Child's Nervous System最新文献

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A novel trans-occipital catheter placement guide for ventriculoperitoneal shunts. 用于脑室腹腔分流的新型经枕导管置入指南。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-03 DOI: 10.1007/s00381-024-06526-1
Hongbin Cao
{"title":"A novel trans-occipital catheter placement guide for ventriculoperitoneal shunts.","authors":"Hongbin Cao","doi":"10.1007/s00381-024-06526-1","DOIUrl":"10.1007/s00381-024-06526-1","url":null,"abstract":"<p><p>We have designed a novel device that facilitates the accurate placement of occipital ventricular catheters in ventriculoperitoneal shunt procedures. After 7 years of clinical use, this device has consistently demonstrated its simplicity, user-friendliness, and effectiveness. It enables both experienced surgeons and novices to confidently and accurately position the ventricular catheter to a satisfactory location.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3811-3812"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strength in silence: the journey of mothers raising children with hydrocephalus. 沉默中的力量:母亲抚养脑积水患儿的历程。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-09 DOI: 10.1007/s00381-024-06530-5
Eesha Yaqoob, Asma Ahmed, Beenish Qazi, Dua Abbas Zaidi, Shahzad Ali Khan, Bipin Chaurasia, Saad Javed
{"title":"Strength in silence: the journey of mothers raising children with hydrocephalus.","authors":"Eesha Yaqoob, Asma Ahmed, Beenish Qazi, Dua Abbas Zaidi, Shahzad Ali Khan, Bipin Chaurasia, Saad Javed","doi":"10.1007/s00381-024-06530-5","DOIUrl":"10.1007/s00381-024-06530-5","url":null,"abstract":"<p><strong>Background: </strong>Raising a child with hydrocephalus can be very challenging, especially in low- and middle-income countries. In Pakistan, mothers being the primary caregivers for their hydrocephalic children are under tremendous stress.</p><p><strong>Methods: </strong>This study explores the challenges faced by Pakistani mothers raising children with hydrocephalus, employing a qualitative methodology through focus group discussions comprising ten mothers of hydrocephalic babies at Tertiary Care Hospital in Pakistan.</p><p><strong>Results: </strong>The findings highlight three main themes: emotional toll, social isolation, and financial strain. Mothers experience significant emotional stress due to societal stigma and a lack of support, particularly from their husbands and family. Social isolation is prevalent, as mothers fear sharing their burdens and face physical confinement due to their children's needs. Financial strain is another major issue, with high medical costs adding to their economic difficulties.</p><p><strong>Conclusion: </strong>The study emphasizes improved access to specialized care, awareness campaigns to reduce stigma, financial assistance, and stronger community support networks to support these mothers better. Addressing these unmet needs is crucial for empowering Pakistani mothers in their caregiving roles and improving the quality of life for their children with hydrocephalus.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3601-3607"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mystery of the Muenke midface: spheno-occipital synchondrosis fusion and craniofacial skeletal patterns. 穆恩科中面之谜:脊枕骨突融合与颅面骨骼模式。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI: 10.1007/s00381-024-06518-1
Meagan Wu, Arastoo Vossough, Benjamin B Massenburg, Dominic J Romeo, Jinggang J Ng, Joseph A Napoli, Jordan W Swanson, Scott P Bartlett, Jesse A Taylor
{"title":"Mystery of the Muenke midface: spheno-occipital synchondrosis fusion and craniofacial skeletal patterns.","authors":"Meagan Wu, Arastoo Vossough, Benjamin B Massenburg, Dominic J Romeo, Jinggang J Ng, Joseph A Napoli, Jordan W Swanson, Scott P Bartlett, Jesse A Taylor","doi":"10.1007/s00381-024-06518-1","DOIUrl":"10.1007/s00381-024-06518-1","url":null,"abstract":"<p><strong>Purpose: </strong>The spheno-occipital synchondrosis (SOS) is an important site of endochondral ossification in the cranial base that closes prematurely in Apert, Crouzon, and Pfeiffer syndromes, which contributes to varying degrees of midface hypoplasia. The facial dysmorphology of Muenke syndrome, in contrast, is less severe with low rates of midface hypoplasia. We thus evaluated the timing of SOS fusion and cephalometric landmarks in patients with Muenke syndrome compared to normal controls.</p><p><strong>Methods: </strong>Patients with Muenke syndrome who had at least one fine-cut head computed tomography scan performed from 2000 to 2020 were retrospectively reviewed. A case-control study was performed of patient scans and age- and sex-matched control scans. SOS fusion status was evaluated as open, partially closed, or closed.</p><p><strong>Results: </strong>We included 28 patients and compared 77 patient scans with 77 control scans. Kaplan-Meier analysis demonstrated an insignificantly earlier timeline of SOS fusion in Muenke syndrome (p = 0.300). Mean sella-orbitale (SO) distance was shorter (44.0 ± 6.6 vs. 47.7 ± 6.7 mm, p < 0.001) and mean sella-nasion-Frankfort horizontal (SN-FH) angle was greater (12.1° ± 3.8° vs. 10.1° ± 3.2°, p < 0.001) in the Muenke group, whereas mean sella-nasion-A point (SNA) angle was similar and normal (81.1° ± 5.7° vs. 81.4° ± 4.7°, p = 0.762).</p><p><strong>Conclusion: </strong>Muenke syndrome is characterized by mild and often absent midfacial hypoplasia, with the exception of slight retropositioning of the infraorbital rim. Interestingly, SOS fusion patterns in these patients are not significantly different from age- and sex-matched controls despite an increased odds of fusion. It is possible that differences in timing of SOS fusion may manifest phenotypically at the infraorbital rim rather than at the maxilla.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3683-3691"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the oversight medical cases in low-middle-income countries: poor mention of shaken baby syndrome in Nigeria; reasons, challenges, and recommendations. 处理中低收入国家的医疗疏忽病例:尼日利亚对婴儿摇晃综合征提及不足;原因、挑战和建议。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI: 10.1007/s00381-024-06624-0
Mubarak Jolayemi Mustapha, Caleb Kolawole Anuoluwapo, Bipin Chaurasia, Saad Javed
{"title":"Addressing the oversight medical cases in low-middle-income countries: poor mention of shaken baby syndrome in Nigeria; reasons, challenges, and recommendations.","authors":"Mubarak Jolayemi Mustapha, Caleb Kolawole Anuoluwapo, Bipin Chaurasia, Saad Javed","doi":"10.1007/s00381-024-06624-0","DOIUrl":"10.1007/s00381-024-06624-0","url":null,"abstract":"<p><strong>Introduction: </strong>Shaken baby syndrome (SBS) is a severe form of child abuse that results in a triad of clinical findings: subdural hematoma, retinal hemorrhages, and encephalopathy. These injuries can lead to significant brain damage, developmental delays, disabilities, or even death. In addition to these, other indicative signs include bruises, vomiting, full fontanelles, sleepiness, seizures, and fractures.</p><p><strong>Methods: </strong>This paper reviews the existing literature on SBS in Nigeria, identifies the challenges contributing to its underrecognition, and provides evidence-based recommendations for improving diagnosis, management, and prevention strategies in the region.</p><p><strong>Conclusions: </strong>Despite the profound impact of SBS, its recognition and management are inadequate, particularly in low- and middle-income countries (LMICs) like Nigeria, due to limited diagnostic capabilities and documentation. Addressing these gaps is crucial for safeguarding the well-being of infants and young children in Nigeria.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3765-3770"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Torticollis as a rare, late complication of VP shunt placement in the pediatric population: a case report. 小儿 VP 分流术后罕见的晚期并发症:病例报告。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-01 DOI: 10.1007/s00381-024-06523-4
Vasiliki Kalliri, Sandro M Krieg, Ahmed El Damaty
{"title":"Torticollis as a rare, late complication of VP shunt placement in the pediatric population: a case report.","authors":"Vasiliki Kalliri, Sandro M Krieg, Ahmed El Damaty","doi":"10.1007/s00381-024-06523-4","DOIUrl":"10.1007/s00381-024-06523-4","url":null,"abstract":"<p><p>The placement of a ventriculoperitoneal (VP) shunt is a common neurosurgical, pediatric procedure with various, well-documented complications occurring both in the immediate postoperative course of the procedure and at later stages. Pediatric patients need frequent revision surgeries due to body growth as well as implant failure over the course of the years. We report a rare case of a 12-year-old patient, presenting with torticollis, 11 years after the initial placement of a VP shunt. The peripheral tube had to be surgically removed due to the severe movement limitation of the cervical spine area and the tilting of the head. This is the fourth case known to be reported with this rare complication. The calcification of the tube and the formation of a rigid scar tissue along the shunt tube, combined with the body growth, are the suspected mechanisms of this mechanical malfunction of the VP-shunt. The complication could be efficiently addressed through the surgical replacement of the peripheral tube and the transection of the scar tissue in the neck area.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3853-3856"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic surgery for craniosynostosis: a bibliometric analysis of primary studies. 颅骨发育不良的内窥镜手术:对主要研究的文献计量分析。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.1007/s00381-024-06552-z
Silvio Porto Junior, Jefferson Heber Marques Fontes, Hugo Pustilnik, Davi Meira, Beatriz da Cunha, Matheus da Paz, Tancredo Alcântara, Jules Dourado, Leonardo de Avellar
{"title":"Endoscopic surgery for craniosynostosis: a bibliometric analysis of primary studies.","authors":"Silvio Porto Junior, Jefferson Heber Marques Fontes, Hugo Pustilnik, Davi Meira, Beatriz da Cunha, Matheus da Paz, Tancredo Alcântara, Jules Dourado, Leonardo de Avellar","doi":"10.1007/s00381-024-06552-z","DOIUrl":"10.1007/s00381-024-06552-z","url":null,"abstract":"<p><strong>Introduction: </strong>Bibliometrics, a statistical method assessing the influence of scholarly works, was employed to analyze the evolution of endoscopic surgery for craniosynostosis.</p><p><strong>Methods: </strong>This comprehensive review followed PRISMA guidelines, sourcing data from PubMed, Embase, and Web of Science, focusing on clinical and surgical outcomes up to December 2023. We identified 1409 records, with 83 papers meeting inclusion criteria.</p><p><strong>Results: </strong>The majority of studies originated from the Americas (79%), predominantly from the United States (75.9%). The typical study design was retrospective cohort studies (62%), involving a total of 8,175 patients with median research duration of 8 years. Citation metrics indicated an average count of 38.9 per paper, with notable contributions from several key authors. A distinct increase in research was observed in recent years, particularly from 2011 onwards, peaking in 2022 and 2023. The top 10 most cited papers, largely emanating from the U.S., had a higher median patient number (103) compared to the overall median (53), suggesting their significant impact. These papers were primarily published in journals with higher impact factors and citation indicators. The most cited research was notably published in the Journal of Neurosurgery-Pediatrics.</p><p><strong>Conclusion: </strong>This analysis provides a comprehensive view of the field, highlighting the growing trend and clinical importance of endoscopic approaches in craniosynostosis, offering a valuable resource for future research and clinical practice.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3647-3654"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mineralizing angiopathy as a rare cause of pediatric stroke: review and report of two cases. 矿化血管病变是小儿中风的罕见病因:两例病例的回顾与报告。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-27 DOI: 10.1007/s00381-024-06548-9
F Javier Brincau-García, Javier López-Pequeño, Yolanda Ruiz-Martín, Almudena Chacón-Pascual, María Vázquez-López
{"title":"Mineralizing angiopathy as a rare cause of pediatric stroke: review and report of two cases.","authors":"F Javier Brincau-García, Javier López-Pequeño, Yolanda Ruiz-Martín, Almudena Chacón-Pascual, María Vázquez-López","doi":"10.1007/s00381-024-06548-9","DOIUrl":"10.1007/s00381-024-06548-9","url":null,"abstract":"<p><p>In the Indian subcontinent, traumatic brain injury stands as the leading cause of pediatric stroke, whereas in Europe, it is considered a rare or potentially underdiagnosed factor. The etiology of post-traumatic stroke is unknown, although it has been associated with the presence of calcification in the lenticulostriate arteries, a condition known as \"mineralizing angiopathy.\" The theory suggests that calcified lenticulostriate vessels in a brain with inadequate myelination could have an increased vulnerability to mechanical injuries, which may result in their obstruction. This ischemic stroke associated with mineralizing angiopathy usually occurs after mild traumatic brain injury, with an asymptomatic interval following the trauma. The typical age of presentation is between 6 and 24 months. Children with mineralizing lenticulostriate vasculopathy generally experience a favorable outcome after stroke, with the majority achieving complete or nearly complete recovery of their motor functions. Despite aspirin treatment, a small proportion of children may still face stroke recurrence following repeat head trauma. We present the cases of two male patients with clinical features compatible with childhood stroke after a mild traumatic brain injury.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3499-3504"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Split Cord Malformation Presentation and Management in Pediatric and Adult Cases: a Case Series. 儿童和成人分裂脐带畸形的表现和处理:病例系列。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-22 DOI: 10.1007/s00381-024-06547-w
HariOm Vaja, Abhay Kapoor, Gurleen Kaur, Jividha Patwa, Jaimin Shah
{"title":"Split Cord Malformation Presentation and Management in Pediatric and Adult Cases: a Case Series.","authors":"HariOm Vaja, Abhay Kapoor, Gurleen Kaur, Jividha Patwa, Jaimin Shah","doi":"10.1007/s00381-024-06547-w","DOIUrl":"10.1007/s00381-024-06547-w","url":null,"abstract":"<p><p>The primary purpose of this study was to enhance the understanding of diastematomyelia, with a particular focus on adult-onset cases, which are infrequent and not fully elucidated. Additionally, the study sought to analyse the clinical features, diagnostic characteristics, and surgical interventions employed to manage the condition. This retrospective case series aimed to investigate diastematomyelia, a rare congenital deformation affecting the spinal cord. The study included 16 patients diagnosed with diastematomyelia, consisting of 13 pediatric cases (mean age: 7.6 years, age range: 5 months to 13 years) and 3 adult cases (mean age: 36 years, age range: 26 to 48 years). Among the paediatric cases, 9 were females, and 4 were males, while the adult cohort comprised 2 males and 1 female. The study design involved a thorough review of medical records, imaging reports, and surgical outcomes without specific inclusion or exclusion criteria. Surgical intervention emerged as the primary treatment modality for all cases, except one. Following surgical intervention, significant improvements were observed in pain management, motor function, and bladder control. Furthermore, additional findings indicated the presence of Dural Ectasia and Vertebral segmentation defects among the study population. This retrospective case series sheds light on the clinical features and surgical outcomes of diastematomyelia in both pediatric and adult patients. The findings underscore the importance of surgical intervention in alleviating symptoms and enhancing motor coordination and bladder control.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3849-3852"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Responsive neurostimulation in pediatric epilepsy: a systematic review and individual patient meta-analysis supplemented by a single institution case series in 105 aggregated patients. 小儿癫痫的反应性神经刺激:系统性综述和单个患者荟萃分析,辅以单个机构对 105 名综合患者的病例系列分析。
IF 1.3 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1007/s00381-024-06546-x
A Rosenberg, R Wang, M Petchpradub, C Beaudreault, A Sacknovitz, F M Cozzi, S M Wolf, P E McGoldrick, C R Muh
{"title":"Responsive neurostimulation in pediatric epilepsy: a systematic review and individual patient meta-analysis supplemented by a single institution case series in 105 aggregated patients.","authors":"A Rosenberg, R Wang, M Petchpradub, C Beaudreault, A Sacknovitz, F M Cozzi, S M Wolf, P E McGoldrick, C R Muh","doi":"10.1007/s00381-024-06546-x","DOIUrl":"10.1007/s00381-024-06546-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To assess responsive neurostimulation (RNS) efficacy in pediatric patients with drug-resistant epilepsy, comparing response (≥ 50% reduction in seizure frequency) rates between patients with two or fewer seizure foci and those with multifocal or generalized epilepsy. This study seeks to address the gap in knowledge regarding RNS effectiveness in pediatric populations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic review and meta-analysis included data from PubMed, Embase, and Web of Science through November 2023, including 17 retrospective studies and a case series of 24 patients from our practice for a total of 105 aggregated patients. The inclusion criteria of patients were age &lt;math&gt;&lt;mo&gt;≤&lt;/mo&gt;&lt;/math&gt; 18 and diagnosis of DRE. Exclusion criteria were nonhuman subjects and cases where RNS was not utilized to treat DRE. Study inclusion criteria were detailing the use of RNS and comparing patients with &lt;math&gt;&lt;mo&gt;≤&lt;/mo&gt;&lt;/math&gt; 2 foci with other focalities. Study exclusion criteria were failure to specify RNS lead placement or type of epilepsy. The risk of bias was assessed using the ROBINS-I tool for all non-randomized studies. Effect sizes and variances were aggregated to provide a comprehensive measure of RNS efficacy, and heterogeneity among the studies was assessed using I&lt;sup&gt;2&lt;/sup&gt; statistics and Cochran's Q test to evaluate the consistency of the findings. Statistical analyses were conducted using IBM SPSS. We analyzed demographics, epilepsy history, treatment outcomes, and RNS details using descriptive and inferential statistics, including Wilcoxon-Mann-Whitney, Fisher's exact, and chi-squared tests. This systematic review was not registered.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Seventeen retrospective studies and a single-institution case series, encompassing 105 pediatric patients, were analyzed. Effect sizes and confidence intervals were calculated to quantify treatment effects. Analyses revealed that RNS reduces seizure frequency across a spectrum of pediatric epilepsy syndromes, irrespective of the seizures' focal, multifocal, or generalized origins. The effectiveness of RNS was not influenced by the patient's sex, age at epilepsy onset, or presence of neurological and psychiatric comorbidities. Prior vagus nerve stimulation surgery and the presence of an epileptic syndrome were factors associated with a lower likelihood of near-complete seizure remission with RNS, underscoring the complexities of treating patients with generalized epilepsies or previous interventional failures. The necessity of further research into individualized surgical strategies for patients was underscored by the mixed results of comparisons of electrode characteristics with responder rates. Limitations of our study include its reliance on retrospective studies, which introduces potential bias and limits the ability to infer causality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;RNS is a safe and effective treatment in pediatric patients with DRE a","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3709-3720"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on the role of S100B in traumatic brain injury in pediatric population: a meta-analysis. S100B在儿科创伤性脑损伤中作用的最新荟萃分析。
IF 16.4 4区 医学
Child's Nervous System Pub Date : 2024-11-01 Epub Date: 2024-08-23 DOI: 10.1007/s00381-024-06565-8
Alberto Morello, Irene Schiavetti, Enrico Lo Bue, Irene Portonero, Stefano Colonna, Andrea Gatto, Marco Pavanello, Michele Maria Lanotte, Diego Garbossa, Fabio Cofano
{"title":"Update on the role of S100B in traumatic brain injury in pediatric population: a meta-analysis.","authors":"Alberto Morello, Irene Schiavetti, Enrico Lo Bue, Irene Portonero, Stefano Colonna, Andrea Gatto, Marco Pavanello, Michele Maria Lanotte, Diego Garbossa, Fabio Cofano","doi":"10.1007/s00381-024-06565-8","DOIUrl":"10.1007/s00381-024-06565-8","url":null,"abstract":"<p><strong>Objective: </strong>Cranial computed tomography (CT) scan is the most widely used tool to rule out intracranial lesions after pediatric traumatic brain injury (TBI). However, in pediatric population, the radiation exposure can lead to an increased risk of hematological and brain neoplasm. Defined in 2019 National Institute for Health and Care Excellence (NICE) guidelines as \"troponins for the brain\", serum biomarkers measurements, particularly S100B, have progressively emerged as a supplementary tool in the management of TBI thanks to their capacity to predict intracranial post-traumatic lesions.</p><p><strong>Methods: </strong>This systematic review was conducted following the PRISMA protocol (preferred reporting items for systematic reviews and meta-analyses). No chronological limits of study publications were included. Studies reporting data from children with TBI undergoing serum S100B measurement and computed tomography (CT) scans were included.</p><p><strong>Results: </strong>Of 380 articles screened, 10 studies met the inclusion criteria. Patients admitted with mild-TBI in the Emergency Department (ED) were 1325 (80.25%). The overall pooled sensitivity and specificity were 98% (95% CI, 92-99%) and 45% (95% CI, 29-63%), respectively. The meta-analysis revealed a high negative predictive value (NVP) (99%; 95% CI, 94-100%) and a low positive predictive value (PPV) (41%; 95% CI, 16-79%). Area under the curve (AUC) was 76% (95% CI, 65-85%). The overall pooled negative predictive value (NPV) was 99% (95% CI, 99-100%).</p><p><strong>Conclusions: </strong>The measurement of serum S100B in the diagnostic workflow of mTBI could help informed decision-making in the ED setting, potentially safely reducing the use of CT scan in the pediatric population. The high sensitivity and excellent negative predictive values look promising and seem to be close to the values found in adults. Despite this, it must be pointed out the high heterogeneity (> 90%) found among studies. In order for S100B to be regularly introduced in the pediatric workflow for TBI, it is important to conduct further studies to obtain cut-off levels based on pediatric reference intervals.</p>","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":" ","pages":"3745-3756"},"PeriodicalIF":16.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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