{"title":"斑马鱼作为药物靶点筛选和验证的模型系统","authors":"Saulius Sumanas , Shuo Lin","doi":"10.1016/S1741-8372(04)02428-4","DOIUrl":null,"url":null,"abstract":"<div><p><span>The zebrafish is becoming an increasingly popular model organism to study human diseases. Novel assays have been and continue to be developed to study human diseases in this model. Methods to identify novel drug targets using zebrafish include chemical mutagenesis<span>, insertional mutagenesis and small-molecule screens. Methods to validate potential drug targets include </span></span>morpholino<span> antisense knockdown technology and target-selected mutagenesis approaches. Here we review advances in these and related technologies.</span></p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 3","pages":"Pages 89-96"},"PeriodicalIF":0.0000,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02428-4","citationCount":"47","resultStr":"{\"title\":\"Zebrafish as a model system for drug target screening and validation\",\"authors\":\"Saulius Sumanas , Shuo Lin\",\"doi\":\"10.1016/S1741-8372(04)02428-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The zebrafish is becoming an increasingly popular model organism to study human diseases. Novel assays have been and continue to be developed to study human diseases in this model. Methods to identify novel drug targets using zebrafish include chemical mutagenesis<span>, insertional mutagenesis and small-molecule screens. Methods to validate potential drug targets include </span></span>morpholino<span> antisense knockdown technology and target-selected mutagenesis approaches. Here we review advances in these and related technologies.</span></p></div>\",\"PeriodicalId\":100382,\"journal\":{\"name\":\"Drug Discovery Today: TARGETS\",\"volume\":\"3 3\",\"pages\":\"Pages 89-96\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02428-4\",\"citationCount\":\"47\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug Discovery Today: TARGETS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1741837204024284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Discovery Today: TARGETS","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1741837204024284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Zebrafish as a model system for drug target screening and validation
The zebrafish is becoming an increasingly popular model organism to study human diseases. Novel assays have been and continue to be developed to study human diseases in this model. Methods to identify novel drug targets using zebrafish include chemical mutagenesis, insertional mutagenesis and small-molecule screens. Methods to validate potential drug targets include morpholino antisense knockdown technology and target-selected mutagenesis approaches. Here we review advances in these and related technologies.
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