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中国临床药理学与治疗学最新文献

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Analysis of the effective components and mechanism of Yufang Fangji II for prevention of COVID-19 based on UHPLC-Q-TOF/MS and network pharmacology 基于UHPLC-Q-TOF/MS和网络药理学的育方防己二世预防新冠肺炎有效成分及作用机制分析
中国临床药理学与治疗学 Pub Date : 2021-01-01 DOI: 10.12092/j.issn.1009-2501.2021.10.005
T. Yu, G. Jiao, D. Huang, Y. Chen, D. Xu, S. Qiu, W. Chen, F. Zhang, B. Wang
{"title":"Analysis of the effective components and mechanism of Yufang Fangji II for prevention of COVID-19 based on UHPLC-Q-TOF/MS and network pharmacology","authors":"T. Yu, G. Jiao, D. Huang, Y. Chen, D. Xu, S. Qiu, W. Chen, F. Zhang, B. Wang","doi":"10.12092/j.issn.1009-2501.2021.10.005","DOIUrl":"https://doi.org/10.12092/j.issn.1009-2501.2021.10.005","url":null,"abstract":"AIM: The main chemical components of Yufang Fangji II (Hubei Fang) of COVID-19 were studied systematically and combined with network pharmacology to provide a reference for the study of its effective substances. METHODS: Ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry (UHPLC-Q-TOF/MS) was applied to identify the absorbed components of the prescription in rat plasma. TCMSP database and Swiss Target Prediction data platform were used to predict the target of the identified blood components, and network visualization software Cytoscape 3.7.2 was used draw the association network diagram, and GO enrichment analysis and KEGG pathway enrichment analysis were conducted for the key targets. With the help of CB-Dock online molecular docking platform, the molecular docking of key targets and blood entering compounds was carried out, and the docking combination with good affinity value was displayed by ligplot software to verify the preventive effect of Yufang Fangji II on COVID-19. RESULTS: A total of 52 chemical components identified in the prescription, in which 13 components were absorbed in the rat plasma as the prototype, and they were from Astragalus membranaceus, Atractylodes macrocephala, Saposhnikoviae Radix, Lonicerae Japonicae Flos, and Citri Reticulatae Pericarpium, respectively. These compounds were recognized to act on 17 core targets, including mapk3, TNF and other targets related to inflammation, MPO and other targets related to oxidative stress, VEGFR, KDR and other targets related to vascular endothelium. The results of molecular docking showed that the absorbed components had good binding activity with the key targets. CONCLUSION: Compounds in Yufang Fangji II are involved in regulating inflammation, oxidative stress, vascular and cellular physiological activities, which have preventive effects on COVID-19 through regulating IL-17, PI3K Akt, MAPK and other pathways.","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"26 1","pages":"1127-1145"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66004508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal Stem Cells: a new discovery in the treatment of novel coronavirus pneumonia 间充质干细胞:治疗新型冠状病毒肺炎的新发现
中国临床药理学与治疗学 Pub Date : 2021-01-01 DOI: 10.12092/j.issn.1009-2501.2021.09.014
J. Peng, J. Song, J. Luan
{"title":"Mesenchymal Stem Cells: a new discovery in the treatment of novel coronavirus pneumonia","authors":"J. Peng, J. Song, J. Luan","doi":"10.12092/j.issn.1009-2501.2021.09.014","DOIUrl":"https://doi.org/10.12092/j.issn.1009-2501.2021.09.014","url":null,"abstract":"Currently, the corona virus disease 2019 was spreading globally, and more than 167.5 million confirmed cases worldwide. The new corona virus was highly contagious. The human body would have respiratory symptoms, fever, severe respiratory syndrome, organ failure, and even death after being infected with the virus. At present, there was no specific treatment for COVID-19. Most of the treatments were symptomatic and supportive treatment, and the prognosis was poor. Mesenchymal stem cells could not only repair damaged lung tissue, but also regulate immunity and anti-inflammatory effects, and had good clinical application prospects. We will review the application of MSCs in the treatment of COVID-19 for the reference of colleagues.","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"26 1","pages":"1073-1079"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66004497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in the management of psoriatic arthritis 银屑病关节炎的治疗进展
中国临床药理学与治疗学 Pub Date : 2020-12-26 DOI: 10.12092/J.ISSN.1009-2501.2020.12.012
Tai Yu, Zhang Zi-xuan, Zhan Ling-ling
{"title":"Advances in the management of psoriatic arthritis","authors":"Tai Yu, Zhang Zi-xuan, Zhan Ling-ling","doi":"10.12092/J.ISSN.1009-2501.2020.12.012","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.12.012","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"1395"},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47133228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress of autophagy in viral pneumonia 自噬在病毒性肺炎中的研究进展
中国临床药理学与治疗学 Pub Date : 2020-11-26 DOI: 10.12092/J.ISSN.1009-2501.2020.11.013
W. Wang, Y. Mao, Y. Zhu
{"title":"Research progress of autophagy in viral pneumonia","authors":"W. Wang, Y. Mao, Y. Zhu","doi":"10.12092/J.ISSN.1009-2501.2020.11.013","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.11.013","url":null,"abstract":"Autophagy, as a highly conserved process of recovery and degradation of eukaryotic components, plays an important role in cell hunger response, maintenance of normal cell activity and specific functions in lung tissue When cells are damaged due to physiological, pathological or chemical factors, autophagosomes and lysosomes fuse to produce a large number of autophagosomes, thus inducing the initiation of autophagy process, which is beneficial to protect cells from injury Recent studies have found that autophagy related signaling pathways are highly correlated with the occurrence and development of a variety of viral pneumonia, such as swine influenza A (H1N1) virus, highly pathogenic avian influenza virus (H5N1), severe acute respiratory syndrome (SARS), middle east respiratory syndrome (MERS) and new coronavirus pneumonia (COVID-19) This paper will introduce the five viral pneumonia that have a great impact on China and even the whole world, and elaborate the mechanism of autophagy in these disease Hopefully it could provide theoretical basis and effective methods and means for targeted autophagy treatment of viral pneumonia","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"1315-1320"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47630100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of DRD2 and 5-HTR2A gene polymorphisms and their interaction on olanzapine in the treatment of schizophrenia DRD2和5-HTR2A基因多态性及其相互作用对奥氮平治疗精神分裂症的影响
中国临床药理学与治疗学 Pub Date : 2020-10-26 DOI: 10.12092/J.ISSN.1009-2501.2020.10.008
Yan Pan, Shi Jian-Fei, Li Jing, Wang Shengdong, Wang Shu-Qi, Wang Cheng-Peng, Song Mingfen
{"title":"Effects of DRD2 and 5-HTR2A gene polymorphisms and their interaction on olanzapine in the treatment of schizophrenia","authors":"Yan Pan, Shi Jian-Fei, Li Jing, Wang Shengdong, Wang Shu-Qi, Wang Cheng-Peng, Song Mingfen","doi":"10.12092/J.ISSN.1009-2501.2020.10.008","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.10.008","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"1131"},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45452270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug clinical trial of COVID-19 in China: A brief analysis 中国新冠肺炎药物临床试验分析
中国临床药理学与治疗学 Pub Date : 2020-08-26 DOI: 10.12092/J.ISSN.1009-2501.2020.08.005
X. Mu, Y. Zhao, L. Zhang, Y. Cui, Y. Zhang, G. Du
{"title":"Drug clinical trial of COVID-19 in China: A brief analysis","authors":"X. Mu, Y. Zhao, L. Zhang, Y. Cui, Y. Zhang, G. Du","doi":"10.12092/J.ISSN.1009-2501.2020.08.005","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.08.005","url":null,"abstract":"AIM: To provide suggestion for research and development of drugs against coronavirus disease 2019 (COVID-19) by analyzing the characteristics of the drug clinical trial registration information of COVID-19 in China METHODS: The clinical trials of COVID-19 were searched from Chinese Clinical Trial Registry, and the type, purpose, and design of the studies were analyzed RESULTS: Totally 271 drug clinical trials have been registered till July 1st, 2020 Most of the drugs are marketed ones, including chemical drugs, traditional Chinese medicines, and biologics Combined applications were adopted in some projects Randomized or non-randomized parallel control trials were conducted in most projects Others included single arm, sequential, and factorial design CONCLUSION: To deal with the epidemic, it is important to conduct emergent drug clinical trials to find out effective drugs as soon as possible However, some weaknesses and deficiencies on trials design, conduct and supervision were exposed in the drug clinical trials against COVID-19 It is suggested to enhance the scientific evaluation of candidate drugs, standardize the investigator initiated trials, and establish the national multi-subject research and development platform, and the collaborative and innovative key-task tackling mechanism, thus to improve the ability and level of antiviral drug research and development","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"869-877"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47496327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in antitumor drugs based on glutamine metabolism#br# 基于谷氨酰胺代谢的抗肿瘤药物研究进展#br#
中国临床药理学与治疗学 Pub Date : 2020-07-26 DOI: 10.12092/J.ISSN.1009-2501.2020.07.014
Li Dan-Yun, Shi Daohua, Niu Peiguang
{"title":"Advances in antitumor drugs based on glutamine metabolism#br#","authors":"Li Dan-Yun, Shi Daohua, Niu Peiguang","doi":"10.12092/J.ISSN.1009-2501.2020.07.014","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.07.014","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"810"},"PeriodicalIF":0.0,"publicationDate":"2020-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49115219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective analysis of voriconazole in the monitoring of therapeutic drugs in patients with liver dysfunction 伏立康唑在肝功能不全患者药物监测中的回顾性分析
中国临床药理学与治疗学 Pub Date : 2020-07-26 DOI: 10.12092/J.ISSN.1009-2501.2020.07.007
Guo Ming-xing, Cui Xiang-li
{"title":"Retrospective analysis of voriconazole in the monitoring of therapeutic drugs in patients with liver dysfunction","authors":"Guo Ming-xing, Cui Xiang-li","doi":"10.12092/J.ISSN.1009-2501.2020.07.007","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.07.007","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"757"},"PeriodicalIF":0.0,"publicationDate":"2020-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43421205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lycium barbarum polysaccharide inhibits the proliferation and promots the apoptosis of osteosarcoma HOS cells by blocking Shh signaling pathway 枸杞多糖通过阻断Shh信号通路抑制骨肉瘤HOS细胞增殖并促进细胞凋亡
中国临床药理学与治疗学 Pub Date : 2020-07-06 DOI: 10.12092/J.ISSN.1009-2501.2020.05.008
Yang Wenteng, L. Xiaojun, Ye Weijian, Y. Lele
{"title":"Lycium barbarum polysaccharide inhibits the proliferation and promots the apoptosis of osteosarcoma HOS cells by blocking Shh signaling pathway","authors":"Yang Wenteng, L. Xiaojun, Ye Weijian, Y. Lele","doi":"10.12092/J.ISSN.1009-2501.2020.05.008","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.05.008","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"533"},"PeriodicalIF":0.0,"publicationDate":"2020-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42715714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in study of phase II metabolic enzyme expression and activity under diseases status 疾病状态下II期代谢酶表达和活性的研究进展
中国临床药理学与治疗学 Pub Date : 2020-06-26 DOI: 10.12092/J.ISSN.1009-2501.2020.06.012
Zhang Yu, P. Ying, Wang Guang-ji, S. Jianguo
{"title":"Advances in study of phase II metabolic enzyme expression and activity under diseases status","authors":"Zhang Yu, P. Ying, Wang Guang-ji, S. Jianguo","doi":"10.12092/J.ISSN.1009-2501.2020.06.012","DOIUrl":"https://doi.org/10.12092/J.ISSN.1009-2501.2020.06.012","url":null,"abstract":"","PeriodicalId":9961,"journal":{"name":"中国临床药理学与治疗学","volume":"25 1","pages":"686"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41870570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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