Chimica Techno Acta最新文献

PAMAM-calix-dendrimers as carriers for 5-fluorouracil: complexation, aggregation, and in vitro antitumor activity pamam -杯状树突状大分子作为5-氟尿嘧啶载体：络合、聚集和体外抗肿瘤活性

Chimica Techno Acta Pub Date : 2025-12-10 DOI: 10.15826/chimtech.9369

Pavel Padnya, Ilona Svintsova, Igor Shiabiev, Dmitry Pysin, Olga Mostovaya, B. A. Ranishenka, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Anastasia Nazarova, Ivan Stoikov

{"title":"PAMAM-calix-dendrimers as carriers for 5-fluorouracil: complexation, aggregation, and <i>in vitro</i> antitumor activity","authors":"Pavel Padnya, Ilona Svintsova, Igor Shiabiev, Dmitry Pysin, Olga Mostovaya, B. A. Ranishenka, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Anastasia Nazarova, Ivan Stoikov","doi":"10.15826/chimtech.9369","DOIUrl":"https://doi.org/10.15826/chimtech.9369","url":null,"abstract":"Despite a number of serious challenges and limitations in clinical use, drug therapy is considered one of the most common approaches to treating cancer. However, many types of cancer become resistant to antitumor drugs. Modern supramolecular chemistry provides a variety of compounds and materials that can be used to develop targeted drug delivery approaches, thereby enhancing therapeutic efficacy. Dendrimers are one example of such materials. This study presents an approach to creating supramolecular systems based on poly(amidoamine) dendrimers with a thiacalix[4]arene core (PAMAM-calix-dendrimers), capable of binding and delivering 5-fluorouracil (5-Fu). Fluorescence spectroscopy has demonstrated the good binding of 5-Fu by G1–G3 PAMAM-calix-dendrimers (logKa = 3.15–3.62) regardless of the macrocyclic core conformation. Self-assembly of the PAMAM-calix-dendrimers/5-Fu supramolecular systems was studied by dynamic light scattering and transmission electron microscopy. Loading and release of 5-Fu were evaluated by UV-Vis spectroscopy. The encapsulation efficiency and loading capacity increased slightly in the following order: G3-cone G3-paco G3-alt. For all dendrimers studied, 95% release of 5-Fu was observed within 4 h. An in vitro HeLa tumor cell model showed a positive trend (up to 20%) toward overcoming resistance to 5-Fu chemotherapy when G3-alt is used. These results provide proof of concept for using macrocyclic dendrimers to create anticancer drug delivery systems.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chimicatechnoacta.ru/article/download/9369/6450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Batch extraction of β-carotene from Gac ( Momordica cochinchinensis Spreng) fruit peel 分批提取桃皮中β-胡萝卜素的研究

Chimica Techno Acta Pub Date : 2025-03-26 DOI: 10.15826/chimtech.2025.12.2.12

Tran Do Phuong Quyen, Do Hoang Thang, Uyen P. N. Tran, Quoc Hai Nguyen, Tran Duy Hai

{"title":"Batch extraction of β-carotene from Gac ( <i>Momordica cochinchinensis</i> Spreng) fruit peel","authors":"Tran Do Phuong Quyen, Do Hoang Thang, Uyen P. N. Tran, Quoc Hai Nguyen, Tran Duy Hai","doi":"10.15826/chimtech.2025.12.2.12","DOIUrl":"https://doi.org/10.15826/chimtech.2025.12.2.12","url":null,"abstract":"β-carotene, a prominent provitamin A carotenoid, functions both as an essential antioxidant beneficial to human health and as a natural food colorant. Gac (Momordica cochinchinensis Spreng) fruit peel, often discarded as biomass waste, represents a promising source of β-carotene. Extracting β-carotene from Gac peel can significantly enhance the value of this waste material. In this study, a conventional solid-liquid method was employed to extract β-carotene from Gac peel. The influence of several factors, including solvent type, particle size, temperature, and solid-to-solvent ratio, on the extraction efficiency was investigated. The results indicated that smaller particle size significantly improved β-carotene extractability. Among acetone, hexane, and ethyl acetate, ethyl acetate proved to be the most effective solvent for β-carotene extraction. At a solvent-to-material ratio of 10:1, the highest β-carotene recovery was attained after three consecutive extractions, with the first extraction accounting for 69.9% of the total recovery. A kinetic model incorporating the effects of driving force and degradation on the kinetics of β-carotene extraction was developed. The calculated activation energies for extraction and degradation were determined to be 9.15 and 69.71 kJ/mol, respectively. This study demonstrates the potential of β-carotene extraction from gac peel and provides valuable insights into the underlying kinetics.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetraarylantimony 2,2′-bipyridinecarboxylates: synthesis, photophysical and molecular docking studies 2,2 ' -联吡啶甲酸四芳基锑：合成、光物理和分子对接研究

Chimica Techno Acta Pub Date : 2024-12-02 DOI: 10.15826/chimtech.2024.11.4.20

Е. В. Артемьева, В.В. Шарутин, Alexey P. Krinochkin, Yulia M. Sayfutdinova, Ilya I. Butorin, В. С. Гавико, Ya. K. Shtaitz, Мaria I. Valieva, Igor S. Коvalev, Olga V. Shabunina, Igor L. Nikonov, Dmitry S. Kopchuk, Grigory V. Zyryanov

{"title":"Tetraarylantimony 2,2′-bipyridinecarboxylates: synthesis, photophysical and molecular docking studies","authors":"Е. В. Артемьева, В.В. Шарутин, Alexey P. Krinochkin, Yulia M. Sayfutdinova, Ilya I. Butorin, В. С. Гавико, Ya. K. Shtaitz, Мaria I. Valieva, Igor S. Коvalev, Olga V. Shabunina, Igor L. Nikonov, Dmitry S. Kopchuk, Grigory V. Zyryanov","doi":"10.15826/chimtech.2024.11.4.20","DOIUrl":"https://doi.org/10.15826/chimtech.2024.11.4.20","url":null,"abstract":"Tetraarylantimony(V) carboxylates based on 5-carboxyl and 6-carboxyl 2,2’-bipyridines (4 compounds) were synthesized for the first time. The structure of one of the compounds was confirmed by X-ray diffraction analysis. It was shown that the carboxyl group participates in the coordination of the antimony(V) cation, but the bipyridine fragment does not. The antitumor activity of the new complexes was assessed by molecular docking, and the most probable targets were determined. It was shown that the affinity of ligands to them is higher than that of the corresponding complexes. The best results were obtained for complex 3a; its inhibition of VEGFR2 is 74% more effective compared to the native ligand. In addition, the primary photophysical properties of the new carboxylates in acetonitrile solutions were studied. It was shown that the luminescence quantum yield values strongly depend on the position of the carboxyl group: for 5-substituted compounds they reach 65.0%, while for 6-substituted ones they have an extremely low ( 0.1%) value. At the same time, the absorption and emission maxima are within 300–314 nm and 364–403 nm, respectively.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the reaction of dimedone with aromatic aldehydes in the presence of copper oxide nanoparticles 氧化铜纳米颗粒存在下二甲基酮与芳香醛反应的研究

Chimica Techno Acta Pub Date : 2024-07-10 DOI: 10.15826/chimtech.2024.11.3.03

Ravina Meena, H. Sachdeva

引用次数: 0

Dispersive surface free energy of adsorbents modified by supramolecular structures of heterocyclic compounds 杂环化合物超分子结构改性吸附剂的分散表面自由能

Chimica Techno Acta Pub Date : 2024-05-13 DOI: 10.15826/chimtech.2024.11.2.10

V. Yu. Guskov, Yulia Yu. Gainullina, Alina F. Gabdulmanova, Albina N. Gareeva

{"title":"Dispersive surface free energy of adsorbents modified by supramolecular structures of heterocyclic compounds","authors":"V. Yu. Guskov, Yulia Yu. Gainullina, Alina F. Gabdulmanova, Albina N. Gareeva","doi":"10.15826/chimtech.2024.11.2.10","DOIUrl":"https://doi.org/10.15826/chimtech.2024.11.2.10","url":null,"abstract":"In the present work, the dispersive surface free energy was calculated by Dorris-Gray method for 30 samples of adsorbents modified with chiral supramolecular structures of uracil, 6-methyluracil, 5-hydroxy-6-methyluracil, 5-fluorouracil, thymine, melamine, cyanuric and barbirutic acids, and perylene-3,4,9,10-tetracarboxylic dianhydride. It was shown that the homologous series of n-alkanes is better suited for measuring dispersive surface free energy than the homologous series of alcohols. It was established that the classical Dorris-Gray method does not allow obtaining well interpretable data for the objects studied. This is due to a noticeable effect that inductive interactions of a polar surface as an inductor with nonpolar alkane molecules have on the calculated values. We suggested to modify the Dorris-Gray method, making it possible to obtain data on the dispersive component of the free energy of adsorption. It was shown that the changes in dispersive surface free energy as a result of the modification correlate well with data on the structure and properties of supramolecular ensembles of the modifiers used. The results obtained can be used to predict the enantioselectivity of chiral adsorbents.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"102 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity 阳离子两亲经络萜类化合物：合成、抗菌、抗真菌和诱变活性

Chimica Techno Acta Pub Date : 2024-05-09 DOI: 10.15826/chimtech.2024.11.2.09

Alan Akhmedov, R. Gamirov, Yulia Panina, Alina Baklagina, Evgenia Sokolova, Pavel V Zelenikhin, Olga Babaeva, Vasily Babaev, D. Shurpik, I. Stoikov

引用次数: 0

Photoelectrochemical properties of Pt- and Ir-modified graphitic carbon nitride 铂和铱改性氮化石墨碳的光电化学特性

Chimica Techno Acta Pub Date : 2024-05-07 DOI: 10.15826/chimtech.2024.11.2.08

D. Markovskaya, Victoria A. Lomakina, E. Kozlova

{"title":"Photoelectrochemical properties of Pt- and Ir-modified graphitic carbon nitride","authors":"D. Markovskaya, Victoria A. Lomakina, E. Kozlova","doi":"10.15826/chimtech.2024.11.2.08","DOIUrl":"https://doi.org/10.15826/chimtech.2024.11.2.08","url":null,"abstract":"In this work, the photoelectrochemical properties of g-C3N4 modified with Pt, Ir and Ir/Pt bimetallic co-catalysts were studied. All prepared photoelectrodes were tested in a two-electrode cell by cyclic voltammetry, impedance spectroscopy, and the Mott-Schottky method. First, the optimal electrolyte (triethanolamine, NaCl, NaOH, Na2SO4) was selected. The highest photocurrents were recorded in 0.5 M Na2SO4. This electrolyte was used for the subsequent tests. Second, the photoelectrodes loaded with the noble metals are studied. It was shown that in case of monometallic co-catalysts, the deposition of noble metal is accompanied by the decrease of the short-circuit current density and the growth of open-circuit voltage. The simultaneous presence of bimetallic co-catalysts can significantly affect the semiconductor electron structure and photogalvanic properties. Some correlations between the short-circuit current density and the oxidation state of the noble metals were found. A linear correlation between Pt0/Pt0+Pt2+ and Jsc was observed. It was also shown that the presence of iridium in Ir3+ form favors the photocurrent generation. The highest values of the photocurrent were obtained for g-C3N4 and were equal to 0.57 mA/cm2.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"137 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141002653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of electronic states in the vicinity of band gap and atomic structure of Ta- and Nb-doped Li7La3Zr2O12 掺钽和掺铌 Li7La3Zr2O12 带隙附近的电子态特征和原子结构

Chimica Techno Acta Pub Date : 2024-05-06 DOI: 10.15826/chimtech.2024.11.2.07

M.I. Vlasov, E.A. Surzhikov, A. Germov, E. Il'ina, I. A. Weinstein

引用次数: 0

CNT thin films based on epoxy mixtures: fabrication, electrical characteristics 基于环氧混合物的碳纳米管薄膜：制造、电气特性

Chimica Techno Acta Pub Date : 2024-04-10 DOI: 10.15826/chimtech.2024.11.2.05

T. Yumalin, Timur Salikhov, Biltu Mahato, Alexey Shiverskii, Sergey Abaimov, R. Salikhov

{"title":"CNT thin films based on epoxy mixtures: fabrication, electrical characteristics","authors":"T. Yumalin, Timur Salikhov, Biltu Mahato, Alexey Shiverskii, Sergey Abaimov, R. Salikhov","doi":"10.15826/chimtech.2024.11.2.05","DOIUrl":"https://doi.org/10.15826/chimtech.2024.11.2.05","url":null,"abstract":"The simple scaling of silicon transistors no longer ensures the advantages of high energy efficiency, driving research into nanotechnologies beyond silicon. Specifically, digital circuits based on carbon nanotube (CNT) field-effect transistors promise significant advantages in energy efficiency. However, the inability to perfectly control internal nanoscale defects and the variability of carbon nanotubes hinder the realization of very large-scale integrated systems. In this study, we investigated a novel method for fabricating transistors based on carbon nanotubes (CNTs) using epoxy mixtures, obtained the electrical properties of the transistors, and compared their microstructure and composition via the scanning electron microscopy. The carrier mobility on epoxy-based transistors was 28.87 cm²/V∙s, and the transistor switching frequency was 2.2 MHz. The samples exhibited electrical and physical stability over an extended period of time. The use of carbon nanotubes in epoxy resin as a conducting layer for transistors opens significant prospects in the field of electronics. The CNT-epoxy mixture technology allows for more flexible and rapid fabrication of thin-film transistors compared to classical methods. However, it is not appropriate to speak of a complete replacement; in this study, we present an alternative method for producing thin-film transistors, which may be of interest for specific purposes.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"609 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140719050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of electrochemical performance of antimony modified screen-printed carbon electrodes 评估锑改性丝网印刷碳电极的电化学性能

Chimica Techno Acta Pub Date : 2024-04-09 DOI: 10.15826/chimtech.2024.11.2.04

Alexander B. Kifle, N. Malakhova, A. Ivoilova, Nataliya Leonova, Svetlana Saraeva, A. Kozitsina

{"title":"Evaluation of electrochemical performance of antimony modified screen-printed carbon electrodes","authors":"Alexander B. Kifle, N. Malakhova, A. Ivoilova, Nataliya Leonova, Svetlana Saraeva, A. Kozitsina","doi":"10.15826/chimtech.2024.11.2.04","DOIUrl":"https://doi.org/10.15826/chimtech.2024.11.2.04","url":null,"abstract":"This study compares the electrochemical performance of screen-printed carbon electrodes (SPCEs) modified with antimony (Sb/SPCEs) under different potentiostatic pre-plating conditions. Neutral Red (NR) was employed as a novel redox probe to evaluate the electrochemical performance of Sb/SPCEs. It was demonstrated that NR in the protonated form performs quasi-reversible redox transformations at bare SPCE and Sb/SPCEs in phosphate buffer solutions (pH 5.5±0.5) in the potential range of (−0.30)–(−0.75) V, where the antimony is not electroactive. Sb/SPCEs were studied electrochemically by cyclic voltammetry (CV) / electrochemical impedance spectroscopy (EIS), and morphologically by scanning electron microscopy (SEM). Cyclic voltammetry investigations revealed the dependence of the electrochemical performance of Sb/SPCEs on the degree of coverage of the substrate with the metal. The obtained CV, EIS, and SEM data are consistent. The lowest charge transfer resistance (Rct) value (6 Ω) was obtained at Sb/SPCE with the highest degree of antimony coverage. To investigate the electroanalytical performance of Sb/SPCEs, nickel (II) ions were utilized as a model analyte. A study of roughness factors and sensitivity towards nickel (II) ions for Sb/SPCEs using two-tailed Pearson's criterion revealed a high degree of correlation between their electrochemical and electroanalytical properties. The results show that using NR as a redox probe can help controlling modification processes during the development of innovative antimony-containing sensors.","PeriodicalId":9964,"journal":{"name":"Chimica Techno Acta","volume":"69 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140723541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0