Engineering Microbiology最新文献

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Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes 放线菌源红霉素的分离、生物合成及生物活性研究
Engineering Microbiology Pub Date : 2022-09-01 DOI: 10.1016/j.engmic.2022.100039
Ping Lin , Xue Li , Yuchen Xin , Hongying Li , Gang Li , Hongxiang Lou
{"title":"Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes","authors":"Ping Lin ,&nbsp;Xue Li ,&nbsp;Yuchen Xin ,&nbsp;Hongying Li ,&nbsp;Gang Li ,&nbsp;Hongxiang Lou","doi":"10.1016/j.engmic.2022.100039","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100039","url":null,"abstract":"<div><p>Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse family of polycyclic polyphenols. Some of them are consequently suggested as lead structures for drug development. Among them, rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannulated [5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit. This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities, including antimicrobial, anticancer, and enzyme inhibition activity. The unique structures, intriguing biosynthesis, and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists. This review covers the isolation, characterization, biosynthesis, and biological studies of these structurally diverse and complex rubromycins.</p></div>","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667370322000303/pdfft?md5=ae5f15035819639d907994f01852234b&pid=1-s2.0-S2667370322000303-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71901147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cascade-Cas3 facilitates high-accuracy genome engineering in Pseudomonas using phage-encoded homologous recombination Cascade-Cas3利用噬菌体编码的同源重组促进假单胞菌的高精度基因组工程
Engineering Microbiology Pub Date : 2022-08-01 DOI: 10.1016/j.engmic.2022.100046
Wentao Zheng, Yandong Xia, Xue Wang, Shiqing Gao, Diao Zhou, Jun Fu, Ruijuan Li, Jia Yin
{"title":"Cascade-Cas3 facilitates high-accuracy genome engineering in Pseudomonas using phage-encoded homologous recombination","authors":"Wentao Zheng, Yandong Xia, Xue Wang, Shiqing Gao, Diao Zhou, Jun Fu, Ruijuan Li, Jia Yin","doi":"10.1016/j.engmic.2022.100046","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100046","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81775011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase 赖氨酸乙酰化降低了大肠杆菌乳酸脱氢酶活性和蛋白质水平
Engineering Microbiology Pub Date : 2022-08-01 DOI: 10.1016/j.engmic.2022.100045
Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, M. Xian, Q. Qi, Wei Liu, Guang Zhao
{"title":"Lysine acetylation decreases enzyme activity and protein level of Escherichia coli lactate dehydrogenase","authors":"Min Liu, Meitong Huo, Likun Guo, Yingxin Fu, M. Xian, Q. Qi, Wei Liu, Guang Zhao","doi":"10.1016/j.engmic.2022.100045","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100045","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86297525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications 铜自由基氧化酶:一组不同的生物催化剂具有不同的性质和广泛的生物技术应用
Engineering Microbiology Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100037
K. Koschorreck, Saadet Alpdağtaş, V. Urlacher
{"title":"Copper-radical oxidases: A diverse group of biocatalysts with distinct properties and a broad range of biotechnological applications","authors":"K. Koschorreck, Saadet Alpdağtaş, V. Urlacher","doi":"10.1016/j.engmic.2022.100037","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100037","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80775857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate 一类新的由焦磷酸六戊烯基衍生的三萜化合物的发现和分析
Engineering Microbiology Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100035
Dan Hu
{"title":"Discovery and analysis of a new class of triterpenes derived from hexaprenyl pyrophosphate","authors":"Dan Hu","doi":"10.1016/j.engmic.2022.100035","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100035","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82321558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals 代谢工程利用醋酸酯作为生产生物基化学品的有前途的基石
Engineering Microbiology Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100036
Guiping Gong, Bo Wu, Linpei Liu, Jianting Li, Qi-li Zhu, Mingxiong He, Guoquan Hu
{"title":"Metabolic engineering using acetate as a promising building block for the production of bio-based chemicals","authors":"Guiping Gong, Bo Wu, Linpei Liu, Jianting Li, Qi-li Zhu, Mingxiong He, Guoquan Hu","doi":"10.1016/j.engmic.2022.100036","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100036","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86154413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Isolation, Biosynthesis, and Biological Activity of Rubromycins Derived from Actinomycetes 放线菌源红霉素的分离、生物合成及生物活性研究
Engineering Microbiology Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100039
Pingzhou Lin, Xue Li, Yu Xin, Hong-Ying Li, Gang Li, H. Lou
{"title":"Isolation, Biosynthesis, and Biological Activity of Rubromycins Derived from Actinomycetes","authors":"Pingzhou Lin, Xue Li, Yu Xin, Hong-Ying Li, Gang Li, H. Lou","doi":"10.1016/j.engmic.2022.100039","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100039","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86836525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Type IX Secretion System: Insights into Its Function and Connection to Glycosylation in Cytophaga hutchinsonii 哈氏细胞吞噬体IX型分泌系统的功能及其与糖基化的关系
Engineering Microbiology Pub Date : 2022-07-01 DOI: 10.1016/j.engmic.2022.100038
Wenxia Song, Xueke Zhuang, Yahong Tan, Q. Qi, Xuemei Lu
{"title":"The Type IX Secretion System: Insights into Its Function and Connection to Glycosylation in Cytophaga hutchinsonii","authors":"Wenxia Song, Xueke Zhuang, Yahong Tan, Q. Qi, Xuemei Lu","doi":"10.1016/j.engmic.2022.100038","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100038","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91291824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels 毒性生命工程:高能量密度燃料微生物合成工业化的关键
Engineering Microbiology Pub Date : 2022-06-01 DOI: 10.1016/j.engmic.2022.100013
Lijuan Liu , Wenzhi Bao , Xiao Men , Haibo Zhang
{"title":"Engineering for life in toxicity: Key to industrializing microbial synthesis of high energy density fuels","authors":"Lijuan Liu ,&nbsp;Wenzhi Bao ,&nbsp;Xiao Men ,&nbsp;Haibo Zhang","doi":"10.1016/j.engmic.2022.100013","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100013","url":null,"abstract":"<div><p>With the growing demand for air transportation combined with global concerns about environmental issues and the instability and lack of renewability of the oil market, microbial production of high energy density fuels for jets (bio-jet fuels) has received more attention in recent years. Bio-jet fuels can be derived from both isoprenoids and fatty acids, and, additionally, aromatic hydrocarbons derived from expanded shikimate pathways are also candidates for jet fuels. Compared to fatty acid derivatives, most of isoprenoids and aromatic hydrocarbons used for jet fuels have higher density energies. However, they are also highly toxic to host microbes. The cytotoxicity induced during the synthesis of isoprenoid or shikimate pathway-derived biofuels remains one of the major obstacles for industrial production even though synthetic and systems biology approaches have reconstructed and optimized metabolic pathways for production of these bio-jet fuels. Here, we review recent developments in the production of known and potential jet fuels by microorganisms, with a focus on alleviating cytotoxicity caused by the final products, intermediates, and metabolic pathways.</p></div>","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667370322000042/pdfft?md5=e63b7a4282b2134c74eb02d6fc218af7&pid=1-s2.0-S2667370322000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71898029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptaibols: diversity, bioactivity, and biosynthesis 肽:多样性,生物活性和生物合成
Engineering Microbiology Pub Date : 2022-06-01 DOI: 10.1016/j.engmic.2022.100026
Xuewen Hou, Ruonan Sun, Yanyan Feng, Runfang Zhang, T. Zhu, Qian Che, Guojian Zhang, Dehai Li
{"title":"Peptaibols: diversity, bioactivity, and biosynthesis","authors":"Xuewen Hou, Ruonan Sun, Yanyan Feng, Runfang Zhang, T. Zhu, Qian Che, Guojian Zhang, Dehai Li","doi":"10.1016/j.engmic.2022.100026","DOIUrl":"https://doi.org/10.1016/j.engmic.2022.100026","url":null,"abstract":"","PeriodicalId":100478,"journal":{"name":"Engineering Microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84087724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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