Ping Lin , Xue Li , Yuchen Xin , Hongying Li , Gang Li , Hongxiang Lou
{"title":"Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes","authors":"Ping Lin , Xue Li , Yuchen Xin , Hongying Li , Gang Li , Hongxiang Lou","doi":"10.1016/j.engmic.2022.100039","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100039","url":null,"abstract":"<div><p>Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse family of polycyclic polyphenols. Some of them are consequently suggested as lead structures for drug development. Among them, rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannulated [5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit. This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities, including antimicrobial, anticancer, and enzyme inhibition activity. The unique structures, intriguing biosynthesis, and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists. This review covers the isolation, characterization, biosynthesis, and biological studies of these structurally diverse and complex rubromycins.</p></div>","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667370322000303/pdfft?md5=ae5f15035819639d907994f01852234b&pid=1-s2.0-S2667370322000303-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71901147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications","authors":"K. Koschorreck, Saadet Alpdağtaş, V. Urlacher","doi":"10.1016/j.engmic.2022.100037","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100037","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80775857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate","authors":"Dan Hu","doi":"10.1016/j.engmic.2022.100035","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100035","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82321558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guiping Gong, Bo Wu, Linpei Liu, Jianting Li, Qi-li Zhu, Mingxiong He, Guoquan Hu
{"title":"Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals","authors":"Guiping Gong, Bo Wu, Linpei Liu, Jianting Li, Qi-li Zhu, Mingxiong He, Guoquan Hu","doi":"10.1016/j.engmic.2022.100036","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100036","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86154413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pingzhou Lin, Xue Li, Yu Xin, Hong-Ying Li, Gang Li, H. Lou
{"title":"Isolation, Biosynthesis, and Biological Activity of Rubromycins Derived from Actinomycetes","authors":"Pingzhou Lin, Xue Li, Yu Xin, Hong-Ying Li, Gang Li, H. Lou","doi":"10.1016/j.engmic.2022.100039","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100039","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86836525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenxia Song, Xueke Zhuang, Yahong Tan, Q. Qi, Xuemei Lu
{"title":"The Type IX Secretion System: Insights into Its Function and Connection to Glycosylation in Cytophaga hutchinsonii","authors":"Wenxia Song, Xueke Zhuang, Yahong Tan, Q. Qi, Xuemei Lu","doi":"10.1016/j.engmic.2022.100038","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100038","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91291824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels","authors":"Lijuan Liu , Wenzhi Bao , Xiao Men , Haibo Zhang","doi":"10.1016/j.engmic.2022.100013","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100013","url":null,"abstract":"<div><p>With the growing demand for air transportation combined with global concerns about environmental issues and the instability and lack of renewability of the oil market, microbial production of high energy density fuels for jets (bio-jet fuels) has received more attention in recent years. Bio-jet fuels can be derived from both isoprenoids and fatty acids, and, additionally, aromatic hydrocarbons derived from expanded shikimate pathways are also candidates for jet fuels. Compared to fatty acid derivatives, most of isoprenoids and aromatic hydrocarbons used for jet fuels have higher density energies. However, they are also highly toxic to host microbes. The cytotoxicity induced during the synthesis of isoprenoid or shikimate pathway-derived biofuels remains one of the major obstacles for industrial production even though synthetic and systems biology approaches have reconstructed and optimized metabolic pathways for production of these bio-jet fuels. Here, we review recent developments in the production of known and potential jet fuels by microorganisms, with a focus on alleviating cytotoxicity caused by the final products, intermediates, and metabolic pathways.</p></div>","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667370322000042/pdfft?md5=e63b7a4282b2134c74eb02d6fc218af7&pid=1-s2.0-S2667370322000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71898029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}