中华行为医学与脑科学杂志最新文献

{"title":"Study on executive function and brain functional connection characteristics of deaf children","authors":"Ruihong Chen, Hang Qu, Aiguo Chen, Xuan Xiong, Wei Wang","doi":"10.3760/CMA.J.CN371468-20190801-00508","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190801-00508","url":null,"abstract":"Objective To explore the relationship between executive dysfunction and brain functional connectivity in deaf children and its mechanisms. Methods Twenty-eight deaf children were recruited from special education schools and twenty-seven children with normal hearing were treated as controls matched with deaf children in age, sex and education. All human subjects were scheduled to complete brain magnetic resonance scanning, based on the voxel-based morphometry (VBM) technique for detecting differences in gray matter volume (GMV) and a set of executive function (EF) tasks for detecting differences in EF behavior performance between deaf and normal hearing children. All human subjects were also performed resting-state fMRI, which were analyzed by independent component analysis (ICA) and the executive control network was selected and compared between the deaf and normal hearing children. Results Compared with the children with normal hearing, deaf children had smaller volume of gray matter in the left angular gyrus (MIN coordinates: -48, -72, 45; 700 voxels), right superior parietal gyrus (MIN coordinates: 20, -62, 57; 594 voxels) and left middle occipital gyrus(MIN coordinates: -32, -87, 42; 782 voxels). Deaf children had weaker functional connectivity (FC) in the left middle frontal gyrus, orbital part/left inferior frontal gyrus (MIN coordinates: -24, 21, 3; 54 voxels) with normal hearing children. In the behavioral test, deaf children had defects in the switching function compared with normal children, which was statistically significant (t(42)=2.39, P=0.02). Conclusion The EF of deaf children has some defects, and its neural mechanism may be related with the reduced functional connectivity and gray matter volume in the brain regions related to executive function. Key words: Deafness; Executive function; Functional connectivity; fMRI","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"33-37"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44227536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect and mechanisms of umbilical cord tissue transplantation on radiation-induced learning and memory impairment in rats","authors":"Zejun Zhu, Yang Zhao, A. Zhang, Nai-yao Chen, Hui Zhao, D. Bai, Xiujun Zhang","doi":"10.3760/CMA.J.CN371468-20190425-00287","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190425-00287","url":null,"abstract":"Objective \u0000To investigate the protective effect and mechanisms of umbilical cord tissue transplantation on radiation-induced learning and memory impairment in rats. \u0000 \u0000 \u0000Methods \u0000Sixty SD rats were randomly divided into three groups with 20 in each group: control group, model group (whole brain X-ray irradiation, dose 20 Gy) and treatment group (whole brain X-ray irradiation, dose 20 Gy + umbilical cord tissue transplantation). The changes of body mass were observed, and the learning and memory of rats were observed by water maze test on the 14th and 28th day after irradiation, the neuron state of hippocampus was observed by HE staining, and the expressions of NF-κB pathway related proteins and IL-6 in hippocampus were detected by Western blot.Descriptive analysis and hypothesis testing were processed by SPSS 17.0. \u0000 \u0000 \u0000Results \u0000(1) On the 28th day, the escaping latency in the water maze experiment of the treatment group was significantly higher than that of the control group and lower than that of the model group (control group: (11.77±3.02) s, model group: (23.75±3.27)s, treatment group: (18.49±2.32)s; t=3.940, -2.943, both P<0.05); the number of crossing platform in the treatment group was significantly lower than that in the control group and higher than that in the model group (control group: (7.20±0.84), model group (3.60±1.14 ), treatment group (5.00±1.00); t=-3.773, 2.064, both P<0.05). (2)HE staining showed that the neurons in the control group were arranged orderly and the cytoplasm was transparent.The neurons in the model group were arranged disorderly and the contraction of the cell body was triangular or irregular.The number of neurons in the treatment group was less than that in the model group. (3) On the 14th day, the relative expression of TLR4 in the treatment group was significantly higher than that in the control group and lower than that in the model group (control group: (0.69±0.03), model group: (1.06±0.11), treatment group: (0.90±0.04); t=7.275, -2.368, both P<0.05). The relative expression of NF-κB p65 in the treatment group was significantly higher than that in the control group and lower than that in the model group (control group: (1.67±0.12), model group: (2.08 ±0.06), treatment group: (1.93±0.08); t=3.236, -2.684, both P<0.05). The relative expression of IL-6 in the treatment group was significantly higher than that in the control group and lower than that in the model group (control group: (0.77±0.08), model group: (1.12±0.07), treatment group: (0.95±0.06); t=3.274, -3.495, both P<0.05). The relative expression of Bcl-2 / Bax in the treatment group was significantly lower than that in the control group and higher than that in the model group (control group: (1.40±0.52), model group: (0.48±0.06), treatment group: (0.72±0.0 3); t=-2.263, 6.350, both P<0.05). The expression trend of IL-6 and Bcl-2 / Bax protein on the 28th day was the same as that on the 14th day. \u0000 \u0000 \u0000Conclusion \u0000Cord tissue transplantation can improv","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42572231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influences of SCN3A gene polymorphism on the efficacy of valproic acid sodium in the treatment of epilepsies","authors":"Jianmin Huang, Chen Haiyan, Xionglin Tang, H. Ling, Liu Guojun, Yongming Jiang, Ce Gao, Lan-qing Meng","doi":"10.3760/CMA.J.CN371468-20190902-00601","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190902-00601","url":null,"abstract":"Objective \u0000To investigate the influences of SCN3A gene polymorphism(c.905A>G/p.N302S and c. 1441C>T/p.L481L) on the efficacy of valproic acid sodium in the treatment of Zhuangzu epilepsies. \u0000 \u0000 \u0000Methods \u0000Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)technique and the way of direct sequence, the SCN3A gene c. 905A>G/p.N302S and c. 1441C>T/p.L481L genotypes in peripheral blood were detected in 244 epileptic patients (85 cases in effective group and 139 cases of ineffective group) in the standardized treatment of valproic acid sodium.The blood concentration of valproic acid sodium was detected by LC-MS.Evaluating the correlation between the genotype and alleles of two groups of patients and the efficacy of valproic acid sodium and analyzing the difference of valproic acid sodium's blood concentration between different genotypes.The linkage disequilibrium of c. 905A>G/p.N302S and c. 1441C>T/p.L481L were analyzed by software SHEsis. \u0000 \u0000 \u0000Results \u0000The allele and genotype distribution in c. 905A>G/p.N302S loci between effective group(A, G allele: 50.6%, 49.4%, AA, AG, GG genotype: 27.1%, 47.1%, 25.8%) and ineffective group(A, G allele: 37.4%, 62.6%, AA, AG, GG genotype: 16.6%, 41.7%, 41.7%) had statistically significant difference(χ2=7.501, P=0.006; χ2=7.907, P=0.019). There was no significant difference in allele and genotype distribution of c. 1441C>T/p.L481L loci between effective group(C, T allele: 47.1%, 52.9%, CC, CT, TT genotype: 23.5%, 47.1%, 29.4%) and ineffective group(C, T allele: 38.8%, 61.2%, CC, CT, TT genotype: 18.7%, 40.3%, 41.0%)(χ2=2.920, P=0.088; χ2=3.099, P=0.212). Compared with the AA + AG genotype, the GG genotype at c. 905A>G/p.N302S locus significantly reduced the efficacy of valproic acid sodium (OR=2.051, 95%CI=1.136-3.703). Compared with genotypes AA+ AG, there were no significant differences in blood concentration of genotype GG of c. 905A>G/p.N302S (t=3.256, P=0.137). Compared with genotypes CC+ CT, there were no significant differences in blood concentration of genotype TT of c. 1441C>T/p.L481L(t=4.628, P=0.082). c.905A>G/p.N302S and c. 1441C>T/p.L481L were without linkage disequilibrium. \u0000 \u0000 \u0000Conclusion \u0000These results suggest that the single nucleotide polymorphisms of c. 905A>G/p.N302S in SCN3A genes may play a role in the resistivity of valproic acid sodium in Zhuangzu epilepsies. \u0000 \u0000 \u0000Key words: \u0000Polymorphism of SCN3A genes; Zhuangzu epilepsie; Valproic acid sodium; Efficacy","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70011333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress sources and anxiety symptoms of medical graduate students: the mediating role of negative emotion and the moderating role of social support","authors":"Linlin Hou, Zhen Zhang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.010","url":null,"abstract":"Objective \u0000To explore the relationship between stress sources and anxiety symptoms of medical graduate students, as well as the mediating role of negative emotion and the moderating role of social support. \u0000 \u0000 \u0000Methods \u0000A questionnaire survey was conducted among 1 216 medical students of 16 medical colleges in 13 provinces (municipalities directly under the Central Government) by using graduate stressors scale, Hopkins symptom checklist, the positive and negative affect scale and perceived social support scale.Correlation analysis, regression analysis, SPSS-process mediation and adjustment methods were used for data processing. \u0000 \u0000 \u0000Results \u0000(1) The whole average score of stress source was (2.45±0.54), and the scores of anxiety symptoms, negative emotions and social support were (1.68±0.59), (2.26±0.70) and (5.28 ±1.01). (2) There was a positive correlation between stress and anxiety symptoms (r=0.37, P<0.01), and negative emotion (r=0.38, P<0.01) and a negative correlation between stress source and social support (r=-0.20, P<0.01). (3) Negative emotion plays a significant partial mediating role between stressors and anxiety symptoms (indirect effect value=0.24, SE=0.02, 95%CI: 0.20-0.28), accounted for 58.54% of the total effect.(4) Social support moderated the effects of stressors on negative emotion (R2=0.24) and the effects of stressors on anxiety symptoms (R2=0.44). \u0000 \u0000 \u0000Conclusion \u0000Negative emotion plays a partial intermediary role in stress sources and anxiety symptoms, and social support plays a multiple moderating role. \u0000 \u0000 \u0000Key words: \u0000Medical graduate students; Stressors; Negative emotion; Anxiety symptoms; Social support","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1108-1112"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44925833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The functional connection of central executive network in patients with depression after clinical cure","authors":"Jiaqi Zhong, Zhenzhen Wang, Yang Han, Changjun Teng, Hui Wang, Ning Zhang, Hui Ma","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.006","url":null,"abstract":"Objective \u0000To study the changes in the functional connections of the central executive network in patients with depression after clinical cure. \u0000 \u0000 \u0000Methods \u0000Seventeen depression patients who met the clinical cure standard (patient group) and twenty-two healthy controls (control group) were selected.The baseline rs-fMRI data were collected from the healthy control group and the patient group respectively, and the rs-fMRI data in the patient group were collected again after 6 months.Compared the changes of central executive network function connection between the two groups. \u0000 \u0000 \u0000Results \u0000At baseline, there was a high functional connection in the left inferior parietal lobule(MNI: x, y, z=-39, -69, 33)and right insula(MNI: x, y, z=15, -45, 30) in the patient group compared with the control group.Compared with the baseline, there were high functional connections in part of the left inferior parietal lobe (MNI: x, y, z=-60, -48, 21) and the right dorsolateral prefrontal lobe (MNI: x, y, z=24, 18, 60), and low functional connections in part of the left inferior parietal lobe (MNI: x, y, z=-51, -69, 18) in patient group 6 months after clinical cure.Compared with the control group, there was a high functional connection in the right dorsolateral prefrontal lobe (MNI: x, y, z=45, 51, -6) and the right inferior parietal lobe (MNI: x, y, z=42, -48, 27) in patient group 6 months after clinical cure. \u0000 \u0000 \u0000Conclusion \u0000The functional connection of central executive network of depression patients has not been restored, and the related abnormality is not stable in six months after reaching the clinical cure standard. \u0000 \u0000 \u0000Key words: \u0000Central executive network; Clinical cure; Major depressive disorder; Resting state function connection","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1085-1090"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45183254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on citation index of Chinese Journal of Behavioral Medicine and Brain Science","authors":"Jing Yang, Xue-quan Feng, Nuo Li, Jingmei Zhang, Xian-fei Yang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.016","url":null,"abstract":"Objective \u0000To analyze the trend of citation index of Chinese Journal of Behavioral Medicine and Brain Sciences(CJBMBS) from 2011 to 2018, and compare to the average level of Chinese Medical Association(CMA) series journals, so as to provide basis for improving academic quality and journal influence. \u0000 \u0000 \u0000Methods \u0000Trend analysis on citation index of CJBMBS from 2011 to 2018 and comparison with the average level of Chinese Medical Association series journals were conducted by Microsoft Excel 2010. \u0000 \u0000 \u0000Results \u0000From 2011 to 2018, the core impact factor(0.849-1.151) and ratio of foundation-supported papers(0.550-0.810) of CJBMBS showed an upward trend, while the core total citation(1 783-2 836) showed a downward trend.The core total citation, core impact factor and ratio of foundation-supported papers of CJBMBS were higher than the average level of CMA series journals(1 355-1 699, 0.497-0.890, 0.335-0.460), but the core other-citation rate was lower than the average level of CMA series journals (0.81-0.85). \u0000 \u0000 \u0000Conclusion \u0000The CJBMBS is at a high level among the core journals of Chinese science and technology, and more attention should be paid to the problem of high self-citation rate. \u0000 \u0000 \u0000Key words: \u0000Core total citation; Core impact factor; Ratio of foundation-supported papers; Core other-citation rate","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1141-1144"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49643238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between bullying and emotional behavior problems in middle school students","authors":"Mining Liang, Xuting Li, Hai-Yan Xiang, Jianjian Wang, Xihong Zhou, Li He, Qiongni Chen","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.013","url":null,"abstract":"Objective \u0000To investigate the current situation of emotional and behavioral problems and analyze the influencing factors of middle school students. \u0000 \u0000 \u0000Methods \u0000The general information questionnaire, the strengths and difficulties questionnaire (student version), and the illinois bullying scale were used to evaluate 680 students in two middle schools in Hunan province.Statistical analysis was performed using t test, analysis of variance, Pearson correlation analysis and stepwise multiple regression analysis. \u0000 \u0000 \u0000Results \u0000(1) The detection rate of total difficulty (12.09±5.67), conduct problem (2.42±1.66), hyperactivity/attention defect (3.65±2.08), emotional (2.82±2.32), peer relationship problem (3.21±1.79) and pre-socialization behavior (7.02±2.39) were 11.2%, 11.2%, 7.7%, 6.9%, 11.0% and 14.5%.(2)The scores of total difficulties, conduct problem, hyperactivity/attention deficit and peer relationship problems of boys were higher than that of girls(t=2.79, 4.03, 2.44, 3.40, all P<0.05), while the score of pre-socialization behavior of boys was lower than that of girls (t=-5.29, P<0.05). (3) The scores of total difficulties, conduct and peer relations, pre-socialization of rural students were significantly different with those of urban students(t=-3.93, -2.55, -7.00, 5.26, all P<0.05). (4) The score of total difficulties, conduct problem, hyperactivity/attention deficit and emotional symptoms of left-behind students were higher than that of un-left-behind students (t=-3.18, -2.50, -2.67, -2.40, 2.19, all P<0.05). (5) Middle school students with different fathers' education levels showed different scores of total difficulties, peer relationship problem and pre-socialized behavior(F=3.84, 7.10, 6.20, all P<0.05), while middle school students with different mothers' education levels showed different scores of total difficulties and peer relationship problem(F=3.97, 7.38, both P<0.05). (6) The scores of total difficulties, emotional symptoms, conduct problems, and hyperactivity/attention deficit of the middle school students were significantly positively correlated with the total score of the bullying total scale, the bullish subscale, the bullying subscale, and the fighting subscale(r=0.165-0.430, P<0.05). (7) Gender, urban and rural areas, left-behind or not, maternal education level, bullying, being bullied, fighting were the influencing factors of middle school students' emotion and behavior problems(β=0.010-0.533, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Some middle school students in Hunan province have emotional and behavioral problems and more attention should bo paid to mental health education. \u0000 \u0000 \u0000Key words: \u0000Strengths and difficulties questionnaire; Emotional and behavioral problems; Left behind children; Middle school students; Rural area; Bullying","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1125-1130"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42449697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of astaxanthin on the expression of NF-κB inflammatory signaling pathway related proteins in hippocampus of rats after acute carbon monoxide poisoning","authors":"Rui-rui Lei, Li Jiang, Gang Gu, Hongyan Peng, Ye Gao, Qingbin Han","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.002","url":null,"abstract":"Objective \u0000To investigate the effects of astaxanthin on neuronal injury in hippocampus of rats after acute carbon monoxide poisoning(ACMP) and the relationship with NF-κB inflammatory signaling pathway. \u0000 \u0000 \u0000Methods \u0000Male SD rats screened by water maze were randomly divided into three group(n=50): control group (NC group), CO poisoning group (COP group), CO poisoning+ astaxanthin group (AST group) . ACMP rat model was established by static inhaled exposure method. Meanwhile, rats in AST group were further given astaxanthin twice a day by gavage.At 1 day, 7 days, 14 days, 21 days and 28 days after CO poisoning (10 rats in each group were selected), the learning and memory abilities were evaluated by Morris water maze test. The pathological changes of the neurons in hippocampal CA1 region were observed by hematoxylin-eosin(HE) staining.The expression and activation of NF-κB in hippocampus were detected by immunoblotting and immunofluorescence, and the expression of TNF-α and IL-6 protein in hippocampus were examined by ELISA. \u0000 \u0000 \u0000Results \u0000Morris water maze test showed that there were no significant difference in escape latency and crossing platform times between the three groups (P>0.05). Compared with NC group, the escape latency of COP group was prolonged at 14, 21 and 28 days after CO poisoning (t=-6.04, -6.28, -8.18, all P<0.05), and the number of crossing platform was decreased (t= 5.96, 7.85, 6.51, all P<0.05). Compared with the COP group, the escape latency of the rats in AST group at the 14, 21 and 28 days was shortened (t=4.74, 4.82, 5.98, all P<0.05), and the number of crossing platform was increased (t=-3.72, -4.45, -6.53, all P<0.05). Compared with NC group, the number of NF-κ B positive cells in CA1 area of hippocampus in COP group increased at every time point (t=-8.62, -18.00, -16.67, -11.15, -6.22, all P<0.05); the number of NF-κ B positive cells in CA1 area in AST group decreased at 7 d, 14 d, 21 d and 28 d after CO poisoning, the difference was statistically significant (t= 6.55, 6.96, 4.40, 4.17; all P<0.05). Western blot showed that the changes of NF-κB protein was similar to that of immunofluorescence. After 7 days of CO poisoning, the level of NF-κB protein in hippocampus of COP group was (1.44±0.08), it was higher than that of NC group (t=-20.07, P<0.05), while that of AST group was (0.68±0.10), it was lower than that of COP group (t=10.23, P<0.05). The results of Elisa showed that TNF-α and IL-6 in the hippocampus of COP group were higher than those of NC group at every time point(all P<0.05), while compared with COP group, TNF-α and IL-6 in AST group were lower (all P<0.05). After 7 days of CO poisoning, TNF -α in COP group ((39.04±5.29) pg/ml)was higher than that in NC group ((14.13±2.12) pg/ml) (t=-7.58, P<0.05); TNF -α in AST group ((25.77±3.31) pg/ml) was lower than that in COP group (t=3.69, P<0.05). After 7 days of CO poisoning, the level of IL-6 in COP group ((181.79±9.12) pg/ml)was higher than that in NC group ((73","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1064-1069"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42293926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cardiac rehabilitation combined with psychological invention on clinical efficacy in high-risk patients with acute myocardial infarction after emergent percutaneous coronary intervention","authors":"Aichun Zhao","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.005","url":null,"abstract":"Objective \u0000To investigate the effects of stage I cardiac rehabilitation combined with structural psychological invention high-risk patients with acute myocardial infarction (AMI) treated by emergent percutaneous coronary intervention (PCI). \u0000 \u0000 \u0000Methods \u0000Totally 120 patients with AMI that received emergent PCI were randomized into experimental group(n=60) and control group(n=60). The experimental group started stage I cardiac rehabilitation combined with structural psychological invention after emergency PCI.The control group received routine treatment.Self-rating Anxiety Scale (SAS) and Self-rating depression Scale (SDS) scores were compared in both groups at before PCI and 1 week after PCI.Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDD) were compared in both groups at before PCI and 1 week, 1 month and 6 months after PCI.The incidence of adverse cardiac events including cardiac death and recurrence myocardial infarction were compared between the two groups at 6 months after PCI. \u0000 \u0000 \u0000Results \u0000The SAS score in the experimental group (36.38±5.15) was lower than that in the control group (42.10±5.79) in 1 week after PCI (t=2.313, P 0.05). The follow-up results after 6 months showed that the experimental group (8.9%) had lower incidence of cardiac death than that in the control group (24.1%) (HR(95%CI): 0.317(0.128-0.835), P<0.05). The follow-up results after 6 months showed that the experimental group (14.2%) had lower incidence of recurrence myocardial infarction than that in the control group (42.2%) (HR(95%CI): 0.263(0.125-0.548), P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Stage I cardiac rehabilitation improved the cardiac function in high-risk patients with AMI treated by emergent PCI and reduced the incidence of cardiac death and recurrence myocardial infarction. \u0000 \u0000 \u0000Key words: \u0000Acute myocardial infarction; Emergent percutaneous coronary intervention; High-risk patients; Stage I cardiac rehabilitation; Structural psychological invention","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1081-1084"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42388955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cognitive processing characteristics of Chinese adjective-noun construction in college students","authors":"Qianqian Ji, Tongquan Zhou","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.012","url":null,"abstract":"Objective \u0000To investigate the cognitive processing characteristics of Chinese adjective-noun constructions. \u0000 \u0000 \u0000Methods \u0000Self-paced reading paradigm was adopted in the experiment, with sixty right-handed native speakers of Chinese (aged from 17 to 20 years old) as the participants/subjects. The sixty pairs of experimental materials were categorized into four conditions: high frequency plus concrete, high frequency plus abstract, low frequency plus concrete, and low frequency plus abstract construction. \u0000 \u0000 \u0000Results \u0000The construction with high frequency was significantly higher than the one with low frequency in terms of collocation judgement accuracy(high frequency plus concrete: (95.7±0.12)%, low frequency plus concrete: (49.2±0.45)%; high frequency plus abstract: (91.7±0.18)%, low frequency plus abstract: (44.0±0.42)%; Ffrequency=312.33, P 0.05), but the constructions with high frequency were processed more quickly and accurately than those with low frequency (high frequency plus concrete: (968.34±229.60) ms , low frequency plus concrete: (1 610.88 ±778.73)ms; high frequency plus abstract: (1 074.64±453.87)ms , low frequency plus abstract: (1 585.36±873.12)ms; Ffrequency=48.258, P 0.05). The ANOVA on the RT of collocation correctness judgement revealed that the whole constructions with high frequency were responded more quickly than those with low frequency (high frequency plus concrete: (330.76±68.08) ms , low frequency plus concrete: (465.69 ±2 014.09)ms; high frequency plus abstract: (357.90±91.11)ms , low frequency plus abstract: (468.26±244.93)ms; Ffrequency=35.29, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000On the processing of the Chinese adjective-noun constructions out of context, the frequency effect of the entire construction is significant but the concreteness effect of head noun doesn't work in the current experiment. \u0000 \u0000 \u0000Key words: \u0000Adjective-noun construction; Self-paced reading; Frequency; Abstraction; College students","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1118-1124"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43104668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}