中华妇产科杂志最新文献

{"title":"[Effects of dexamethasone on short-term and long-term outcomes in late preterm infants with twin pregnancy: an observational study].","authors":"X D Zhang, Y Wei, T C Wu, Y Y Zhao, X D Liu, P B Yuan, Y Wang","doi":"10.3760/cma.j.cn112141-20240522-00288","DOIUrl":"10.3760/cma.j.cn112141-20240522-00288","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the effect of prenatal dexamethasone on short-term outcomes and long-term neurological development in late preterm infants with twin pregnancy. <b>Methods:</b> A total of 315 pregnant women with twin pregnancy and their preterm infants who delivered in Peking University Third Hospital from January 2019 to December 2022 were retrospectively analyzed. The clinical data of pregnant women and preterm infants were collected. They were divided into non-medication group (93 pregnant women and 186 preterm infants), medication after 34 weeks group (123 pregnant women and 246 preterm infants), and medication before 34 weeks group (99 pregnant women and 198 preterm infants). Short-term outcomes of preterm infants were analyzed, including the incidence of neonatal respiratory distress syndrome (NRDS), wet lung, hypoglycemia, neonatal septicemia, intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD) and neonatal necrotizing enterocolitis (NEC). \"Ages and Stages Questionnaire-Third Edition (ASQ-3) scale\" was used to follow up the late neurological development of preterm infants at the corrected age of 6-54 months, and the level of neurological development was compared. <b>Results:</b> (1) General conditions: the gestational age at delivery in the non-medication group [36.1 weeks (35.6, 36.6 weeks)] was later than that in the medication after 34 weeks group [36.1 weeks (35.2, 36.4 weeks)] and medication before 34 weeks group [35.2 weeks (34.2, 36.2 weeks)] groups, and the differences were statistically significant (all <i>P</i><0.05). After correcting for gestational age, there was no significant difference in birth weight among the three groups (<i>H</i>=3.808, <i>P</i>=0.149). There were no significant differences in gender and the proportion of small for gestational age among the three groups (all <i>P</i>>0.05). (2) Short-term outcome: the incidence of wet lung was 7.0% (13/186), 11.0% (27/246) and 16.2% (32/198) in the non-medication group, medication after 34 weeks group and medication before 34 weeks group, respectively, and the difference was statistically significant (<i>P</i>=0.018). There were no significant differences in the incidence rates of NRDS, hypoglycemia, sepsis, IVH, BPD, and NEC among the three groups (all <i>P</i>>0.05). Logistic regression analysis with gestational age and newborn birth weight as confounding factors showed that early gestational age (<i>OR</i>=0.884, 95%<i>CI</i>: 0.837-0.933, <i>P</i><0.001) and increased incidence of selective intrauterine growth restriction type I (<i>OR</i>=2.967, 95%<i>CI</i>: 1.153-7.639, <i>P</i>=0.024) could both lead to an increased incidence of wet lung. (3) Long-term outcomes: a total of 109 pregnant women completed the follow-up, and 218 preterm infants with a corrected age of 6-54 months at the end of follow-up were enrolled, including 86 cases in the non-medication group, 66 cases in the medication after 34 weeks group, and 66 cases in t","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"675-681"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Chinese expert consensus on diagnosis management of accessory cavitated uterine malformation].","authors":"","doi":"10.3760/cma.j.cn112141-20240325-00184","DOIUrl":"10.3760/cma.j.cn112141-20240325-00184","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"657-660"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Strengthen the prevention and treatment of preterm birth, improve the health quality of the birth population].","authors":"Y L Hu, H X Yang","doi":"10.3760/cma.j.cn112141-20240523-00289","DOIUrl":"10.3760/cma.j.cn112141-20240523-00289","url":null,"abstract":"","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"661-666"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Transabdominal-transvaginal ultrasound cervical length sequential screening to predict the risk of spontaneous preterm birth in singleton pregnancy women with low risk of preterm birth].","authors":"L Yang, Y Wang, Y Zhang, H R Tang, Y Wang, L L Wang, T S Li, M M Zheng, Y L Hu, C Y Dai, Y Xu","doi":"10.3760/cma.j.cn112141-20240508-00266","DOIUrl":"10.3760/cma.j.cn112141-20240508-00266","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the feasibility of predicting the risk of spontaneous preterm birth in singleton pregnancy women with low risk of preterm birth by transabdominal-transvaginal ultrasound cervical length sequential screening in the second trimester. <b>Methods:</b> This prospective longitudinal cohort study included singleton pregnant women at 11-13⁺⁶ gestational weeks who were admitted to Nanjing Drum Tower Hospital from January 2023 to September 2023. Transabdominal and transvaginal cervical lengths were measured during the mid-trimester fetal ultrasound scan at 18-24 weeks, and pregnancy outcomes were obtained after delivery. A short cervix was defined as a transvaginal cervical length of ≤25 mm, and the outcomes were defined as spontaneous preterm birth occurs between 20 and 36⁺⁶ weeks and extremely preterm birth before 32 weeks. The area under the receiver operating characteristic (ROC) curve was used to evaluate the effectiveness of predicting spontaneous preterm birth by transabdominal and transvaginal cervix length, as well as the effectiveness of predicting short cervix by transabdominal cervical length. The relationship between transabdominal and transvaginal cervical length was evaluated using a scatter plot. <b>Results:</b> A total of 562 cases were included in this study, comprising 33 cases of spontaneous preterm birth (7 cases occurring before 32 weeks) and 529 cases of term birth. (1) Compared to the term birth group, transabdominal cervical length (median: 37.6 vs 33.2 mm; <i>Z</i>=-3.838, <i>P</i><0.001) and transvaginal cervical length (median: 34.0 vs 29.9 mm, <i>Z</i>=-3.030, <i>P</i>=0.002) in the spontaneous preterm birth group were significantly shorter. (2) The areas under the ROC curve for predicting spontaneous preterm birth by transabdominal and transvaginal cervical length were 0.699 (95%<i>CI</i>: 0.588-0.809) and 0.657 (95%<i>CI</i>: 0.540-0.774), respectively. The sensitivity, specificity and positive predictive value of transvaginal cervical length <b>Conclusions:</b> In singleton pregnancy women with low risk of preterm birth, transabdominal-transvaginal cervical length sequential screening can reduce unnecessary transvaginal ultrasounds by approximately 41% without missing the diagnosis of pregnant women with a short cervix. This method also enhances the effectiveness of transvaginal cervical length to spontaneous preterm birth.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"667-674"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oncological and reproductive outcomes after fertility-sparing surgery in patients with stage Ⅱ-Ⅲ borderline ovarian tumor].","authors":"G Zheng, Y N Liu, Q Wang, H L Fu, L L Si, T J Lai, R X Guo","doi":"10.3760/cma.j.cn112141-20240420-00232","DOIUrl":"10.3760/cma.j.cn112141-20240420-00232","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate oncological and reproductive outcomes of women ≤40 years undergoing fertility-sparing surgery (FSS) for stage Ⅱ or Ⅲ borderline ovarian tumor (BOT). <b>Methods:</b> The patients with BOT and ≤40 years old with stage Ⅱ-Ⅲ BOT who underwent FSS enrolled from the First Affiliated Hospital of Zhengzhou University between January 2011 and March 2023 were analyzed retrospectively. The clinical data and follow-up results were obtained and analyzed. The univariate and multivariate Cox proportional hazard regression analysis were used to explore high-risk factors associated with prognosis. Additionally, pregnancy outcomes were also analyzed. <b>Results:</b> (1) A total of 79 patients with stage Ⅱ-Ⅲ BOT who have been treated with FSS were conducted, with an average age of (27.5±6.7) years old. The median tumor maximum diameter were 10.4 cm (range: 4.8-90.0 cm). The International Federation of Gynecology and Obstetrics (FIGO) stage was stage Ⅱ in 45 cases and stage Ⅲ in 34 cases. According to the pathological types, there were 48 cases of serous tumor, 21 cases of mucinous tumor, 1 case of endometrioid tumor, and 9 cases of mixed types. There were 41 cases of unilateral ovarian involvement, 38 cases of bilateral ovarian involvement. There were 5 cases of microinvasion, 17 cases of micropapillary subtype. Extra-ovarian invasive implants were found in 5 cases, and there were 31 cases of merged ascites. (2) Tumor outcomes: the median follow-up time from primary cytoreduction were 58 months (range: 8-146 months). At the end of the observation period, 24 cases (30%, 24/79) recurred, among them 5 cases had two recurrences and 2 cases had three recurrences. There were 2 cases (3%, 2/79) of death and 1 case (1%, 1/79) of survival with tumor. (3) Analysis of prognostic risk factors: the results of univariate analysis showed that mucinous tumor, tumor maximum diameter >13.15 cm, FIGO stage Ⅲ, merged ascites, micropapillary subtype, invasive implantation, and bilateral ovarian involvement were independent risk factors (all <i>P</i><0.05) for disease-free survival (DFS). FIGO stage Ⅲ (<i>HR</i>=4.555, 95%<i>CI</i>: 1.525-13.607; <i>P</i>=0.007) and micropapillary subtype (<i>HR</i>=2.396, 95%<i>CI</i>: 1.003-5.725; <i>P</i>=0.049) were found to be related to DFS through the multivariable Cox proportional hazard regression analysis. (4) Pregnancy outcomes: among the patients with fertility intentions 36 cases (46%,36/79), 29 cases (81%, 29/36) had successful pregnancies, and 27 cases (75%, 27/36) had successful births. <b>Conclusions:</b> Patients with stage Ⅱ-Ⅲ BOT underwent FSS have favorable survival and pregnancy rates. Micropapillary subtypes and FIGO staging (stage Ⅲ) are the significant risk factors of DFS.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"702-709"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Placental mesenchymal stem cell exosome-derived miR-139-5p regulates PTEN gene and influences chemotherapeutic-induced ovarian dysfunction].","authors":"X F Bai, S W Wang","doi":"10.3760/cma.j.cn112141-20240419-00228","DOIUrl":"10.3760/cma.j.cn112141-20240419-00228","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the impact of exosomes and microRNA (miRNA) from placental mesenchymal stem cells on chemotherapy-damaged ovarian granulosa cells. <b>Methods:</b> Various public databases were searched for miRNA targeting phosphatase and tensin homologue deleted on chromosome 10 (PTEN) gene. After miRNA transfection into human ovarian granulosa cells, cell growth and expressions of the target miRNA and PTEN were detected. Cisplatin was utilized to induce damage to human ovarian granulosa cells, which were subsequently co-cultured with human placental mesenchymal stem cells and exosomes generated from mesenchymal stem cells, then apoptosis and expressions of PTEN and the target miRNA were detected. <b>Results:</b> After analyzing several databases, miRNA 139-5p (miR-139-5p) was chosen as the target miRNA for this research. Transfection of miR-139-5p mimics into human ovarian granulosa cells elevated miR-139-5p expression level (9 882.080±1 049.130), reduced PTEN protein expression level (0.78±0.11), and increased cell proliferation absorbance (0.85±0.07). Cisplatin treatment severely damaged human ovarian granulosa cells and increased apoptosis, cisplatin-treated cells had a higher apoptosis ratio compared to untreated cells [ (41.9±1.0)% vs (5.0±0.3)%, <i>P</i><0.001]. In damaged human ovarian granulosa cells, co-cultured with human placental mesenchymal stem cells and exosomes increased miR-139-5p expression levels (1.31±0.04 and 1.20±0.03, respectively) and decreased apoptosis ratios [(20.0±0.4)% and (22.3±1.1)%, respectively]. <b>Conclusion:</b> Placental mesenchymal stem cell-derived exosomes repair damages of cisplatin-induced ovarian granulosa cell and could target PTEN gene through miR-139-5p, which might be a potential option for the treatment of chemotherapy-induced ovarian dysfunction.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"710-718"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy and safety of dienogest on ovarian endometrioma].","authors":"J F Sun, X L Wang, W N Yu, S Y Pan, Y Ding, H H Dai, X L Wang","doi":"10.3760/cma.j.cn112141-20240516-00282","DOIUrl":"10.3760/cma.j.cn112141-20240516-00282","url":null,"abstract":"<p><p><b>Objective:</b> To observe the effects and safety of dienogest on the volume and symptoms of ovarian endometrioma (OMA). <b>Methods:</b> The clinical data of 75 patients with OMA who underwent treatment with dienogest (2 mg/day) at the First Affiliated Hospital of Nanjing Medical University from July 1st 2020 to March 31st 2024 were retrospectively analysed, mainly comparing the changes in the volume of OMA and the visual analogue scale (VAS) scores of endometriosis-related pain before and after the treatment, as well as observing the changes in the blood biological indicators, liver and kidney function, coagulation function and changes in breast. <b>Results:</b> The median cyst volumes of the OMA patients at 3, 6 and 12 months of dienogest treatment were 13.21 cm³ (volume reduction rate: 36.00%), 8.33 cm³ (volume reduction rate: 56.00%) and 4.10 cm³ (volume reduction rate: 77.62%), respectively, which were all significantly decreased from the pre-treatment period (all <i>P</i><0.05). The VAS scores of pain of the OMA patients at 3, 6 and 12 months of dienogest treatment all were 0 mm. Blood cancer antigen 125 (CA₁₂₅) and cancer antigen 19-9 (CA_19-9) levels decreased progressively during treatment (all <i>P</i><0.05). There were no statistical differences in the coagulation indexes, liver and kidney function indexes of the patients during dienogest treatment compared with those before treatment (all <i>P</i>>0.05). During the follow-up period, there were a few patients with changes in the growth sites or lesion category of the breast nodules, but there were no occurrence of breast cancer or precancerous lesions. <b>Conclusion:</b> Dienogest is effective in reducing OMA volume and alleviating endometriosis-related pain with few adverse effects.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"692-701"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Changes in the rates of preterm birth and multiparity over a 10-year period and multiparity as a possible risk factor for preterm birth].","authors":"Z X Li, Y N Liu, S T Qin, Y M Wei","doi":"10.3760/cma.j.cn112141-20240323-00178","DOIUrl":"10.3760/cma.j.cn112141-20240323-00178","url":null,"abstract":"<p><p><b>Objective:</b> To analyze the changes of preterm birth rate and proportion of multipara in 10 years, and to explore the possibility of multipara as a risk factor for preterm birth. <b>Methods:</b> This study was a cohort study. The general clinical data and pregnancy outcomes of 53 979 parturients delivered in Peking University First Hospital from January 2013 to December 2022 were collected, and the changes of preterm birth rate and proportion of multipara in the past 10 years were analyzed retrospectively. Single factor and multivariate logistic regression analysis were used to explore the risk factors of spontaneous preterm birth and the influence of multipara on pregnancy outcome. <b>Results:</b> (1) The total preterm birth rate of 53 979 parturients was 8.3%(4 478/53 979), and the overall preterm birth rate showed an upward trend in the past 10 years, among which the preterm birth rate was higher in 2017 and 2018, which were 8.9% and 9.2% respectively. The proportion of multipara was 24.9% (13 440/53 979), which showed a trend of rising first, then declining and then stabilizing. In 2017 and 2018, the proportion of multipara was the highest, accounting for 35.0%. (2) Multivariate logistic regression analysis showed that multipara was a risk factor for spontaneous preterm birth before 37 weeks of pregnancy (<i>OR</i>=1.678, 95%<i>CI</i>: 1.523-1.850; <i>P</i><0.001), which was also a risk factor for spontaneous preterm birth before 34 weeks of pregnancy (<i>OR</i>=1.937, 95%<i>CI</i>: 1.632-2.301; <i>P</i><0.001). The high risk factors of spontaneous preterm birth also include multiple pregnancies, hyperglycemia during pregnancy, abnormal amniotic fluid volume, premature rupture of membranes, intrauterine infection, cervical incompetence, history of cervical surgery and abnormal uterine development. (3) Compared with primiparas, multiparas was older, had earlier delivery weeks, higher premature delivery rate, higher birth weight and fewer multiple pregnancies. Among pregnancy complications, the incidence of gestational diabetes mellitus, placenta previa, placenta implantation, urgent delivery and macrosomia was higher, while the incidence of pregnancy-induced hypertension, pre-eclampsia, intrahepatic cholestasis of pregnancy, oligohydramnios, fetal growth restriction, premature rupture of membranes, intrauterine infection and postpartum hemorrhage was lower, and the differences were statistically significant (<i>P</i><0.05). <b>Conclusions:</b> In recent 10 years, the overall rate of preterm birth is on the rise, and the risk factors of preterm birth are basically similar to those in previous studies. Multipara is a high-risk group of spontaneous preterm birth, and the risk of various pregnancy complications increases, which should be paid attention to in pregnancy care.</p>","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 9","pages":"682-691"},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of baseline LH/FSH ratio in PCOS on IVF-ET outcomes: a retrospective cohort study].","authors":"C Y Wang, A H Wang, J Y Wang, J X Cheng, C M Liang, F M Pan, G Y Luo","doi":"10.3760/cma.j.cn112141-20240526-00300","DOIUrl":"10.3760/cma.j.cn112141-20240526-00300","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To exlplore the association between the baseline luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio of polycystic ovary syndrome (PCOS) and in vitro fertilisation-embryo transfer outcomes. &lt;b&gt;Methods:&lt;/b&gt; This was a retrospective cohort study. A total of 2 868 PCOS patients were enrolled, all of the participants were patients in The First Affiliated Hospital of Anhui Medical University Hospital from October 2015 to October 2021. Propensity score matching (1∶2.5) was conducted to regulate the non-random allocation of patients. Data were extracted from the hospital's medical records. Patients with baseline LH/FSH ratio&gt;2 were deemed as study group, patients with baseline LH/FSH ratio≤2 were deemed as control group. Single factor analysis was applied to compare the differences of pregnancy outcomes between two groups. &lt;b&gt;Results:&lt;/b&gt; After propensity score matching (1∶2.5), there were no statistically significant differences in baseline data between the two groups (all &lt;i&gt;P&lt;/i&gt;&gt;0.05), indicating that the data were comparable. In the study group, the total dose of gonadotropin (Gn) and duration of Gn were lower than those of the control group (&lt;i&gt;t&lt;/i&gt;=4.989, &lt;i&gt;P&lt;/i&gt;&lt;0.001; &lt;i&gt;t&lt;/i&gt;=3.267, &lt;i&gt;P&lt;/i&gt;=0.001), the rate of in vitro maturation was higher than that of the control group (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=4.938, &lt;i&gt;P&lt;/i&gt;=0.026), the number of retrieved oocytes and cleavage were higher than those of the control group (&lt;i&gt;t&lt;/i&gt;=-2.305, &lt;i&gt;P&lt;/i&gt;=0.021; &lt;i&gt;t&lt;/i&gt;=-2.816, &lt;i&gt;P&lt;/i&gt;=0.005), but there were no differences in the number and rate of high-quality embryos between the two groups (&lt;i&gt;t&lt;/i&gt;=-1.636, &lt;i&gt;P&lt;/i&gt;=0.102; &lt;i&gt;t&lt;/i&gt;=-0.123, &lt;i&gt;P&lt;/i&gt;=0.902). The incidence of moderate to severe ovarian hyperstimulation syndrome in the study group was significantly higher than that in the control group (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=17.277, &lt;i&gt;P&lt;/i&gt;&lt;0.001). Regardless of fresh embryo transfer or frozen-thawed embryo transfer cycles, the incidences of gestational diabetes mellitus in the study group were higher than those in the control group (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=9.174, &lt;i&gt;P&lt;/i&gt;=0.002; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=4.204, &lt;i&gt;P&lt;/i&gt;=0.040) of singleton pregnancy. In the fresh embryo transfer cycle, the clinical pregnancy rate [30.30% (20/66) vs 47.75% (53/111)] and delivery rate [30.30% (20/66) vs 46.85% (52/111)] in the study group were lower than those in the control group (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=5.198, &lt;i&gt;P&lt;/i&gt;=0.023; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=4.695, &lt;i&gt;P&lt;/i&gt;=0.030). In the frozen-thawed embryo transfer cycle, the delivery rate in the study group was higer than that in the control group [59.41% (423/712) vs 55.04% (1 053/1 913); &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=7.526, &lt;i&gt;P&lt;/i&gt;=0.023]. The clinical pregnancy rate and delivery rate of fresh embryo transfer cycle in the study group were significantly lower than those of frozen-thawed embryo transfer cycle (&lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=21.308, &lt;i&gt;P&lt;/i&gt;&lt;0.001; &lt;i&gt;χ&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;=20.871, &lt;i&gt;P&lt;/i&gt;&lt;0.001), but there were no signi","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 8","pages":"608-616"},"PeriodicalIF":0.0,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Preliminary exploration of the clinical warning value of ischemic modified albumin in the development of pre-eclampsia].","authors":"J M Shi, F Q Li, Z Yang, H L Liang, Y W Han, H D Zhang, S Wang","doi":"10.3760/cma.j.cn112141-20240415-00218","DOIUrl":"10.3760/cma.j.cn112141-20240415-00218","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the clinical warning value of ischemic modified albumin (IMA) and IMA to human serum albumin (HSA) ratio (IMAR) in the development of pre-eclampsia (PE) and its severity. &lt;b&gt;Methods:&lt;/b&gt; A total of 156 pregnant women with PE admitted to the Haidian District Maternal and Child Health Hospital of Beijing from April 2022 to March 2023 were collected as the PE group, and 156 healthy pregnant women with the same age and gestational age were matched as the control group. PE pregnant women were further divided into severe PE group (78 cases) and non-severe PE group (78 cases). Severe PE pregnant women were divided into emergency group (42 cases) and non-emergency group (36 cases) according to the disease progression time.All pregnant women were stratified according to their HSA levels (&lt;30 g/L, 30-32 g/L, ≥32 g/L), and the peripheral blood IMA, HSA, and IMAR of pregnant women in different periods and subgroups were compared, and also the difference of IMA levels in umbilical artery blood. Bivariate correlation analysis was used to explore the correlation between severe PE and IMA or IMAR, and receiver operating characteristic (ROC) curves was used to analyze the diagnostic value of IMA, HSA, and IMAR for PE and severe PE. &lt;b&gt;Results:&lt;/b&gt; (1) The IMA level and IMAR in peripheral serum of pregnant women in the PE group at diagnosis, and the IMA level in umbilical artery blood at delivery, and peripheral serum at 2 days after delivery were higher than those in the control group. The HSA level in peripheral serum was lower than that in the control group at diagnosis, and the differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.001). (2) The IMA level and IMAR in the peripheral serum of pregnant women with severe PE were higher than those in the non-severe PE group at diagnosis, while the HSA level were lower than those in the non-severe PE group. The differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). At diagnosis, the IMA level and IMAR in peripheral serum of pregnant women in the emergency group were higher than those in the non-emergency group, while the HSA level was lower than that in the non-emergency group. The differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.05). When diagnosed, the peripheral serum IMA levels of pregnant women in the PE group were compared between subgroups with HSA&lt;30 g/L, 30-32 g/L, ≥32 g/L, and there was no statistically significant difference (&lt;i&gt;F&lt;/i&gt;=0.366, &lt;i&gt;P&lt;/i&gt;=0.694). However, the IMAR was compared between the three subgroups, and the difference was statistically significant (&lt;i&gt;F&lt;/i&gt;=28.544, &lt;i&gt;P&lt;/i&gt;&lt;0.001), which increased with the decrease of HSA levels. In the subgroup with HSA≥32 g/L, the peripheral serum IMA level and IMAR of pregnant women in the PE group were higher than those in the control group at diagnosis, and the differences were statistically significant (all &lt;i&gt;P&lt;/i&gt;&lt;0.001). (3) The severe PE manifestations positively correlated with peripher","PeriodicalId":10050,"journal":{"name":"中华妇产科杂志","volume":"59 8","pages":"583-590"},"PeriodicalIF":0.0,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}