Cationic amphiphilic meroterpenoids: synthesis, antibacterial, antifungal and mutagenic activity

Q4 Materials Science
Alan Akhmedov, R. Gamirov, Yulia Panina, Alina Baklagina, Evgenia Sokolova, Pavel V Zelenikhin, Olga Babaeva, Vasily Babaev, D. Shurpik, I. Stoikov
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引用次数: 0

Abstract

In this research, using the thia-Michael reaction, cationic amphiphilic meroterpenoids containing fragments of mono- and sesquiterpenoids were synthesized. The bacteriostatic and fungistatic activity of synthesized meroterpenoids against the fungi Saccharomyces cerevisiae and Candida sp., Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis) and Gram-negative (Salmonella typhimurium, Klebsiella pneumoniae, Pseudomonas aeruginosa) bacteria was studied. The compound containing the farnesyl fragment was most active against Saccharomyces cerevisiae (MIC 0.039 mg/mL), Candida sp. (MIC 0.078 mg/mL), Gram-positive bacteria Staphylococcus epidermidis (MIC 0.02 mg/mL) and Gram-negative Salmonella typhimurium (MIC 0.078 mg/mL). Besides, the Ames test demonstrated the absence of direct mutagenic action in all the studied compounds.
阳离子两亲经络萜类化合物:合成、抗菌、抗真菌和诱变活性
本研究利用噻-迈克尔反应合成了含有单萜和倍半萜片段的阳离子两亲经络萜类化合物。研究了合成的经皮类化合物对真菌酿酒酵母和念珠菌、革兰氏阳性菌(金黄色葡萄球菌、表皮葡萄球菌)和革兰氏阴性菌(鼠伤寒沙门氏菌、肺炎克雷伯菌、绿脓杆菌)的抑菌和杀真菌活性。含有法尼基片段的化合物对酿酒酵母(MIC 0.039 mg/mL)、念珠菌(MIC 0.078 mg/mL)、革兰氏阳性菌表皮葡萄球菌(MIC 0.02 mg/mL)和革兰氏阴性菌鼠伤寒沙门氏菌(MIC 0.078 mg/mL)的活性最强。此外,艾姆斯试验表明,所有研究化合物都不存在直接诱变作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Chimica Techno Acta
Chimica Techno Acta Chemical Engineering-Chemical Engineering (all)
CiteScore
1.00
自引率
0.00%
发文量
67
审稿时长
4 weeks
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