Alvaro Andrés Montenegro Apraez , Marcela Rivera Portilla , Alejandro Bejarano Zuleta , Eduardo Echeverry , Juan Pablo Garaicoa Garzon
{"title":"Manejo rápido y escalonado en la tormenta arrítmica: reporte de un caso","authors":"Alvaro Andrés Montenegro Apraez , Marcela Rivera Portilla , Alejandro Bejarano Zuleta , Eduardo Echeverry , Juan Pablo Garaicoa Garzon","doi":"10.1016/j.acci.2024.04.001","DOIUrl":"10.1016/j.acci.2024.04.001","url":null,"abstract":"<div><div>Arrhythmic storm is usually defined as the presentation of 3 or more episodes of ventricular arrhythmias within 24<!--> <!-->hours. It is widely accepted that this entity is a medical emergency due to the potential for adverse events such as death in up to 54% of cases, probably because the reduction in cardiac chamber filling time significantly reduces cardiac output, leading to cardiogenic shock, multiple organ failure, and death.</div><div>The present case describes a patient with arrhythmic storm secondary to viral myocarditis, due to the recurrence of arrhythmic events despite initial management with antiarrhythmic drugs required a stepwise therapeutic approach guided by a multidisciplinary team and early use of extracorporeal membrane oxygenation (ECMO), which allowed maintaining adequate systemic perfusion while implementing therapeutic measures to control arrhythmic events; The patient was discharged early at 14 days, with no recurrence of arrhythmic events. At 6 months outpatient follow-up, the patient did not require cardiac transplantation, with no recurrence of arrhythmic events, with adequate NYHA functional class I and no left ventricular systolic dysfunction; clinical outcomes are attributed to timely decision making, guided by a multidisciplinary team and early use of early mechanical circulatory support, preventing hypoperfusion, multiple organ failure, and death.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 432-436"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Presión inspiratoria máxima y presión espiratoria máxima en pacientes de 2 unidades de Cuidados Intensivos en Antioquia, Colombia","authors":"Mónica Alejandra Mondragón Barrera, Natalia Tabares Echeverri, Susana María Álvarez Montoya, Nicolás Eugenio Gómez Suárez","doi":"10.1016/j.acci.2024.07.001","DOIUrl":"10.1016/j.acci.2024.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Muscle weakness is a common problem in the Intensive Care Unit (ICU), which becomes more critical when it affects the respiratory muscles, as they are essential for maintaining proper ventilation. To assess respiratory muscle strength, measurements of Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP) are used, with values related to age, sex, anthropometric measures (height, weight, body mass index), presence of diseases, their chronicity, functionality, among various aspects. In Colombia, the results of measurements in a healthy population differ from those found in North America and European countries, suggesting that there may also be differences in populations with morbidity, such as in the intensive care setting.</div></div><div><h3>Objective</h3><div>To describe MIP and MEP values based on some sociodemographic, anthropometric, functional, and clinical characteristics in patients from 2<!--> <!-->ICUs in Antioquia, Colombia.</div></div><div><h3>Methods</h3><div>Observational, descriptive study with an analytical intention, cross-sectional design. MIP and MEP were measured, and sociodemographic, anthropometric, functional, clinical, and smoking habit variables were obtained in patients from 2<!--> <!-->ICUs in Antioquia.</div></div><div><h3>Results</h3><div>43 people participated, with most showing muscle weakness compared to the normal limit value. Correlation was found between MIP/MEP and age, sex, height, smoking habit, underlying respiratory disease, having received mechanical ventilation, and handgrip strength weakness.</div></div><div><h3>Conclusions</h3><div>Values in the studied population allow for a more objective functional assessment and individualized approach.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 360-369"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ronald Medina , Daniel Molano , Andrés Villa , Cristian Duran , Víctor Gerardino , Said Sánchez
{"title":"Síndrome de distrés respiratorio agudo por Plasmodium vivax con coinfección de tuberculosis pulmonar en época de pandemia por covid-19. Reporte de caso","authors":"Ronald Medina , Daniel Molano , Andrés Villa , Cristian Duran , Víctor Gerardino , Said Sánchez","doi":"10.1016/j.acci.2024.05.004","DOIUrl":"10.1016/j.acci.2024.05.004","url":null,"abstract":"<div><div>Adult respiratory distress syndrome is a common cause of admission to the intensive care unit, which has been related to high morbidity, mortality and costs. Malaria is a disease mainly caused by <em>Plasmodium falciparum</em> infection and occasionally by <em>Plasmodium vivax</em>. We report the case of a 53-year-old patient who presents with acute respiratory distress syndrome due to <em>Plasmodium vivax</em> and coinfection with Mycobacterium tuberculosis. The diagnosis was made by microbiological and molecular studies respectively. From a clinical perspective, this case represents a diagnostic challenge since it occurs during the SARS CoV-2/covid-19 virus pandemic, being this the main an etiology of adult respiratory distress syndrome during the period of time when our case presented, leaving the microorganisms described in our patient to the minority of causes of adult respiratory distress syndrome.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 451-459"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felipe Hernández Silvano, Edgar Bravo Santibañez, Carlos Jiménez Correa, Luis Pedro González Carrillo
{"title":"Correlación del índice resistivo renal y presión de perfusión renal con la severidad de la lesión renal aguda","authors":"Felipe Hernández Silvano, Edgar Bravo Santibañez, Carlos Jiménez Correa, Luis Pedro González Carrillo","doi":"10.1016/j.acci.2024.04.002","DOIUrl":"10.1016/j.acci.2024.04.002","url":null,"abstract":"<div><h3>Background</h3><div>Acute kidney injury is a frequent complication in the intensive care unit (ICU) leading to prolonged stay and increased mortality; severity staging requires markers such as creatinine which is late and with multiple factors that bias its measurement and interpretation. Renal ultrasound has increased its use, mainly the resistive index, in addition, the evaluation of renal perfusion in post-surgical patients has been described, however, its relationship with severity in acute kidney injury has not been demonstrated.</div></div><div><h3>Objective</h3><div>To establish the correlation of the resistive index and renal perfusion pressure with the severity of acute kidney injury in the Intensive Care Unit.</div></div><div><h3>Material and methods</h3><div>Cross-sectional study in the Intensive Care Unit; patients with acute kidney injury were included and severity was staged according to KDIGO criteria, and renal vascular ultrasonographic measurements were obtained. Statistical analysis was with Kendal's Tau-b test and linear regression analysis.</div></div><div><h3>Results</h3><div>Final population of 81 patients, the variable that correlated with severity was renal perfusion pressure (r<!--> <!-->=<!--> <!-->0.62, p<!--> <!-->≤<!--> <!-->0.001) and diastolic velocity (r<!--> <!-->=<!--> <!-->0.30, p<!--> <!-->=<!--> <!-->0.007), however, the resistive index had no correlation (r<!--> <!-->=<!--> <!-->0.135, p<!--> <!-->=<!--> <!-->0.314). Similarly, renal perfusion pressure correlated with changes in creatinine (r<!--> <!-->=<!--> <!-->−0.554), BUN (r<!--> <!-->=<!--> <!-->−0.480) and bicarbonate (r<!--> <!-->=<!--> <!-->0.331).</div></div><div><h3>Conclusion</h3><div>No statistically significant results were found in relation to the resistive index, however, we found that the decrease in renal perfusion pressure correlates with greater severity of acute kidney injury in the intensive care unit.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 337-343"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Diego Galindo Dávila , Derly Mileidy Gomez Sandoval , Iván José Ardila Gómez , Doris Martha Salgado García
{"title":"Ecografía en dengue: 10 hallazgos claves","authors":"Juan Diego Galindo Dávila , Derly Mileidy Gomez Sandoval , Iván José Ardila Gómez , Doris Martha Salgado García","doi":"10.1016/j.acci.2024.05.011","DOIUrl":"10.1016/j.acci.2024.05.011","url":null,"abstract":"<div><div>Dengue virus infection is a public health problem, especially in tropical and subtropical countries like Colombia. Vascular leakage is the central component in the pathophysiology of severe dengue and can be assessed through ultrasound. As a non-invasive method, it can be used as a tool for both diagnosis and clinical stratification, providing timely management and avoiding complications. The aim of this review is to describe key ultrasonographic points in patients with dengue exhibiting warning signs and severe dengue, with a focus on the application of the Point-of-Care Ultrasound (POCUS) strategy. Among the most common findings reported in the literature for dengue patients are thickening of the vesicular wall, pleural effusion, ascites, and pericardial effusion. The integration of POCUS training into routine clinical practice for dengue has the potential to reduce both mortality rates and healthcare costs.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 404-412"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141717085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga Helena Hernández Ortiz , Andrés Felipe Naranjo Ramírez , Andrea Sierra Ramírez , Mariana Restrepo Arias , Natalia Betancourt Rodriguez , Francisco José Molina Saldarriaga , Fabian A. Jaimes B. , Jorge E. Osorio , Juan Pablo Hernández Ortiz
{"title":"Post-COVID-19 syndrome: When an acute infection causes a chronic illness","authors":"Olga Helena Hernández Ortiz , Andrés Felipe Naranjo Ramírez , Andrea Sierra Ramírez , Mariana Restrepo Arias , Natalia Betancourt Rodriguez , Francisco José Molina Saldarriaga , Fabian A. Jaimes B. , Jorge E. Osorio , Juan Pablo Hernández Ortiz","doi":"10.1016/j.acci.2024.05.001","DOIUrl":"10.1016/j.acci.2024.05.001","url":null,"abstract":"<div><div>We are currently contending with a significant consequence of the SARS-CoV-2 virus pandemic, termed post-COVID syndrome, which has escalated into another global crisis. Conservative estimates suggest that at least 76 million individuals worldwide are grappling with this condition, based on a projected 10% incidence rate among those previously infected. Daily, the tally of cases associated with this syndrome continues to mount. The emergence of long COVID has spurred intensified research endeavors, yet the current volume of ongoing studies falls short, and patient prognosis remains largely unchanged. Consequently, there is an urgent need for enhanced research methodologies to tackle this emerging condition effectively and to mount a robust response to the crisis. Management of post-COVID syndrome primarily revolves around symptomatic relief and rehabilitation strategies aimed at ameliorating the most prevalent symptoms that profoundly impact patients’ quality of life, such as fatigue, dyspnea, and loss of taste and smell. Despite sustained investigative efforts, specific treatments, including steroid therapies, have thus far failed to yield clinically significant outcomes. In this review, we delve into the multifaceted nature of post-COVID syndrome, exploring its impact, current management strategies, and the imperative for advancing research to better understand and address this pressing global health challenge.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 387-397"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Rebolledo Maldonado , Ricardo Luis Romero Figueroa , Evasandrid Romero Jiménez , Iván Alberto Salas Pinzón , Claudia Pacheco Escorcia , Jorge Salazar Amaris
{"title":"Paciente joven con angina de Ludwig, mediastinitis necrosante descendente y shock séptico en relación con absceso odontogénico. Reporte de caso en Colombia","authors":"Carlos Rebolledo Maldonado , Ricardo Luis Romero Figueroa , Evasandrid Romero Jiménez , Iván Alberto Salas Pinzón , Claudia Pacheco Escorcia , Jorge Salazar Amaris","doi":"10.1016/j.acci.2024.05.012","DOIUrl":"10.1016/j.acci.2024.05.012","url":null,"abstract":"<div><div>Mediastinitis is a potentially fatal infection, and due to its low incidence, little epidemiological information is available. Complicated odontogenic infections, such as Ludwig's angina, are a rare cause of descending necrotizing mediastinitis but cause 90% of necrotizing infections. We present the case of a 34-year-old male patient with periodontal disease who develops Ludwig's angina. He progresses to descending necrotizing mediastinitis and septic shock, requiring emergency surgical management, ICU stay, invasive mechanical ventilation and broad-spectrum antibiotic management, with multiple complications associated with mediastinal involvement. Key aspects of the case such as epidemiology, physiopathology, diagnosis, and treatment of descending necrotizing mediastinitis secondary to odontogenic infections are analyzed. Ludwig's angina with descending necrotizing mediastinitis is a serious but preventable complication of this type of infections. Its management requires a timely multidisciplinary approach to reduce morbidity and mortality.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 460-465"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utilidad del PCR múltiplex de hemocultivo para el diagnóstico microbiológico de infecciones nosocomiales del sistema nervioso central en pacientes críticos","authors":"Sofía Mauro , Federico Verga , Antonio Galiana , Mariela Vieytes , Marcelo Barbato","doi":"10.1016/j.acci.2024.08.002","DOIUrl":"10.1016/j.acci.2024.08.002","url":null,"abstract":"<div><h3>Background and objective</h3><div>To determine the usefulness of a molecular biology technique for nucleic acid amplification using real-time polymerase chain reaction (PCR) originally designed for microbiological diagnosis in blood cultures, when applied to cerebrospinal fluid (CSF) samples.</div></div><div><h3>Materials and methods</h3><div>Retrospective, observational, single-center study, carried out between January 2017 and February 2024 in a 28-bed multipurpose critical care unit. All patients with suspected postneurosurgical infection and CSF cytochemical alterations were included. In addition to the microbiological study of the CSF by traditional methods, the BioFire® Blood Culture Identification<!--> <!-->2 (BCID) panel was applied directly to CSF samples. Traditional culture methods were considered as the reference standard for microbiological identification. The main variable of interest was the percentage of concordance of microbial identification between traditional cultures and BCID.</div></div><div><h3>Results</h3><div>29 patients were included. The diagnosis of central nervous system infection was confirmed in 14 cases (48.2%), 7 post-neurosurgical meningitis, 6 infections associated with ventriculostomy and 1<!--> <!-->subdural empyema. The most frequently found microorganisms were <em>Acinetobacter baumannii</em> and <em>Klebsiella pneumoniae</em>. No discordances were found between PCR and cultures, so both the positive (14/14) and negative identification concordance (15/15) were 100% between both methods.</div></div><div><h3>Conclusions</h3><div>In patients with suspected post-neurosurgical infection and compatible CSF alterations, multiplex PCR blood cultures applied directly to CSF samples could be considered a useful and accurate tool for rapid microbiological diagnosis in infections of the central nervous system.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 379-386"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142659188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yordanys Paez Candelaria , Lázaro Ibrahim Romero García , Karima Maricel Gondres Legró , Pedro Alexei Bacardí Zapata
{"title":"Desnutrición carencial al ingreso en pacientes intervenidos quirúrgicamente sobre el tubo digestivo","authors":"Yordanys Paez Candelaria , Lázaro Ibrahim Romero García , Karima Maricel Gondres Legró , Pedro Alexei Bacardí Zapata","doi":"10.1016/j.acci.2024.03.002","DOIUrl":"10.1016/j.acci.2024.03.002","url":null,"abstract":"<div><h3>Objectives</h3><div>To characterize the population of critically ill patients, surgically operated on digestive tract, according to selected epidemiological, clinical and nutritional variables, as well as to determine the predictive load of the nutritional status on admission on unfavorable clinical evolution.</div></div><div><h3>Design</h3><div>Frame of reference and patients: An applied, explanatory, analytical cohort research was carried out from January 2023 to December 2023 in critically ill patients surgically operated on digestive tract, who were admitted to the Intensive and Intermediate Care Service of the “Saturnino Lora” Provincial Hospital in Santiago de Cuba.</div></div><div><h3>Measurements</h3><div>A nutritional profile was carried out, which included anthropometric, biochemical, and immunological indicators, which allowed the classification of the patients as malnourished and nourished.</div></div><div><h3>Results</h3><div>There was a predominance of males (51.85%), albumin was altered in 35.15% and 32.99% at admission and discharge, respectively. Acute hemorrhagic abdomen accounted for 39.51% of the total. Malnutrition was 44.44% at admission and 59.25% at discharge. The logistic regression model estimated that malnutrition at the patient's admission is a significant causal factor (p<!--> <!-->=<!--> <!-->0.000) of unfavorable evolution in the population of patients exposed to this risk [OR<!--> <!-->=<!--> <!-->6.95; I.C 95%: 2,55; 18,91]</div></div><div><h3>Conclusions</h3><div>Deficiency malnutrition on admission has a high incidence in patients surgically operated on digestive tract in the intensive care unit, who have a high probability of suffering complications during their stay, evolving unfavorably during the postoperative period.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 330-336"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deivi Barrios Andradez , Edgardo Gonzalez Puche , Rafael Orozco Marun , Johana Criado Urzola , Daniela Páez Jiménez
{"title":"Parálisis hipopotasémica familiar: reporte de caso","authors":"Deivi Barrios Andradez , Edgardo Gonzalez Puche , Rafael Orozco Marun , Johana Criado Urzola , Daniela Páez Jiménez","doi":"10.1016/j.acci.2024.03.004","DOIUrl":"10.1016/j.acci.2024.03.004","url":null,"abstract":"<div><div>Familial hypokalemic paralysis is a rare muscular channelopathy, predominantly in males, characterized by generalized muscle weakness associated with hypokalemia, with complete recovery of symptoms after normalization of serum potassium levels; The main triggers are cessation of effort after strenuous exercise and carbohydrate-rich dinners. Below we present the case of a male adolescent with a family history of a similar condition, who after high carbohydrate intake presents with the first episode of acute muscle weakness associated with severe hypokalemia, whose symptoms resolve with the correction of the electrolyte disorder, thus meeting the criteria. Diagnoses of familial hypokalemic paralysis. The main lesson that this case leaves us is that although it is a rare disease, its suspected diagnosis should be included in a patient with muscle weakness.</div></div>","PeriodicalId":100016,"journal":{"name":"Acta Colombiana de Cuidado Intensivo","volume":"24 4","pages":"Pages 428-431"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}