Dentistry Review最新文献

{"title":"The Use of Micro-needling with Therapeutic Agents for Tissue Regeneration","authors":"Courtney Morrow,&nbsp;Hannah Grach,&nbsp;Trina Hutto RDH, MS, EdD","doi":"10.1016/j.dentre.2024.100119","DOIUrl":"10.1016/j.dentre.2024.100119","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>The purpose of this literature review is to analyze the current body of literature regarding the use of microneedling with a therapeutic agent, to encourage tissue regeneration and gingival health in the periodontium.</p></div><div><h3>METHODS</h3><p>The database used for this literature review was Google Scholar with Augusta University Library accessible articles. The keywords used to find these articles were micro-needling, tissue regeneration, periodontal tissue attachment, guided tissue regeneration, and therapeutic agents. The mesh terms used were needles, periodontitis, tissues, regeneration, and epithelial attachment with the word “AND” between. Articles that were older than five years were filtered out, leaving 428 articles. Then irrelevant articles were manually filtered out. Six articles were then selected, with one of the articles being a literature review used for background information.</p></div><div><h3>RESULTS</h3><p>Each article reviewed showed how micro-needling with therapeutic adjuncts can have a positive effect on the gingiva. These effects range from increased interdental papilla height, increased gingival thickness and collagen formation, decreased inflammation, and decreased severity of the destruction of the periodontal tissues. Micro-needling initiates a natural wound-healing process in the gingiva, and with the help of different therapeutic agents, positive results can be observed.</p></div><div><h3>CONCLUSIONS</h3><p>Each of the articles selected used a different agent and a different micro-needling procedure. The patient's needs and wants are determining factors in which therapeutic agent would be used to assist the micro-needling procedure. Future research is needed to compare additives and procedures, in addition to micro-needling. More long-term studies are necessary to determine the lasting effects on the periodontium and overall health of the patient. In conclusion, micro-needling seems to be a cost-effective, non-invasive treatment with noticeable improvement for tissue regeneration and gingival health, proving to show validity and worth in becoming an accepted practice and treatment option in dentistry.</p></div><div><h3>IMPLICATIONS</h3><p>Micro-needling with a therapeutic adjunct is an efficient way for dental practices to incorporate a minimally invasive treatment into a wide variety of different treatment regimens.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000427/pdfft?md5=2e3b05cf3063401f244ac6f49a450020&pid=1-s2.0-S2772559624000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Small Extra-Cellular Vesicles for Endogenous Mesenchymal Stem Cells Recruitment and in situ Periodontal Tissue Regeneration","authors":"Cathy Tran,&nbsp;Ranya Elsayed PhD MBA","doi":"10.1016/j.dentre.2024.100113","DOIUrl":"10.1016/j.dentre.2024.100113","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>Exo released by immune-regulatory dendritic cells (regDCs) have been used as an effective nanodelivery system for the reprogramming of immune response at inflammatory bone defects in mice. This study aims to determine the efficacy of engineered SDF-1-loaded immune-regulatory DC-derived exosomes (SDF-1exo) in MSC recruitment and bone regeneration.</p></div><div><h3>METHODS</h3><p>Exo were purified from human and murine regDCs. Exo were loaded with SDF-1 using ultrasonication. In vitro studies of exo cargo including resistance of SDF-1 to proteolysis, MSC recruitment, and osteogenic differentiation were carried out. The therapeutic effect of SDF-1exo in hyaluronic acid-based hydrogel carrier was then tested in mandibular defects in a murine model. Five groups (n=5) were tested: group 1 (negative control), group 2 (carrier alone), group 3 (carrier with unloaded exo), group 4 (carrier with free SDF-1) and group 5 (carrier with SDF-1-exo). Biodistribution of DiI-prelabeled SDF-1-exo was performed using in-vivo imaging. Specimens were collected at 2- and 4-weeks post-operative. 3D volumetric micro-CT, histologic, qPCR, and IHC analyses were performed.</p></div><div><h3>RESULTS</h3><p>SDF-1exo protected its cargo against lysine gingipains and DPP4 proteolytic cleavage and promoted MSC migration, and osteogenesis. TEM revealed SDF-1 localization in the exo lumen and in the transmembrane domain. Blocking experiments revealed that sustainable SDF-1 signaling required interaction between SDF-1exo and CXCR4 receptor. In vivo, SDF-1exo showed a high affinity at the defect sites and sustained SDF-1 expression during the first 2 weeks of healing, promoting MSC migration. Significantly greater bone maturation in the SDF-1exo group was observed at 4 weeks.</p></div><div><h3>CONCLUSIONS</h3><p>This study demonstrated the efficacy of SDF-1exo delivery in promoting bone regeneration.</p></div><div><h3>IMPLICATIONS</h3><p>This study provides the basis for a novel natural nano-therapeutic strategy for periodontal tissue regeneration in humans.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000361/pdfft?md5=0f8fdcb25f9c52ff85e89462b618f667&pid=1-s2.0-S2772559624000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SRC Phosphorylation of EPS8 Regulates SOX2 Expression and HNSCC Stemness","authors":"Harshit Singhania,&nbsp;Linah A. Shahoumi,&nbsp;W. Andrew Yeudall","doi":"10.1016/j.dentre.2024.100095","DOIUrl":"10.1016/j.dentre.2024.100095","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>Epidermal growth factor receptor pathway substrate 8 (EPS8) is a key driver of head and neck squamous cell carcinogenesis (HNSCC). SOX2, a stem cell transcription factor, is overexpressed in high-grade HNSCC and is correlated with poor prognosis. We discovered that overexpression of EPS8 in HNSCC cells led to an increase in SOX2 expression because of increased transcription. EPS8 is phosphorylated by multiple upstream kinases, including SRC, and we found that the Y602 target site is key in regulating multiple oncogenic properties. However, the impact of these posttranslational modifications on cancer stemness is unknown. In this study, we investigated the effect of SRC phosphorylation of EPS8 on SOX2 expression and cancer stem cell properties.</p></div><div><h3>METHODS</h3><p>HNSCC cells expressing EPS8 mutants harboring phenylalanine substitutions at four SRC target sites (485/525/602/774; EPS8-F4), three sites (485/525/774; EPS8-F3) or at only one site (602; EPS8-Y602F) were used, with cells expressing low endogenous EPS8 or overexpressing wild-type EPS8 as controls. The effect of blocking SRC phosphorylation sites of EPS8 on SOX2 expression was determined by western blotting and RNA sequencing.</p></div><div><h3>RESULTS</h3><p>Blocking the four SRC phosphorylation sites (EPS8-F4), but not in EPS8-F3, resulted in significantly reduced SOX2 expression as compared to cells overexpressing wild-type EPS8. However, pharmacological inhibition of SRC activity increased SOX2 expression in the presence of wild-type EPS8 but not in its absence. RNA sequencing studies indicated that EPS8-F4 or EPS8-Y602F cells expressed significantly less SOX2 compared to cells overexpressing wild-type EPS8.</p></div><div><h3>CONCLUSIONS</h3><p>EPS8 expression and its phosphorylation by SRC regulate SOX2 expression. Studies also indicate a role for EPS8 and SOX2 in regulating HNSCC stemness.</p></div><div><h3>IMPLICATIONS</h3><p>HNSCC, one of the most prevalent cancers worldwide, is associated with a high mortality and recurrence rate, in part due to the presence of cancer stem cells (CSCs). Understanding the interplay between key molecules (EPS8, SRC and SOX2) involved in the development and maintenance of the HNSCC CSC phenotype will be pivotal in identifying effective therapeutic strategies.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277255962400018X/pdfft?md5=db295a19470c2ba3da7f61e7cecb899d&pid=1-s2.0-S277255962400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Clear Aligners with a Surgery-First Approach for Treatment of the Anterior Open Bite: A Systematic Review and Comparison with Conventional Fixed Appliances","authors":"Joshua Stewart DMD,&nbsp;Marshall F. Newman DMD, FAAP","doi":"10.1016/j.dentre.2024.100098","DOIUrl":"10.1016/j.dentre.2024.100098","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>To complete a systematic review of the use of clear aligner therapy (CAT) when employing a surgery-first approach (SFA) to management of patients with an anterior open bite. To determine in patients undergoing surgery-first orthognathic surgery for treatment of an anterior open bite, is the use of clear aligners, compared to conventional fixed orthodontic appliances, as effective in the management of the anterior open bite with the primary outcome being residual anterior open bite. To provide a patient example demonstrating the use of SFA to orthognathic surgery and CAT approach to orthodontic management of an anterior open bite.</p></div><div><h3>METHODS</h3><p>A systematic review of the literature was undertaken for evaluation of available literature using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Boolean operators “(clear aligner) AND (anterior open bite)”, “(clear aligner) AND (surgery-first),” and “(clear aligner) AND (orthognathic surgery)” were used. PRISMA flow diagram was used to identify, screen, and determine studies to be included in the review. The LEGEND Evidence Evaluation Tool was used to help evaluate validity, reliability and applicability and determine the evidence levels of each individual study. Studies that reported the use of CAT for management of anterior open bite without orthognathic surgery were not included. Studies that reported CAT in a surgery-first approach to manage patients without an anterior open bite were not included.</p></div><div><h3>RESULTS</h3><p>2 studies were included in this systematic review that reported the use of CAT in a surgery-first approach specifically for management of anterior open bite. One study, a retrospective study of 12 patients, found no residual anterior open bite at a 1 year of post-orthodontic follow up. The second, a case study, implemented twenty clear-aligner trays designed for crossbite correction and for passive movements post-operatively which, at the end of treatment, also functioned as ‘active retainers’ helping to prevent the relapse of the open bite.</p></div><div><h3>CONCLUSIONS</h3><p>The literature supports that CAT is as effective as traditional fixed orthodontic appliances when used in a surgery-first approach. Similarly, there is a body of evidence that supports the use of CAT to treat anterior open bite non-surgically. Based on the findings of this systematic review, there is growing supportive evidence to suggest that CAT can be used in a surgery-first approach to achieve predictable results specifically in management of the anterior open bite.</p></div><div><h3>IMPLICATIONS</h3><p>Clear aligners have obvious advantages compared with fixed appliances in terms of quality of life and esthetics and can be used following orthognathic surgery to correct an anterior open bite.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277255962400021X/pdfft?md5=07c20181869a9d0ac8922eb3e4a875a0&pid=1-s2.0-S277255962400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis Gingival Tissue Exosomes Cross and Compromise Human BBB in an In-Vitro 3D Model","authors":"Tigerwin Yang,&nbsp;Ranya Elsayed PhD MBA","doi":"10.1016/j.dentre.2024.100114","DOIUrl":"10.1016/j.dentre.2024.100114","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>The objective of this aim was to test the hypothesis that human gingival EXO from PD patients (PD-EXO) promote BMEC dysfunction and increase BBB permeability by degrading tight junction proteins, using a human in-vitro 3D BBB model.</p></div><div><h3>METHODS</h3><p>EXO purified from human gingiva (n=7) of stage III-IV, grade A/B PD (PD-EXO) and healthy subjects(con-EXO) (n=5) were characterized by NTA, TEM, WB, and multiplexed bead-based flow cytometry. DiI prelabeled PD-EXO or con-EXO and FITC dextran were added simultaneously to the luminal side (endothelial cells) of an in-vitro human 3D model of BBB (Neuromics,USA) and the media in the abluminal side (astrocytes and pericytes) was sampled for fluorescent measurement by plate reader at 0.5,4 and 24 hrs post-treatment. TEER was measured and tight junction proteins were examined using qPCR.</p></div><div><h3>RESULTS</h3><p>IL-1β and IL-6 were expressed in PD-EXO while not detected in con-EXO. PD-EXO significantly decreased TEER measurements at 0.5, 4, and 24 hrs post-treatment while FITC and DiI EXO fluorescent signals in the lower compartment (abluminal side) of the BBB were significantly increased with PD-EXO relative to con-EXO. Furthermore, there was a significant downregulation of tight junction mRNA gene expression claudin-1 and -4 in BBB BMECs with PD-EXO.</p></div><div><h3>CONCLUSIONS</h3><p>Using an in-vitro 3D model of BBB, our study illustrates that gingival EXO from PD patients could cross BBB and play a significant role in mediating a damaging effect on recipient BMECs of the BBB compromising its integrity. This suggests a novel mechanism of oral microbially induced EXO for AD risk.</p></div><div><h3>IMPLICATIONS</h3><p>These findings shed light on the possible mechanism behind the association between periodontitis and alzheimer's disease.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000373/pdfft?md5=c3c2ed09584bf688cc2c56f32f0f7012&pid=1-s2.0-S2772559624000373-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Microbially Induced Exosomes promote Neuroinflammation and Microglial Cell Senescence","authors":"Cayla Paradise,&nbsp;Ranya Elsayed PhD MBA","doi":"10.1016/j.dentre.2024.100110","DOIUrl":"10.1016/j.dentre.2024.100110","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>Porphyromonas gingivalis (Pg) and its gingipain proteases contribute to Alzheimer's disease (AD) pathogenesis through yet unclear mechanisms. Cellular secretion of small extracellular vesicles or exosomes (exo) increases with aging as part of the senescence-associated secretory phenotype (SASP). We have shown that exo isolated from Pg-infected dendritic cells (PgDCexo) contain Pg antigens, transmit senescence to bystander gingival cells, and can cross the blood-brain barrier in mice. This study aims to determine the ability of PgDCexo to induce senescence and neuroinflammation in the brain using a microglial cell line in vitro.</p></div><div><h3>METHODS</h3><p>Isolated PgDCexo were quantitated and characterized using NTA, western blot (WB), and transmission electron microscopy (TEM). DiI labeled PgDCExo were co-cultured with murine SIMA9 microglial cells for 24 hrs, and uptake was analyzed by confocal microscopy. The effect of PgDCexo on microglial senescence and inflammation was tested using western blot, qPCR, and flow cytometry analysis (FACS).</p></div><div><h3>RESULTS</h3><p>DiI labeled PgDCexo were internalized in microglial cells. PgDCexo induced senescence in SIMA9 cells in a dose-dependent manner as shown by an increase in senescence biomarkers, p16 INK4A and P53 by WB and qPCR . SIMA9 cells treated with PgDCExo showed upregulated levels of IL-1β, TNFa and IL-6 by FACS and activated NLRP3 inflammasome pathway by WB.</p></div><div><h3>CONCLUSIONS</h3><p>Extracellular vesicles induced by P. gingivalis infection promote senescence and inflammation in microglial cells. These results suggest a potential role of Pg-induced extracellular vesicles in neuroinflammation and AD pathogenesis.</p></div><div><h3>IMPLICATIONS</h3><p>This study sheds light on a novel mechanism through which P.gingivalis-induced extracellular vesicles affect neurodegenerative processes in Alzheimer's disease.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000336/pdfft?md5=5803fe22d71a93e6d8faabedfa75c3b1&pid=1-s2.0-S2772559624000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Suture Technique to Stabilize Vestibule for a Double Laterally Positioned Flap","authors":"Kevin A. Shepherd,&nbsp;Mira Ghaly DMD MS","doi":"10.1016/j.dentre.2024.100138","DOIUrl":"10.1016/j.dentre.2024.100138","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>The goal of treatment is to establish a band of attached keratinized tissue to facilitate pain free oral hygiene and to eliminate the muscle attachment in order to help mitigate future recession.</p></div><div><h3>METHODS</h3><p>A 62yo white female presented with RT2 recession on teeth numbers 24,25. Due to extensive use of antiplatelet medication, the decision to limit surgical sites to one was made, ruling out free tissue grafts. The surgical plan consisted of preparing two partial thickness flaps and securing them over the deficient sites of 24,25. To maintain good adaptation of the flap to the periosteum, a 4.0 PTFE suture was used to secure the flaps by using the adjacent periosteum and teeth as anchors points. To obtain hemostasis, microfibrillar collagen was used directly on the site. The patient was followed up at one week and one month for post operative evaluation.</p></div><div><h3>RESULTS</h3><p>The evaluation at one month revealed elimination of the aberrant frenum and the re-establishment of a 4mm healthy band of attached keratinized tissue. During the healing there was no evidence of any flap necrosis as the flap was adequately secured against the periosteum.</p></div><div><h3>CONCLUSIONS</h3><p>Using the Periosteal-Tooth Anchor suture technique, the laterally positioned flaps were able to be secured in a manner that ensured survivability of the flaps and established a band of attached keratinized gingiva.</p></div><div><h3>IMPLICATIONS</h3><p>By informing clinicians of this suture technique, it will improve the predictability of these demanding and technique sensitive cases.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000610/pdfft?md5=93815d5715d97c0ad620a1a634da938e&pid=1-s2.0-S2772559624000610-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Silver Nanoparticles in Fixed Orthodontic Appliances Inhibit Bacterial Growth?","authors":"Kailyn Owens,&nbsp;Anasha Williamson,&nbsp;Ashley Christman RDH, BS","doi":"10.1016/j.dentre.2024.100120","DOIUrl":"10.1016/j.dentre.2024.100120","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>The purpose of this literature review is to aid in oral hygiene instruction for clinicians with patients undergoing orthodontic treatment.</p></div><div><h3>METHODS</h3><p>Specific criteria were required to formulate this literature review. Articles were accessed through PubMed and were peer-reviewed, original research that were published within the last five years, and relevant to the topic. Keywords for this research included orthodontics, fixed orthodontic appliances, orthodontic appliances, silver nanoparticles, silver coating, nanoparticles, bioreduction, oral bioreduction, and plaque reduction. A section from one published book was also referenced for background and comparative information. Filters for our search excluded articles posted before 2018, literature reviews, meta-analyses, or articles that were not peer reviewed. Four articles were selected to be included in this review.</p></div><div><h3>RESULTS</h3><p>Fabricated wires, brackets, and orthodontic bands were organized into control and experimental groups. In some groups, the metal was coated with silver nanoparticles, some had zinc oxide nanoparticles, and some were left uncoated. The appliances were exposed to oral bacteria for various amount of time and then tested to see which metals accumulated the most bacteria. In one study, a combination of silver and zinc-oxide nanoparticles produced the greatest bacterial inhibition. However, each study proved silver nanoparticle coated appliances resulted in the least amount of bacterial accumulation with all bacteria tested.</p></div><div><h3>CONCLUSIONS</h3><p>The reduction of plaque, bacteria, gingivitis, and bracket scars during and after orthodontic treatment is a direct result of silver nanoparticles and increases patient compliance to commit to an oral hygiene routine.</p></div><div><h3>IMPLICATIONS</h3><p>Silver nanoparticles can be implemented throughout all aspects of dentistry in toothpastes, mouthwashes, and other dentifrices. Hygienists, dental professionals, and patients can benefit from the antimicrobial effects of silver nanoparticles.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000439/pdfft?md5=c6b7415d334b63a4bbfcedc08db14471&pid=1-s2.0-S2772559624000439-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects Of Enamel Matrix Derivative On Periodontal Patients","authors":"Abbi Rushton,&nbsp;Maddie White,&nbsp;Krystal Herring RDH, MPH","doi":"10.1016/j.dentre.2024.100102","DOIUrl":"10.1016/j.dentre.2024.100102","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>The purpose of this literature review was to describe enamel matrix derivative (EMD) and how it benefits periodontal patients. EMD's rejuvenating abilities were identified as well as the different functions of EMD.</p></div><div><h3>METHODS</h3><p>Articles chosen for this literature review were randomized control trials that were peer reviewed and published within the last five years. PubMed was accessed through Augusta University's database for research. Keywords used to search included enamel matrix derivative, bone loss, periodontitis, enamel matrix proteins, gum disease, regeneration, therapy, and growth.</p></div><div><h3>RESULTS</h3><p>Studies chosen for this literature review all showed that EMD improves clinical attachment level. It is able to promote hard and soft tissue regeneration because it contains the same proteins that are involved in amelogenesis. These proteins stimulate fibroblasts, anti-inflammatory cytokines, and clotting factors. All these factors make EMD a great adjunct to periodontal surgical procedures. EMD is also able to reduce inflammation, promote wound healing, and stabilize blood clots.</p></div><div><h3>CONCLUSIONS</h3><p>Overall, EMD's ability to assist in the formation of new bone, cementum, and periodontal ligaments makes it an excellent treatment option for periodontally involved patients. It is frequently used with scaling and root planing, flap surgery, and the treatment of infrabony defects.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000257/pdfft?md5=21c602bb1af224ea6d00b2b2e5169413&pid=1-s2.0-S2772559624000257-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker","authors":"Daniel Lee,&nbsp;Jules Gouron,&nbsp;Jules Gouron,&nbsp;Henrique Shimaoka Chagas,&nbsp;Bidhan Bhandari,&nbsp;Sahar Emami Naeini,&nbsp;Babak Baban,&nbsp;Pablo Shimaoka Chagas,&nbsp;Evila Salles","doi":"10.1016/j.dentre.2024.100105","DOIUrl":"10.1016/j.dentre.2024.100105","url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker.</p></div><div><h3>METHODS</h3><p>Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter.</p></div><div><h3>RESULTS</h3><p>Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=&lt;0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues.</p></div><div><h3>CONCLUSIONS</h3><p>For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients.</p></div><div><h3>IMPLICATIONS</h3><p>No further implications other than specified in conclusion.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000282/pdfft?md5=38c1a1f72a7925c967bf13070598fd5e&pid=1-s2.0-S2772559624000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}