Simplification of Antiretroviral Therapy: A Good Choice for Our Patients and the Sustainability of Our Health Care System

Farmacia Hospitalaria (English Edition) Pub Date : 2011-11-01 DOI:10.1016/j.farmae.2011.01.001

L. González Rivas , E. Sánchez Gómez , R. Sánchez del Moral , S. Grutzmancher Saiz , E. Pujol de la Llave , C. Bocanegra Martín

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引用次数: 4

Abstract

Objective

To describe the efficacy, safety, compliance and cost savings of lopinavir/ritonavir monotherapy.

Method

Observational, descriptive and retrospective study evaluating monotherapy. Adherence was calculated using an objective method. We estimated the direct costs of dispensing non-triple therapy.

Results

We identified 17 patients. Interval adherence was >95% in 9 patients, 90%–95% in 2 patients, 90%–85% in 2 patients, and less than 85% in 4 patients. Viral load was undetectable during weeks 12, 24, 36, and 48, except in 2 patients. The CD4 count in most analytical tests remained at >350 cells/ml, only 1 patient had a lower figure. The average savings was 4819 Euros/patient/year (range 1116–8700).

Conclusions

In selected patients, monotherapy can be a cost-effective treatment option.

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简化抗逆转录病毒治疗:一个很好的选择，为我们的病人和我们的卫生保健系统的可持续性

目的评价洛匹那韦/利托那韦单药治疗的疗效、安全性、依从性和成本节约。方法采用观察性、描述性和回顾性研究评价单药治疗。采用客观方法计算依从性。我们估计了分配非三联疗法的直接成本。结果17例患者。9例患者的间歇依从性为95%，2例患者为90% ~ 95%，2例患者为90% ~ 85%，4例患者小于85%。在第12、24、36和48周，除2例患者外，未检测到病毒载量。在大多数分析测试中，CD4细胞计数保持在350细胞/ml，只有1例患者的数字较低。平均节省4819欧元/病人/年(范围1116-8700)。结论在选定的患者中，单药治疗是一种经济有效的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Farmacia Hospitalaria (English Edition)

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