Farmacia Hospitalaria (English Edition)最新文献

Variability in Activity and Results From Drug Assessments by Pharmacy and Therapeutics Committees in Spanish Hospitals 西班牙医院药学和治疗委员会药物评估的活性和结果的可变性

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2010.07.003

F. Puigventós Latorre , B. Santos-Ramos , A. Ortega Eslava , M.E. Durán-García , on behalf of the Grupo de Evaluación de Novedades, Estandarización e Investigación en Selección de Medicamentos (GENESIS) de la Sociedad Española de Farmacia Hospitalaria (SEFH)

{"title":"Variability in Activity and Results From Drug Assessments by Pharmacy and Therapeutics Committees in Spanish Hospitals","authors":"F. Puigventós Latorre , B. Santos-Ramos , A. Ortega Eslava , M.E. Durán-García , on behalf of the Grupo de Evaluación de Novedades, Estandarización e Investigación en Selección de Medicamentos (GENESIS) de la Sociedad Española de Farmacia Hospitalaria (SEFH)","doi":"10.1016/j.farmae.2010.07.003","DOIUrl":"https://doi.org/10.1016/j.farmae.2010.07.003","url":null,"abstract":"<div><h3>Objective</h3><p>To quantify the Spanish Pharmacy and Therapeutics Commission (P&TC) activity with regard to assessing and selecting drugs and describing variability in decisions made to include them.</p></div><div><h3>Method</h3><p>Descriptive, cross-sectional study based on a questionnaire aimed at 513 hospitals with more than 75 beds. We included questions referring to the P&TC resolutions, the therapeutic positioning and assessment reports. Recruitment was carried out between November 2007 and January 2008. Variability among P&TC conclusions was presented in five categories or levels of coincidence.</p></div><div><h3>Results</h3><p>One hundred and seventy-five hospitals participated, with a response rate of 34% (54% of beds). The mean number of drug-indications assessed per hospital was 10.35 (7.45). The proportion of assessments that conclude with drug inclusion or rejection was 75.3% and 21.4%, respectively. 16.2% concluded with therapeutic equivalence. Conditions for use were established for 64% of them, and 33% were included in a clinical guide. With regard to variability, 81.0% of assessments coincided with the conclusion to include or reject the drug. A contradictory decision was made for 19.0%.</p></div><div><h3>Conclusions</h3><p>Drug assessment and selection in hospitals are considerable. The proportion of drugs approved is similar in different types of hospitals. There is extensive variability as regards deciding upon inclusion and is similar to studies conducted in other countries. They indicate that a standardising methodology would be recommendable.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 6","pages":"Pages 305-314"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2010.07.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136934670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Application of the Technology Web 2.0 in a Drug Information Centre Web 2.0技术在药物资讯中心的应用

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2011.07.001

J.C. Juárez Giménez , C. Puyal González , C. Valdivia Vadell , M.E. Palacio Lacambra , J. Vidal Otero , M.J. Cerqueira Dapena

{"title":"Application of the Technology Web 2.0 in a Drug Information Centre","authors":"J.C. Juárez Giménez , C. Puyal González , C. Valdivia Vadell , M.E. Palacio Lacambra , J. Vidal Otero , M.J. Cerqueira Dapena","doi":"10.1016/j.farmae.2011.07.001","DOIUrl":"10.1016/j.farmae.2011.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>To develop a Web 2.0 resource map and select those that may be useful in a Drug Information Centre at a Hospital Pharmacy Department (CIMSF).</p></div><div><h3>Method</h3><p>A multidisciplinary working group under the Biomedical Information Commission selected some of the Web 2.0 resources included in the <em>Guía d’usos i estil a les xarxes Socials</em> guide of the Catalonian Government.</p></div><div><h3>Results</h3><p>Six resources were selected: <em>Netvibes</em>, <em>Delicious</em>, <em>Google groups</em>, <em>Google Docs</em>, <em>Slideshare</em> and <em>Twitter</em>. These tools were used for 5 months to manage biomedical information for the medical staff, and to provide external visibility by providing information to other health professionals. More than a thousand hits were recorded on the portal <em>Netvibes</em> and more than 100 professionals followed CIMSF on <em>Twitter</em>.</p></div><div><h3>Conclusions</h3><p>The Web 2.0 offers useful, user-friendly and cost-efficient tools which could be implemented in a CIMSF, while also enabling participation in external networks of pharmacotherapeutic interest, increasing its visibility to other professionals.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 6","pages":"Pages 315.e1-315.e5"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2011.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Simplification of Antiretroviral Therapy: A Good Choice for Our Patients and the Sustainability of Our Health Care System 简化抗逆转录病毒治疗:一个很好的选择，为我们的病人和我们的卫生保健系统的可持续性

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2011.01.001

L. González Rivas , E. Sánchez Gómez , R. Sánchez del Moral , S. Grutzmancher Saiz , E. Pujol de la Llave , C. Bocanegra Martín

引用次数: 4

Effectiveness and Use of Linezolid in Hospitalisation Wards 利奈唑胺在住院病房的有效性和使用

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2011.04.001

R. Rivas, M. Barrera, L. González, V. Domínguez, R. Sánchez, M.M. Romero

{"title":"Effectiveness and Use of Linezolid in Hospitalisation Wards","authors":"R. Rivas, M. Barrera, L. González, V. Domínguez, R. Sánchez, M.M. Romero","doi":"10.1016/j.farmae.2011.04.001","DOIUrl":"10.1016/j.farmae.2011.04.001","url":null,"abstract":"<div><h3>Objective</h3><p><span>To describe the use and effectiveness of linezolid as an alternative treatment for methicillin-resistant </span><em>Staphylococcus aureus</em>.</p></div><div><h3>Method</h3><p>Demographic, clinical and safety data were collected from hospitalised patients. The information sources were the clinical records and the pharmacy programme.</p></div><div><h3>Results</h3><p>Thirty patients were treated with linezolid (median age 69.3, 63% male). The median duration of treatment was 8 days. The most prevalent indication was soft tissues and skin infections (46.7%). The indications were off-label in 40% of cases. Linezolid was used as a targeted therapy in 53%, especially for coagulase-negative Staphylococcus. Clinical healing occurred in 83.3% and microbiological healing in 40%. Three patients (10%) experienced side effects from using linezolid.</p></div><div><h3>Conclusion</h3><p>The effectiveness and safety of linezolid is similar to that described in the trials. Its off-label use and the high number of empirical treatments mean that new strategies must be developed.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 6","pages":"Pages 322-325"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2011.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacokinetic Monitoring of Antiepileptic Drugs 抗癫痫药物的药代动力学监测

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2011.09.001

A. Aldaz , R. Ferriols , D. Aumente , M.V. Calvo , M.R. Farre , B. García , R. Marqués , P. Mas , B. Porta , M. Outeda , D. Soy , Grupo PK-gen de la Sociedad Española de Farmacia Hospitalaria

引用次数: 5

Toxicity Profile and Adherence to the Pharmacotherapeutic Regimen of Gemcitabine–carboplatin in Non-small Cell Lung Cancer 吉西他滨-卡铂治疗非小细胞肺癌的毒性和依从性

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI: 10.1016/j.farmae.2010.09.001

D. Gómez Herrero , A. Albert Marí , M. Merino Sanjuán , M.L. Boquera Ferrer , N. Víctor Jiménez Torres

{"title":"Toxicity Profile and Adherence to the Pharmacotherapeutic Regimen of Gemcitabine–carboplatin in Non-small Cell Lung Cancer","authors":"D. Gómez Herrero , A. Albert Marí , M. Merino Sanjuán , M.L. Boquera Ferrer , N. Víctor Jiménez Torres","doi":"10.1016/j.farmae.2010.09.001","DOIUrl":"10.1016/j.farmae.2010.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>To analyse the relationship between doses of gemcitabine–carboplatin (GEM-CARBO) administered and incidence and level of haematological and renal toxicity, and the adherence to the treatment in patients with non-small cell lung cancer.</p></div><div><h3>Methods</h3><p>Retrospective study, which lasted for 37 months. We were able to obtain the minimum set of data needed to carry out the follow-up with the help of Farmis-Oncofarm<sup>®</sup> software and the medical and pharmacotherapeutic records.</p><p>The haematological toxicity was assessed in accordance with the Common Toxicity Criteria 3.0. Renal toxicity was evaluated using serum creatinine levels and creatinine clearance.</p></div><div><h3>Results</h3><p><span><span>Thirty-one patients were included in the study who were administered a total of 122 cycles. There was a 34.0% and 30.8% incidence of anaemia and grade 3 neutropenia, respectively. There was also a 3.8% and 7.7% incidence of grade 3 and grade 4 </span>thrombocytopenia, respectively. No cases of renal toxicity were found. 65.0% of patients received more than 85.0% of the planned theoretical dosage of </span>carboplatin<span> and 58% of patients received more than 85.0% of the planned theoretical dosage of gemcitabine. Administration was delayed in 18.0% of the cycles prescribed.</span></p></div><div><h3>Conclusions</h3><p>The indication and prescription of the GEM-CARBO regimen was adjusted in accordance with solid scientific evidence, but its haematological toxicity limited its use and made it difficult to maintain the dose intensity foreseen in the study. This compromised the effectiveness of the treatment.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 6","pages":"Pages 298-304"},"PeriodicalIF":0.0,"publicationDate":"2011-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2010.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Assessing a Therapeutic Exchange Protocol for Second-generation Antidepressants: Clinical Results 评估第二代抗抑郁药的治疗交换方案:临床结果

Farmacia Hospitalaria (English Edition) Pub Date : 2011-09-01 DOI: 10.1016/j.farmae.2010.06.007

F. Martínez-Granados, E. Climent-Grana, E. Pérez-Martínez, J.P. Ordovás-Baines, J. Selva Otaolaurruchi, M.A. Bernabéu Martínez

{"title":"Assessing a Therapeutic Exchange Protocol for Second-generation Antidepressants: Clinical Results","authors":"F. Martínez-Granados, E. Climent-Grana, E. Pérez-Martínez, J.P. Ordovás-Baines, J. Selva Otaolaurruchi, M.A. Bernabéu Martínez","doi":"10.1016/j.farmae.2010.06.007","DOIUrl":"10.1016/j.farmae.2010.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>To design a therapeutic exchange protocol for antidepressants and clinically assess variables, such as compliance level, frequency of cases with clinically significant increase on the Udvalg-für-Kliniske-Undersogelser (UKU) psychopharmacological scale, adverse effects analysis, overall analysis of UKU rating development and patients’ level of acceptance. Secondary objectives were to correlate psychopharmacological treatment aspects with the pharmacological morbidity level, and evaluate the clinical impact of pharmacotherapeutic optimisation measures.</p></div><div><h3>Method</h3><p>The protocol is designed in accordance with a bibliographical review, which was approved by the Pharmacy and Therapeutics Commission. Sequential study was carried out with a sample of 30 patients. Three measurements were taken (base line, at 48–72h and at 1–3weeks) to calculate the pharmacotherapeutic morbidity with the UKU rating scale and the Global Clinical Impression. Pharmacotherapeutic optimisation measures were used for those patients with high pharmacotherapeutic morbidity levels.</p></div><div><h3>Results</h3><p>The compliance level was 73.3%. One patient experienced ≥25% increase on the UKU rating scale and another patient suffered from an adverse effect. The final UKU rating reached statistical significance compared with the measurements taken at 48–72h (<em>P</em>=.032) and with the base line measurement (<em>P</em>=.007). Patient acceptance was 90%. The impact of optimisation measurements on the pharmacotherapeutic morbidity level was clinically and statistically significant (<em>P</em><.001).</p></div><div><h3>Conclusions</h3><p>The proposed protocol has been widely accepted and it is quite certain that it is to be introduced in at a general hospital level.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 5","pages":"Pages 244-253"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2010.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Neoadjuvant Chemotherapy Used for Colorectal Liver and Lung Metastasis Resections 新辅助化疗用于大肠癌肝、肺转移切除

Farmacia Hospitalaria (English Edition) Pub Date : 2011-09-01 DOI: 10.1016/j.farmae.2010.07.002

S. Redondo Capafons, A. Planas Giner, R. Garriga Biosca, R. Pla Poblador

{"title":"Neoadjuvant Chemotherapy Used for Colorectal Liver and Lung Metastasis Resections","authors":"S. Redondo Capafons, A. Planas Giner, R. Garriga Biosca, R. Pla Poblador","doi":"10.1016/j.farmae.2010.07.002","DOIUrl":"10.1016/j.farmae.2010.07.002","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study is to determine the hospital's efficiency as regards neoadjuvant chemotherapy for the resection of initially unresectable metastases for patients with metastatic primary colorectal cancer and to describe the chemotherapy used.</p></div><div><h3>Methods</h3><p>Descriptive, retrospective study of patients with colorectal cancer from 2004 to 2007. The percentage of resection for metastases following neoadjuvant chemotherapy administration was studied.</p></div><div><h3>Results</h3><p>Clinical histories of 118 patients diagnosed with metastatic colorectal cancer were reviewed. Metastases were initially resectable in ten patients (8.5%) and unresectable in the remaining 108 patients (91.5%). Following neoadjuvant chemotherapy, metastatic resection was performed on 19 patients.</p></div><div><h3>Conclusions</h3><p>Neoadjuvant chemotherapy played an important role in treating patients with disseminated metastatic colorectal cancer by reducing, in some cases, tumour size and treating initially unresectable metastases susceptible to subsequent surgical resection.</p><p>FOLFOX scheme was the most used neoadjuvant chemotherapy treatment.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 5","pages":"Pages 255.e1-255.e5"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2010.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comprehensive Pharmaceutical Care in a Vascular Surgery Department 血管外科的综合药学服务

Farmacia Hospitalaria (English Edition) Pub Date : 2011-09-01 DOI: 10.1016/j.farmae.2011.02.002

I. Martínez López , F. Do Pazo-Oubiña , P. Lozano Vilardell

{"title":"Comprehensive Pharmaceutical Care in a Vascular Surgery Department","authors":"I. Martínez López , F. Do Pazo-Oubiña , P. Lozano Vilardell","doi":"10.1016/j.farmae.2011.02.002","DOIUrl":"10.1016/j.farmae.2011.02.002","url":null,"abstract":"<div><h3>Objective</h3><p>The pharmacist must work with the clinical team across the continuum of care to develop and therefore improve the patient's quality of life. In this study, we present the results from a continuous pharmaceutical care programme for patients admitted to an angiology and vascular surgery department.</p></div><div><h3>Material and methods</h3><p>A 5-month prospective study to evaluate the results of a pharmaceutical care programme in an angiology and vascular surgery department. The pharmacist went on the rounds with the clinical team from Monday to Friday and helped make decisions on treatment, and detect and resolve conciliation discrepancies upon admission and discharge, and drug-related problems during the hospital stay.</p></div><div><h3>Results</h3><p>We detected and resolved 273 conciliation discrepancies in 99 patients and 76 drug-related problems in 46 patients. Global acceptance of pharmacist interventions was 96%.</p></div><div><h3>Conclusions</h3><p>Seventy-four percent of patients presented conciliation discrepancies. Efficiency of pharmaceutical activity across the continuum of care is demonstrated by the high acceptance of the interventions.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 5","pages":"Pages 260-263"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2011.02.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Developing a Search Engine for Pharmacotherapeutic Information that is Not Published in Biomedical Journals 开发未在生物医学期刊上发表的药物治疗信息的搜索引擎

Farmacia Hospitalaria (English Edition) Pub Date : 2011-09-01 DOI: 10.1016/j.farmae.2010.11.001

F. Do Pazo-Oubiña , C. Calvo Pita , F. Puigventós Latorre , L. Periañez-Párraga , P. Ventayol Bosch

{"title":"Developing a Search Engine for Pharmacotherapeutic Information that is Not Published in Biomedical Journals","authors":"F. Do Pazo-Oubiña , C. Calvo Pita , F. Puigventós Latorre , L. Periañez-Párraga , P. Ventayol Bosch","doi":"10.1016/j.farmae.2010.11.001","DOIUrl":"10.1016/j.farmae.2010.11.001","url":null,"abstract":"<div><h3>Objective</h3><p>To identify publishers of pharmacotherapeutic information not found in biomedical journals that focuses on evaluating and providing advice on medicines and to develop a search engine to access this information.</p></div><div><h3>Methods</h3><p>Compiling web sites that publish information on the rational use of medicines and have no commercial interests. Free-access web sites in Spanish, Galician, Catalan or English. Designing a search engine using the Google “custom search” application.</p></div><div><h3>Results</h3><p>Overall 159 Internet addresses were compiled and were classified into 9 labels. We were able to recover the information from the selected sources using a search engine, which is called “AlquimiA” and available from <span>http://www.elcomprimido.com/FARHSD/AlquimiA.htm</span><svg><path></path></svg></p></div><div><h3>Conclusions</h3><p>The main sources of pharmacotherapeutic information not published in biomedical journals were identified. The search engine is a useful tool for searching and accessing “grey literature” on the Internet.</p></div>","PeriodicalId":100521,"journal":{"name":"Farmacia Hospitalaria (English Edition)","volume":"35 5","pages":"Pages 254.e1-254.e5"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.farmae.2010.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54576585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2