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Patent News 专利新闻
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02433-8
Douglas Drysdale
{"title":"Patent News","authors":"Douglas Drysdale","doi":"10.1016/S1741-8372(04)02433-8","DOIUrl":"https://doi.org/10.1016/S1741-8372(04)02433-8","url":null,"abstract":"<div><p><em>Patent Update</em><span> is a regular column dedicated to the complex issues that affect patents in the genomics and proteomics field. In each issue, there are two sections compiled by patent attorneys. The first section, </span><em>Patent Perspective</em>, is a commentary on current issues, landmark patents, useful patent resources and how to search them, and legislative changes that impact the pharma and biotech industries. The second section, <em>Patent News</em>, provides brief synopses of recently issued patents and other patent events, and their significance to drug discovery R&amp;D.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Page 124"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02433-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137257148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Looking at a single enzyme molecule 看一个酶分子
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02440-5
Vida Foubister
{"title":"Looking at a single enzyme molecule","authors":"Vida Foubister","doi":"10.1016/S1741-8372(04)02440-5","DOIUrl":"10.1016/S1741-8372(04)02440-5","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Page 87"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02440-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74335904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The targetable G protein proteome: where is the next generation of drug targets? 可靶向G蛋白蛋白质组:下一代药物靶点在哪里?
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02429-6
R.Victor Rebois , Bruce G. Allen, Terence E. Hébert
{"title":"The targetable G protein proteome: where is the next generation of drug targets?","authors":"R.Victor Rebois ,&nbsp;Bruce G. Allen,&nbsp;Terence E. Hébert","doi":"10.1016/S1741-8372(04)02429-6","DOIUrl":"10.1016/S1741-8372(04)02429-6","url":null,"abstract":"<div><p>G protein-coupled signaling systems are the most important targets for therapeutic drugs, most of which are ligands for heptahelical receptors (7TM-R). A single receptor can activate various signaling pathways<span> in different cells; consequently, drugs that target the receptor binding site are not necessarily specific for particular pathways. However, other downstream signaling partners that interact with heptahelical receptors can be unique for a given pathway and peptide motifs that are involved in these interactions are potential targets for the development of drugs with greater specificity and fewer side effects. Furthermore, it is becoming apparent that these systems are organized as protein complexes<span>, making proteomic techniques ideal tools for identifying system components.</span></span></p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 104-111"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02429-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87434398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Case study: use of a library of antisense inhibitors for gene functionalization and drug target validation 案例研究:利用反义抑制剂文库进行基因功能化和药物靶标验证
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02430-2
Eric G Marcusson, Thomas M Vincent, Kumar L Hari, MingYi Chiang, Nicholas M Dean
{"title":"Case study: use of a library of antisense inhibitors for gene functionalization and drug target validation","authors":"Eric G Marcusson,&nbsp;Thomas M Vincent,&nbsp;Kumar L Hari,&nbsp;MingYi Chiang,&nbsp;Nicholas M Dean","doi":"10.1016/S1741-8372(04)02430-2","DOIUrl":"10.1016/S1741-8372(04)02430-2","url":null,"abstract":"<div><p>The genomics revolution of the past decade has allowed the sequences of all human genes to be determined. The challenge for the future is to establish the functions of all of these genes. Antisense technology is a powerful tool for gene functionalization. This review describes a system used to test antisense oligonucleotides to over 2000 genes in multiple cell-based assays. These assays were designed to help assign gene function. The data generated from these assays is subsequently added to a searchable database that allows potential drug targets to be identified.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 117-122"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02430-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84154041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Target discovery using the yeast two-hybrid system 利用酵母双杂交系统发现靶标
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02414-4
Robert Hollingsworth, Julia H. White
{"title":"Target discovery using the yeast two-hybrid system","authors":"Robert Hollingsworth,&nbsp;Julia H. White","doi":"10.1016/S1741-8372(04)02414-4","DOIUrl":"10.1016/S1741-8372(04)02414-4","url":null,"abstract":"<div><p><span>A major goal of molecular biology is to understand protein interactions and how interaction networks form the functional circuitry of cells. This goal is also relevant to drug development, as molecular target discovery and validation require an understanding of the function and disease relevance of proteins. One of the best approaches available to achieve this goal is the yeast two-hybrid system and its variants. This powerful tool can be used not only to identify and characterize individual drug targets, but also to dissect whole pathways and map protein interactions on a </span>proteomic scale.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 97-103"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02414-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91486585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Whole genome variation analysis using single molecule sequencing 单分子测序全基因组变异分析
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02423-5
Tony Smith
{"title":"Whole genome variation analysis using single molecule sequencing","authors":"Tony Smith","doi":"10.1016/S1741-8372(04)02423-5","DOIUrl":"10.1016/S1741-8372(04)02423-5","url":null,"abstract":"<div><p><span><span>Discovering the genetic factors associated with common diseases and drug response has proved a daunting challenge. Genotyping has been preferred over </span>DNA sequencing, despite its lower information content, because the latter has been prohibitively expensive. Even accepting this compromise, the scale of whole genome scans has proved unaffordable, despite advances in genotyping technology. This challenge is being addressed by technologies that seek to analyse </span>genomic DNA at the single molecule level, as this offers the potential to re-sequence the genome of an individual human at a cost and throughput that represents five orders of magnitude improvement over conventional sequencing.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 112-116"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02423-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88837646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Zebrafish as a model system for drug target screening and validation 斑马鱼作为药物靶点筛选和验证的模型系统
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02428-4
Saulius Sumanas , Shuo Lin
{"title":"Zebrafish as a model system for drug target screening and validation","authors":"Saulius Sumanas ,&nbsp;Shuo Lin","doi":"10.1016/S1741-8372(04)02428-4","DOIUrl":"10.1016/S1741-8372(04)02428-4","url":null,"abstract":"<div><p><span>The zebrafish is becoming an increasingly popular model organism to study human diseases. Novel assays have been and continue to be developed to study human diseases in this model. Methods to identify novel drug targets using zebrafish include chemical mutagenesis<span>, insertional mutagenesis and small-molecule screens. Methods to validate potential drug targets include </span></span>morpholino<span> antisense knockdown technology and target-selected mutagenesis approaches. Here we review advances in these and related technologies.</span></p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 89-96"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02428-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88939177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Patent perspective 专利的角度来看
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02432-6
Russell Thom
{"title":"Patent perspective","authors":"Russell Thom","doi":"10.1016/S1741-8372(04)02432-6","DOIUrl":"https://doi.org/10.1016/S1741-8372(04)02432-6","url":null,"abstract":"<div><p><em>Patent Update</em><span> is a regular column dedicated to the complex issues that affect patents in the genomics and proteomics field. In each issue, there are two sections compiled by patent attorneys. The first section, </span><em>Patent Perspective</em>, is a commentary on current issues, landmark patents, useful patent resources and how to search them, and legislative changes that impact the pharma and biotech industries. The second section, <em>Patent News</em>, provides brief synopses of recently issued patents and other patent events, and their significance to drug discovery R&amp;D.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 123-124"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02432-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137257147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Streamlining the hunt for genes 简化对基因的寻找
Drug Discovery Today: TARGETS Pub Date : 2004-06-01 DOI: 10.1016/S1741-8372(04)02436-3
Martina Habeck
{"title":"Streamlining the hunt for genes","authors":"Martina Habeck","doi":"10.1016/S1741-8372(04)02436-3","DOIUrl":"10.1016/S1741-8372(04)02436-3","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Page 88"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02436-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87319338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target-based compound library design and synthesis 基于靶标的化合物库设计与合成
Drug Discovery Today: TARGETS Pub Date : 2004-04-01 DOI: 10.1016/S1741-8372(04)02402-8
Mark R. Player
{"title":"Target-based compound library design and synthesis","authors":"Mark R. Player","doi":"10.1016/S1741-8372(04)02402-8","DOIUrl":"10.1016/S1741-8372(04)02402-8","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 2","pages":"Pages 48-50"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02402-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87364408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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