Chemotherapy最新文献

筛选
英文 中文
Contents, Vol. 66, 2021 目录,第66卷,2021年
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-12-01 DOI: 10.1159/000520921
{"title":"Contents, Vol. 66, 2021","authors":"","doi":"10.1159/000520921","DOIUrl":"https://doi.org/10.1159/000520921","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"238 1","pages":"I - IV"},"PeriodicalIF":3.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77014942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acknowledgement to Reviewers 审稿人致谢
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-12-01 DOI: 10.1159/000520920
{"title":"Acknowledgement to Reviewers","authors":"","doi":"10.1159/000520920","DOIUrl":"https://doi.org/10.1159/000520920","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"63 1","pages":"210 - 210"},"PeriodicalIF":3.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74230809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front & Back Matter 正面和背面
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-10-01 DOI: 10.1159/000520121
{"title":"Front & Back Matter","authors":"","doi":"10.1159/000520121","DOIUrl":"https://doi.org/10.1159/000520121","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"24 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84540097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front & Back Matter 正面和背面
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-06-01 DOI: 10.1159/000517678
{"title":"Front & Back Matter","authors":"","doi":"10.1159/000517678","DOIUrl":"https://doi.org/10.1159/000517678","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"6 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81533939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal Contact Concentration of Paclitaxel in the Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test for Human Oral Squamous Cell Carcinoma and Evaluation of Combination with Cetuximab. 人口腔鳞状细胞癌胶原凝胶滴浸培养药敏试验中紫杉醇的最佳接触浓度及与西妥昔单抗联合用药的评估
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-02-09 DOI: 10.1159/000512542
Tomoyuki Kii, Kaname Sakuma, Akira Tanaka
{"title":"Optimal Contact Concentration of Paclitaxel in the Collagen Gel Droplet-Embedded Culture Drug Sensitivity Test for Human Oral Squamous Cell Carcinoma and Evaluation of Combination with Cetuximab.","authors":"Tomoyuki Kii, Kaname Sakuma, Akira Tanaka","doi":"10.1159/000512542","DOIUrl":"10.1159/000512542","url":null,"abstract":"<p><strong>Objective: </strong>A combination of the taxane anticancer drug paclitaxel (PTX) and molecular target drug cetuximab (cMab) is effective for the treatment of head and neck squamous cell carcinoma (HNSCC). However, its use is associated with serious side effects, such as neuropathy and myelosuppression. In addition, it is administered regardless of patient sensitivity because biomarkers indicating its efficacy are unavailable. Therefore, we investigated the usefulness of setting the indicated contact concentration of PTX and predicted the antitumor effect of combined contact with cMab using the collagen gel droplet-embedded culture drug sensitivity test (CD-DST).</p><p><strong>Method: </strong>Twelve human oral squamous cell carcinoma (OSCC) cell lines (i.e., SAS, HSC-2, HSC-3, HSC-4, OSC-19, OSC-20, KON, HO-1-N-1, HO-1-u-1, SAT, SCC-4, and Nialym) were used. Using the CD-DST, we calculated the optimal contact concentration of the cells with PTX based on the clinical response rate of HNSCC and evaluated the combined contact with cMab. Furthermore, nude mice were treated with standalone PTX and PTX + cMab, and the results were compared with those of the CD-DST.</p><p><strong>Results: </strong>Based on the CD-DST, 0.1 μg/mL was the optimal contact concentration of PTX, to which the cells showed dose-dependent sensitivity. Moreover, the CD-DST method was used to evaluate the antitumor effects on OSCC even when PTX was used in combination with cMab. The antitumor effects in the CD-DST and nude mice were correlated (p < 0.05).</p><p><strong>Conclusion: </strong>The CD-DST results suggested that it was possible to predict the clinical effects of single-contact PTX and the enhancing effect of cMab + PTX.</p>","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"65 5-6","pages":"147-157"},"PeriodicalIF":3.3,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25349779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing the Journey of Patients under Chemotherapy in a Pandemic Era: A Nursing Perspective. 大流行病时代化疗患者的旅程管理:护理视角。
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-02-04 DOI: 10.1159/000513140
Raffaella Gualandi, Anna De Benedictis, Maria Grazia De Marinis, Daniela Tartaglini
{"title":"Managing the Journey of Patients under Chemotherapy in a Pandemic Era: A Nursing Perspective.","authors":"Raffaella Gualandi, Anna De Benedictis, Maria Grazia De Marinis, Daniela Tartaglini","doi":"10.1159/000513140","DOIUrl":"10.1159/000513140","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, cancer patients' care needs to be reconsidered by integrating the patient's clinical pathway with the hospital patient journey and the family context in a safe and patient-centered way. So far, no systematic reports are available regarding the impact of the COVID-19 pandemic on cancer care. This work gives a first overview of patients' care needs undergoing chemotherapy treatment from a nursing perspective.</p>","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":" ","pages":"1-4"},"PeriodicalIF":3.3,"publicationDate":"2021-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900452/pdf/che-0065-0115.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10540076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contents Vol. 65, 2020 目录2020年第65卷
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-02-01 DOI: 10.1159/000515092
{"title":"Contents Vol. 65, 2020","authors":"","doi":"10.1159/000515092","DOIUrl":"https://doi.org/10.1159/000515092","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"1 1","pages":"I - IV"},"PeriodicalIF":3.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86436246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acknowledgement to Reviewers 审稿人致谢
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-02-01 DOI: 10.1159/000515093
{"title":"Acknowledgement to Reviewers","authors":"","doi":"10.1159/000515093","DOIUrl":"https://doi.org/10.1159/000515093","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"73 1","pages":"171 - 171"},"PeriodicalIF":3.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86074204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front & Back Matter 正面和背面
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-02-01 DOI: 10.1159/000515486
{"title":"Front & Back Matter","authors":"","doi":"10.1159/000515486","DOIUrl":"https://doi.org/10.1159/000515486","url":null,"abstract":"","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"3 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78485553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities. 癌症中的戊糖磷酸通路:调控和治疗机会。
IF 3.3 4区 医学
Chemotherapy Pub Date : 2021-01-01 Epub Date: 2021-11-12 DOI: 10.1159/000519784
Noorhan Ghanem, Chirine El-Baba, Khaled Araji, Riyad El-Khoury, Julnar Usta, Nadine Darwiche
{"title":"The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities.","authors":"Noorhan Ghanem,&nbsp;Chirine El-Baba,&nbsp;Khaled Araji,&nbsp;Riyad El-Khoury,&nbsp;Julnar Usta,&nbsp;Nadine Darwiche","doi":"10.1159/000519784","DOIUrl":"https://doi.org/10.1159/000519784","url":null,"abstract":"<p><strong>Background: </strong>Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions. Unlike their normal cell counterparts, tumor cells rely on aerobic glycolysis, through the Warburg effect.</p><p><strong>Summary: </strong>The pentose phosphate pathway (PPP) is a major glucose metabolic shunt that is upregulated in cancer cells. The PPP comprises an oxidative and a nonoxidative phase and is essential for nucleotide synthesis of rapidly dividing cells. The PPP also generates nicotinamide adenine dinucleotide phosphate, which is required for reductive metabolism and to counteract oxidative stress in tumor cells. This article reviews the regulation of the PPP and discusses inhibitors that target its main pathways. Key Message: Exploiting the metabolic vulnerability of the PPP offers potential novel therapeutic opportunities and improves patients' response to cancer therapy.</p>","PeriodicalId":10047,"journal":{"name":"Chemotherapy","volume":"66 5-6","pages":"179-191"},"PeriodicalIF":3.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39710197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信