Biomedical Technology最新文献_第7页

Sustaining the healthcare systems through the conceptual of biomedical engineering: A study with recent and future potentials 通过生物医学工程概念维持医疗保健系统:一项具有近期和未来潜力的研究

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.004

Mohd Javaid , Abid Haleem , Ravi Pratap Singh , Rajiv Suman

{"title":"Sustaining the healthcare systems through the conceptual of biomedical engineering: A study with recent and future potentials","authors":"Mohd Javaid , Abid Haleem , Ravi Pratap Singh , Rajiv Suman","doi":"10.1016/j.bmt.2022.11.004","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.004","url":null,"abstract":"<div><p>Biomedical engineering is an interdisciplinary branch of engineering & technology that combines biomedical sciences with engineering principles. This discipline covers broad areas where biomedical engineers are involved in the fields of medicine, regenerative medicine & associated areas and in developing better products and services. Biomedical engineering offers software for simulation, 3D motion-catching and printing technologies for computer modelling and engineering. The discipline of biomedical engineering is a fast-moving, cross-disciplinary field covering medicine, biology, chemistry, engineering, nanotechnology and informatics. Innovative medical gadgets, vaccinations, disease control products, robotics, and algorithms that enhance human health worldwide are being developed by bioengineers. Living tissues are formed of bioactive cells and stored in regulated circumstances on biodegradable scaffolds. The use of biomedical engineering concepts is to address issues with healthcare. Biomedical engineers create medical tools and procedures that enhance people's health by combining their understanding of engineering, virology, and healthcare. Blood glucose monitoring, pacemakers, and prosthetic limbs are examples of biomedical equipment. The main purpose of this paper is to study Biomedical Engineering and its need in healthcare. The paper discusses various innovations and research aspects of Biomedical Engineering in the healthcare domain. The paper further identified and discussed significant applications of Biomedical engineering for healthcare. Biomedical engineering is a fascinating field of life science that can change healthcare and open the door to new technologies in prostheses, operating equipment, diagnoses, imaging and more. The multidisciplinary area of biomedical technology provides better possibilities for biological research and engineering and changes how we interact with the world.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"1 ","pages":"Pages 39-47"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Screening and validation of prognostic indicator genes in the progression of HBV related hepatocellular carcinoma HBV相关肝细胞癌进展中预后指示基因的筛选和验证

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.10.002

Jinglin Wang , Senzhe Xia , Yuyan Chen , Xueqian Qin , Shujun Liu , Haozhen Ren

{"title":"Screening and validation of prognostic indicator genes in the progression of HBV related hepatocellular carcinoma","authors":"Jinglin Wang , Senzhe Xia , Yuyan Chen , Xueqian Qin , Shujun Liu , Haozhen Ren","doi":"10.1016/j.bmt.2022.10.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.10.002","url":null,"abstract":"<div><p>Hepatocellular carcinoma (HCC) is a rapidly progressing cancer and the main reason for cancer-related deaths. There are numerous risk factors for HCC, of which hepatitis B virus (HBV) infection is recognized as a high risk. HBV infection is accompanied by gene integration, and the liver has undergone the process of continuous and repeated damage and repair. However, predictive factors of HBV-related HCC are still limited, and the prognostic regulatory genes have not been fully elucidated. This study aims to use bioinformatics analysis to search potential prognostic genes of HBV-related HCC. Based on the full utilization of the GEO database, we screened out prognostic-related genes by performing systematic Kaplan-Meier survival analysis. The differences of the transcriptional information and protein expression were verified in the TCGA and HPA databases respectively, and the clinical characteristics of the screened genes were described by the boxplot. Five prognostic-related genes we screened, including CDK1, MAD2L1, SPP1, TYMS, and CCNA2, are strongly linked with poor prognosis in HBV-related HCC. The five prognostic-related genes have realistic clinical significance and potential as prognostic markers, and may provide new directions for basic research and clinical diagnosis.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"1 ","pages":"Pages 10-17"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Transplanted brain organoids become mature and intelligent 移植的脑类器官变得成熟和智能

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.006

Xiangyi Wu , Ye Xu , Guopu Chen , Qian Tan , Yujuan Zhu

引用次数: 0

Injectable hydrogel microspheres in cartilage repair 可注射水凝胶微球在软骨修复中的应用

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.002

Feng Lin, Yihan Li, Wenguo Cui

{"title":"Injectable hydrogel microspheres in cartilage repair","authors":"Feng Lin, Yihan Li, Wenguo Cui","doi":"10.1016/j.bmt.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.002","url":null,"abstract":"<div><p>The key to regenerative medicine is in situ regeneration of lesion cells, so as to achieve lesion repair and regeneration. However, the complex environment of the joint cavity where cartilage is located leads to poor efficacy of traditional therapies to promote cartilage repair and regeneration. Development of hydrogel microspheres offers an attractive solution for regenerative medicine aimed at cartilage repair to address these limitations. Hydrogel microspheres have the potential of injectable and multi-functional transformation, which can effectively regulate the pathophysiological changes of cells and extracellular matrix at the site of cartilage injury. This review summarizes the application of various functional modified hydrogel microspheres in cartilage repair and regeneration. The common techniques and biomaterials used to prepare hydrogel microspheres are first briefly introduced. In particular, the microfluidic technology is highlighted in detail. Besides, the construction strategies of hydrogel microspheres with different functions and their mechanisms to promote cartilage repair and regeneration are further presented. Finally, the problems and challenges of hydrogel microspheres for cartilage repair are summarized.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"1 ","pages":"Pages 18-29"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Bio-inspired adhesive hydrogel for wound healing 用于伤口愈合的仿生粘合剂水凝胶

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.009

Wenzhao Li , Yuandong Zheng , Weiran Pang , Puxiang Lai

{"title":"Bio-inspired adhesive hydrogel for wound healing","authors":"Wenzhao Li , Yuandong Zheng , Weiran Pang , Puxiang Lai","doi":"10.1016/j.bmt.2022.11.009","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.009","url":null,"abstract":"<div><p>Wound healing introduces a series of interesting challenges in healthcare, such as open wounds, burn wounds, and chronic infection wounds. Hence more accurate and effective biomedical materials are expected, for which emerging hydrogels with unique and excellent properties have demonstrated great potential. When they are applied as wound dressings, tissue patches, plugging agent, drug carriers, and biosensors, <em>etc</em>., there are urgent requirements for adhesive capabilities. The existence of interfacial water, soft tissue and moving surfaces, safety, and harmlessness, however, constitutes major constraints for medical adhesive hydrogels. In nature, organisms often adhere through unique structures or specific chemical components, which stimulates inspirations for medical hydrogels to overcome the above challenges. In this review, we will classify adhesive hydrogels into glue-like adhesives and tape-like patches according to their form. First, this review will introduce the principles and design ideas of biomedical adhesive hydrogels. Then, as biomedical materials, the applications and effects of their interactions with organisms through adhesion will be summarized. Finally, this review will summarize the achievements, challenges, and future development of bio-inspired adhesive hydrogel towards wound healing.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"1 ","pages":"Pages 65-72"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Microfluidics-derived microcarrier systems for oral delivery 口服给药用微流体衍生的微载体系统

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.001

Lijun Cai , Ning Li , Yong Zhang , Hongcheng Gu , Yujuan Zhu

引用次数: 8

Biomedical Technology Call for Papers 生物医学技术征文

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/S2949-723X(23)00024-7

引用次数: 0

Living probiotic biomaterials for osteoporosis therapy 用于骨质疏松症治疗的活菌生物材料

Biomedical Technology Pub Date : 2023-03-01 DOI: 10.1016/j.bmt.2022.11.007

Zhijie Chen , Zhengwei Cai , Pengzhen Zhuang , Fan Li , Wenguo Cui , Zhanchun Li

{"title":"Living probiotic biomaterials for osteoporosis therapy","authors":"Zhijie Chen , Zhengwei Cai , Pengzhen Zhuang , Fan Li , Wenguo Cui , Zhanchun Li","doi":"10.1016/j.bmt.2022.11.007","DOIUrl":"https://doi.org/10.1016/j.bmt.2022.11.007","url":null,"abstract":"<div><p>Osteoporosis (OP) is a chronic metabolic bone disease characterized by diminished bone mass, decreased bone strength, deterioration of bone microarchitecture, and increased bone fragility with fracture risk. The aging population has made OP a public health problem that has serious effects on individuals, families, and society as a whole. It is urgent that new strategies that are safe, effective, and inexpensive for the treatment of OP should be developed. Increasing evidence has suggested that the gut microbiota (GM) is inextricably linked to bone homeostasis through cross-talk between host and microbiota. During the development of OP, GM perturbations can initiate and reinforce the disruption of bone remodeling balance. In this review, we first review the current knowledge of how the GM affects bone metabolism, and conclude that GM changes bone metabolism and participates in the formation of OP by affecting intestinal barrier, host metabolites, immune system and endocrine system. Then, we discuss that probiotics are expected to be a potential oral therapeutic strategy for OP, but there are limitations. Furthermore, we discuss how bioactive functional materials for providing probiotics to the gut can be constructed based on the chemical barrier, biological barrier, immune barrier, and mechanical barrier in the gut. This review is anticipated to stimulate further innovative thinking focusing on the intestinal barrier as a key target for delivery of probiotics and treatment of OP.</p></div>","PeriodicalId":100180,"journal":{"name":"Biomedical Technology","volume":"1 ","pages":"Pages 52-64"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5