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[Determination of heavy metals in samples of herbal drugs using differential pulse polarography]. [用差示脉冲极谱法测定中草药样品中的重金属]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
M Sviceková, E Havránek, V Novák
{"title":"[Determination of heavy metals in samples of herbal drugs using differential pulse polarography].","authors":"M Sviceková,&nbsp;E Havránek,&nbsp;V Novák","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The contamination of the environment requires the content of heavy metals in medicinal plants to be limited and controlled. The present paper aims to demonstrate the possibilities of application and advantages of a modern polarographic method, differential pulse chromatography (DPP), in the identification and determination of heavy metals in the plant material. In the plant drugs Flos chamomillae and Flos calendulae, the heavy metals Pb, Cd, Ni, Zn, Cu and Fe were identified and determined. The World Health Organization (WHO) indicated Pb, Cd and Ni as dangerous toxic trace elements.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of ionizing radiation on enzymes. X. The effect of gamma irradiation on pancreatic amylase in pancreatin]. 电离辐射对酶的影响。X. γ辐照对胰腺淀粉酶的影响[j]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
A Libický, V Kubánková, J Fidlerová, J Pipota
{"title":"[The effect of ionizing radiation on enzymes. X. The effect of gamma irradiation on pancreatic amylase in pancreatin].","authors":"A Libický,&nbsp;V Kubánková,&nbsp;J Fidlerová,&nbsp;J Pipota","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper examined the effect of ionizing radiation (source, 60Co) within a range of doses from 10 to 120 kGy on amylolytic efficacy of pancreatin of two types: pancreatin obtained by isolation from an extract of the pancreas (sample 1) and pancreatin containing parts of the pancreatic tissue, but with higher amylolytic efficacy (sample 2). Efficacy was expressed in F.I.P. units. As shown in the chart, a percentual decrease in efficacy is higher in the more active sample 2. Graphical representation is in good agreement with the statistical evaluation of the significance between the decreases in efficacy in both samples irradiated with doses of 30 and 120 kGy, if the median test was used and probability was calculated with the use of Fisher's test. This is not, however, the case of irradiation with a dose of 10 kGy. The residual, graphically corrected efficacy after irradiation with a sterilizing dose of 25 kGy was 84.1% (sample 1) and 80.3% (sample 2). With the maximal dose used, the residual efficacy was 43.7% (sample 1) and 36.7% (sample 2).</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"77-81"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18694521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Changes in basic nitrogen in a group of potential new beta- adrenolytics--derivatives of p-hydroxyacetophenone and p-hydroxypropiofenone]. [一组潜在的新型β -肾上腺素-对羟基苯乙酮和对羟基丙烯酮衍生物中碱性氮的变化]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
R Cizmáriková, E Racanská, O Greksáková
{"title":"[Changes in basic nitrogen in a group of potential new beta- adrenolytics--derivatives of p-hydroxyacetophenone and p-hydroxypropiofenone].","authors":"R Cizmáriková,&nbsp;E Racanská,&nbsp;O Greksáková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Within the relationship of the structure and effect of new beta-adrenolytic agents derivatived from p-hydroxyacetophenone and p-hydroxypropiophenone with a propoxymethyl group in the lipophilic part of the molecule and with a propanamine, a butanamine and a pyrrolidine in the side-chain were studied. In order to prepare these substances, a procedure was selected from several tested ones, in which 4-hydroxy-3propoxymethylphenylketone were treated with chloromethyloxirane and subsequent reaction a hydrobromic acid were prepared 4-(3-brom-2-hydroxypropoxy)-3-propoxymethylalkylketone. Final substances were prepared reaction with amine. The structure of prepared compounds was confirmed on the basic interpretation of the IR, UV and 1H NMR spectra. The results of pharmacological evaluation of selected compounds showed a significant beta 1-blocking activity lower than acebutolol. Their local anesthetic activity is low according with their partition coefficients. The characteristic of the prepared compounds was supplemented by the determination of their partition coefficients, surface tension, dissociation constants and acute toxicity.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"82-5"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19097245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Local anesthetics. CX. Preparation, activity and partition coefficients of pyrrolidinoethylesters of 2-, 3- and 4-alkoxy-substituted phenylcarbamic acids]. (局部麻醉剂。残雪。2-、3-和4-烷氧基取代苯氨基甲酸吡咯烷二乙基酯的制备、活性和分配系数
Ceskoslovenska farmacie Pub Date : 1993-04-01
J Cizmárik, E Polásek, P Svec, E Racanská
{"title":"[Local anesthetics. CX. Preparation, activity and partition coefficients of pyrrolidinoethylesters of 2-, 3- and 4-alkoxy-substituted phenylcarbamic acids].","authors":"J Cizmárik,&nbsp;E Polásek,&nbsp;P Svec,&nbsp;E Racanská","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By pyrrolidinoethylalcohol addition on 2-, 3- and 4-alkoxy-substituted phenylisocyanate in non-aqueous toluene medium a series of 30 compounds of the type Pyrrolidinoethylesters of 2-, 3- and 4-alkoxy substituted phenylcarmabim acids were prepared. Pharmacological evaluation results shown after comparing with cocaine and procaine standards that these compounds have a higher index of effectiveness in both types of local anaesthesia. The maximum effectiveness of surface anaesthesia shows Pyrrolidinoethylester of 2-octyloxy phenylcarbamic acid which is 204-times more effective as cocaine. The maximum effectiveness of infiltration anaesthesis shows Pyrrolidinoethylester of 2-heptyloxy phenylcarbamic acid which is 66-times more effective as procaine. Prepared compounds are more effective in the case of surface anaesthesia as in the case of infiltration anaesthesia and they have comparatively high values of partition coefficients P' and P' cal. Comparison of prepared compounds effectiveness and analogic piperidinoethylesters shows that in more cases they are either equal or nearer effective. The values of their P' and P' cal correlate with these results.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"88-91"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Herbal drugs in Kampo preparations]. [汉布制剂中的草药]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
J Hubík, J Spilková
{"title":"[Herbal drugs in Kampo preparations].","authors":"J Hubík,&nbsp;J Spilková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Medicaments of the Kampo medicine are composed from vegetable drugs. This article describes drugs unknown in European medicine and used in Kampo preparations--Radix bupleuri, Tuber pinelliae, Hoelen, Radix scutellariae, Cortex magnoliae, Fructus zizyphi, Herba perillae, Radix paeoniae, Rhizoma atractylodis, Rhizoma alismatis, Radix alismae, Rhizoma cnidii, Radix angelicae, Rhizoma coptidis, Fructus gardeniae, Cortex phellodendri, Polyporus, Radix ginseng.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"65-7"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Protective effect of propentophylline (HWA 285) in ischemic spinal cord injury]. [预茶碱(HWA 285)对缺血性脊髓损伤的保护作用]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
M Chavko, V Danielisová
{"title":"[Protective effect of propentophylline (HWA 285) in ischemic spinal cord injury].","authors":"M Chavko,&nbsp;V Danielisová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of propentophylline (HWA 285) on the course of the functional regeneration of the hind extremities and on the regeneration of the energetic metabolism in the spinal cord after ischaemia produced by ligating the abdominal aorta for 20 or 30 mins was investigated. Administration of 20 mg/kg i.v. propentophylline after the induction of ischaemia produced marked regeneration of these parameters in comparison with ischaemia without administration of the drug in the course of four days. The protective effect of propentophylline administered prior to ischaemia was markedly weaker.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"71-3"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Densitometric determination of dithiadenoxide in blood]. 血中二硫腺苷氧化物的密度测定。
Ceskoslovenska farmacie Pub Date : 1993-04-01
M Peterková, O Matousová
{"title":"[Densitometric determination of dithiadenoxide in blood].","authors":"M Peterková,&nbsp;O Matousová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present paper describes a method of dithiadenoxide determination in blood plasma. Dithiadenoxide was reduced to dithiaden with zinc dust in acidified plasma. The solution was alkalified and dithiaden extracted into n-hexane and isolated on a thin layer of silica gel using the system chloroform--n-heptane-methanol (60:22:18). After spraying the plate with a solution of m-nitrophenyldiazoniumfluoroborate in acid medium, dithiaden stains were evaluated densitometrically in the absorption maximum of the reaction product at 565 nm (RF = 0.37). Detection limit of dithiadenoxide in the proposed method is 0.004 microgram in an applied amount.</p>","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"86-7"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19097791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[75th anniversary of the State Institute for Drug Control. Its evolution, present status and perspectives]. 国家药品监督管理研究所成立75周年。它的演变、现状和前景]。
Ceskoslovenska farmacie Pub Date : 1993-04-01
J Portych
{"title":"[75th anniversary of the State Institute for Drug Control. Its evolution, present status and perspectives].","authors":"J Portych","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 2","pages":"55-9"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacy in Belgium]. [比利时药房]。
Ceskoslovenska farmacie Pub Date : 1993-02-01
Z Sterbáková
{"title":"[Pharmacy in Belgium].","authors":"Z Sterbáková","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 1","pages":"37-9"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19493536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacy and the present time]. [药房和现在]。
Ceskoslovenska farmacie Pub Date : 1993-02-01
V Smecka
{"title":"[Pharmacy and the present time].","authors":"V Smecka","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":9871,"journal":{"name":"Ceskoslovenska farmacie","volume":"42 1","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"1993-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19493537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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