Animal Research and One Health最新文献

{"title":"Cattle Genomics: Aurochs Admixture in East Asia","authors":"James A. Ward, David E. MacHugh","doi":"10.1002/aro2.102","DOIUrl":"https://doi.org/10.1002/aro2.102","url":null,"abstract":"<p>The genetic origins and dispersal of domesticated cattle, in common with other livestock species, is getting increasingly complex the closer we look [<span>1, 2</span>]. This trend has accelerated over the last decade, particularly through comparative analyses of whole-genome sequence (WGS) data sets (paleogenomes) generated using ancient DNA (aDNA) from the extinct wild aurochs (<i>Bos primigenius</i>), the progenitor of modern cattle populations [<span>3-7</span>]. These and other high-resolution population genomics studies of domestic cattle have led to a reappraisal of simple models for understanding cattle genetic origins, domestication, and diversity, which developed from the first surveys of maternally inherited mitochondrial DNA (mtDNA) in modern and ancient cattle [<span>8-10</span>]. In a similar fashion to our more nuanced understanding of recent human evolution and the evidence for gene flow from archaic hominins [<span>11</span>], it is now clear that nuclear genomic introgression from wild aurochsen populations during the Holocene has had a significant impact on the ancestry of modern cattle breeds. The rich landscape of cattle genetic and phenotypic diversity across the globe does not derive solely from the small number of domestication centres in Southwest Asia that gave rise to modern humpless taurine (<i>Bos taurus</i>), humped indicine (<i>Bos indicus</i>), and <i>B</i>. <i>taurus</i> × <i>B</i>. <i>indicus</i> hybrid populations.</p><p>Recently published work from Jiawen Hou and her colleagues provides important new insights into the biogeography of <i>B</i>. <i>primigenius</i> and adds to the growing body of evidence for aurochs admixture in East Asian cattle [<span>12</span>]. Bovine archeological material representing 59 specimens collected from the Songnen Plain in Northeast China and from the Qinghai–Tibet Plateau (QTP), was used to generate paleogenomic data for 16 different aurochsen, which were radiocarbon dated to between 3.7 and 37.0 kya (thousand years ago). These data sets were integrated with previously published paleogenomes from 74 ancient wild and domestic cattle [<span>6, 7, 13</span>] plus WGS data from almost 200 modern cattle (taurine, indicine, and hybrid) and related species. Mitochondrial genomic diversity and phylogeography was also examined using more than 200 mitogenomes from ancient and modern cattle and several outgroup species.</p><p>Comparative phylogenetic analysis of the East Asian aurochs mitogenomes revealed that the mtDNA haplotypes possessed by all 16 Songnen Plain and QTP aurochsen are representative of the “C” haplogroup, which is an outgroup (with the K haplogroup) to all non-indicine <i>B</i>. <i>primigenius</i> haplogroups (P, Q, R, and T), splitting from these other mtDNA lineages approximately 150 kya. Hou et al. propose that this observation, coupled with a comparable nuclear genomic divergence, provides support for the taxonomic classification of the East Asian aurochs as a subsp","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 3","pages":"341-343"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haemato-biochemistry, erythromorphology, and histopathology of Oreochromis niloticus as influenced by Aeromonas hydrophila infection and florfenicol therapy","authors":"Joshi Sharon,&nbsp;Thangapalam Jawahar Abraham,&nbsp;Arya Sen,&nbsp;Ratnapriya Das,&nbsp;Priyanka Sinha,&nbsp;Satyanarayana Boda,&nbsp;Prasanna Kumar Patil","doi":"10.1002/aro2.100","DOIUrl":"https://doi.org/10.1002/aro2.100","url":null,"abstract":"<p><i>Aeromonas hydrophila</i> infection is one of the key factors limiting tilapia production, and antibiotics play important roles in the control of diseases. This study evaluated the effectiveness of florfenicol (FFC) when administered orally at the therapeutic dose of 15 mg/kg fish biomass/day for 10 days against <i>A. hydrophila</i> infection in <i>Oreochromis niloticus</i> in terms of survival, changes in haemato-biochemistry, erythrocyte morphology, and histoarchitecture of the vital organs. <i>A. hydrophila</i> was moderately virulent to tilapia with an LD₅₀ of 1.15 × 10⁷ cells/fish. When challenged, it caused systemic infection in fish. The challenged fish were lethargic, wandered around the corners, rested at the bottom, swam vertically, and darkly pigmented. The FFC therapy effectively reduced bacteria-induced mortalities and physiological stress as the measured haemato-biochemical parameters indicated. The histopathological findings suggested alterations in tissue architecture of the kidney and liver tissues, which improved in the treated fish. Erythrocytes of the challenged fish showed elongated, irregular-shaped, tear-drop-shaped, crenated, and hypochromic erythrocytes, ragged cytoplasmic membranes, vacuolation, hypertrophied nucleus, and eccentric nucleus. These morphological alterations were reduced with FFC therapy. Compared to the untreated group, the FFC treatment normalized the haemato-biochemical parameters, improved wound healing, and promoted fish recovery against bacterial infections. The results hinted at the effectiveness of FFC against <i>A. hydrophila</i> infection in <i>O. niloticus</i> juveniles at the therapeutic dose. However, care must be taken for its judicious aquacultural application to avoid its negative impacts on fish, the environment, and consumers.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 1","pages":"54-70"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single-cell multi-omics analysis","authors":"Fang Li,&nbsp;Minghao Li,&nbsp;Tongtong Zhang,&nbsp;Menghua Sui,&nbsp;Hasan Khatib,&nbsp;Xin Wang","doi":"10.1002/aro2.99","DOIUrl":"https://doi.org/10.1002/aro2.99","url":null,"abstract":"<p>Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs. To identify cell-type-specific chromatin accessibility patterns in the developing HF, we integrated chromatin accessibility and transcriptome profiles at single-cell resolution during the murine HF induction stage. We applied unbiased analyses to identify seven major HF cell types and reclustered dermal (Der) and epithelium (Epi) subtypes to trace their cell fate specification. Our analysis showed that gene regulation in Der and Epi lineages is largely determined by <i>cis</i>-regulatory elements that direct gene expression in response to specific developmental cues. The chromatin accessibility of <i>Twist2</i>, <i>Enpp2</i>, <i>Dkk1,</i> and <i>Sox2</i> varied from fibroblasts (Fb) to pre-DC lineage, while that of <i>Edar</i>, <i>Lhx2,</i> and <i>Wnt10b</i> varied from Epi to Pc lineage. Cell-type-specific enrichment of transcription factor binding motifs implicated Twist2 and Nfatc4 as key regulators in Fb to pre-DC fate specification, and Fos, Bach1, and Klf1 in Epi to Pc niche fate specification. Additionally, alignment of cell-type-specific peaks to super-enhancer databases identified key regulatory elements in both lineages. We identified and validated the critical <i>cis</i>-regulatory elements in pre-DC and Pc fate specifications through embryonic dorsal skin culture in vitro, suggesting that these elements may regulate critical genes essential for HF induction. Overall, our results provide a foundation for a comprehensive analysis of gene regulatory programs that initiate HF development, offering insights into the molecular mechanism of HF morphogenesis and clinical treatments of alopecia by skin grafts.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 3","pages":"297-315"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.99","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRIB3 suppresses milk fatty acids metabolism by inhibiting p-AKT/PPARG signaling in goat mammary epithelial cells","authors":"Xinglong Gong,&nbsp;Tan Pan,&nbsp;Tiantian Xiong,&nbsp;Yifan Zhu,&nbsp;Juan J. Loor,&nbsp;Chengming Han,&nbsp;Yifan Li,&nbsp;Huan Lei,&nbsp;Jun Luo,&nbsp;Cong Li","doi":"10.1002/aro2.98","DOIUrl":"https://doi.org/10.1002/aro2.98","url":null,"abstract":"<p>Tribbles pseudokinase 3 (<i>TRIB3</i>) interacts with a variety of proteins and plays a key role in the regulation of glucose metabolism and glycolysis in nonruminants, but whether it has a specific role in goat mammary lipid metabolism has still been kept unknown. In this study, we observed that <i>TRIB3</i> is highly expressed in the mammary tissues of lactating dairy goats. Overexpressing <i>TRIB3</i> in goat mammary epithelial cells (GMECs) suppressed the mRNA expression of <i>GPAM</i>, <i>DGAT1</i>, and <i>PLIN1</i>, which are associated with the formation of triacylglycerol and lipid droplets (<i>p</i> &lt; 0.05). The fatty acid-sensitive transcription regulator <i>PPARG</i> was also downregulated. Interfering <i>TRIB3</i> had the opposite effect and decreased Akt phosphorylation. The <i>TRIB3</i> gene influenced fatty acid composition in GMECs, and its overexpression reduced the total concentration of intracellular triacylglycerol (<i>p</i> &lt; 0.01), this response was verified using BODIPY staining. Overall, these data indicated that <i>TRIB3</i> suppresses milk fatty acids metabolism through inhibiting p-AKT/PPARG signaling in GMECs.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 3","pages":"268-277"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.98","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plants, plant-derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review","authors":"Pan Chen,&nbsp;Kaili Liu,&nbsp;Taojing Yue,&nbsp;Yanan Lu,&nbsp;Senyang Li,&nbsp;Fuchun Jian,&nbsp;Shucheng Huang","doi":"10.1002/aro2.96","DOIUrl":"https://doi.org/10.1002/aro2.96","url":null,"abstract":"<p>The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment. Therefore, normal intestinal structure and function are essential for animal health. Poultry coccidiosis is an intestinal disease primarily caused by the parasitization of intestinal epithelial cells by protozoa of the genus <i>Eimeria</i>. The occurrence of coccidiosis not only compromises the intestinal integrity of poultry but also increases their disease susceptibility, thus posing a serious threat to the overall health and productivity of poultry. Nowadays, the primary methods for controlling and preventing coccidiosis in poultry are anticoccidial drugs or live oocyst vaccines. However, the use of the former may be associated with problems of resistance and drug residues, while the use of the latter may cause intestinal damage and significantly increase farming costs. For these reasons, it is critical to investigate green, safe, and cost-effective natural alternative strategies such as phytochemicals and probiotics for controlling coccidiosis as well as mitigating the deleterious effects of coccidial infections in production. In this review, we aim to summarize the role, mechanisms, and therapeutic potential of natural products in the treatment of coccidiosis to lay a theoretical foundation for effective coccidiosis control.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 3","pages":"240-260"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.96","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The E-volution in swine nutrition: Current perspectives on vitamin E","authors":"Yauheni Shastak,&nbsp;Wolf Pelletier","doi":"10.1002/aro2.93","DOIUrl":"https://doi.org/10.1002/aro2.93","url":null,"abstract":"<p>This review provides an in-depth analysis of vitamin E's multifaceted role in swine nutrition, incorporating both traditional insights and contemporary research. It begins with an exploration of vitamin E from an evolutionary perspective, followed by a detailed examination of its absorption, metabolism, and excretion in swine. The review emphasizes the micronutrient's critical functions in swine physiology, particularly its antioxidant properties and its emerging links to epigenetics, which include deoxyribonucleic acid methylation, histone modification, and noncoding ribonucleic acid regulation. The interactions of vitamin E with other dietary components are discussed, along with established nutritional requirements and current recommendations for supplementation. Additionally, the health benefits and performance improvements associated with vitamin E are presented, emphasizing its importance in immune function, growth, and meat quality. Despite extensive research, the review identifies gaps in understanding the bioavailability and long-term impacts of different vitamin E isoforms and supra-nutritional supplementation levels. It concludes with a discussion of research gaps and future directions, particularly the need for studies on the long-term effects of high-dose vitamin E supplementation and the influence of environmental factors on its metabolism. Through this comprehensive synthesis, this study aims to provide a holistic understanding of vitamin E's essential contributions to swine health and nutrition, with the goal of informing better dietary practices and enhancing swine productivity.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 1","pages":"2-30"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.93","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of terracotta drinker and/or water addition of ASPRO-C plus on behavior, growth, and physiological response of broiler chickens exposed to high temperature","authors":"Tadondjou Tchingo Cyrille d’Alex,&nbsp;Edmond Gilhoube,&nbsp;Denis Djaomanwe,&nbsp;Narcisse Ledang,&nbsp;Roger Ponka,&nbsp;Ferdinand Ngoula,&nbsp;Alexis Teguia","doi":"10.1002/aro2.94","DOIUrl":"https://doi.org/10.1002/aro2.94","url":null,"abstract":"<p>This study aimed to evaluate the effects of a terracotta drinker and/or water supplementation with ASPRO-C Plus on the zootechnical performance of broiler chickens reared in a hot environment. A total of 160 Cobb 500 broiler chicks of 15 days old (240.2 ± 39.82 g) were divided into four treatment groups in a 2 x 2 factorial arrangement of drinker type (plastic or terracotta) and water with or without ASPRO-C Plus (1 g/L) supplementation, each consisting of 4 replicate pens. Respiratory rate, water intake, feed intake, and live body weight were recorded weekly. At 49 days old, 12 birds per group were randomly selected, fasted for 12 h, weighed, and slaughtered for carcass evaluation and blood collection. The respiration rate of broilers decreased significantly (<i>p</i> &lt; 0.01) with the terracotta drinker as compared to the plastic drinker. The water intake, the feed intake and the body weight gain increased significantly (<i>p</i> &lt; 0.01) with the terracotta drinker as compared to the plastic drinker. The water addition of ASPRO-C Plus significantly increased (<i>p</i> &lt; 0.01) the relative weight of abdominal fat and spleen in broilers. The alpha-amylase activity was significantly decreased (<i>p</i> &lt; 0.01) with the water addition of ASPRO-C Plus. The serum content of total cholesterol was significantly increased (<i>p</i> &lt; 0.01) with the terracotta drinker. It can be concluded that ASPRO-C Plus can slightly improve liveability, but using the terracotta drinker can be more efficient in reducing the behavioral response to heat stress and can improve the growth performance.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 2","pages":"206-216"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.94","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal biotech breeding and reproduction: A new engine for high-quality development of animal husbandry","authors":"Yong Zhang,&nbsp;Jun Liu","doi":"10.1002/aro2.84","DOIUrl":"https://doi.org/10.1002/aro2.84","url":null,"abstract":"&lt;p&gt;Animal-based products, such as meat, eggs, milk, and their by-products, serve as the predominant protein sources for humans and are vital for supporting physiological functions. Animal proteins align more closely with our nutritional requirements compared to plant-based proteins. With the ever-growing global population, the demand for these fundamental food sources is increasing. Globally, about 97.64 million tons of livestock products, including meat, eggs, and milk, are consumed annually, accounting for nearly 48% of all feed grain usage. Nevertheless, the livestock industry imposes a substantial environmental footprint, contributing to 57% of the total CO&lt;sub&gt;2&lt;/sub&gt; emissions from food production. Amidst escalating resource limitations and evolving geopolitical dynamics, the security of our livestock food supply is in threat. To address these challenges, the livestock sector must prioritize high-quality growth through innovative scientific and technological breakthroughs.&lt;/p&gt;&lt;p&gt;Exceptional livestock and poultry breeds contribute over 40% to the advancement of the livestock industry and are instrumental in enhancing its productivity. The integration of biotechnology, information technology, and artificial intelligence is driving animal breeding into a more efficient and precise phase known as Animal Breeding 4.0. A new wave of high-efficiency breeding technologies, exemplified by genomic selection (GS), gene editing, and in vitro embryo production accelerates targeted animal breeding significantly by enhancing breeding efficiency and reducing the breeding cycle time. GS has been widely adopted for cattle, pig, and sheep breeding, cutting breeding costs by 90% and boosting the genetic progress of critical traits by 50%. The industrialization of genetically modified animals is gaining momentum and promises to offer competitive advantages over conventional breeding methods. Currently, several types of gene-edited animals have passed safety evaluations, including GalSafe, a gene-knockout pig approved by the U.S. FDA in 2020, gene-edited heat stress-resistant beef cattle approved by the U.S. FDA in 2022, and gene-edited tiger puffer-fish and red snapper approved by the Japanese Ministry of Health, Labor, and Welfare in 2021. With the progression of multi-omics technology, key trait-related functional genes in livestock and poultry are continually being uncovered. The application of novel biological breeding techniques is anticipated to generate more diverse livestock and poultry varieties with high-yield, high-quality, disease-resistant, and environmentally friendly phenotypes.&lt;/p&gt;&lt;p&gt;This special issue, entitled &lt;i&gt;Animal Biotech Breeding and Reproduction&lt;/i&gt;, is designed to facilitate academic dialog in this special domain, fostering the convergence of significant insights, breakthroughs, technological advancements, and industrial growth in the areas of molecular breeding and reproduction. The scope is to accelerate the pace of scientific and t","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"2 4","pages":"354-355"},"PeriodicalIF":0.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.84","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in synergistic fermentation of probiotics and enzymes for non-grain feed raw materials","authors":"Xiangrong Deng,&nbsp;Kai Chen,&nbsp;Dahai Jiang,&nbsp;Liming Lu","doi":"10.1002/aro2.90","DOIUrl":"https://doi.org/10.1002/aro2.90","url":null,"abstract":"<p>To address the escalating challenge of food scarcity and the associated conflicts between human and animal consumption, it is imperative to seek alternative resources that can substitute for traditional feed. Non-grain feed (NGF) raw materials represent a category of biomass resources that are distinct from grains in their composition. These materials are characterized by their high nutritional content, cost-effectiveness, ample availability, and consistent supply, which contribute to their significant economic potential. Nonetheless, the extensive application of NGF is currently hindered by several limitations, including a high concentration of antinutritional factors, suboptimal palatability, and an offensive odor, among other shortcomings. The synergistic fermentation of probiotics and enzymes (SFPE) is an innovative approach that integrates the use of a diverse array of enzymes during the feed fermentation process, as well as various strains of probiotics throughout the feed digestion process. This method aims to enhance the nutritional value of the feed, diminish the presence of antinutritional factors, and improve the overall palatability, thereby facilitating the optimal utilization of NGF. This strategy holds the promise of not only replacing conventional feed options but also mitigating the pressing issue of grain scarcity. This paper delves into the practical applications of NGF and presents an overview of the latest research advancements in SFPE fermentation techniques, which can provide cutting-edge and valuable reference for researchers who devote themselves to research in this field in the future.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"3 1","pages":"31-42"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.90","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Duck 1000 Genomes Project: Achievements and perspectives","authors":"Wenlei Fan,&nbsp;Shuisheng Hou,&nbsp;Zhengkui Zhou","doi":"10.1002/aro2.89","DOIUrl":"https://doi.org/10.1002/aro2.89","url":null,"abstract":"<p>The duck (<i>Anas platyrhynchos</i>) is not only a vital farm animal but also an excellent model for genetic dissection of economic traits. The integration of multiomics data provides a powerful approach to elucidate the genetic basis of domestication and phenotype variation. Since its inception in 2014, the Duck 1000 Genomes Project has aimed to uncover the genetic foundation of key economic traits in ducks by combining multiomics data including genomic, transcriptomic, and metabolomic from various natural and segregating populations. This paper summarizes the strategies and achievements of the Duck 1000 Genomes Project, highlighting the reference genome assembly, genome evolution analysis, and the identification of genes and causative mutations responsible for key economic traits in ducks. We also discuss perspectives and potential challenges in functional genomic studies that could further accelerate duck molecular breeding.</p>","PeriodicalId":100086,"journal":{"name":"Animal Research and One Health","volume":"2 4","pages":"366-376"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aro2.89","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}