detached band episode was documented in targeted group and none in the conventional group (<em>p</em> <!-->=<!--> <!-->0.418). TIPS were not used during this study due to health system policy. There were no significant differences in mortality, rebleeding or transfusion requirements between groups.</div></div><div><h3>Conclusions</h3><div>The targeted technique for EV with stigma of recent bleeding had a low band detachment incidence and fewer bleeding events during endoscopy, however, the limitations of the study should be considered.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"48 4","pages":"Article 502282"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}