Clínica e Investigación en Arteriosclerosis (English Edition)最新文献

{"title":"Habit of physical-sports practice and the healthy lifestyle among Spanish adults from 22 to 72 years of age","authors":"Pedro Luis Rodríguez García ,&nbsp;Juan José Pérez Soto ,&nbsp;Eliseo García Cantó ,&nbsp;Pedro Javier Tarraga Marcos ,&nbsp;Pedro Juan Tárraga López","doi":"10.1016/j.artere.2025.500756","DOIUrl":"10.1016/j.artere.2025.500756","url":null,"abstract":"<div><h3>Background</h3><div>Physical-sports habits in adulthood constitute one of the predictors of physical, psychological and social health within healthy lifestyles.</div></div><div><h3>Methods</h3><div>The Acquired Healthy Lifestyle Assessment Scale was applied to a sample of 788 subjects between the ages of 22 and 72 and the dimension that makes up physical-sports practice habits was analyzed.</div></div><div><h3>Results</h3><div>74.4% of adults have habits of physical-sports practice that are not healthy or unhealthy, 18.8% tend towards health and only 6.9% are healthy. Pearson's 2 tests show a significant association between men and healthy habits, without observing changes associated with the age variable. The <em>t</em>-Student and one-factor ANOVA tests confirm the relationship between the level of health and physical-sports practice habits depending on sex and age.</div></div><div><h3>Conclusions</h3><div>It is necessary to promote preventive programs to increase participation in the practice of physical and sports exercise in the adult population that has unhealthy or unhealthy levels of lifestyle.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500756"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferon stimulated gene 15 (ISG15) modulates phenotype of vascular smooth muscle cells and pathological vascular remodelling","authors":"Julius Soudant ,&nbsp;Raquel González-Blázquez ,&nbsp;Abraham Merino ,&nbsp;Constanza Ballesteros-Martínez ,&nbsp;Raquel Rodrigues-Diez ,&nbsp;Rosa Moreno-Carriles ,&nbsp;J. Francisco Nistal ,&nbsp;Susana Guerra ,&nbsp;Juan Miguel Redondo ,&nbsp;Mercedes Salaices ,&nbsp;Ana M. Briones ,&nbsp;Ana B. García-Redondo","doi":"10.1016/j.artere.2025.500769","DOIUrl":"10.1016/j.artere.2025.500769","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Inflammation is a major determinant of abdominal aortic aneurysms<span> (AAA). Interferon stimulated gene 15 (ISG15) has a role in </span></span>vascular remodelling<span> in AAA. This study investigates the mechanisms whereby ISG15 might affect vascular remodelling and function.</span></div></div><div><h3>Methods</h3><div><span>We used vascular smooth muscle cells (VSMC) from wild type (ISG15</span>^+/+) o ISG15 knockout (ISG15^−/−) mice, aorta from ISG15^+/+ and ISG15^−/−<span> mice infused with angiotensin II (1.44</span> <span>mg/kg/day, sc, 14 days), and human AAA. We also performed a model of recombinant ISG15 infusion (rISG15, sc, 100 and 500</span> <!-->ng/day, 14 days) in mice.</div></div><div><h3>Results</h3><div>In VSMC, ISG15 deficiency increased the expression of contractile (<em>Acta2</em>, <em>Tagln</em>) and synthetic (<em>Fn1</em>, <em>Col1a2</em>, <span><span>Col3</span></span>, <em>Col4</em>) markers and decreased the expression of the calcification marker <em>Spp1</em>. Ang II infusion changed the expression of phenotype markers differently in aorta from ISG15^+/+ or ISG15^−/− mice. ISG15 expression showed a negative correlation with expression of contractile markers (<span><em>ACTA2</em></span>, <em>CNN1</em>), and with <em>COL3a1</em><span>, in human samples from patients with AAA or with stenotic aorto-iliac pathology. rISG15 infusion induced hypotrophic vascular remodelling in mesenteric arteries without affecting vascular mechanics. Aorta of ISG15</span>^−/− contracted more to thromboxane A₂<span> analogue U46619, compared to ISG15</span>^−/−<span> mice. Both aorta and mesenteric arteries from rISG15-treated mice showed less contractility than control mice.</span></div></div><div><h3>Conclusions</h3><div>ISG15 participates in pathological vascular remodelling probably by modulating VSMC phenotype. These changes could also impact in the vascular function.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500769"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COPD and cardiovascular risk","authors":"Carlos Santiago Díaz ,&nbsp;Francisco J. Medrano ,&nbsp;N. Muñoz-Rivas ,&nbsp;Luis Castilla Guerra ,&nbsp;M. Belén Alonso Ortiz ,&nbsp;on behalf of the COPD and Vascular Risk working groups of the Sociedad Española de Medicina Interna","doi":"10.1016/j.artere.2025.500757","DOIUrl":"10.1016/j.artere.2025.500757","url":null,"abstract":"<div><div>Chronic Obstructive Pulmonary Disease<span><span> (COPD) usually presents joined to other pathologies we call comorbidities. The more frequent of them are those related to cardiovascular risk, either its risk factors or its clinical manifestations. Cardiovascular risk of these patients grows up with the severity of the airflow obstruction<span>, specially during and after an exacerbation of COPD. Patients with COPD have between 2 and 5 times more risk of ischaemic heart disease than people without COPD, even after adjusting for cofounding factors. Cardiovascular diseases are up to the second cause of mortality in these patients, close to those due to the </span></span>lung disease. Although COPD is associated to several cardiovascular risk factors such as tobacco, arterial hypertension or Diabetes Mellitus, they don’t explain all the excess in cardiovascular risk these patients have. Despite that excess of cardiovascular risk in COPD patients, most widely used cardiovascular risk scores don’t include COPD as a risk factor itself, so global risk is understimated in these patients. In this review, we make a bibliography revision of the avaliable evidence about COPD and cardiovascular risk factors as well as the excess of cardiovascular risk COPD itself involves.</span></div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500757"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabesity and cardiovascular mortality in a prospective population cohort followed for more than 20 years","authors":"Julio A. Carbayo-Herencia ,&nbsp;Marta Simarro Rueda ,&nbsp;Luis Miguel Artigao Ródenas ,&nbsp;Juan A. Divisón Garrote ,&nbsp;Francisca Molina Escribano ,&nbsp;Isabel Ponce García ,&nbsp;Antonio Palazón Bru ,&nbsp;Pilar Torres Moreno ,&nbsp;David Caldevilla Bernardo ,&nbsp;Rosalina Martínez López ,&nbsp;Vicente Francisco Gil Guillén ,&nbsp;José R. Banegas ,&nbsp;on behalf of the Albacete Vascular Diseases Group (GEVA)","doi":"10.1016/j.artere.2025.500768","DOIUrl":"10.1016/j.artere.2025.500768","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Control of the main cardiovascular risk factors had succeeded in reducing cardiovascular diseases (CVD). However, the general increase in the prevalence of type 2 diabetes mellitus (DM2) and obesity has slowed this decline. Both CVRFs are strongly associated, and the term diabesity has been coined to refer to this relationship. The main objective of this study was to assess the influence of diabesity on </span>cardiovascular mortality.</div></div><div><h3>Methods</h3><div>Prospective cohort study<span> involving 1246 individuals (54.3% women) followed for 20.9 years (SD = 7.31) and selected by random two-stage sampling in a province in southeastern Spain. Diabesity was defined as the combination of DM2 with overweight and obesity. Survival curves (Kaplan-Meier) were calculated and two Cox regression models were used, one unadjusted and the other adjusted by the main explanatory variables in which the diabesity variable consisted of 6 categories (normal weight, overweight, obesity, normal weight + DM2, overweight + DM2 and obesity + DM2).</span></div></div><div><h3>Results</h3><div>There were 95 deaths due to CV causes (7.6% of the total; 6.2% women and 9.3% men; <em>P</em><span> = .01). After adjustment, the combination of DM2 and overweight increased the incidence of cardiovascular mortality by 133% (HR = 2.33; 95% CI: 1.18-4.58; </span><em>P</em> = .014) and the combination of DM2 and obesity by 49% (HR = 1.49; 95% CI: 0.64−3.45; <em>P</em> = .351), not reaching statistical significance in the latter case.</div></div><div><h3>Conclusions</h3><div>In the general population, the results of our study show that the combination of overweight and DM2 is associated with higher CV mortality. It seems a priority to intervene intensively in the control of both overweight and DM2.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500768"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of PCSK9 inhibitors in real life","authors":"Antón González-Guerrero ,&nbsp;Eugenia Navarrete-Rouco ,&nbsp;David Benaiges ,&nbsp;Eva Giralt-Steinhauer ,&nbsp;Lidia Marcos ,&nbsp;Anna Oliveras ,&nbsp;Lluis Recasens ,&nbsp;Juan Pedro-Botet","doi":"10.1016/j.artere.2025.500755","DOIUrl":"10.1016/j.artere.2025.500755","url":null,"abstract":"<div><h3>Objective</h3><div>To confirm the effectiveness and safety of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in daily clinical practice.</div></div><div><h3>Methods</h3><div>Retrospective observational study of patients from hospital registry of PCSK9 inhibitor treatment with a follow-up ≥<!--> <!-->6<!--> <!-->mo. The lipid-lowering effect and safety were evaluated.</div></div><div><h3>Results</h3><div><span><span>Of the 193 patients included in the study, 168 (87%) had cardiovascular disease, and 54 (28%) had familial hypercholesterolemia; 85 (44%) were intolerant to statins/ezetimibe. No differences between </span>alirocumab<span> and evolocumab groups regarding the rate of LDL-C reduction ≥</span></span> <span>50% (82.8% vs. 83.1%), achievement of the therapeutic target (60.9% vs. 65.5%), or complete remission (60.2% vs. 58.5%) were found. An erythema at the injection site<span><span> in one patient treated with alirocumab and </span>urticaria<span><span> in one patient treated with evolocumab were recorded. According to the </span>logistic regression analysis, complete remission of LDL-C in subjects treated with PCSK9 inhibitors was positively associated with increased age (OR 1.045; 95% CI 1.0–1.092; p</span></span></span> <!-->=<!--> <!-->0.049) and active smoking (OR 4.562; 95% CI 1.434–14.515; p<!--> <!-->=<!--> <!-->0.010), and negatively associated with female gender (OR 0.403; 95% CI 0.171–0.949; p<!--> <!-->=<!--> <!-->0.038), baseline LDL-C levels (OR 0.969; 95% CI: 0.957–0.981; p<!--> <!-->&lt;<!--> <!-->0.001)and statin/ezetimibe intolerance (OR 0.403; 95% CI 0.176–0.925; p<!--> <!-->=<!--> <!-->0.041).</div></div><div><h3>Conclusion</h3><div>This real-world practice study has confirmed that PCSK9 inhibitors are effective, safe and well tolerated, with lipid-lowering effects comparable to those described in randomized controlled trials<span>, regardless of the monoclonal antibody used.</span></div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500755"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145160272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of early diagnosis and multidisciplinary intervention in the prevention of cardiovascular complications in people with diabesity","authors":"Carlos Morillas Ariño","doi":"10.1016/j.artere.2025.500857","DOIUrl":"10.1016/j.artere.2025.500857","url":null,"abstract":"","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 5","pages":"Article 500857"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative exposure to cholesterol: Lost time cannot be recovered","authors":"Pablo Pérez-Martínez ,&nbsp;José López-Miranda","doi":"10.1016/j.artere.2025.500805","DOIUrl":"10.1016/j.artere.2025.500805","url":null,"abstract":"","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 4","pages":"Article 500805"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of the adhesion of the elements of atheroma and the causes of thrombosis","authors":"Irving Mauricio Lecona Licona ,&nbsp;José María Rodríguez Lelis ,&nbsp;Joaquín Pérez Ortega ,&nbsp;José Alfredo Rodríguez Ramírez","doi":"10.1016/j.artere.2025.500801","DOIUrl":"10.1016/j.artere.2025.500801","url":null,"abstract":"<div><h3>Introduction</h3><div>Ischemic diseases are the second leading cause of death in Mexico and account for over 30% of deaths worldwide. Atherosclerosis, in particular, obstructs arteries and impairs blood circulation, contributing to increased mortality and reduced quality of life.</div></div><div><h3>Objective</h3><div>In this study, adhesion energies and their influence on the structural arrangement of an atheroma were determined.</div></div><div><h3>Methodology</h3><div>Adhesion energies were measured for each main component of the atheroma, including arteries and plaque components such as cholesterol, calcium, collagen, glucose, and elastin. The relationship between adhesion and atheroma formation is demonstrated, highlighting the significant interaction of adhesion energies between fibrinogen and cholesterol. Numerical results showed that fibrinogen and cholesterol have the highest adhesion energy, followed by collagen-glucose and cholesterol-elastin combinations.</div></div><div><h3>Results</h3><div>Additionally, interactions with the highest adhesion energy, such as Fib-Fib with an energy value of 9.60<!--> <em>x</em> <!-->10⁻⁵ <!-->J/m², CML-GB with a value of 2.76<!--> <em>x</em> <!-->10⁻⁹ <!-->J/m², along with LDL-LDL with an adhesion value of 6.35<!--> <em>x</em> <!-->10⁻⁵ <!-->J/m² and Elas-LDL with a J value of 3.40<!--> <em>x</em> <!-->10⁻⁵ <!-->J/m², influence the atheroma structure formation.</div></div><div><h3>Conclusions</h3><div>These results demonstrate the association between adhesion energy in forming an atheroma that obstructs arteries, reduces blood flow, and the pathology of thrombus formation.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 4","pages":"Article 500801"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to improve cardiovascular health and treatment of dyslipidemia in Spain. Expert Insights Project","authors":"Juan Pedro-Botet ,&nbsp;Román Freixa ,&nbsp;Juan José Tamarit ,&nbsp;José López-Miranda ,&nbsp;Rosa Fernández-Olmo ,&nbsp;Ovidio Muñiz-Grijalvo ,&nbsp;Rafael Vázquez-García ,&nbsp;Carlos Guijarro ,&nbsp;Luis Rodríguez-Padial ,&nbsp;José Luis Díaz-Díaz ,&nbsp;Marisol Bravo-Amaro ,&nbsp;José Luís Hernández ,&nbsp;José Antonio Alarcón-Duque ,&nbsp;José Alfredo Martin-Armas ,&nbsp;Martín García-López ,&nbsp;Juan Cosín-Sales","doi":"10.1016/j.artere.2025.100738","DOIUrl":"10.1016/j.artere.2025.100738","url":null,"abstract":"<div><h3>Objectives</h3><div>To gather opinions, recommendations, and proposals for improvement from Spanish clinicians on cardiovascular (CV) health, with particular focus on dyslipidemia management.</div></div><div><h3>Methods</h3><div>The Expert Insights project involved 8 face-to-face sessions held throughout Spain, attended by 138 CV health experts. Clinicians answered to 25 questions survey related to CV health and dyslipidemia control. Each session included an analysis and a discussion on the perceived realities and areas for improvement.</div></div><div><h3>Results</h3><div>72% of centres have a standardised process for monitoring patients after a CV episode at discharge, but only 37% during their clinical follow-up. Patient care and management are dependent on the physician, with a lack of coordination between hospital specialties and primary care (PC). 95% of clinicians believe it is necessary to standarise treatment optimisation. 65% of centres prescribe combined lipid-lowering treatment after a CV episode. Updating cLDL levels in the Therapeutic Positioning Report and standardising and globalising the prescription document would reduce iPCSK9 prescription barriers and lead to more equitable access.</div></div><div><h3>Conclusions</h3><div>In Spain, there are significant deficiencies in the management of dyslipidemia, with a great need for a consensus on standardising management processes and optimising patient treatment. The opinions, recommendations, and improvement proposals from Spanish clinicians on CV health are an important starting point to improve the situation.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 4","pages":"Article 100738"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of new therapeutic targets related to endoplasmic reticulum stress and mitochondrial dysfunction to reduce the risk of rupture in degenerative ascending aortic aneurysm","authors":"Rafael Almendra-Pegueros ,&nbsp;Antonio J. Barros-Membrilla ,&nbsp;Elvira Pérez-Marlasca ,&nbsp;Josep Julve ,&nbsp;José Martinez-González ,&nbsp;Cristina Rodriguez ,&nbsp;María Galán","doi":"10.1016/j.artere.2025.100740","DOIUrl":"10.1016/j.artere.2025.100740","url":null,"abstract":"<div><h3>Background</h3><div>Ascending Thoracic Aortic Aneurysm (ATAA) is a progressive dilation of the aorta that can be complicated by its dissection leading to death in 80–90% of the patients. When associated with ageing and atherosclerosis, the outcome is worse and reconstructive surgery is the only effective therapy. Our objective was to characterise differential expressed genes (DEG) involved in endoplasmic reticulum (ER) and mitochondria dysfunction in patients with degenerative ATAA.</div></div><div><h3>Methods</h3><div>a transcriptomic analysis was performed by RNA sequencing using RNA isolated from ATAA of patients classified as degenerative (<em>n</em> = 13) and multi-organ healthy donors (<em>n</em> = 6). DEGs related to ER stress and mitochondrial dysfunction were identified with the DESeq2 package. Enriched pathway (Reactome) and protein interaction (PPI) analysis was performed with the clusterProfiles package. PPI of the selected DEGs was analysed based on the string database and visualised by Cytoscape software.</div></div><div><h3>Results</h3><div>histology revealed a complete disorganisation of the extracellular matrix (ECM) and cell loss in the aortic wall of ATAA patients where the upregulation of 15 DEGs and the downregulation of 13 DEGs that encode proteins related to ER stress (ATF4, EIF2AK3, HSPA5, ERN1, SEL1L), mitochondrial dysfunction (DNML1, IMMT, MT-CO3, MT-CYB, MT ND2, TIMM17B, MT-ERF1, TOMM5) and ECM was detected. The results of GO term and enriched pathway analysis indicated that these DEGs are mainly enriched in pathways related to aortic diseases.</div></div><div><h3>Conclusions</h3><div>our data show that proteins related to mitochondrial dysfunction and ER stress might be therapeutic targets for the treatment of ATAA.</div></div>","PeriodicalId":100263,"journal":{"name":"Clínica e Investigación en Arteriosclerosis (English Edition)","volume":"37 4","pages":"Article 100740"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}