Chinese Journal of Clinical Hepatology最新文献

{"title":"IDDF2021-ABS-0008 Is fatty liver associated with depression? A meta-analysis and systematic review on prevalence, risk factors and outcomes of depression and non-alcoholic fatty liver disease","authors":"C. Ng, J. Xiao, Lincoln Kai En Lim, D. Tan, W. Lim, Cyrus S. H. Ho, E. Tan, A. Sanyal, M. Muthiah","doi":"10.1136/gutjnl-2021-iddf.61","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.61","url":null,"abstract":"IDDF2021-ABS-0008 Figure 1 Abstracts A64 Gut 2021;70(Suppl 2):A1–A150 on S etem er 1, 2021 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-ID D F 61 on 2 S etem er 221. D ow nladed fom aimed to assess the association between depression and NAFLD. Methods A search of the literature was conducted on Medline and Embase databases to identify articles relating to NAFLD and depression. A meta-analysis of proportions was conducted using the generalized linear mix model with Copper Pearson intervals to stabilize the variance. Risk factors were analyzed using the odds ratios and mean difference for dichotomous and continuous variables respectively. To compare between the rate of depression between NAFLD (non-alcholic fatty liver disease) and NASH (nonalcoholic steatohepatitis), the relative risks (RR) were calculated using the depression in NASH vs NAFLD as the ratio of the pooled proportion and confidence interval by the Katz-logarithmic method. Results Of 1315 unique abstracts identified, 10 articles involving 2,041,752 NAFLD patients were included (IDDF2021ABS-0008 Figure 1. Overall Prevalence of Depression in NAFLD). In a pooled analysis of studies, there was a significant relationship between the diagnosis of depression and NAFLD (OR: 1.29, CI: 1.02 1.64, p=0.03). The overall pooled prevalence of depression in NAFLD was14.39% (CI: 8.89% 22.45%). The prevalence of depression in nonalcoholic steatohepatitis (NASH) is 40.68% (CI: 25.11% 58.37%), significantly higher than that in NAFLD at 14.39% (CI: 8.89% 22.45%). Compared to NAFLD, patients with NASH had a significantly higher risk of depression (RR: 2.83, CI: 2.41 3.32, p <0.001). Diabetes, BMI, female sex, history of smoking and history of lung disease were significant risk factors associated with depression in NAFLD patients and depression in NAFLD patients was an independent predictor of all-cause 1-year mortality. Conclusions To our knowledge, this is the first meta-analysis to describe a positive association between NAFLD and depression with an increasing rate of depression in NASH compared to NAFLD (IDDF2021-ABS-0008 Figure 2. Graphical Depiction of the Overall Results). However, more studies are required to observe the impact of depression and clinical outcomes in NAFLD. IDDF2021-ABS-0010 A META-ANALYSIS AND METAREGRESSION BETWEEN LIVER RESECTION AND LIVER TRANSPLANT WITHIN MILIAN CRITERIA Cheng Han Ng*, Jin Hean Koh, Yuki Ong, Wen Hui Lim, Darren Jun Hao Tan, Mark Muthiah, Nicholas Syn, Brian Goh, Daniel Huang. Yong Loo Lin School of Medicine, Singapore; Singapore General Hospital, Singapore 10.1136/gutjnl-2021-IDDF.62 Background Hepatocellular carcinoma (HCC) is the dominant form of primary liver cancer and a leading cause of cancer globally. Liver transplantation (LT) confers excellent long-term survival outcomes, but its effectiveness is hampered by the dire shortage of liver allografts. Liver resection (LR) is a promising alternative due to favorable","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89698910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0079 Switching from tenofovir disoproxil fumarate (TDF) and/or other oral antivirals (OAVS) to tenofovir alafenamide (TAF) in virally suppressed chronic hepatitis B (CHB) patients with hepatic impairment: final 2-year efficacy and safety results from a phase 2","authors":"Y. Lim, Chun‐Yen Lin, J. Heo, H. Bae, W. Chuang, T. Tsang, C. Fournier, A. Hui, H. Trinh, Carol Yee Kwan Chan, Susanna K. Tan, Yang Zhao, J. Flaherty, V. Suri, A. Gaggar, Dianna M Brainard, S. Ryder, H. Janssen","doi":"10.1136/gutjnl-2021-iddf.81","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.81","url":null,"abstract":"(HBV DNA <LLOQ x 6 months, <20 IU/mL at screening) with moderate or severe RI or with ESRD on HD at screening while receiving TDF and/or other OAVs for 48 weeks were enrolled and switched to TAF for 96 weeks. Safety assessments including adverse events (AEs), changes in bone BMD and renal (eGFRCG, serum phosphorus serum creatinine except in ESRD patients) parameters, viral suppression, serological and biochemical responses were serially assessed. Results Of 93 patients (mod-severe RI 78; ESRD on HD 15), most (74%) were male and Asian (77%), 51% 65 y, 83% HBeAg-negative, 34% cirrhosis, and median ALT 17 U/L. Up to 24% had osteoporosis at hip and/or spine, with most having comorbidities. Twelve (13%; 11 mod-severe RI and 1 ESRD) patients discontinued the study early (5-withdrew consent, 3-deaths [none treatment-related], 2-AE, 2investigator decision). Viral suppression (HBV DNA<20IU/ mL) was maintained in all patients remaining on treatment (i.e. missing equals excluded); a high proportion had target not detected. Overall, TAF was well tolerated with no Grade 3 ,4 or serious AEs related to study treatment. Relative to baseline levels, switching to TAF resulted in small median% increases in hip/spine BMD in those with moderate to severe RI, and small median decreases in ESRD patients. 2 patients with mod-severe RI had a bone fracture (ankle, rib). Median eGFRCG increased while urinary markers of proximal tubular function progressively decreased in mod-severe RI patients. Conclusions Renally-impaired CHB patients, including ESRD patients on HD, who were switched to TAF from TDF and/or other OAVs maintained high rates of viral suppression, and bone and renal parameters remained stable or slightly improved after 2 years of treatment.","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90877222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0159 The effect of curcumin supplement among overweight/obese non-alcoholic fatty liver disease (NAFLD) patients","authors":"Eduward Thendiono","doi":"10.1136/gutjnl-2021-iddf.98","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.98","url":null,"abstract":"","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82246883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0010 A meta-analysis and meta-regression between liver resection and liver transplant within milian criteria","authors":"C. Ng, J. H. Koh, Y. Ong, W. Lim, Darren Jun Hao Tan, M. Muthiah, N. Syn, Brian Goh, Dan-chi Huang","doi":"10.1136/gutjnl-2021-iddf.62","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.62","url":null,"abstract":"","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83530539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0019 An epidemiological meta-analysis on the worldwide prevalence, resistance and outcomes of spontaneous bacterial peritonitis in cirrhosis","authors":"C. Ng, Phoebe Wen Lin Tay, J. Xiao, Darren Jun Hao Tan, Yan Nerng Lye, W. Lim, Vanessa Xin Yi Teo, Ryan Rui Yang Heng, Marcus Wei Xuan Yeow, Lionel Hon Wai Lum, Eunice Xiang Xuan Tan, G. S. Kew, G. Lee, M. Muthiah","doi":"10.1136/gutjnl-2021-iddf.64","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.64","url":null,"abstract":"","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87157004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0084 Tuberculosis as a common cause of post-liver transplant ascites","authors":"T. Sowmya","doi":"10.1136/gutjnl-2021-iddf.84","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.84","url":null,"abstract":"Background To assess the quality of life (QoL) of patients with hepatocellular carcinoma (HCC) by the European Organi-zation for the Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ- C30). Methods A prospective study was conducted from August 2020 to August 2021. We evaluated the QoL of 30 patients diagnosed of HCC at Bach Mai and Hanoi Medical University Hospital after a month of treatment. EORTC-QLQ C30 items were converted to scores according to an available formula, the total score for each section ranged from 0 to 100. A low functional score reflected a low QoL, while a lower symptom score indicated a higher QoL. The overall EORTC score (C30 index score) would be calculated according to the available formula. The lower the C30 index score was, the better the QoL would be. and","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73377122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0070 Predictive performance of the hap score at patients with hepatocellular carcinoma following trans-arterial chemoembolisation (TACE)","authors":"Anh Tran Ngoc, H. Trung, Lieu Dau Quang","doi":"10.1136/gutjnl-2021-iddf.77","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.77","url":null,"abstract":"","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79082647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0040 Less liver fibrosis marker increment in overweight chronic hepatitis b patients observed by age-adjusted fibrosis-4 index","authors":"Tasia Liu","doi":"10.1136/gutjnl-2021-iddf.68","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.68","url":null,"abstract":"","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74771880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0184 Global incidence and risk factors of pancreatic cancer among young adults: an epidemiological study","authors":"Junjie Huang, Alfonse Ngai, Veeleah Lok, Xianjing Liu, Lin Zhang, Jinqiu Yuan, Wanghong Xu, Zhi‐Jie Zheng, Martin C. S. Wong","doi":"10.1136/gutjnl-2021-iddf.101","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.101","url":null,"abstract":"IDDF2021-ABS-0184 Figure 1 Global incidence of youngonset pancreatic cancer in 2020 Abstracts Gut 2021;70(Suppl 2):A1–A150 A91 on S etem er 5, 2021 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-ID D F .02 on 2 S etem er 221. D ow nladed fom Methods A cross-sectional study of all eligible LT recipients from 2008 to 2020 in a leading transplant centre in Singapore was conducted to determine the vaccine response in HBV-naïve subjects. A standardised workflow was devised to identify barriers in vaccination and response monitoring. Transplant coordinators and pharmacists assisted physicians to identify and prescribe CDC-recommended vaccinations using a template, which include Engerix 40mcg of three doses, followed by rechecking anti-HBs titre one month after. A second 3-dose Engerix regimen was given if anti-HBs remains <10 mIU/mL. Non-responder is defined as failure to achieve protective anti-HBs titre after completing two cycles. Results Of the 279 LT recipients, we excluded patients not on follow-up and patients with anti-HBc positivity. 75 patients were included. Prior to vaccination implementation, 9/75 (12%) were not checked for anti-HBs. Of the 66 checked, 40 required vaccination. 29/40 (72.5%) were started on the first cycle, and 21/40 (52.5%) completed. 11/20 (55%) patients were initiated on the second cycle. Post workflow implementation, 40 needed vaccination. 34/40 (85%) were started on the first cycle and 24/40 (60%) completed. 18/23 (78.3%) were started on a second cycle. 3/4 (75%) were non-responders (IDDF2021-ABS-0190 Figure 1). Our implementation coincided with the COVID-19 pandemic where more teleconsultation was used. COVID-19 vaccination was also prioritised over HBV vaccination. We postulate that these results would be further improved once physical consultations resumed. Conclusions The development of a standardised workflow can lead to improvement in anti-HBs testing and compliance to vaccination post-LT. These findings may be useful for other patients who are on long-term immunosuppression. Continual efforts from the multidisciplinary team are required to ensure the sustainability of effect. IDDF2021-ABS-0203 A SCREENING MODEL FOR OBSTRUCTIVE SLEEP APNEA ON THE BASIS OF FATTY LIVER DISEASE-RELATED PARAMETERS Yang-Bor Lu*, Yu-Chieh Weng, Yung-Ning Huang, Hsiung-Ying Huang, PeiTing Cheng, Hui-Shan Hsieh, Ming-Shao Tsai. Department of Digestive Disease, Xiamen Chang Gung Hospital, Xiamen, China; Hepatobiliary and Pancreatic Unit, Xiamen Chang Gung Hospital, Xiamen, China; Department of Pulmonary and Critical Care Medicine, Sleep center, Xiamen Chang Gung Hospital, Xiamen, China; Formosa Biomedical Technology Corp., Taipei, Taiwan; Department of Otolaryngology-Head and Neck Surgery, Sleep center, Xiamen Chang Gung Hospital, Xiamen, China; Department of Otolaryngology-Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; College of Medicine, Chang Gung University, Taoyua","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84852702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDDF2021-ABS-0102 Retrospective analysis of characteristics, indications and outcomes of ercp in a tertiary referral center of Saudi Arabia","authors":"Laeeque Ahmed, Ahmed Basalim, N. Alwagdani, Bsaim Altirkistani, Ziyad M. Albassam, Mohammed A Almatrafi, Faisal S Alrubaei, Adnan Alzanbagi","doi":"10.1136/gutjnl-2021-iddf.90","DOIUrl":"https://doi.org/10.1136/gutjnl-2021-iddf.90","url":null,"abstract":"IDDF2021-ABS-0116 Figure 2 Abstract IDDF2021-ABS-0116 Figure 3 AbstractsIDDF2021-ABS-0116 Figure 3 Abstracts Gut 2021;70(Suppl 2):A1–A150 A85 on S etem er 5, 2021 by gest. P rocted by coright. http/gut.bm jcom / G t: frst pulished as 10.113utjnl-2021-ID D F 92 on 2 S etem er 221. D ow nladed fom 32 studies described tumors with a specified primary, with gastric cancer being the most common. (IDDF2021-ABS-0116 Figure 1) Pooled data showed that the 3and 5-year OS were 45% (95% CI 0.40-0.50) and 35% (95% CI 0.31-0.19), (IDDF2021-ABS-0116 Figure 2, IDDF2021-ABS-0116 Figure 3) respectively, whereas the 3and 5-year DFS were 33% (95% CI 0.29-20.37) and 27% (95% CI 0.23-0.32), respectively (IDDF2021-ABS-0116 Figure 4, IDDF2021-ABS-0116 Figure 5). The postoperative morbidity rate was 24% (95% CI 0.20-0.29), whereas the 30-day mortality was 2% (95% CI 0.01-0.03). Gastric cancer with liver metastasis had 3-year and 5-year OS of 39% (95% CI 0.32-0.46) and 25% (95% CI 0.20-0.31). Conclusions Hepatectomy for NCNNLM may achieve favourable survival outcomes, with low surgical morbidities and mortalities in selected patients. IDDF2021-ABS-0118 FACTORS ASSOCIATED WITH THE PRESENCE OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) DETECTED IN JAPANESE ADULTS UNDERGOING HEALTH","PeriodicalId":9921,"journal":{"name":"Chinese Journal of Clinical Hepatology","volume":"66 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91511588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}