Gastroenterología y Hepatología (English Edition)最新文献

{"title":"The Argentinian Crohn's Disease and Ulcerative Colitis Registry (RADECCU): Methodological aspects and objectives","authors":"Domingo Balderramo ,&nbsp;Joaquín Montero ,&nbsp;Juan Lasa ,&nbsp;Ramiro Cruz González Sueyro ,&nbsp;Pablo Andrés Olivera ,&nbsp;Alicia Sambuelli ,&nbsp;Abel Novillo ,&nbsp;Juan Andrés De Paula","doi":"10.1016/j.gastre.2026.502652","DOIUrl":"10.1016/j.gastre.2026.502652","url":null,"abstract":"<div><h3>Objective</h3><div>There is little information available at the national level on inflammatory bowel disease (IBD) in Argentina. The objective was to describe the methodology of the Argentinian Crohn's Disease and Ulcerative Colitis Registry (RADECCU).</div></div><div><h3>Patient and methods</h3><div>RADECCU was developed in 2023 with the aim of facilitating the collection of relevant information from patients with IBD in Argentina. After the registry's website platform was developed (01/2023), a nationwide promotion campaign was carried out to incorporate centers into RADECCU.</div></div><div><h3>Results</h3><div>From 02/2023 to 6/2025, 69 centers (41 private, 28 public) were incorporated, including 142 professionals, and 4081 patients (2275 women and 1806 men) were enrolled in the registry.</div></div><div><h3>Conclusion</h3><div>RADECCU is the first national IBD registry in Argentina. This registry will provide information on the status of IBD in Argentina and contribute to Latin American data with the potential to generate real-world evidence on different aspects of interest.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502652"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective evaluation by expert endoscopists in on-label indications of a novel cautery-tipped lumen-apposing metal stent with a conventional delivery system (Hot-Spaxus©): a pilot study","authors":"Antonio Martinez-Ortega ,&nbsp;Marina de Benito Sanz ,&nbsp;Francisco J. García Alonso ,&nbsp;Irene Latras Cortés ,&nbsp;José Ramón Aparicio Tormo ,&nbsp;Vicente Sanchiz Soler ,&nbsp;Joan B. Gornals ,&nbsp;José Carlos Subtil Iñigo ,&nbsp;Belén Martínez Moreno ,&nbsp;Albert Sumalla-Garcia ,&nbsp;Ramón Sánchez Ocaña ,&nbsp;Carlos de la Serna-Higuera ,&nbsp;Manuel Perez-Miranda","doi":"10.1016/j.gastre.2026.502641","DOIUrl":"10.1016/j.gastre.2026.502641","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the potential acceptance of Hot-Spaxus in routine practice through a subjective technical assessment by expert endoscopists, and to assess its short-term efficacy and safety.</div></div><div><h3>Patients and methods</h3><div>Observational multicenter study based on a prospective database of the first cases of EUS-guided therapeutic drainage of on-label targets (pancreatic fluid collections [PFC] and gallbladder drainage [GD]) using Hot-Spaxus© doing by 6 expert endoscopist. After the endoscopic procedure, experts completed two questionnaires with 9 items each: one assessing technical difficulty and another evaluating preference for Hot-Spaxus, Hot-Axios, or no preference/similar.</div></div><div><h3>Results</h3><div>Twelve patients were included (4 PFC / 8 GD); 66% were women, with a median age of 84.8 years (IQR 71.7–89.4). In the questionnaire on perceived difficulty, most items were rated as easy or moderate, while the “very difficult” category was reported infrequently. Endoscopists preferred Hot-Axios© over Hot-Spaxus© regarding position control during deployment (58.3%) and management of the delivery system (58.3%). Technical and clinical success rates were 91.7% and 90.9%, respectively. One case of bleeding was reported as an adverse event (8.3%).</div></div><div><h3>Conclusions</h3><div>Deployment system friction, endoscope channel friction, and guidewire passage through the delivery system were perceived as less complex. In contrast, penetration, position control, and LAMS deployment were considered more challenging and were rated less favorably compared with Hot-Axios©.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 5","pages":"Article 502641"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of ASGE criteria for choledocholithiasis in acute biliary pancreatitis: A retrospective cohort study","authors":"Romario Ruiz ,&nbsp;Milagros Dávalos ,&nbsp;Edson Guzmán ,&nbsp;Ramiro Díaz ,&nbsp;Edgar Alva ,&nbsp;Javier Contreras ,&nbsp;Felipe De La Torre ,&nbsp;Luis Cervera","doi":"10.1016/j.gastre.2026.502610","DOIUrl":"10.1016/j.gastre.2026.502610","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic performance of the 2019 American Society for Gastrointestinal Endoscopy (ASGE) criteria for choledocholithiasis in patients with acute biliary pancreatitis (ABP).</div></div><div><h3>Patients and methods</h3><div>We retrospectively analyzed patients diagnosed with ABP and suspected choledocholithiasis at a tertiary hospital between January and December 2024. Common bile duct (CBD) stones were confirmed by magnetic resonance cholangiopancreatography (MRCP) or computed tomography (CT) followed by endoscopic retrograde cholangiopancreatography (ERCP). Patients were stratified according to ASGE 2019 criteria. Diagnostic accuracy was assessed, and cut-off values for alkaline phosphatase (ALP), total bilirubin (TB), and CBD diameter were determined using receiver operating characteristic (ROC) analysis and logistic regression. Biochemical follow-up was analyzed in intermediate-risk patients without confirmed stones.</div></div><div><h3>Results</h3><div>A total of 197 patients were included; 52 (26.4%) had confirmed choledocholithiasis. Prevalence was 46.9% in the high-risk group and 22.4% in the intermediate group. High-risk classification showed low sensitivity (28.8%) but high specificity (88.3%). Alkaline phosphatase (ALP) was the only independent predictor (cut-off 518<!--> <!-->IU/L). In intermediate-risk patients without stones, 95% achieved biochemical normalization within 2 weeks.</div></div><div><h3>Conclusions</h3><div>ASGE 2019 criteria overestimate the risk of choledocholithiasis in ABP, particularly in intermediate-risk patients. Early biochemical follow-up may avoid unnecessary imaging and procedures in this group, while ALP remains the most consistent independent predictor. These results support more conservative and cost-effective management strategies in ABP.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502610"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value and clinical implications of 75SeHCAT scan in bile acid diarrhea","authors":"Daniel Riado Mínguez ,&nbsp;Flor María Fernández-Gordón ,&nbsp;Miguel Casado Portolés ,&nbsp;Celia Gómez Labrador ,&nbsp;Cristina Cuadrado Tiemblo ,&nbsp;Carolina Georgina Suárez Cabredo ,&nbsp;Luis Wesley Wong Becerra ,&nbsp;Carlos Castaño Milla","doi":"10.1016/j.gastre.2026.502584","DOIUrl":"10.1016/j.gastre.2026.502584","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502584"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of GLP-1 receptor agonists on capsule endoscopy: Proposal for adaptation of preparation protocols","authors":"Ana García-Rodríguez,&nbsp;Beatriz García Zafra,&nbsp;Natacha Llopart,&nbsp;Carla Santos","doi":"10.1016/j.gastre.2026.502627","DOIUrl":"10.1016/j.gastre.2026.502627","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502627"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sister Mary Joseph’s nodule in colon cancer","authors":"José Richard Tenazoa-Villalobos ,&nbsp;Edgar Fermín Yan-Quiroz ,&nbsp;Olga Mercedes Viviana Burgos-García ,&nbsp;Gladys Llerena-Cobián","doi":"10.1016/j.gastre.2026.502590","DOIUrl":"10.1016/j.gastre.2026.502590","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502590"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal bleeding from gastric metastases of renal carcinoma: An uncommon cause","authors":"Guillén Bernal-Bandrés ,&nbsp;María Escuín-Sanmartín ,&nbsp;Sergio García-Mateo ,&nbsp;Reynaldo Alfonso Vilorio-Guzmán ,&nbsp;Enrique Ceamanos-Ibarra ,&nbsp;Marta Latre-Santos ,&nbsp;Gonzalo Hijos-Mallada","doi":"10.1016/j.gastre.2026.502626","DOIUrl":"10.1016/j.gastre.2026.502626","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502626"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary gastric melanoma","authors":"José Richard Tenazoa-Villalobos ,&nbsp;Edgar Fermín Yan-Quiroz ,&nbsp;Mónica Alexandra Olivera-Aldana","doi":"10.1016/j.gastre.2026.502588","DOIUrl":"10.1016/j.gastre.2026.502588","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502588"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the role of ammonia in MASLD: From a neurotoxin to a metabolic by-product","authors":"Carola Zurita-Palomo ,&nbsp;Franz Martín-Bermudo ,&nbsp;Douglas Maya-Miles ,&nbsp;Javier Ampuero ,&nbsp;Manuel Romero-Gómez ,&nbsp;Rocío Gallego-Durán","doi":"10.1016/j.gastre.2026.502664","DOIUrl":"10.1016/j.gastre.2026.502664","url":null,"abstract":"","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502664"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish clinical practice guidelines for the diagnosis and management of cholestatic liver diseases in adult and pediatric population: Joint report from AEEH and SEGHNP","authors":"Álvaro Díaz-González ,&nbsp;Cristina Molera ,&nbsp;Elena Gómez-Domínguez ,&nbsp;Gema Muñoz-Bartolo ,&nbsp;Javier Ampuero ,&nbsp;Conrado Fernández-Rodríguez ,&nbsp;Jesus Quintero ,&nbsp;Esther Molina ,&nbsp;Magdalena Salcedo ,&nbsp;Antonio Olveira ,&nbsp;Rosa Morillas ,&nbsp;María Alós Díez ,&nbsp;Marta Casado ,&nbsp;Luisa García-Buey ,&nbsp;Sergio Rodríguez-Tajes ,&nbsp;Francisco Jorquera ,&nbsp;Marina Berenguer ,&nbsp;Jose Luis Montero ,&nbsp;Maria Carlota Londoño","doi":"10.1016/j.gastre.2026.502629","DOIUrl":"10.1016/j.gastre.2026.502629","url":null,"abstract":"<div><div>Cholestatic liver diseases comprise a heterogeneous group of disorders affecting both adult and pediatric population, characterized by alterations in bile formation, secretion, or flow, leading to the accumulation of bile acids and other toxic substances in the liver. In recent years, advances in new pharmacological therapies, the availability of next-generation genetic sequencing techniques, and the development of specific treatments for genetic cholestasis have transformed the diagnostic and therapeutic approach to these conditions. This document, jointly prepared by the “Asociación Española para el Estudio del Hígado” (AEEH) and the “Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica” (SEGHNP), presents a national evidence-based guideline for the diagnosis and management of hepatic cholestasis in Spain. It addresses recommendations for differential diagnosis, diagnostic algorithms, indications for genetic studies, treatment and follow-up criteria in diseases such as primary biliary cholangitis, primary sclerosing cholangitis, genetic cholestasis, intrahepatic cholestasis of pregnancy, and vanishing bile duct syndrome. In addition, recommendations are included for the management of extrahepatic complications, indications for liver transplantation, and special considerations in pregnancy and childhood. The guideline emphasizes the importance of a multidisciplinary approach, the use of non-invasive tools for risk stratification, and the incorporation of new targeted therapies, with the aim of improving the prognosis and quality of life of patients affected by cholestatic liver diseases.</div></div>","PeriodicalId":100569,"journal":{"name":"Gastroenterología y Hepatología (English Edition)","volume":"49 4","pages":"Article 502629"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147614609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}