Brazilian Journal of Anesthesiology (Edicion en Espanol)最新文献

{"title":"Réplica","authors":"Edmundo Pereira de Souza Neto","doi":"10.1016/j.bjanes.2014.05.001","DOIUrl":"https://doi.org/10.1016/j.bjanes.2014.05.001","url":null,"abstract":"","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 5","pages":"Page 375"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2014.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136715553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio comparativo, aleatorizado y doble ciego, de la petidina y del ketoprofeno como adyuvantes de la lidocaína en la anestesia regional intravenosa","authors":"Sameer N. Desai,&nbsp;M.C.B. Santhosh","doi":"10.1016/j.bjanes.2013.03.016","DOIUrl":"10.1016/j.bjanes.2013.03.016","url":null,"abstract":"<div><h3>Background and objectives</h3><p>A review of all the adjuncts for intravenous regional anaesthesia concluded that there is good evidence to recommend NonSteroidal Anti-Inflammatory agents and pethidine in the dose of 30<!--> <!-->mg dose as adjuncts to intravenous regional anaesthesia. But there are no studies to compare pethidine of 30<!--> <!-->mg dose to any of the NonSteroidal Anti-Inflammatory agents.</p></div><div><h3>Methods</h3><p>In a prospective, randomized, double blind study, 45 patients were given intravenous regional anaesthesia with either lignocaine alone or lignocaine with pethidine 30<!--> <!-->mg or lignocaine with ketprofen 100<!--> <!-->mg. Fentanyl was used as rescue analgesic during surgery. For the first 6<!--> <!-->h of postoperative period analgesia was provided by fentanyl injection and between 6 and 24<!--> <!-->h analgesia was provided by diclofenac tablets. Visual analogue scores for pain and consumption of fentanyl and diclofenac were compared.</p></div><div><h3>Results</h3><p>The block was inadequate for one case each in lignocaine group and pethidine group, so general anaesthesia was provided. Time for the first dose of fentanyl required for postoperative analgesia was significantly more in pethidine and ketoprofen groups compared to lignocaine group (156.7<!--> <!-->±<!--> <!-->148.8 and 153.0<!--> <!-->±<!--> <!-->106.0 vs. 52.1<!--> <!-->±<!--> <!-->52.4<!--> <!-->min respectively). Total fentanyl consumption in first 6<!--> <!-->h of postoperative period was less in pethidine and ketoprofen groups compared to lignocaine group (37.5<!--> <!-->±<!--> <!-->29.0<!--> <!-->mcg, 38.3<!--> <!-->±<!--> <!-->20.8<!--> <!-->mcg vs. 64.2<!--> <!-->±<!--> <!-->27.2<!--> <!-->mcg respectively). Consumption of diclofenac tablets was 2.4<!--> <!-->±<!--> <!-->0.7, 2.5<!--> <!-->±<!--> <!-->0.5 and 2.0<!--> <!-->±<!--> <!-->0.7 in the control, pethidine and ketoprofen group respectively, which was statistically not significant. Side effects were not significantly different between the groups.</p></div><div><h3>Conclusion</h3><p>Both pethidine and ketoprofen are equally effective in providing postoperative analgesia up to 6<!--> <!-->h, without significant difference in the side effects and none of the adjuncts provide significant analgesia after 6<!--> <!-->h.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 221-226"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.03.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54222208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación del C-MAC convencional y C-MAC D-blade con laringoscopios directos en simulación de lesión de la columna cervical (estudio en modelo)","authors":"Divya Jain,&nbsp;Mandeep Dhankar,&nbsp;Jyotsna Wig,&nbsp;Amit Jain","doi":"10.1016/j.bjanes.2013.06.006","DOIUrl":"10.1016/j.bjanes.2013.06.006","url":null,"abstract":"<div><h3>Background</h3><p>CMAC videolaryngoscope has recently been introduced for videoscope guided intubation. The aim of our study was to compare and evaluate the efficacy of the conventional blade and the angulated D blade of the CMAC videolaryngoscope with the direct laryngoscopes in simulated cervical spine injury patients on the airway manikin.</p></div><div><h3>Materials and methods</h3><p>Following power analysis, 33 resident doctors were enrolled to perform endotracheal intubation using all the 4 different laryngoscopes namely the Macintosh laryngoscope, McCoy laryngoscope, conventional CMAC videolaryngoscope and the D blade of the CMAC videolaryngoscopes on the airway manikin in simulated cervical spine injury. The demographic variables of the resident doctors were recorded. The outcomes measured included vocal cord visualization (Cormack–Lehane grading), time taken to intubate, number of attempts for successful intubation and optimizing maneuvers required.</p></div><div><h3>Results</h3><p>The use of indirect videolaryngoscopes resulted in better glottic visualization in comparison to the direct laryngoscopes (CL-I) in 20/33 (60.6%) in the Macintosh group, 24/33 (72.7%) in McCoy group, 30/33 in (90.9%) in Vlc group and 32/33 (96.9%) in Vld group. The time taken to intubate averaged to 15.54<!--> <!-->±<!--> <!-->2.6 in Macintosh group, 18.90<!--> <!-->±<!--> <!-->4.47 in McCoy group, 20.21<!--> <!-->±<!--> <!-->7.9 in Vlc group and 27.42<!--> <!-->±<!--> <!-->9.09 in Vld group. The 1st attempt intubation success rate was 84.8% (Macintosh), 72.7% (McCoy), 90.9% (Vlc) and, 78.7% (Vld).</p></div><div><h3>Conclusions</h3><p>The overall performance of the conventional CMAC blade proved to be the best when compared with the D-blade CMAC, Macintosh blade and the McCoy blade for intubation in simulated cervical spine patients by anesthesia residents.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 269-274"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morfina como primer medicamento para el tratamiento del dolor de cáncer","authors":"Beatriz C. Nunes,&nbsp;João Batista dos Santos Garcia,&nbsp;Rioko Kimiko Sakata","doi":"10.1016/j.bjanes.2013.06.018","DOIUrl":"10.1016/j.bjanes.2013.06.018","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The medications used according to the recommendation of the World Health Organization do not promote pain relief in a number of patients with cancer pain. The aim of this study was to evaluate the use of morphine as first medication for the treatment of moderate cancer pain in patients with advanced and/or metastatic disease, as an option to the recommendations of the World Health Organization analgesic ladder.</p></div><div><h3>Method</h3><p>Sixty patients without opioid therapy, with ≥18 years of age, were randomized into two groups. G1 patients received medication according to the analgesic ladder and started treatment with non-opioids in the first, weak opioids in the second, and strong opioids in the third step; G2 patients received morphine as first analgesic medication. The efficacy and tolerability of initial use of morphine were evaluated every two weeks for three months.</p></div><div><h3>Results</h3><p>The groups were similar with respect to demographic data. There was no significant difference between the groups regarding pain intensity, quality of life, physical capacity, satisfaction with treatment, need for complementation and dose of morphine. In G1 there was a higher incidence of nausea (<em>p</em> <!-->=<!--> <!-->0.0088), drowsiness (<em>p</em> <!-->=<!--> <!-->0.0005), constipation (<em>p</em> <!-->=<!--> <!-->0.0071) and dizziness (<em>p</em> <!-->=<!--> <!-->0.0376) in the second visit and drowsiness (<em>p</em> <!-->=<!--> <!-->0.05) in the third.</p></div><div><h3>Conclusions</h3><p>The use of morphine as first medication for pain treatment did not promote better analgesic effect than the ladder recommended by World Health Organization, with higher incidence of adverse effects.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 236-240"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.06.018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación del esmolol en bolos e infusión continua en la respuesta hemodinámica a la laringoscopia, intubación orotraqueal y esternotomía en cirugía de revascularización coronaria","authors":"Esra Mercanooglu Efe,&nbsp;Basak Atabey Bilgin,&nbsp;Zekeriyya Alanoglu,&nbsp;Murat Akbaba,&nbsp;Cigdem Denker","doi":"10.1016/j.bjanes.2013.07.005","DOIUrl":"10.1016/j.bjanes.2013.07.005","url":null,"abstract":"<div><h3>Background and objective</h3><p>The aim of this randomized, prospective and double blinded study is to investigate effects of different esmolol use on hemodynamic response of laryngoscopy, endotracheal intubation and sternotomy in coronary artery bypass graft surgery.</p></div><div><h3>Methods</h3><p>After approval of local ethics committee and patients’ written informed consent, 45 patients were randomized into three groups equally. In Infusion Group; from 10<!--> <!-->min before intubation up to 5th minute after sternotomy, 0.5<!--> <!-->mg/kg/min esmolol infusion, in Bolus Group; 2<!--> <!-->min before intubation and sternotomy 1.5<!--> <!-->mg/kg esmolol IV bolus and in Control Group; %0.9 NaCl was administered. All demographic parameters were recorded. Heart rate and blood pressure were recorded before infusion up to anesthesia induction in every minute, during endotracheal intubation, every minute for 10<!--> <!-->min after endotracheal intubation and before, during and after sternotomy at first and fifth minutes.</p></div><div><h3>Results</h3><p>While area under curve (AUC) (SAP<!--> <!-->×<!--> <!-->time) was being found more in Group B and C than Group I, AUC (SAP<!--> <!-->×<!--> <em>T</em>_int and <em>T</em>_st) and AUC (SAP<!--> <!-->×<!--> <em>T</em>₂) was found more in Group B and C than Group I (<em>p</em> <!-->&lt;<!--> <!-->0.05). Moreover AUC (HR<!--> <!-->×<!--> <em>T</em>_st) was found less in Group B than Group C but no significant difference was found between Group B and Group I.</p></div><div><h3>Conclusion</h3><p>This study highlights that esmolol infusion is more effective than esmolol bolus administration on controlling systolic arterial pressure during endotracheal intubation and sternotomy in CABG surgery.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 247-252"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La estructuración de un servicio de cuidados paliativos en Brasil – Relato de una experiencia","authors":"João Batista Santos Garcia ,&nbsp;Rayssa Fiterman Rodrigues ,&nbsp;Sara Fiterman Lima","doi":"10.1016/j.bjanes.2013.06.007","DOIUrl":"10.1016/j.bjanes.2013.06.007","url":null,"abstract":"<div><h3>Background and objectives</h3><p>In Brazil, palliative care (PC) is not properly structured and that reality transforms this theme in a public health problem; therefore, initiatives become relevant in this context. This paper aims to share the experience that occurred in an oncology referral hospital in the State of Maranhão and present initiatives that helped in the development of PC Service.</p></div><div><h3>Experience report</h3><p>The hospital had an outpatient Pain and PC Service, but without specialized beds. The terminally ill patients stayed in common wards, which caused much unrest. A sensitization process was initiated in the hospital through initiatives, such as a photo contest called Flashes of Life and a ward called Room of Dreams, designed in partnership with the architecture course at the Universidade Estadual do Maranhão. The process culminated in the granting of wards to the PC and in the commitment of the Foundation, sponsor of the hospital, to run the project.</p></div><div><h3>Conclusion</h3><p>This experience was a reproducible local initiative for the establishment of PC in a cancer hospital. Local initiatives are valuable in Brazil because they favor a significant number of patients and show its effectiveness in practice to governments and society. To structure a PC service, it is essential to establish priorities that include the assignment of drugs for management of symptoms, humanization, multidisciplinarity, sensitization and education of professionals.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 286-291"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de Kounis intraoperatorio con mejoría de las alteraciones electrocardiográficas y de la situación hemodinámica después de la administración de nitroglicerina","authors":"Victoria O. Sánchez,&nbsp;Luisa C. Roca,&nbsp;Angel del P. Moreno","doi":"10.1016/j.bjanes.2013.06.016","DOIUrl":"10.1016/j.bjanes.2013.06.016","url":null,"abstract":"<div><p>A 58-year-old female without cardiovascular risk factors, was going to be operated to repair the rotator cuff. Induction and interscalene brachial plexus block were uneventful, but after her placement for surgery the patient started with severe bronchospasm, hypotension, cutaneous allergic reaction and ST elevation on the electrocardiogram. An anaphylactic shock was suspected and treated but until the perfusion of nitroglycerina was started no electrocardiographic changes resolved. After necessary diagnostic test the final diagnosis was variant I of Kounis syndrome due to cefazolin and rocuronium. Ephinephrine is the cornerstone of treatment for anaphylaxis but should we use it if the anaphylactic reaction is also accompanied by myocardial ischemia? The answer is that we should not use it because myocardial ischemia in this syndrome is caused by vasospasm, so it would be more useful drugs such as nitroglycerin. But what if we do not know if it is a Kounis syndrome or not? In this article we report our experience that maybe could help you in a similar situation.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 281-285"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.06.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluación del club de la revista de anestesiología por medio de cambios semánticos","authors":"Joaquim Edson Vieira ,&nbsp;Marcelo Luís Abramides Torres ,&nbsp;Regina Albanese Pose ,&nbsp;José Otávio Costa Auler Junior","doi":"10.1016/j.bjanes.2013.11.003","DOIUrl":"10.1016/j.bjanes.2013.11.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The interactive approach of a journal club has been described in the medical education literature. The aim of this investigation is to present an assessment of journal club as a tool to address the question whether residents read more and critically.</p></div><div><h3>Methods</h3><p>this study reports the performance of medical residents in anesthesiology from the Clinics Hospital – University of São Paulo Medical School. All medical residents were invited to answer five questions derived from discussed papers. The answer sheet consisted of an affirmative statement with a Likert type scale (totally disagree–disagree–not sure–agree–totally agree), each related to one of the chosen articles. The results were evaluated by means of item analysis – difficulty index and discrimination power.</p></div><div><h3>Results</h3><p>Residents filled one hundred and seventy three evaluations in the months of December 2011 (<em>n</em> <!-->=<!--> <!-->51), July 2012 (<em>n</em> <!-->=<!--> <!-->66) and December 2012 (<em>n</em> <!-->=<!--> <!-->56). The first exam presented all items with straight statement, second and third exams presented mixed items. Separating “totally agree” from “agree” increased the difficulty indices, but did not improve the discrimination power.</p></div><div><h3>Conclusions</h3><p>The use of a journal club assessment with straight and inverted statements and by means of five points scale for agreement has been shown to increase its item difficulty and discrimination power. This may reflect involvement either with the reading or the discussion during the journal meeting.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 258-262"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54233296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloqueo facetario guiado por ultrasonido para lumbalgia: relato de caso","authors":"Ana Ellen Q. Santiago,&nbsp;Plinio C. Leal,&nbsp;Elmiro Helio M. Bezerra,&nbsp;Ana Laura A. Giraldes,&nbsp;Leonardo C. Ferraro,&nbsp;Andre H. Rezende,&nbsp;Rioko Kimiko Sakata","doi":"10.1016/j.bjanes.2012.09.006","DOIUrl":"10.1016/j.bjanes.2012.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Osteoarthrosis is a common cause of low back pain. The diagnosis is clinical and can be confirmed by imaging studies. Pain treatment and confirmation of diagnosis are made by intra-articular injection of corticosteroid and by local anesthetic use, due to clinical improvement. A direct monitoring of the procedure can be done under fluoroscopy, a classic technique, or else by an ultrasound-guided procedure.</p></div><div><h3>Case report</h3><p>Female patient, 88 years old, 1.68<!--> <!-->m and 72<!--> <!-->kg, with facet osteoarthrosis at L2–L3, L3–L4 and L4–L5 for two years. On physical examination, she exhibited pain on lateralization and spinal extension. We opted in favor of an ultrasound-guided facet joint block. A midline spinal longitudinal scan was obtained, with identification of the desired joint space at L3–L4. A 25<!--> <!-->G needle was inserted into the skin by the echographic off-plane ultrasound technique. 1<!--> <!-->mL of contrast was administered, with confirmation by fluoroscopy. After aspiration of the contrast, 1<!--> <!-->mL of solution containing 0.25% bupivacaine hydrochloride and 10<!--> <!-->mg of methylprednisolone acetate was injected. Injections into L3–L4, L2–L3 and L1–L2 to the right were applied.</p></div><div><h3>Conclusions</h3><p>The visualization of the facet joint by ultrasound involves minimal risk, besides reduction of radiation. This option is suitable for a large part of the population. However, fluoroscopy and computed tomography remain as monitoring techniques indicated for patients with specific characteristics, such as obesity, severe degenerative diseases and anatomical malformations, in which the ultrasound technique is still in need of further study.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 278-280"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2012.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54220490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveles plasmáticos de interleucina-10 y óxido nítrico en respuesta a 2 tasas de flujo en anestesia con desflurano","authors":"Dilek Kalaycı ,&nbsp;Bayazit Dikmen ,&nbsp;Murat Kaçmaz ,&nbsp;Vildan Taşpınar ,&nbsp;Dilşen Örnek ,&nbsp;Özlem Turan","doi":"10.1016/j.bjanes.2013.06.009","DOIUrl":"10.1016/j.bjanes.2013.06.009","url":null,"abstract":"<div><h3>Objective</h3><p>this study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation.</p><p>Materials and methods forty patients between 18 and 70 years and ASA I–II physical status who were scheduled to undergo thyroidectomy were enrolled in the study.</p></div><div><h3>Interventions patients</h3><p>were allocated into two groups to receive two different desflurane anesthesia flow rates: high flow (Group HF) and low flow (Group LF).</p></div><div><h3>Measurements</h3><p>blood samples were drawn at the beginning (t0) and end (t1) of the operation and after 24 h (t2). Plasma interleukin-10 and nitric oxide levels were measured using an enzyme-linked-immunosorbent assay and a Griess reagents kit, respectively. Hemodynamic and respiratory parameters were assessed.</p></div><div><h3>Results</h3><p>there was no statistically significant difference between the two groups with regard to interleukin-10 levels at the times of measurement. Interleukin-10 levels were increased equally in both groups at times t1 and t2 compared with preoperative concentrations. For both groups, nitric oxide circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations. However, the nitric oxide value was lower for Group HF compared to Group LF at t2. No correlation was found between the IL-10 and nitric oxide levels.</p></div><div><h3>Conclusion</h3><p>clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations; however, at 24 h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels.</p></div>","PeriodicalId":100199,"journal":{"name":"Brazilian Journal of Anesthesiology (Edicion en Espanol)","volume":"64 4","pages":"Pages 292-298"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bjanes.2013.06.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54224634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}