Dentistry Review最新文献

{"title":"Evaluation of Barrier Membrane Immunogenicity in Human Gingival Fibroblast Cell Cultures","authors":"Kristen Quartararo DMD","doi":"10.1016/j.dentre.2026.100404","DOIUrl":"10.1016/j.dentre.2026.100404","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Evaluate the immunogenicity of native collagen (NC), crosslinked collagen (CC), dense polytetrafluoroethylene (dPTFE), amnion-chorion (AC), and electrospun nanofiber poly(ester urea) (NP) membranes cultured with human gingival fibroblasts cells (HGFCs).</div></div><div><h3>METHODS</h3><div>Five barrier membranes will be introduced into culture wells seeded with HGFCs (ATCC primary fibroblasts PCS201-018). The cells will be grown for a 5-day period; 250 microliters of media will be taken at time points of 1, 3, and 5 days for cytokine analysis. IL-1B, IL-6, IL-8 and TNFa will be assessed using a cytokine screening panel (BioPlex Pro Human Cytokine panel, BIO-RAD). After evaluation of the cell media, cells will be stained with Trypan blue for viability assessment. Scanning electron microscope images will be obtained after 5 days of incubation to evaluate the integration of HGFCs and the membrane material. A second analysis will be conducted to evaluate the innate growth factor and cytokine release profiles of five membranes when cultured in a cell free media. This analysis is to determine what proportion of cytokine and growth factor release originated from HGFCs versus innate release from the membrane.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Not applicable.</div></div><div><h3>CONCLUSIONS</h3><div>Not applicable.</div></div><div><h3>IMPLICATIONS</h3><div>In contemporary periodontics barrier membranes are used in both regenerative and alveolar ridge augmentation applications. One of the most common complications for both procedures is membrane exposure. One contributing factor is inflammation in marginal tissues. Increased inflammation can cause wound dehiscence even in cases with tension-free wound closure, allowing bacterial invasion and a severely compromised treatment outcome. Selecting barrier membranes that do not promote inflammation in the marginal tissue may reduce the likelihood of complication occurrence.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100404"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced platelet rich fibrin in periodontal plastic surgery: a case report demonstrating multiple Applications","authors":"CPT Alan George DDS","doi":"10.1016/j.dentre.2026.100401","DOIUrl":"10.1016/j.dentre.2026.100401","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Describe multiple applications of advanced platelet rich fibrin in root coverage procedures.</div></div><div><h3>METHODS</h3><div>Patients in this report presented to the Department of Periodontics, Army Postgraduate Dental School (APDS) Postgraduate Dental College, Fort Eisenhower, Georgia. All patients received intravenous cannulation for moderate sedation and elected to provide blood samples for advanced platelet rich fibrin (A-PRF) preparation using a protocol previously described by our group. In all cases, a single 20-gauge intravenous catheter placed in the antecubital fossa was used for both blood collection and fluid/medication delivery. Blood was promptly transferred into glass vacuum sterile plain tubes and spun at 1300 RPM for 14 minutes in a Duo Quatro centrifuge (applying a relative centrifugal force RCF ∼ 200 g). Five minutes after centrifugation the A-PRF clots were taken from the tubes with sterile forceps, separated from the red corpuscle base with scissors and placed on a condensing tray. A-PRF membranes were then applied in a variety of ways while performing the surgical correction of mucogingival deficiencies.</div></div><div><h3>CONCLUSIONS</h3><div>The goals of therapy to augment gingival recession were met with patient satisfaction. No complications associated with the application of autologous blood derived products were encountered in these clinical cases. Patients were receptive to the application of A-PRF for potential wound healing benefits.</div></div><div><h3>IMPLICATIONS</h3><div>This report serves as case examples for multiple applications of A-PRF in periodontal plastic surgery. Randomized clinical trials comparing these applications to controls and other versions of autologous blood derived products are warranted to investigate wound healing and patient reported outcomes.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100401"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging a Failing Implant to Enhance Soft Tissue Contours; A Case Report","authors":"Kevin A. Shepherd","doi":"10.1016/j.dentre.2026.100398","DOIUrl":"10.1016/j.dentre.2026.100398","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>1. Showcase the complexity of implant complications in the esthetic zone</div><div>2. Demonstrate how the field of periodontics is uniquely qualified to handle the hard and soft tissue complications that can occur with dental implants.</div></div><div><h3>METHODS</h3><div>The failing implant was permanently submerged with a tuberosity connective tissue graft and the intrabony defect was grafted with autogenous bone scrapings. The flap was advanced to achieve primary closure and significantly reduced the pre-existing recession defect and partially recreated an interproximal papilla. The submerged implant is acting as a mechanical support for the overlying soft tissue that will receive a fixed prosthetic denture with an ovate pontic.</div></div><div><h3>RESULTS</h3><div>(If applicable) The results consist of radiographs, clinical photos, and future periodontal charting. Preliminary outcome seems to show gaining or at least stable vertical height.</div></div><div><h3>CONCLUSIONS</h3><div>The combined use of guided tissue regeneration and mucogingival surgery were utilized to treat peri-implantitis via a permanently submerged protocol. The outcomes of this case also allowed the clinician to address the esthetic complaint of recession and a lost papilla.</div></div><div><h3>IMPLICATIONS</h3><div>This case report stresses the importance of multi-disciplinary care in order to have the best opportunity to predictably address the needs of the patient. It should also cause the reader to reconsider mainstream ideology with regards to seemingly simple restorative plans that include quickly sacrificing the natural dentition for ‘predictable’ titanium implants.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100398"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Vertical Skeletal Pattern on Lower Incisor Proclination During Herbst Therapy: A Retrospective Study","authors":"Blake Eaton,&nbsp;Lee Holman","doi":"10.1016/j.dentre.2026.100366","DOIUrl":"10.1016/j.dentre.2026.100366","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>The primary goal of this retrospective study was to compare lower incisor proclination during Herbst therapy in hyperdivergent, normo-divergent, and hypodivergent patients using lateral cephalograms. Additionally, amount of initial crowding, presence or absence of fixed appliances, molar classification was compared to changes in IMPA. Change in ANB angle was also measured.</div></div><div><h3>METHODS</h3><div>Thirty-two Herbst patients who met the inclusion criteria were divided into three groups based on Frankfort mandibular angle (FMA) (hypodivergent S:20°, normodivergent21°-29°, hyperdivergent;30°). Pre-Herbst and post-Herbst lateral cephalograms were used to determine vertical skeletal pattern, IMPA, and SNB. Initial records photos were used to determine amount of crowding initial molar classifications</div></div><div><h3>RESULTS</h3><div>Amount of initial crowding showed a statistically significant effect on increase in incisor proclination. The other factors did not affect the amount of increase in IMPA. There was a minimal average change in SNB angle of 1.1°.</div></div><div><h3>CONCLUSIONS</h3><div>Vertical skeletal patterns does not influence the amount of lower incisor proclination during Herbst therapy. Amount of initial crowding however, does affect change in IMPA angle in about a 1:1 fashion.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100366"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Hyaluronic Acid and Platelet-Rich-Plasma on Peri-Implantitis","authors":"Haley Clary,&nbsp;Savannah Hughes,&nbsp;Madison Lamontagne,&nbsp;Kathleen Cantey MEd, RDH","doi":"10.1016/j.dentre.2026.100351","DOIUrl":"10.1016/j.dentre.2026.100351","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Identify the clinical outcomes of hyaluronic acid and platelet-rich-plasma in peri-implantitis, compare the use of platelet-rich-plasma over hyaluronic acid in peri-implantitis, and explain the poncho technique and why it is used.</div></div><div><h3>METHODS</h3><div>The PICO question used for the research was “In patients suffering from peri-implantitis, can the use of hyaluronic acid and platelet-rich-plasma aid in the healing or prevention of peri-implantitis?” To search, the PubMed database was utilized, and sources were discovered using keywords <em>hyaluronic acid, platelet-rich-plasma,</em> and <em>peri-implantitis</em>. Exclusion criteria consisted of literature reviews and articles older than five years. A total of thirty-one results were retrieved.</div></div><div><h3>RESULTS</h3><div>Publications meeting the inclusion criteria consisted of a total of five randomized controlled trials. Inflammation, probing depths, bleeding on probing, and/or density of peri-implant bacteria were measured periodically for a set amount of time.</div></div><div><h3>CONCLUSIONS</h3><div>Evidence shows an overall decrease in probing depths, bleeding on probing, and peri-implant bacteria thickness. Platelet-rich-plasma is shown to be more favorable out of the two due to the autologous factor and the promotion of soft tissue regeneration.</div></div><div><h3>IMPLICATIONS</h3><div>Further studies must be conducted in order to examine the long-term results of both hyaluronic acid and platelet-rich-plasma on different types of implants, placed in different areas of the mouth. In addition, different types of hyaluronic acid gel at different concentrations must also be studied. Based on the indirect evidence, practitioners placing dental implants may consider the placement of hyaluronic acid or platelet-rich-plasma for greater implant success rates.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100351"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Aloe Vera Gel on Periodontal Pockets","authors":"Fabiola Kpendi,&nbsp;Nancy Kalu,&nbsp;Trina Hutto EdD, RDH","doi":"10.1016/j.dentre.2026.100357","DOIUrl":"10.1016/j.dentre.2026.100357","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>This aim of this research is to assess the effectiveness of aloe gel as a cost-effective adjunct to scaling and root planning (SRP) in reducing periodontal pockets.</div></div><div><h3>METHODS</h3><div>The PICO question was, In patients with Chronic Periodontitis, is the use of aloe gel as an adjunct more effective at reducing periodontal pockets than the use of SRP alone. The inclusion criteria for the selected articles were peer reviewed articles written within the years of 2019-2024. The search engines were Pubmed, and Science Direct. The keywords were Aloe vera, therapeutics, periodontitis, and natural.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Publications that met the inclusion criteria consisted of 4 articles. For this literature review, we used 3 studies, all of which were randomized control studies.</div></div><div><h3>CONCLUSIONS</h3><div>Evidence supports numerous instances where aloe vera gel offers greater benefits than scaling and root planning alone (SRP). All three studies proved that aloe vera gel improves periodontal health by reducing gingival index, bleeding, CFU counts, and probing pocket depth (PPD).</div></div><div><h3>IMPLICATIONS</h3><div>Based on the data observed, using aloe can help in the healing process of chronic periodontitis and offer homeopathic option for patients.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100357"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficiency of Desiccant Agents as an Adjunct to Scale and Root Planing","authors":"Kennedy Miles,&nbsp;Deja Samuel,&nbsp;Trina Hutto EdD, RDH","doi":"10.1016/j.dentre.2026.100359","DOIUrl":"10.1016/j.dentre.2026.100359","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>The use of a desiccant agent can be used in conjunction with SPR. This review investigates the effectiveness of HybenX gel as an adjunct with root debridement.</div></div><div><h3>METHODS</h3><div>Following the guidelines, we conducted a literature review using PubMed database. The key words desiccant therapy/agent, irrigation, SRP, root debridement, and periodontal attachment loss. For this analysis we included peer reviewed articles no more than five years old. Our Pico question included (P) Chronic Periodontists, (I) HybenX as an Adjunct (C) HybenX gel vs SRP alone, (O) Decrease BOP, Decrease Inflammation &amp;Increase Probing Depths. Our keys words for the search string included: \"Hygroscopic Agents\" AND \"SRP” OR Periodontal Attachment Loss.</div></div><div><h3>RESULTS</h3><div>Publications that met the criteria consisted of 5 research articles and 3 of which were clinical trials. We found five articles the fit our inclusion criteria, four of which were randomized control trials. Two of the four shared common elements such as addressing BOP, PPD, CAL and plaque/ gingival index. There was no risk of bias.</div></div><div><h3>CONCLUSIONS</h3><div>Evidence supporting the Efficiency of Desiccant Agents as an Adjunct to SRP appeared to be limited. Due to there being only 4 research articles and 3 of the 4 were clinical studies found. Thus, practitioners must exercise caution when drawing conclusions from available data. However, the research articles and clinical studies that were found indicated that the use of a desiccant agent showed improvement in patients probing depth, bleeding on probing, and plaque index/gingival index.</div></div><div><h3>IMPLICATIONS</h3><div>Based on literature reviews, incorporating the use of HybenX gel as an adjunct to SRP may maximum patients' debridement results.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100359"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethylene fiber reinforcement versus glass fiber posts for endodontically treated premolars: a systematic review and meta-analysis of in-vitro studies","authors":"Karla Nogueira Matos ,&nbsp;Hugo Henrique dos Santos Dantas Guimarães ,&nbsp;Pedro Vitor dos Santos Sobrinho ,&nbsp;Amanda Cypriano Alves","doi":"10.1016/j.dentre.2026.100425","DOIUrl":"10.1016/j.dentre.2026.100425","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically compare the biomechanical performance reported in vitro studies of endodontically treated maxillary premolars restored with glass fiber posts or polyethylene fiber reinforcement, focusing on fracture resistance and failure pattern. The review protocol was prospectively registered in PROSPERO (CRD420251008728).</div></div><div><h3>Material and methods</h3><div>A comprehensive electronic search was conducted without restrictions. Eligible studies were in vitro investigations using extracted human maxillary premolars restored with either polyethylene fiber reinforcement or glass fiber posts and subsequently subjected to fracture testing. The primary outcomes were fracture resistance (Newtons) and failure pattern, classified as unfavorable (root or sub-bony fracture) or favorable (crown or suprabony fracture). Data were synthesized using random-effects models and expressed as mean difference or risk ratio, with heterogeneity assessment. Certainty of evidence was evaluated using the GRADE approach.</div></div><div><h3>Results</h3><div>Five in vitro studies fulfilled the inclusion criteria. Polyethylene fiber reinforcement showed significantly higher fracture resistance than glass fiber posts (mean difference −69.84 N; 95% confidence interval −135.96 to −3.71; I² = 6%). Sensitivity analysis confirmed the robustness of this finding. No significant difference was observed in the proportion of unfavorable fractures between groups (risk ratio 0.92; 95% confidence interval 0.69 to 1.24; I² = 32%). Certainty of evidence was assessed separately for each outcome and should be interpreted in light of the preclinical nature of the included evidence.</div></div><div><h3>Conclusions</h3><div>Based on the available in vitro evidence, polyethylene fiber reinforcement was associated with greater fracture resistance than glass fiber posts in endodontically treated maxillary premolars, whereas no significant difference was found between the two strategies in the proportion of unfavorable fractures. These findings suggest a biomechanical advantage of polyethylene fiber reinforcement in load-bearing capacity, but do not indicate a clear difference in fracture reparability.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100425"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Obstructive Sleep Apnea And The Role Of The Dentist","authors":"Craig Rodgers","doi":"10.1016/j.dentre.2026.100350","DOIUrl":"10.1016/j.dentre.2026.100350","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Provide a basic understanding of adult obstructive sleep apnea. Gain knowledge on screening and treating obstructive sleep apnea patients in the dental office.</div></div><div><h3>METHODS</h3><div>Conducted a literature review. Gathered relevant information from the American Academy of Dental Sleep Medicine (AADSM) Guidelines, the American Board of Dental Sleep Medicine (ABDSM) recommended readings, and the textbook “Principles and Practice of Sleep Medicine”.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Not Applicable</div></div><div><h3>CONCLUSIONS</h3><div>Adult OSA is a highly prevalent disorder with a complex pathophysiology that often goes unnoticed by patients and undiagnosed by medical providers. Including adult OSA screening in the dental office and providing mandibular advancement devices as a treatment option can increase patients' quality of life and lifespan.</div></div><div><h3>IMPLICATIONS</h3><div>My findings and presentation will give dental students access to information about sleep apnea and different resources that can be used during patient treatment. I hope to bring awareness to this disease and equip dentists to incorporate screening into their offices.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol (CBD) and Fentanyl","authors":"Aruba Khan,&nbsp;Bidhan Bhandari","doi":"10.1016/j.dentre.2026.100412","DOIUrl":"10.1016/j.dentre.2026.100412","url":null,"abstract":"<div><h3>Introduction</h3><div>Fentanyl and non-pharmaceutical fentanyl use have been the leading causes of opioid-induced death worldwide. Fentanyl is a potent opioid with overdoses causing over 250,000 deaths since 2018 in the US alone. The treatment of fentanyl addiction is a complex process and a clinical challenge and is in dire need to find other innovative and alternative modalities in the fight against the crisis. Increasing evidence suggests a correlation between neuroinflammation and symptoms of drug abuse, opening the possibility of immunoregulatory agents as therapy for fentanyl addiction as well as other opioid-induced addiction.</div><div>Cannabidiol (CBD) is a non-opioid, relatively safe, non-psychoactive phyto-cannabinoid produced by cannabis plants. Importantly, recent reports have documented the benefits of CBD in the treatment and management of complications related to opioid withdrawal. We investigated if inhaled CBD could reverse the fentanyl addiction and whether the CBD treatment could ameliorate the addiction symptoms by regulating cellular stress and senescence signals and re-establishing the homeostasis in CNS.</div></div><div><h3>Method</h3><div>We used a fentanyl-induced conditioned place preference (CPP) model in mouse to test whether inhaled CBD could reverse the fentanyl addiction and ameliorate the adversarial symptoms. By employing a combination of flow cytometry as well as behavioral tests, we further assessed the impact of fentanyl addiction on cells, and cellular stress and senescence signals in CNS and we measured the effects of CBD in the treatment of addiction symptoms and cellular stress and senescence signals.</div></div><div><h3>RESULTS</h3><div>Our findings suggest that inhalation CBD could be used effectively in the treatment of fentanyl addiction as CBD mitigated the cellular stress and senescence.</div></div><div><h3>Conclusion</h3><div>Inhaled CBD could alleviate the fentanyl addiction and regulate cellular stress and senescence signals. This novel approach is non-invasive, accessible, effective, and warrants further research.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100412"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}