Gastroenterología y Hepatología (English Edition)最新文献

{"title":"Hiatal hernia with cardiac impact: When syncope is not what it seems","authors":"Ana Plaza Fernández, Marta Fernández Carrasco, María del Mar Calvo Bernal","doi":"10.1016/j.gastre.2026.502630","DOIUrl":"10.1016/j.gastre.2026.502630","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502630"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation due to hepatocellular adenoma rupture associated with anabolic androgenic steroid abuse","authors":"Iñigo Jon Garaizabal Azkue , Jon Stampa Ferro , Silvia Torrente Iranzo , Verónica Velasco Benito , Eva García Alberdi , Agustin Castiella Eguzkiza","doi":"10.1016/j.gastre.2026.502636","DOIUrl":"10.1016/j.gastre.2026.502636","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502636"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of refractory ulcerative proctitis","authors":"Manuel Barreiro-de Acosta ,&nbsp;Francisco Mesonero ,&nbsp;Rocío Ferreiro-Iglesias ,&nbsp;Santiago García-López ,&nbsp;Mariam Aguas Peris ,&nbsp;Mónica Sierra Ausín ,&nbsp;Noelia Cano Sanz ,&nbsp;Antonio Valdivia Martínez ,&nbsp;Ana Cábez ,&nbsp;Susan Ramírez ,&nbsp;Daniel Ginard","doi":"10.1016/j.gastre.2026.502646","DOIUrl":"10.1016/j.gastre.2026.502646","url":null,"abstract":"<div><h3>Objective</h3><div>Ulcerative proctitis (UP) usually presents a milder course, but some patients develop significant symptom burden, severe forms, or refractory UP (RUP). Our objective was to characterise RUP and generate recommendations for daily practice.</div></div><div><h3>Methods</h3><div>A systematic review (SR) was conducted to analyze epidemiological, clinical, and pharmacological treatment aspects of RUP. The results were discussed in a nominal focus group meeting composed of seven gastroenterologists specialized in the management of inflammatory bowel disease, a nurse, and a patient. Several statements on the management of PU were proposed and voted to achieve agreement.</div></div><div><h3>Results</h3><div>The SR included 43 articles of low to moderate quality. Nearly 30% of patients presented RUP, and the impact of the disease on their quality of life was highly significant. Different gaps of knowledge related to the clinical characteristics and course of the disease, efficacy, safety, and selection of pharmacological treatments were identified. The experts proposed 13 practical statements that reached the established level of agreement. These address the diagnosis of UP and RUP, their therapeutic goals and treatment selection, monitoring, treatment response, and the role of the nurse.</div></div><div><h3>Conclusions</h3><div>RUP is common and can have a significant impact on patients. More research is needed to characterise UP and the long-term efficacy of available treatments. The proposed statements aim to address the knowledge gaps related to RUP.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502646"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum. Multidisciplinary clinical practice guideline on the management of metabolic hepatic steatosis","authors":"Manuel Romero-Gómez ,&nbsp;Javier Escalada ,&nbsp;Mar Noguerol ,&nbsp;Antonio Pérez ,&nbsp;Juana Carretero ,&nbsp;Javier Crespo ,&nbsp;Juan J. Mascort ,&nbsp;Ignacio Aguilar ,&nbsp;Francisco Tinahones ,&nbsp;Pedro Cañones ,&nbsp;Ricardo Gómez-Huelgas ,&nbsp;Daniel de Luis ,&nbsp;Idoia Genúa Trullos ,&nbsp;Rocío Aller ,&nbsp;Miguel A. Rubio ,&nbsp;José Luis Calleja","doi":"10.1016/j.gastre.2026.502639","DOIUrl":"10.1016/j.gastre.2026.502639","url":null,"abstract":"<div><div>Metabolic hepatic steatosis (MetHS) is a clinically heterogeneous, multisystemic, dynamic, and complex disease, whose progression is one of the main causes of cirrhosis and hepatocarcinoma. This clinical practice guideline aims to respond to its main challenges, both in terms of disease burden and complexity. To this end, recommendations have been proposed to experts through the Delphi method. The consensus was optimal in recommendations regarding type 2 diabetes as a risk factor (1.5.1, 4.5.1), in which cases early detection of MetHS should be carried out (4.5.2). Its results also emphasize the importance of the use of non-invasive tests (FIB-4, NFS, HFS) for the exclusion of significant fibrosis in patients with suspected MetHS (2.3.1, 2.3.3). Diagnosis should be carried out through the sequential combination of non-invasive indices and transient elastography by FibroScan® for its risk stratification (2.3.3). A nearly unanimous consensus was reached regarding the role of early prevention in the impact on the quality of life and survival of patients (5.1.2), as well as on the effectiveness of the Mediterranean diet and physical exercise in relation to the improvement of steatosis, steatohepatitis and fibrosis in MetHS patients (5.2.2) and on the positive results offered by resmiterom and semaglutide in promoting fibrosis regression (5.4.1). Finally, a great consensus has been reached regarding the importance of multidisciplinary management in MetHS, for which it is essential to agree on multidisciplinary protocols for referral between levels in each health area (6.2.1), as well as ensuring that referrals to Hepatology/Digestive and Endocrinology or Internal Medicine services are effective and beneficial to prevent the risk of disease progression (6.2.3, 6.3.1).</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502639"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etrasimod: Review of the safety and practical management considerations of a new oral therapy for the treatment of ulcerative colitis","authors":"Yamile Zabana ,&nbsp;Ana Cábez ,&nbsp;Ana Gutiérrez Casbas","doi":"10.1016/j.gastre.2026.502647","DOIUrl":"10.1016/j.gastre.2026.502647","url":null,"abstract":"<div><div>Modulation of sphingosine-1-phosphate (S1P) receptors represents a relatively recent approach in the treatment of inflammatory bowel disease, although S1P modulators have been approved since 2010 for other inflammatory conditions such as multiple sclerosis. Etrasimod is a S1P receptor (S1PR) modulator that binds to S1PR1, S1PR4 and S1PR5 receptors, and its efficacy has been demonstrated in the treatment of moderately to severely active ulcerative colitis. It is a small molecule and synthetic drug administered orally, with a proper bioavailability and a fast elimination rate, predictable pharmacokinetics and lack of immunogenicity, which are convenient characteristics for both efficacy and safety. This article reviews the pharmacological characteristics of etrasimod and its safety profile.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502647"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex perianal fistulas: Not everything is Crohn’s Disease","authors":"Anna Porta-Vilaro ,&nbsp;Patricia Garbayo-Salmons ,&nbsp;Lucía Madero ,&nbsp;Margalida Calafat ,&nbsp;Iria Baston-Rey ,&nbsp;Eduard Brunet-Mas ,&nbsp;Grupo Joven de GETECCU","doi":"10.1016/j.gastre.2026.502663","DOIUrl":"10.1016/j.gastre.2026.502663","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502663"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Multidisciplinary clinical practice guideline on the management of metabolic hepatic steatosis” Gastroenterología y Hepatología (English Edition) 48 (2025) 502442","authors":"Manuel Romero-Gómez ,&nbsp;Javier Escalada ,&nbsp;Mar Noguerol ,&nbsp;Antonio Pérez ,&nbsp;Juana Carretero ,&nbsp;Javier Crespo ,&nbsp;Juan J. Mascort ,&nbsp;Ignacio Aguilar ,&nbsp;Francisco Tinahones ,&nbsp;Pedro Cañones ,&nbsp;Ricardo Gómez-Huelgas ,&nbsp;Daniel de Luis ,&nbsp;Idoia Genúa Trullos ,&nbsp;Rocío Aller ,&nbsp;Miguel A. Rubio ,&nbsp;José Luis Calleja","doi":"10.1016/j.gastre.2026.502640","DOIUrl":"10.1016/j.gastre.2026.502640","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502640"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond a permeable TIPS: The role of PET/CT in endoTIPSitis","authors":"Julio Otero Figar,&nbsp;Daniel Muíño Dominguez,&nbsp;Inés Magide Yañez,&nbsp;Mario Álvarez Diez,&nbsp;Blanca Mesonero de la Cruz,&nbsp;Elena Granda Villanueva,&nbsp;Javier Fernández Gil,&nbsp;María Ponte Romo,&nbsp;Ana Diaz Simal,&nbsp;Lissa Franco Aguirre","doi":"10.1016/j.gastre.2026.502643","DOIUrl":"10.1016/j.gastre.2026.502643","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502643"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emphysematous hepatitis: radiological diagnosis and intraoperative correlation of an extremely rare infectious disease","authors":"Paloma Montosa Ródenas,&nbsp;Sergio Molina Espinoza,&nbsp;Manuel Jesús Rabaza Espigares,&nbsp;Antonio Jesús Láinez Ramos-Bossini","doi":"10.1016/j.gastre.2026.502637","DOIUrl":"10.1016/j.gastre.2026.502637","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502637"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridioides difficile infection: Position paper of the Catalan Society of Gastroenterology","authors":"Clàudia Aràjol ,&nbsp;Begoña González Suárez ,&nbsp;María Bonilla Moreno ,&nbsp;Mireia Puig-Asensio ,&nbsp;Virginia Robles-Alonso ,&nbsp;Gerard Surís ,&nbsp;Cristina Solé ,&nbsp;José Ramón Santos ,&nbsp;Lorena Rodríguez-Alonso","doi":"10.1016/j.gastre.2026.502634","DOIUrl":"10.1016/j.gastre.2026.502634","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Clostridioides difficile</em> infection (CDI) is the leading cause of healthcare-associated infectious diarrhea and is associated with significant morbidity and mortality, primarily due to its high recurrence rate. For this reason, the Catalan Society of Gastroenterology commissioned the development of a position paper aimed at providing practical recommendations, grounded in scientific evidence and expert consensus, on the diagnosis and management of CDI.</div></div><div><h3>Methods</h3><div>This position paper was developed by specialists in Gastroenterology, Infectious Diseases and Microbiology. It was based on a non-systematic review of the scientific evidence. Recommendations were formulated through expert consensus.</div></div><div><h3>Results</h3><div>The document presents a structured approach to the diagnosis and treatment of CDI, emphasizing individualized management and strategies to reduce recurrence rates. Key components include the role of fecal microbiota transplantation and a therapeutic algorithm informed by disease severity and by whether the episode is initial or recurrent.</div></div><div><h3>Conclusions</h3><div>This position paper aims to serve as a practical, evidence-based guide for healthcare professionals involved in the clinical management of CDI, promoting the implementation of optimal therapeutic strategies and addressing the main challenges associated with this infection.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502634"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}