British Veterinary Journal最新文献_第8页

Bovine spongiform encephalopathy—the beginning of the end? 牛海绵状脑病——结束的开始?

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80004-2

D.M. Taylor

引用次数: 15

Pharmacokinetics of amoxicillin/ciavulanic acid combination and of both drugs alone after intravenous administration to goats 山羊静脉给药后阿莫西林/卡维酸联合用药及单独用药的药代动力学

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80007-8

E. Escudero, C.M. Carceles, S. Vicente

{"title":"Pharmacokinetics of amoxicillin/ciavulanic acid combination and of both drugs alone after intravenous administration to goats","authors":"E. Escudero, C.M. Carceles, S. Vicente","doi":"10.1016/S0007-1935(96)80007-8","DOIUrl":"10.1016/S0007-1935(96)80007-8","url":null,"abstract":"<div><p>The pharmacokinetic behaviour of an amoxicillin/clavulanic acid combination(25 mg kg<sup>−1</sup>), and both drugs alone (amoxicillin 20 mg kg<sup>−1</sup>), clavulanic acid 5 mg kg<sup>−1</sup>), was studied after intravenous (i.v.) administration of single doses to 10 goats. The objective was to determine whether there were differences in the plasma kinetics of these drugs when administered in combination or alone. The plasma concentration-time data were analysed by compartmental pharmacokinetics and non-compartmental methods. The disposition curves for both drugs alone and in combination were best described by a biexponential equation (two-compartment open model). The elimination half-lives of amoxicillin were 1.05±0.09 h alone and 1.13±0.19 h in combination, and those of clavulanic acid were 0.87±0.07 h and 0.85±0.09 h, respectively. The apparent volumes of distribution of amoxicillin and clavulanic acid were similar in the two treatments. Body clearances of amoxicillin were 0.12±0.01 l h<sup>−1</sup> · kg alone and 0.11±0.01 l h<sup>−1</sup> · kg in combination, and of clavulanic acid were 0.12±0.02 l h<sup>−1</sup> · kg alone and 0.12±0.01 l h<sup>−1</sup> · kg in combination with amoxicillin. The half-lives and body clearances of amoxicillin and clavulanic acid did not differ significantly when administered alone and in combination. It was concluded that the ix. administration of amoxicillin and ciavulanic acid as a combination product did not alter the disposition kinetics of either drug.</p></div>","PeriodicalId":100203,"journal":{"name":"British Veterinary Journal","volume":"152 5","pages":"Pages 551-559"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0007-1935(96)80007-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19850831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Development of a diagnostic DNA probe to detect Setaria digitata: The causative parasite of cerebrospinal nematodiasis in goats, sheep and horses 一种用于检测山羊、绵羊和马的脑脊液线虫病的致病寄生虫——狗尾草(Setaria digitata)诊断性DNA探针的研制

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80008-X

W.S.S. Wijesundera, N.V. Chandrasekharan, E.H. Karunanayake, S.P. Dharmasena

引用次数: 15

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80018-2

B.W. Eagles

引用次数: 0

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80021-2

Julian A. Skidmore

引用次数: 0

Bovine spongiform encephalopathy—Too early to relax 牛海绵状脑病——过早放松

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80001-7

D. Matthews (Senior Veterinaty Officer)

引用次数: 0

Medetomidine, alpha2 adrenoceptors and small animal practice 美托咪定、α 2肾上腺素受体与小动物实验

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80002-9

L.W. Hall

引用次数: 0

British Veterinary Journal Pub Date : 1996-09-01 DOI: 10.1016/S0007-1935(96)80019-4

David Murphy

引用次数: 10

Retroviral aetiopathogenesis of ovinepulmonary carcinoma: A critical appraisal 肺癌逆转录病毒的发病机制:一个关键的评估

British Veterinary Journal Pub Date : 1996-07-01 DOI: 10.1016/S0007-1935(96)80034-0

S.J. Hecht , J.M. Sharp , J.C. Demartini

{"title":"Retroviral aetiopathogenesis of ovinepulmonary carcinoma: A critical appraisal","authors":"S.J. Hecht , J.M. Sharp , J.C. Demartini","doi":"10.1016/S0007-1935(96)80034-0","DOIUrl":"10.1016/S0007-1935(96)80034-0","url":null,"abstract":"<div><p>Although it has long been thought that a retrovirus is the responsible agent for ovine pulmonary carcinoma (OPC), identification of a replicative viral agent has proven difficult. Recently, the genome of a new retrovirus, jaagsiekte sheep retrovirus (JSRV), found in the lung-was of affected sheep lung, has bee cloned and sequenced; characterization of this virus and its consistent presence in tumor cells argue for its role as the aetiologic agent of OPC. Analysis of the nucleic acid sequence of the JRSV genome, suggests a new class of retrovirus, one that is chimeric according to the morphological classification scheme used for retroviruses. The genome of this virus does not appear to contain an oncogene, and the mechanism by which it causes disease is still unknown. The presence of multiple copies of endogenous retroviruses related to JSRV in DNA of OPC-affected and unaffected sheep further complicates investigation of oncogenesis in OPC. This review examines the evidence for a retrovirus as the causative agent for OPC, with particular emphasis on the viruses studied to date. The significance of endogenous, JSRV-related sequences is considered. The mechanisms by which a retrovirus such as JSRV might induce lung tumours in sheep, and which of these are most likely, are discussed in light of these developments, as are the prospects for new means of diagnosis and treatment of this disease.</p></div>","PeriodicalId":100203,"journal":{"name":"British Veterinary Journal","volume":"152 4","pages":"Pages 395-409"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0007-1935(96)80034-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Taurine- and glycine-conjugated bile acids inthe preruminant goat: Identification by high performance liquid chromatography 山羊前乳中牛磺酸和甘氨酸共轭胆汁酸的高效液相色谱鉴别

British Veterinary Journal Pub Date : 1996-07-01 DOI: 10.1016/S0007-1935(96)80037-6

J.I. Fernández , M. Manas , A. Rueda , E. Martínez-Victoria , J.A. Naranjo

引用次数: 2