{"title":"Complement inhibitors as therapeutic agents","authors":"M. Liszewski, V. Subramanian, J. Atkinson","doi":"10.1016/S0197-1859(00)80025-4","DOIUrl":"https://doi.org/10.1016/S0197-1859(00)80025-4","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"1 1","pages":"168-173"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73047332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Natural killer cells in immune regulation","authors":"Mary C. Nakamura","doi":"10.1016/S0197-1859(00)80020-5","DOIUrl":"10.1016/S0197-1859(00)80020-5","url":null,"abstract":"<div><p>NK cells can influence the immune response through cytokine production and cytolysis of specific target cells. The identification of MHC-Class I specific-receptors on NK cells and their inhibitory effect on signal transduction has greatly enhanced our understanding of the mechanism of action of NK cells. NK cell function is dependent on the balance of inhibitory and activating signals received by the cell, from both direct interaction with target cells and from local immunoregulatory cytokines.</p><p>The recent progress in understanding the molecular basis of NK cell function has renewed considerable interest in the exact biological role of these cells. The role NK cells play in cancer, infectious disease, bone marrow transplantation, pregnancy and autoimmunity are currently active areas of research as well as further studies to define the molecular basis for NK activation and specificity.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 10","pages":"Pages 151-154"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80020-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90186689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapid, economical testing in the clinical laboratory: A new flow cytometry-based multiplex system","authors":"Ralph L. McDade, Michael D. Spain","doi":"10.1016/S0197-1859(00)80021-7","DOIUrl":"10.1016/S0197-1859(00)80021-7","url":null,"abstract":"<div><p>Luminex Corp. has developed a multiplex assay system (FlowMetrix) that incorporates the most advanced digital signal processing technology into an established assay platform, enhancing its speed, economy, sensitivity, precision, and throughput. Microsphere-based assays are now multiplexed assays, capable of performing up to 64 discrete tests in a single tube from the same sample at the same time. The flow cytometer becomes an absolute measurement instrument, acquiring and analyzing the data generated by thousands of microspheres every second, and reporting the values in real time. With applications in routine immunoassay and advanced molecular diagnostics, this system should provide significant benefit to the clinical laboratory today and in the future.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 10","pages":"Pages 154-158"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80021-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78717087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Major histocompatibility class II associated antigen processing","authors":"Daniel M. Eisenstein , Susan K. Pierce","doi":"10.1016/S0197-1859(00)80019-9","DOIUrl":"10.1016/S0197-1859(00)80019-9","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 10","pages":"Pages 141-151"},"PeriodicalIF":0.0,"publicationDate":"1997-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80019-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83647656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}