Clinical Surgical Oncology最新文献

{"title":"Corrigendum to “Chinese guidelines for the diagnosis and comprehensive treatment of colorectal liver metastases (V. 2023)” [Clin. Surg. Oncol. 2 (2023) 100013]","authors":"Li Ren , Dexiang Zhu , Jin Gu , Baoqing Jia , Jin Li , Xinyu Qin , Xishan Wang , Ruihua Xu , Yingjiang Ye , Suzhan Zhang , Zhongtao Zhang , Jianmin Xu , Jia Fan , China CRLM Guideline Group, Chinese College of Surgeons, Chinese Medical Doctor Association, Section of Gastrointestinal Surgery, Branch of Surgery, Chinese Medical Association, Section of Colorectal & Anal Surgery, Branch of Surgery, Chinese Medical Association, Colorectal Cancer Professional Committee, Chinese Anti-Cancer Association, Colorectal Cancer Professional Committee, Chinese Medical Doctor Association, Colorectal Cancer Expert Committee, Chinese Society of Clinical Oncology, Chinese Society of Colon & Rectal Surgeons, Chinese College of Surgeons, Chinese Medical Doctor Association, Metastasis Research Committee, Anorectal Branch of Chinese Medical Doctor Association, Colorectal Oncology Group, Branch of Oncology, Chinese Medical Association, Metastatic Tumor Therapy Branch of China International Exchange and Promotive Association for Medical and Health Care, Colorectal Disease Branch of China International Exchange and Promotive Association for Medical and Health Care","doi":"10.1016/j.cson.2024.100039","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100039","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000072/pdfft?md5=716731643ffb962e6432a3e7938503ec&pid=1-s2.0-S2773160X24000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation therapy of renal cell carcinoma skeletal metastases – Does histologic subtype predict progression?","authors":"Kavin Sundaram ,&nbsp;Joshua M. Lawrenz ,&nbsp;Precious C. Oyem ,&nbsp;Aditya Banerjee ,&nbsp;Shannon Wu ,&nbsp;Paras Shah ,&nbsp;Shireen Parsai ,&nbsp;Chirag Shah ,&nbsp;Nathan W. Mesko ,&nbsp;John Reith ,&nbsp;Lukas M. Nystrom","doi":"10.1016/j.cson.2024.100040","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100040","url":null,"abstract":"<div><h3>Introduction</h3><p>This investigation assessed whether the following factors were associated with radiographic local progression in bone metastases from renal cell carcinoma (RCC): (1) high-risk histologic features (2) lesional surgery (3) biologically effective dose (BED) of radiation therapy.</p></div><div><h3>Methods and materials</h3><p>A single-institution database identified all patients who underwent surgery and radiation therapy for bone metastases from RCC to the appendicular skeleton and pelvis from 2006 to 2016. Thirty-six patients underwent radiotherapy for 80 metastases. While all patients had surgical stabilization, 17/36 also had lesional surgery to address the metastatic lesion. Progression of each individual lesion was determined using the application of RECIST criteria to imaging at last follow-up.</p></div><div><h3>Results</h3><p>The rate of progressive disease was 8/25 (32%) in the high-risk group versus 5/55 (9%) in the standard-risk group (p ​= ​0.019). The rate of progression among high-risk metastases undergoing lesional surgery was 0/9 versus 8/16 (50%) having non-lesional surgery (p ​= ​0.0218). The rate of progression among standard-risk metastases undergoing lesional surgery was 1/16 (6%) versus 4/39 (10%) with non-lesional surgery (p ​= ​1.00). High-risk histologic features (OR: 10.592, 95% confidence interval: 1.347–83.271, p ​= ​0.025) and as well as a reduction in risk with every additional Gray of BED (OR: 0.902, 95% confidence interval: 0.827–0.984, p ​= ​0.021) were found to predict progressive disease.</p></div><div><h3>Conclusions</h3><p>Bone metastases from renal cell carcinoma with high-risk histologic features are associated with less favorable response to radiotherapy than those with standard-risk histology. Delivery of a higher BED was associated with lower odds of progression.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000084/pdfft?md5=aea0076e2d0d2be703db1b01c4dfab5a&pid=1-s2.0-S2773160X24000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing statements in previously published articles","authors":"","doi":"10.1016/j.cson.2024.100041","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100041","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000096/pdfft?md5=d0437200b706eb597a20ca458ffa2dd4&pid=1-s2.0-S2773160X24000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term outcomes of metachronous tumors for non-small cell lung cancer","authors":"Celalettin Kocaturk ,&nbsp;Cem Emrah Kalafat ,&nbsp;Celal Bugra Sezen ,&nbsp;Mustafa Vedat Dogru ,&nbsp;Levent Cansever ,&nbsp;Muzaffer Metin ,&nbsp;Mehmet Ali Bedirhan","doi":"10.1016/j.cson.2024.100035","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100035","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to identify prognostic factors for mortality and survival in patients operated on for metachronous primary lung cancer (MPLC).</p></div><div><h3>Materials and methods</h3><p>The data of 67 non-small cell lung cancer patients with MPLC, diagnosed and operated upon between January 2000 and December 2015, were retrospectively analyzed.</p></div><div><h3>Results</h3><p>Of the 67 included patients, 63 (94%) were male and 4 (6%) were female. The overall survival rate after second surgery was 53.6% at 5 years and 34.1% at 10 years. The mean survival time was 64 months (95% confidence interval: 35–92 months). Adjuvant treatment improved survival (p ​= ​0.039). Although the survival of grade N0 and N1 patients did not differ, four grade N2 patients exhibited poor survival (p ​= ​0.02). Cox's regression analysis revealed that grade N2 disease decreased survival 5.3- fold, the absence of adjuvant treatment decreased survival 2 fold and pT4 grade decreased survival 3.4 fold.</p></div><div><h3>Conclusions</h3><p>New lung tumors may be detected during follow-up of lung cancer patients who have been definitively treated. In such cases, if extrapulmonary metastases and N2 lymphatic involvement are absent, there is no recurrence in the surgical margins of the first operation, and there is only one new tumor, we suggest that surgical treatment should be initially chosen for patients with adequate cardiopulmonary reserves regardless of the time of appearance of the second tumor, whether or not the histopathological type is the same as that of the first tumor.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000035/pdfft?md5=88aaf5b8d7fea618ca4f1b4fb9e6b82e&pid=1-s2.0-S2773160X24000035-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding Jejunostomy in Pancreatico-Duodenectomy patients: Is it important","authors":"Ahmed Mohamed Abdelaziz Hassan ,&nbsp;Hesham A. Elmeligy ,&nbsp;Magdy Elsebae ,&nbsp;Mohamed Abdo ,&nbsp;Ahmed M. Azzam ,&nbsp;Mahmoud Rady","doi":"10.1016/j.cson.2024.100038","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100038","url":null,"abstract":"<div><h3>Background</h3><p>During a pancreaticoduodenectomy, Feeding Jejunostomy (FJ) is frequently placed to improve postoperative nutrition. Our aim is to ascertain the effects of the FJ tube after pancreaticoduodenectomy.</p></div><div><h3>Methods</h3><p>Prospective analysis was performed on all patients who underwent concurrent FJ after pancreaticoduodenectomy (Whipples surgery) between 2022 and 2023. On POD 1, FJ feeds were frequently initiated. After the patient had taken enough oral feeds, the jejunostomy feeds were stopped. Frequency and mean were used to represent the data.</p></div><div><h3>Results</h3><p>A total of 48 patients underwent pancreaticoduodenectomy with concomitant FJ. A total of 35 (72.9%) were men and the mean age was 49.2 years. The majority (28, 58.3 %) of these patients had cancer head of the pancreas as an indication for surgery. Only 13 out of 48 (27%) patients required nutrition supplementation through FJ on POD 10. Only 1 out of 48 (2%) patients required FJ feeds on POD 30. None of these patients had tube-related complications in the 30-day postoperative period. There was a single FJ-related mortality in the 30-day postoperative period due to pulmonary embolism. The patients, who required prolonged FJ feeds had grade C pancreatic leaks, delayed gastric emptying, and surgical site infection.</p></div><div><h3>Conclusion</h3><p>The routine use of concurrent FJ in patients undergoing pancreaticoduodenectomy has a good outcome, especially for those who require prolonged postoperative nutritional supplementation because of grade c pancreatic leak and delayed gastric emptying.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000060/pdfft?md5=ce107e4945998100e18df0061588be08&pid=1-s2.0-S2773160X24000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of preoperative subcutaneous adipose, visceral adipose and skeletal muscle on the outcomes of the oldest-old colorectal cancer patients after surgery","authors":"Jinxin Shi ,&nbsp;Jian Cui ,&nbsp;Wenrui Xu ,&nbsp;Zhexue Wang ,&nbsp;Junge Bai ,&nbsp;Zijian Li ,&nbsp;Fuhai Ma ,&nbsp;Tianming Ma ,&nbsp;Ju Cui ,&nbsp;Guoju Wu ,&nbsp;Gang Zhao ,&nbsp;Qi An","doi":"10.1016/j.cson.2024.100036","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100036","url":null,"abstract":"<div><h3>Background</h3><p>Colorectal cancer (CRC) is one of the most common tumors worldwide, with rising numbers of elderly patients affected. Nutritional status significantly influences tumor prognosis. We aimed to investigate the association of subcutaneous and visceral adipose tissue and skeletal muscle mass with the prognosis of the oldest-old patients with CRC, after surgery.</p></div><div><h3>Patients</h3><p>We retrospectively reviewed 210 patients &gt;75 years who underwent surgical treatment at the Department of Gastrointestinal Surgery, Beijing Hospital, between December 2010 and December 2020.</p></div><div><h3>Materials</h3><p>Subcutaneous adipose, visceral adipose, and skeletal muscle areas were measured using BMI_CT. The cut-off values of the CT measurements were then confirmed using receiver operating characteristic (ROC) curve analysis.</p></div><div><h3>Results</h3><p>Subcutaneous adipose tissue index (SATI), visceral adipose tissue index (VATI), and total adipose tissue index (TATI) were significantly associated with sex and BMI. Notably, the oldest-old CRC patients with high SATI, VATI, and TATI scores exhibited significantly higher rates of wound complications and reduced postoperative hospitalization durations. Intriguingly, patients with high VATI and TATI demonstrated significantly better 5-year Overall survival (OS), Cancer-specific survival (CSS), and Disease-free survival (DFS) than patients in the other groups. Similar results were observed in patients with a high visceral-to-subcutaneous fat ratio (VSR) and skeletal muscle index (SMI) scores.</p></div><div><h3>Conclusion</h3><p>Significantly improving skeletal muscle content while concurrently managing the total adipose content, especially visceral adipose tissue, may aid in extending the survival time of oldest-old patients with CRC after surgery.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100036"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000047/pdfft?md5=8581fda3ca25b541d05c5bba599d25e9&pid=1-s2.0-S2773160X24000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed classification of Langer’s arch and its clinical implication in regard to axillary dissection","authors":"Soumen Das ,&nbsp;Sidhartha Misra ,&nbsp;Kamalesh Rakshit ,&nbsp;Sandipan Purkait ,&nbsp;Rahul Agarwal","doi":"10.1016/j.cson.2024.100037","DOIUrl":"10.1016/j.cson.2024.100037","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000059/pdfft?md5=673f7ad1a5145be238a32e76a16747ba&pid=1-s2.0-S2773160X24000059-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery patterns and survival of T4N2 non-small cell lung cancer – A population-based analysis","authors":"Chenxi Zhang ,&nbsp;Meiqing Zhang ,&nbsp;Jingxuan Chen ,&nbsp;Xiyang Tang ,&nbsp;Jincan Zhang ,&nbsp;Congwen Zhuang ,&nbsp;Xiaofei Li ,&nbsp;Zhiyong Zeng ,&nbsp;Jinbo Zhao","doi":"10.1016/j.cson.2024.100034","DOIUrl":"10.1016/j.cson.2024.100034","url":null,"abstract":"<div><h3>Objectives</h3><p>Present study aims to explore the surgery patterns and survival of T4N2 non-small cell lung cancer (NSCLC) in real-world condition.</p></div><div><h3>Materials and methods</h3><p>Clinical stage T4N2 NSCLC patients in Surveillance, Epidemiology and End Result Program were extracted. Cox regression was used for calculation of hazard ratio (HR) and confidence interval (CI), and landmark analysis was used for survival test at different cut-off time points.</p></div><div><h3>Results</h3><p>There were 1445 eligible patients included, of which 306 patients received surgery alone, 390 patients received induction therapy, and 749 patients received adjuvant therapy. For resection types, 1210 patients received lobectomy and 235 received pneumonectomy. Among patient receiving induction therapy, the overall survival (OS) HRs of pneumonectomy at 1-year, 3-year, 5-year, and 8-year cut-off points were 1.330, 0.972, 1.231, and 1.332 (P ​= ​0.708, 0.972, 0.281 and 0.145), respectively, and cancer-specific survival (CSS) HRs at these landmark points were 2.386, 1.231, 1.455, and 1.480 (P ​= ​0.293, P ​= ​0.409, 0.059 and 0.056), respectively. Among patients receiving adjuvant therapy, the OS HRs of pneumonectomy at 1-year and 8-year cut-off points were 1.570 and 1.274 (P ​= ​0.050 and 0.087), respectively, and CSS HRs at these landmark points were 1.493 and 1.284 (P ​= ​0.096 and 0.094), respectively. Both OS and CSS of patients receiving lobectomy were superior than pneumonectomy at 3-year and 5-year in this cohort. For patients receiving surgery alone, pneumonectomy resulted in inferior survival than lobectomy at all cut-off points (all P ​&lt; ​0.05).</p></div><div><h3>Conclusions</h3><p>Surgery after induction therapy is still an optional choice for T4N2 NSCLC, and pneumonectomy should not be excluded from treatment strategy.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100034"},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000023/pdfft?md5=945e1c87a7cb804d2b5eddaec515798f&pid=1-s2.0-S2773160X24000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgery patterns and survival of T4N2 non-small cell lung cancer – A population-based analysis","authors":"Chenxi Zhang, Meiqing Zhang, Jingxuan Chen, Xiyang Tang, Jincan Zhang, Congwen Zhuang, Xiaofei Li, Zhiyong Zeng, Jinbo Zhao","doi":"10.1016/j.cson.2024.100034","DOIUrl":"https://doi.org/10.1016/j.cson.2024.100034","url":null,"abstract":"","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139876491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pooled analysis of rhabdoid pancreatic carcinomas: Should they be resected?","authors":"Wiktoria I. Batog ,&nbsp;Philip McEntee ,&nbsp;Niall Swan ,&nbsp;Paul F. Ridgway","doi":"10.1016/j.cson.2024.100033","DOIUrl":"10.1016/j.cson.2024.100033","url":null,"abstract":"<div><h3>Background</h3><p>Pancreatic undifferentiated carcinomas with rhabdoid features (PUCR) are infrequent, yet incredibly aggressive neoplasms. Recent advances in the histopathological understanding of PUCR have been made, however the optimal treatment of PUCR remains unclear and the decision to operate on the neoplasm is left to the physicians own judgement. Most of the literature published on this neoplasm constitutes case reports and case series, therefore our aim is to present a pooled analysis including the up-to-date literature and elucidate whether surgical treatment is the finest choice for PUCR.</p></div><div><h3>Methods</h3><p>This pooled analysis compared the data from 9 articles and a case that presented to our unit, yielding 28 cases. Treatment modalities reported in the literature were noted, and the surgical and post-operative adjuvant chemotherapy and &gt;3month survival were screened for dependence using a Chi-square test.</p></div><div><h3>Results</h3><p>The patient's median survival following a surgical resection of the neoplasm was three months. 77.7% who were treated surgically died within one year following the surgery. The relationship between surgical resection and survival calculated using the chi-square is not significant (p-value: 0.261). The median survival of patients who received post-operative chemotherapy was 7 months. The relationship between the post-operative adjuvant chemotherapy and survival 3 months is also not significant (p-value: 0.065)</p></div><div><h3>Conclusions</h3><p>The aggressive nature of PUCR results in a rapid deterioration regardless of the treatment modality chosen. Surgery even in resectable patients doesn't carry a significant survival benefit. Chemotherapy should remain the mainstay of therapy for this patient cohort.</p></div>","PeriodicalId":100278,"journal":{"name":"Clinical Surgical Oncology","volume":"3 1","pages":"Article 100033"},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773160X24000011/pdfft?md5=c9b34149f131eae0606f533d4882a553&pid=1-s2.0-S2773160X24000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}