Child and Adolescent Psychiatry and Mental Health最新文献

{"title":"Parent-mediated Paediatric Autism Communication Therapy (PACT): a focus group study of parental experience.","authors":"Nora Bouaziz, Chloé Poulinet, Avgustina Martirosyan, Scila Toscana, Anna-Gaëlle Lambert, Christophe Recasens, Chantal Arcade Pichon, Canelle Creantor, Lorena Negrescu, Joséphine Frères, Laelia Benoit, Jean-Marc Baleyte","doi":"10.1186/s13034-026-01072-x","DOIUrl":"10.1186/s13034-026-01072-x","url":null,"abstract":"<p><strong>Background: </strong>Parent-mediated interventions are increasingly recommended for children with Autism Spectrum Disorder (ASD). This study explores parental experiences of Paediatric Autism Communication Therapy (PACT), a parent-mediated intervention focused on social communication. PACT uses video feedback to analyze parent-child play sequences with the parent and to support parental reflexivity about the most appropriate interactive style for developing their child's socio-communicative skills.</p><p><strong>Method: </strong>We conducted a qualitative study using focus groups with 20 parents, among the 60 families who completed PACT with their children with ASD. Data analysis was conducted using Interpretative Phenomenological Analysis.</p><p><strong>Results: </strong>Five main key themes stand out (1) Video feedback enhanced parental perspective and recognition of children's emergent skills; (2) Parents transitioned from feeling incompetent to supported and empowered; (3) Daily integration and mutual shared enjoyment reinforced the intervention's effects; (4) Parent-child play is not a prerequisite that is uniformly present among all parents, yet it is one of the main levers in PACT. Cultural approaches are necessary to support this skill to prevent it from becoming an obstacle to the course of therapy; and (5) PACT had systemic repercussions on partners and siblings we have to deal with to support the engagement of parents who are concerned about this family impact.</p><p><strong>Conclusions: </strong>PACT was positively received by parents, enhancing their observational skills and sense of competence. However, cultural factors and family dynamics significantly influenced its implementation and outcomes.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13147595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and psychosocial correlates of self-compassion in adolescents with physical health conditions.","authors":"Burak Uslu, Robert Busching, Petra Warschburger","doi":"10.1186/s13034-026-01074-9","DOIUrl":"10.1186/s13034-026-01074-9","url":null,"abstract":"<p><p>BACKGROUND: Adolescents with physical health conditions (PHCs) face the dual demands of both normative developmental and disease-related burdens. Self-compassion (SC) represents a potentially important resource, yet little is known about its correlates. This study investigated sociodemographic, health-related, and interpersonal predictors of compassionate self-responding (CS) and uncompassionate self-responding (UCS) among adolescents with PHCs. METHODS: In total, 498 adolescents (ages 12–21) with type 1 diabetes, cystic fibrosis, and juvenile idiopathic arthritis completed measures of SC, depression, anxiety, disease severity and duration, parental support, peer group integration, and seeking social support. Hierarchical multiple regressions were conducted separately for CS and UCS. Predictors were entered as follows: (1) sociodemographic variables, (2) health-related factors, and (3) social resources. RESULTS: CS was primarily explained by social resources, namely parental support, peer integration, and seeking social support. In contrast, UCS was explained by depression, anxiety, and disease severity, alongside lower parental and peer support. The final hierarchical regression models accounted for 27.8% of the variance in CS and 42.9% in UCS. CONCLUSIONS: Findings reveal two distinct pathways that should be considered in future practice: Results for UCS emphasize the need for early identification and targeted intervention, whereas strengthening supportive interpersonal contexts seems crucial with respect to CS. </p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between emotional competence, dissociative symptoms and borderline personality disorder traits in female adolescents engaging in non-suicidal self-injury.","authors":"Alexandra Otto, Ricarda Jacob, Irina Jarvers, Stephanie Kandsperger, Romuald Brunner","doi":"10.1186/s13034-026-01067-8","DOIUrl":"10.1186/s13034-026-01067-8","url":null,"abstract":"<p><p>BACKGROUND: Non-suicidal self-injury (NSSI) is a prevalent maladaptive coping strategy among adolescents, often associated with difficulties in emotional processing. METHODS: This study investigated the relationship between emotional competence and NSSI in a clinical sample of 93 adolescent females (aged 12–21 years), 47% of whom met DSM-5 diagnostic criteria for NSSI. Dissociation and borderline personality disorder (BPD) traits were examined as potential moderators. Emotional competence and dissociation were assessed using self-report questionnaires, while BPD traits were evaluated dimensionally via a semi-structured clinical interview. Robust linear regression models were employed to examine main and interaction effects. RESULTS: Findings revealed that higher emotional competence was generally associated with reduced lifetime NSSI. This protective effect was particularly evident in individuals with high levels of dissociation, especially when self-reported competencies in recognizing one’s own emotions and emotional expressiveness were high. However, a divergent pattern emerged in relation to BPD traits. While emotional competence was protective at low to moderate trait level, it was associated with increased NSSI at high BPD trait levels. This paradoxical effect was especially pronounced when individuals reported high competence in emotion recognition, regulation, and expressiveness. CONCLUSIONS: These findings suggest that the protective role of emotional competence in reducing NSSI may be limited or even reversed in the context of severe psychopathology. Identifying such moderating effects enhances our understanding of emotional processing in clinical populations and underscores the importance of tailored interventions. Particularly emotion-based therapeutic approaches may need to be adapted for individuals with high BPD symptoms or pronounced dissociative tendencies to improve treatment outcomes. </p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a school-based universal prevention program on self-efficacy and mental health problems in Japanese children: differences between universal- and indicated-level effects.","authors":"Kohei Kishida, Noriko Hida, Kohei Matsubara, Haruko Kihara, Yuko Sakaue, Yoshihiro Takeuchi, Shin-Ichi Ishikawa","doi":"10.1186/s13034-026-01070-z","DOIUrl":"10.1186/s13034-026-01070-z","url":null,"abstract":"<p><p>BACKGROUND: Mental health problems among children and adolescents have been increasing worldwide, highlighting the need for preventive interventions in schools. This study examined the effectiveness of a school-based universal prevention program on self-efficacy and mental health problems in Japanese children using a quasi-experimental design with intervention and control groups. METHODS: A total of 1,281 third- and fourth-grade students participated, with 264 assigned to the intervention group and 1,017 to the control group. The intervention group received the Universal Unified Prevention Program for Diverse Disorders (Up2-D2), a 12-session program based on cognitive-behavioral and positive psychological interventions. RESULTS: A significant universal-level effect was found for positive attitude (a self-efficacy subscale), which improved over time in the intervention group but not in the control group. At the indicated level, a Time × Group interaction was observed for depressive symptoms among children with elevated baseline depression; however, the group effect at Time 4 did not reach statistical significance after covariate adjustment. Effect sizes at Time 4 were small for positive attitude at the universal level (g = 0.19) and small-to-moderate for depressive symptoms at the indicated level (g = 0.36). CONCLUSIONS: These findings suggest that Up2-D2 may promote positive attitude at the universal level, while potential indicated-level benefits for depressive symptoms may warrant further confirmation. Evaluating outcomes in both general and at-risk subgroups may help clarify for whom and on which outcomes universal school-based prevention programs are most beneficial. </p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal dose and type of physical activity for enhancing executive functions in children and adolescents: a network meta-analysis.","authors":"Junyu Wang, Yong Yang, Hao Mei, Yuan Yuan, Kui Mei, Hui Fang, Weiqi Ruan, Tian Wang, Lanzhi Chen, Yixin Liang, Tao Wang, Jie Zhuang","doi":"10.1186/s13034-026-01066-9","DOIUrl":"10.1186/s13034-026-01066-9","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of different physical activity (PA) types on executive functions (EFs) in children (6-12 years) and adolescents (13-18 years).</p><p><strong>Methods: </strong>Data were analyzed using Bayesian network meta-analysis combined with model-based dose-response modeling. PA dose was standardized to metabolic equivalent of task minutes per week (METs-min/week). Effect sizes were estimated using standardized mean differences (SMDs) and 95% credible intervals (CrIs). Risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool, and certainty of evidence was evaluated with CINeMA. The protocol was registered in PROSPERO (CRD42023422762).</p><p><strong>Results: </strong>Dance was identified as the most effective PA for enhancing working memory accuracy (SMD = 0.64, 95% CrI: 0.20 to 1.07) and cognitive flexibility reaction time (SMD = - 0.99, 95% CrI: - 1.91 to - 0.06) at optimal doses of 500 METs-min/week and 150 METs-min/week, respectively. Mixed exercise significantly improved inhibitory control accuracy (SMD = 0.52, 95% CrI: 0.21 to 0.82) at an optimal dose of 1500 METs-min/week. The certainty of evidence varied, with moderate confidence for some outcomes and low to very low confidence for others.</p><p><strong>Conclusions: </strong>These findings highlight the importance of structured PA interventions optimized according to the most effective PA modality and dosage thresholds for improving specific executive function components. Such tailored PA programs may provide a more effective approach for enhancing cognitive development in children and adolescents.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple trajectories of family adversity and poverty and adolescent self-harm and suicide attempts: findings from the UK Millennium Cohort Study.","authors":"Yanhua Chen, Michelle Black, Davara Bennett, Ruth McGovern, Helen Sharp, David H Rehkopf, David C Taylor-Robinson, Nicholas Kofi Adjei","doi":"10.1186/s13034-026-01023-6","DOIUrl":"10.1186/s13034-026-01023-6","url":null,"abstract":"<p><strong>Background: </strong>Exposure to family adversities including domestic violence, parental mental ill-health, and poverty in childhood increases the risk of self-harm and suicide attempts in adolescents. However, few studies have assessed the influence of clustered family adversity and poverty trajectories throughout childhood on self-harm behaviours and suicide attempts.</p><p><strong>Methods: </strong>In this population-based longitudinal study, we used data on 9316 children from the UK Millennium Cohort Study. Exposure trajectories of poverty and family adversities were characterised using group-based multi-trajectory models (age 9 months-14 years). Multivariable logistic regression models were used to examine the association of trajectories with self-harm and suicide attempts at age 17. Population-attributable fractions were calculated to quantify the contribution of family adversity and poverty to the outcomes at the country level.</p><p><strong>Results: </strong>Of 9316 participants, 2087 (22.4%) reported self-harm behaviours and 659 (7.1%) had made a suicide attempt. Compared with children experiencing low poverty and adversity, children in the persistent adversity groups were more likely to report both self-harm and suicide attempts; those exposed to persistent poverty and poor parental mental health were particularly at increased risk of self-harm (OR = 1.71, 95% CI: 1.30-2.24) and suicide attempts (OR = 3.98, 95% CI: 2.76-5.74). Overall, we estimated that about 13.2% of self-harm behaviours and 36.9% of suicide attempts were attributable to persistent family adversities and poverty.</p><p><strong>Conclusions: </strong>Children growing up with persistent exposure to family adversities and poverty are more likely to harm themselves and attempt suicide, particularly those who experience the combination of persistent poverty and long-term poor parental mental health. Early detection of children at risk and intervention such as anti-poverty approaches to prevent long-lasting adversities are key to alleviating risky behaviours in UK adolescents.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention-deficit/hyperactivity disorder in pediatric cancer survivors: risk and medication use in a nationwide population-based study.","authors":"Jae Sik Kim, Jung Lee, Joo Ho Lee","doi":"10.1186/s13034-026-01062-z","DOIUrl":"10.1186/s13034-026-01062-z","url":null,"abstract":"<p><p>BACKGROUND: Pediatric cancer survivors experience attention or behavioral deficits. This study assessed the risk and medication use of attention-deficit/hyperactivity disorder (ADHD) in pediatric cancer survivors compared with the general population. METHODS: Using nationwide cohort data from Korea’s National Health Insurance Service, we studied a pediatric cancer population (brain tumors [n = 3,517], acute lymphoblastic leukemia [ALL, n = 2,093], and other tumors [n = 30,639]) diagnosed between 2004 and 2011 and 125,663 healthy children. We analyzed the incidence of ADHD, medication patterns, and factors affecting ADHD using the Cox proportional hazards model and logistic regression analysis. RESULTS: Patients with brain tumors had the highest 10-year ADHD incidence (4.0%, 95% confidence interval [CI] 3.3–4.6) compared with healthy children (2.0%, 95% CI 1.9–2.1), patients with ALL (2.9%, 95% CI 2.2–3.7), and patients with other tumors (2.6%, 95% CI 2.4–2.8). Brain tumor survivors had the highest ADHD risk (hazard ratio [HR] 1.85, 95% CI 1.57–2.17, p < 0.001). Chemotherapy was associated with increased ADHD in children diagnosed at ages 0–3 years (HR 2.89, 95% CI 1.14–7.38, p = 0.03), whereas radiotherapy increased ADHD in patients with ALL (HR 4.10, 95% CI 1.63–10.28, p = 0.003). The use of ADHD medications was significantly higher in younger age groups (0–3 years, HR 2.62, 95% CI 1.98–3.45, p < 0.001; and 4–12 years, HR 3.44, 95% CI 2.30–4.86, p < 0.001) and among brain tumor survivors (HR 1.79, 95% CI 1.32–2.31, p < 0.001). Brain tumor survivors required long-term (> 7 months) ADHD medication (odds ratio 2.06, 95% CI 1.20–3.59, p = 0.01). CONCLUSIONS: Pediatric cancer survivors, particularly those with brain tumors or diagnosed at a young age, face a higher risk of ADHD and increased use of ADHD medications. Chemotherapy significantly increases the risk of ADHD in infants and toddlers, whereas radiotherapy increases this risk in patients with ALL. Ongoing monitoring and tailored interventions for high-risk groups are needed. </p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitating transition between adolescent and adult psychiatry: patient and parent experiences from a jointly run ward for 16-25-year-olds in Germany.","authors":"Lena-Sophie Over-Pluschke, Annette Duve, Sevinc Jürgens, Sebastian von Peter, Julian Schwarz","doi":"10.1186/s13034-026-01059-8","DOIUrl":"10.1186/s13034-026-01059-8","url":null,"abstract":"<p><strong>Background: </strong>Young people in the transition from adolescence to adulthood face particular challenges in psychiatric care. Continuity of treatment is often disrupted, as services are typically divided between child and adolescent psychiatry and adult psychiatry. Few frameworks provide age-appropriate, integrated care for individuals aged 16-25. In Germany, a model project was established to address this gap. It offers treatment tailored to this age group within a cross-sector, integrated care model that combines outpatient and inpatient services under a jointly run ward staffed by both child and adolescent psychiatrists and adult psychiatrists. This study explores the distinctive features of this integrated adolescent ward and examines the experiences of patients and their parents.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 27 patients and 7 parents. Data were analyzed using qualitative content analysis, focusing on three domains: (1) framework conditions and access to care, (2) the concept and content of treatment, and (3) the environment of the integrated adolescent ward.</p><p><strong>Results: </strong>Participants particularly valued the individualized therapeutic approach, flexible treatment across different settings, and transparent, responsive communication by staff. Age homogeneity and a focus on adolescence facilitated mutual identification and supportive peer interactions. Opportunities for self-determination and participation were also emphasized as important.</p><p><strong>Conclusion: </strong>Findings suggest that specific structural elements contribute to the ward being perceived as an age-appropriate therapeutic environment. Further research should identify and define specific care components of integrated treatment for young people aged 16-25 to enable replication and evaluation of its implementation.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with social inclusion of parents of children with autism spectrum disorder: a multicenter cross-sectional study in China.","authors":"Binbin Ji, Bohan Zhang, Siyu Chen, Yun Chen, Wanrui Wei, Longgang Zhao, Jing Li, Zhao Ni, Xiaojian Jiang","doi":"10.1186/s13034-026-01065-w","DOIUrl":"10.1186/s13034-026-01065-w","url":null,"abstract":"<p><strong>Background: </strong>Social inclusion of parents of children with autism spectrum disorder (ASD) affects their well-being and caregiving capacity. However, evidence on its factors remains limited in China. This study aimed to assess the social inclusion of parents of children with ASD and identify key factors, with attention to gender differences.</p><p><strong>Methods: </strong>1007 parents were enrolled from 33 rehabilitation centers in Hunan, China. Self-reported psychometric scales and a revised Chinese Social Inclusion Scale were used. Guided by the ecological model, univariate and multivariate regression analyses were performed to identify factors associated with social inclusion. Subgroup analyses and interaction effect tests were carried out to explore potential gender differences.</p><p><strong>Results: </strong>At the individual level, higher education (B = 1.764, P = 0.02), self-esteem (B = 0.472, P < 0.001), and hope (B = 0.139, P = 0.03) demonstrated positive associations with social inclusion. At the external level, intergroup relations (B = 0.271, P = 0.001) and social support (B = 0.238, P < 0.001) showed significant positive associations, while perceived discrimination (B=-0.189, P < 0.001) exhibited a significant negative association. Gender subgroup analyses showed fathers' inclusion was mainly influenced by self-esteem and social support, while mothers' patterns aligned with the overall group, except hope was not significant.</p><p><strong>Conclusions: </strong>Both psychological and social factors influence the social inclusion of parents of children with ASD, with gender-specific patterns. To enhance social inclusion of parents, healthcare providers could consider gender-responsive approaches that strengthen psychological resources while addressing external barriers.</p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The renaissance of research on psychedelics in child and adolescent psychopharmacology.","authors":"Marc-Antoine Crocq, Philippe Auby","doi":"10.1186/s13034-026-01069-6","DOIUrl":"10.1186/s13034-026-01069-6","url":null,"abstract":"<p><p>AIMS: The recent regulatory approval of esketamine in adults heralded the renaissance of research into psychedelic compounds. However, the relevance of this resurgence for children and adolescents remains unclear. This review examines the rationale for investigating psychedelics in pediatric psychopharmacology. METHODS: We reviewed recent literature, regulatory documents, and clinical trial registries addressing the psychiatric use of classic serotonergic psychedelics (e.g., psilocybin, LSD), the entactogen MDMA, and dissociative compounds such as ketamine and esketamine in adolescent and young populations. Although ketamine is not a classic serotonergic psychedelic, it represents a paradigm for innovative pharmacological approaches. RESULTS: Ongoing and planned trials primarily involve adolescents aged 16 years and older. Interest in these compounds is driven by significant unmet needs in child and adolescent psychiatry, where few medications are approved, and unsatisfactory therapeutic response is common. Potential targets include anorexia nervosa, core symptoms of autism spectrum disorders, obsessive-compulsive disorder, resistant depression, and severe PTSD. The fact that psychedelics may have long-lasting effects after only a few sessions raises the question of their effects on neuroplasticity. CONCLUSIONS: Although psychedelic research has entered a new phase in adult psychiatry, translation to pediatric populations requires caution due to developmental vulnerabilities and limited long-term safety data. Rigorous clinical trials, ethical safeguards, and regulatory oversight are essential before broader application in children and adolescents can be considered. </p>","PeriodicalId":9934,"journal":{"name":"Child and Adolescent Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}