{"title":"Genetic link to drug-induced weight gain identified","authors":"Treasa Creavin","doi":"10.1016/S1741-8372(04)02463-6","DOIUrl":"10.1016/S1741-8372(04)02463-6","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 223-224"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02463-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74213164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The recombinant protein array: use in target identification and validation","authors":"Mark J. Schofield, Neil Sharma, Hui Ge","doi":"10.1016/S1741-8372(04)02460-0","DOIUrl":"10.1016/S1741-8372(04)02460-0","url":null,"abstract":"<div><p><span>The human genome contains ∼30,000 genes, but it is proposed that these genes could encode up to a million different proteins. Alternative splicing of genes results in the same gene encoding for multiple proteins that can then undergo further transformation via various posttranslational modifications – it is a combination of these two processes that could lead to diversity in the proteins produced. Characterization of the interaction of proteins with each other, DNA and ligands remains an enormous challenge, particularly for traditional techniques that typically enable resolution of the interactions of a single protein. It is not surprising that the technologies that facilitate the direct and concurrent probing of all (or a significant subset of) the proteins of an organism have generated considerable interest from researchers and pharmaceutical companies alike. This review highlights new technologies available for the study of protein function, with a particular focus on the applications of </span>recombinant protein arrays.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 246-252"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02460-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76855509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The end of the beginning is nigh","authors":"Henry Nicholls","doi":"10.1016/S1741-8372(04)02462-4","DOIUrl":"10.1016/S1741-8372(04)02462-4","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Page 223"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02462-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85242840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pleiotropy: the BAFFling truth of the TNF superfamily","authors":"Eugene A. Zhukovsky , Richard J. Morse","doi":"10.1016/S1741-8372(04)02457-0","DOIUrl":"10.1016/S1741-8372(04)02457-0","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 225-227"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02457-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84237523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomedical marker molecules for cancer – current status and perspectives","authors":"Oliver Stoss, Thomas Henkel","doi":"10.1016/S1741-8372(04)02459-4","DOIUrl":"10.1016/S1741-8372(04)02459-4","url":null,"abstract":"<div><p>Driven by the development of new techniques, such as DNA microarrays, mass spectroscopy, tissue microarrays or protein chips, a large number of biomarkers have been identified in the past few years with the aim to classify cancer subtypes or to predict disease progression or therapeutic response. However, few of the described markers have been developed into clinically validated diagnostic tools. This review provides an overview of recent cancer biomarker developments and the difficulties of moving biomarkers from basic research into the clinic.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 228-237"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02459-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81347780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ethics and patents: are patents bad or just misunderstood?","authors":"D. Drysdale","doi":"10.1016/S1741-8372(04)02461-2","DOIUrl":"https://doi.org/10.1016/S1741-8372(04)02461-2","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"30 1","pages":"253-254"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81164647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ethics and patents: are patents bad or just misunderstood?","authors":"Douglas Drysdale","doi":"10.1016/S1741-8372(04)02461-2","DOIUrl":"https://doi.org/10.1016/S1741-8372(04)02461-2","url":null,"abstract":"","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 253-254"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02461-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91669009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gregory A. Michaud, Rhonda Bangham, Michael Salcius, Paul F. Predki
{"title":"Functional protein microarrays for pathway mapping","authors":"Gregory A. Michaud, Rhonda Bangham, Michael Salcius, Paul F. Predki","doi":"10.1016/S1741-8372(04)02458-2","DOIUrl":"10.1016/S1741-8372(04)02458-2","url":null,"abstract":"<div><p><span><span>Functional protein microarrays present an important new tool that is ideally suited to the mapping of biological pathways. Almost every basic feature of pathways, from binary and multi-component </span>molecular interactions<span> to enzymatic activity, has now been recapitulated and studied using protein microarrays. The generation of microarrays comprising whole </span></span>proteomes of organisms will enable this technology to make significant contributions towards our understanding of disease pathways. We will review recent developments in functional protein microarrays, with a focus on their use for pathway mapping.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 6","pages":"Pages 238-245"},"PeriodicalIF":0.0,"publicationDate":"2004-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02458-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90321788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Target identification and validation through genetics","authors":"Maxine J. Allen, Alisoun H. Carey","doi":"10.1016/S1741-8372(04)02450-8","DOIUrl":"10.1016/S1741-8372(04)02450-8","url":null,"abstract":"<div><p>Drug target selection and validation is the goal of commercial genetic research. Human studies are beginning to deliver on their early promise of identifying complex disease susceptibility genes as the first step in validating potential new targets. Although the genes identified to date have shed light on some of the biological mechanisms that underlie complex disease, they have not always been tractable as drug targets. The current genetic strategies for disease gene identification are now being applied to specifically identify genetically associated drug targets in a high-throughput manner.</p></div>","PeriodicalId":100382,"journal":{"name":"Drug Discovery Today: TARGETS","volume":"3 5","pages":"Pages 183-190"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1741-8372(04)02450-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85807975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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