原发性硬化性胆管炎与克罗恩病的患病率及双向相关性：一项系统综述和荟萃分析

Gastroenterología y Hepatología (English Edition) Pub Date : 2025-10-01 DOI:10.1016/j.gastre.2025.502346

Dongyuan Zheng , Qinke Xu , Jin Wu , Zhouyue Gu , Jieya Chen , Yingchao Liu

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引用次数: 0

摘要

目的：本荟萃分析旨在评估克罗恩病原发性硬化性胆管炎（PSC）的患病率和克罗恩病（CD）原发性硬化性胆管炎的发病率及其相互关系。方法在PubMed和Embase中进行广泛检索，以确定截至2023年12月的可用出版物。如果研究报告了PSC患者中CD的患病率，则纳入研究，反之亦然。使用DerSimonian和Laird方法评估比例，然后通过Freeman-Tukey双重反正弦变换进行变换。使用乔安娜布里格斯研究所关键评估清单的纳入研究的质量。结果基于61项研究的定量分析，CD患者PSC患病率为0.88% （95% CI: 0.53-1.30%）。男性CD患者中PSC的患病率为0.45% （95% CI: 0.03-1.16%）。在女性CD患者中，患病率为0.51% （95% CI: 0.09-1.14%）。CD合并PSC的患病率为11.27% （95% CI: 9.56-13.10%）。男性PSC患者CD患病率为10.71% （95% CI: 7.42-14.50%）。女性PSC患者中，CD的总患病率为13.05% （95% CI: 11.05-15.19%）。结论：我们发现PSC和CD之间存在显著的双向关联，女性PSC患者的CD患病率高于男性。这些发现为临床实践提供了重要的流行病学资料。

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Prevalence and bidirectional association between primary sclerosing cholangitis and Crohn's disease: A systematic review and meta-analysis

Purpose

This meta-analysis aimed to evaluating the prevalence of Crohn's disease in primary sclerosing cholangitis (PSC) and the incidence of primary sclerosing cholangitis in Crohn's disease (CD), along with their interrelation.

Methods

An extensive search was conducted in the PubMed and Embase to identify available publications up to December 2023. Studies were included if they reported the prevalence of CD in PSC patients, or vice versa. Proportions were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman–Tukey double inverse sine transformation. The quality of the included studies utilizing the Joanna Briggs Institute Critical Appraisal Checklist.

Results

Based on quantitative analysis of 61 studies, the prevalence of PSC in patients with CD was 0.88% (95% CI: 0.53–1.30%). The prevalence of PSC in male CD patients was 0.45% (95% CI: 0.03–1.16%). In female CD patients, the prevalence was 0.51% (95% CI: 0.09–1.14%). The prevalence of CD with PSC was 11.27% (95% CI: 9.56–13.10%). The prevalence of CD in male PSC patients was 10.71% (95% CI: 7.42–14.50%). Among female PSC patients, the pooled prevalence of CD was 13.05% (95% CI: 11.05–15.19%).

Conclusions

We found a significant bidirectional association between PSC and CD, with a higher prevalence of CD in female with PSC compared to male. These findings provide important epidemiological data for clinical practice.

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Gastroenterología y Hepatología (English Edition)

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