Clinical Immunology Newsletter最新文献

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Cytoprotective vs. Cytotoxic effects of nitric oxide in ischemic and inflammatory bowel disease 一氧化氮在缺血性和炎症性肠病中的细胞保护作用与细胞毒性作用
Clinical Immunology Newsletter Pub Date : 1997-09-01 DOI: 10.1016/S0197-1859(00)80017-5
D.V.M., Ph.D. Rustin M. Moore (Diplomate American College of Veterinary Surgeons), D.V.M., M.S. Thomas L. Seaborn (Diplomate American College of Veterinary Internal Medicine)
{"title":"Cytoprotective vs. Cytotoxic effects of nitric oxide in ischemic and inflammatory bowel disease","authors":"D.V.M., Ph.D. Rustin M. Moore (Diplomate American College of Veterinary Surgeons),&nbsp;D.V.M., M.S. Thomas L. Seaborn (Diplomate American College of Veterinary Internal Medicine)","doi":"10.1016/S0197-1859(00)80017-5","DOIUrl":"10.1016/S0197-1859(00)80017-5","url":null,"abstract":"<div><p>Nitric oxide is a simple molecule that exerts complex physiologic and pathophysiologic effects in mammalian biologic systems. The biosynthesis of NO is controlled by the availability of the substrate and enzyme, L-arginine and NOS, respectively. Nitric oxide derived from cNOS is principally involved in cytoprotective functions including vasodilatation, inhibition of platelet aggregation and adhesion, inhibition of neutrophil adhesion and emigration, and non vascular smooth muscle relaxation. On the other hand, iNOS-derived NO is involved with cytoxicity via the synthesis of peroxynitrite through the reaction of NO with superoxide. The cNOS-derived NO exerts a predominanty anti-inflammatory effect during acute gastrointestinal tract inflammation such as intestinal I-R injury, whereas iNOS-derived NO serves principally as a pro-inflammatory agent during chronic gastrointestinal tract inflamamtion such as IBD. Administration of NO donors during early stages and selective iNOS inhibitors during later stages of of gastrointestinal inflammation appear to have therapeutic potential.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 9","pages":"Pages 125, 131-139"},"PeriodicalIF":0.0,"publicationDate":"1997-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80017-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85181333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Chronic lymphocytic leukemia: A disease of dysregulated programmed cell death 慢性淋巴细胞白血病:一种失调的程序性细胞死亡疾病
Clinical Immunology Newsletter Pub Date : 1997-09-01 DOI: 10.1016/S0197-1859(00)80016-3
M.D., Ph.D. John C. Reed
{"title":"Chronic lymphocytic leukemia: A disease of dysregulated programmed cell death","authors":"M.D., Ph.D. John C. Reed","doi":"10.1016/S0197-1859(00)80016-3","DOIUrl":"10.1016/S0197-1859(00)80016-3","url":null,"abstract":"<div><p>Chronic lymphocytic leukemia (CLL) represents a quintessential example of a human malignancy which is caused principally by defects that prevent cell turnover due to programmed cell death rather than by alterations in cell cycle regulation. In the vast majority of patients, CLL cells are predominantly G<sub>0</sub> quiescent lymphocytes that gradually accumulate in the patient's body not because they are dividing more rapidly than normal, but because they are surviving too long. Investigations of the genetics of CLL therefore seem likely to teach us much about the molecular mechanisms that regulate programmed cell death (PCD). Moreover, since defects in the pathway for PCD can render neoplastic cells resistant to the cytotoxic effects of chemotherapeutic drugs and radiation, investigations of the aberrant regulation of cell death in CLL may also prove informative for gaining a better understanding of drug- and radiation-resistance mechanisms. In this review, I summarize current knowledge about the cytogenetic abnormalities associated with CLL and the role of deregulated cell death in the pathogenesis of this most common of the adult leukemias.</p></div>","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 9","pages":"Pages 125-130"},"PeriodicalIF":0.0,"publicationDate":"1997-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80016-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75666695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Immune Regulation by Transforming Growth Factor Beta 1 转化生长因子β 1的免疫调节作用
Clinical Immunology Newsletter Pub Date : 1997-08-01 DOI: 10.1016/S0197-1859(00)80013-8
Regory P., V.M., M.S. Boivin D.
{"title":"Immune Regulation by Transforming Growth Factor Beta 1","authors":"Regory P.,&nbsp;V.M., M.S. Boivin D.","doi":"10.1016/S0197-1859(00)80013-8","DOIUrl":"10.1016/S0197-1859(00)80013-8","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 8","pages":"Pages 109-113"},"PeriodicalIF":0.0,"publicationDate":"1997-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80013-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74500447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming Growth Factor β3: Pharmacological Properties and Physiological Functions 转化生长因子β3:药理性质和生理功能
Clinical Immunology Newsletter Pub Date : 1997-08-01 DOI: 10.1016/S0197-1859(00)80014-X
Ph.D. Philip N. Howles
{"title":"Transforming Growth Factor β3: Pharmacological Properties and Physiological Functions","authors":"Ph.D. Philip N. Howles","doi":"10.1016/S0197-1859(00)80014-X","DOIUrl":"10.1016/S0197-1859(00)80014-X","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 8","pages":"Pages 109, 114-117"},"PeriodicalIF":0.0,"publicationDate":"1997-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80014-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81938324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Nitric oxide as a pulmonary inflammatory mediator 一氧化氮作为肺部炎症介质
Clinical Immunology Newsletter Pub Date : 1997-08-01 DOI: 10.1016/S0197-1859(00)80015-1
D.V.M, M.S. Thomas L. Seahorn, D.V.M., Ph.D. Rustin M. Moore
{"title":"Nitric oxide as a pulmonary inflammatory mediator","authors":"D.V.M, M.S. Thomas L. Seahorn,&nbsp;D.V.M., Ph.D. Rustin M. Moore","doi":"10.1016/S0197-1859(00)80015-1","DOIUrl":"10.1016/S0197-1859(00)80015-1","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 8","pages":"Pages 118-122"},"PeriodicalIF":0.0,"publicationDate":"1997-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(00)80015-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84312060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bone marrow and the GH/IGF-I Axis: Bone remodeling and immune function 骨髓和GH/IGF-I轴:骨重塑和免疫功能
Clinical Immunology Newsletter Pub Date : 1997-07-01 DOI: 10.1016/S0197-1859(97)80319-6
Susan E. Sparks , Donna King
{"title":"Bone marrow and the GH/IGF-I Axis: Bone remodeling and immune function","authors":"Susan E. Sparks ,&nbsp;Donna King","doi":"10.1016/S0197-1859(97)80319-6","DOIUrl":"10.1016/S0197-1859(97)80319-6","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 7","pages":"Pages 93, 99-102"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(97)80319-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77428975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical relevance of chemokines 趋化因子的临床相关性
Clinical Immunology Newsletter Pub Date : 1997-07-01 DOI: 10.1016/S0197-1859(97)80318-4
Alice Gilman-Sachs, Brian DuChateau
{"title":"Clinical relevance of chemokines","authors":"Alice Gilman-Sachs,&nbsp;Brian DuChateau","doi":"10.1016/S0197-1859(97)80318-4","DOIUrl":"10.1016/S0197-1859(97)80318-4","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 7","pages":"Pages 93-98"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(97)80318-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91491364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Thymocytes Expressing Both αβ and γδ TCRs: Implications for Models of Lineage Commitment 表达αβ和γδ tcr的胸腺细胞:谱系承诺模型的意义
Clinical Immunology Newsletter Pub Date : 1997-07-01 DOI: 10.1016/S0197-1859(97)80320-2
Chong-kil Lee , Kyungjae Kim , Kathrin Muegge , Scott K. Durum
{"title":"Thymocytes Expressing Both αβ and γδ TCRs: Implications for Models of Lineage Commitment","authors":"Chong-kil Lee ,&nbsp;Kyungjae Kim ,&nbsp;Kathrin Muegge ,&nbsp;Scott K. Durum","doi":"10.1016/S0197-1859(97)80320-2","DOIUrl":"10.1016/S0197-1859(97)80320-2","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 7","pages":"Pages 102-107"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(97)80320-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79796418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of CD40 ligand (CD154) expression on neonatal cord blood T cells using a rapid whole blood flow cytometry procedure 利用快速全血流式细胞术评估新生儿脐带血T细胞中CD40配体(CD154)的表达
Clinical Immunology Newsletter Pub Date : 1997-06-01 DOI: 10.1016/S0197-1859(97)80300-7
M. Paniagua, D. Zaas, M.R.G. O'Gorman
{"title":"Evaluation of CD40 ligand (CD154) expression on neonatal cord blood T cells using a rapid whole blood flow cytometry procedure","authors":"M. Paniagua,&nbsp;D. Zaas,&nbsp;M.R.G. O'Gorman","doi":"10.1016/S0197-1859(97)80300-7","DOIUrl":"10.1016/S0197-1859(97)80300-7","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 6","pages":"Page 90"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(97)80300-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85434455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstracts from the 10th Annual AMLI Meeting 第十届AMLI年会摘要
Clinical Immunology Newsletter Pub Date : 1997-06-01 DOI: 10.1016/S0197-1859(97)80293-2
{"title":"Abstracts from the 10th Annual AMLI Meeting","authors":"","doi":"10.1016/S0197-1859(97)80293-2","DOIUrl":"10.1016/S0197-1859(97)80293-2","url":null,"abstract":"","PeriodicalId":100270,"journal":{"name":"Clinical Immunology Newsletter","volume":"17 6","pages":"Page 87"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0197-1859(97)80293-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"111146615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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