中华实用儿科临床杂志最新文献

{"title":"Efficacy of negative pressure suction and external testosterone cream in the treatment of small penis after hypospadias surgery","authors":"Liang Zhao, Cuiping Song, Haiyang Zhang, Hui Liu, Wang Rao, Xusheng Tian, Dan-chen Su, Xinhui Sun","doi":"10.3760/CMA.J.CN101070-20190222-00124","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190222-00124","url":null,"abstract":"Objective \u0000To explore the effective method for treatment of small and short penis after hypospadias surgery. \u0000 \u0000 \u0000Method \u0000s From November 2017 to November 2018, 57 children aged 4 to 14[mean age(7.91±2.89)years] with hypospadias who met the diagnostic criteria of small penis were reexamined at the First Affiliated Hospital of Xin-xiang Medical University.They were randomly divided into the physical treatment group and the drug treatment group according to the order of visits, and the untreated patients were included in the control group.Among them, 21 patients in the physical treatment group were treated with penile rehabilitation therapy apparatus, supplemented by Salvia mil-tiorrhiza bath (30 minutes/time, once/day, 10 days), and 20 patients in the drug treatment group were treated with Testosterone cream topically (3 times/day, 10 days). Penile relaxation length, stretch length, transverse and longitudinal diameters of glans in 2 groups before and after the treatment were measured.The relevant indexes of 16 patients in the control group measured before and after 10 days and compared with those in the treatment group. \u0000 \u0000 \u0000Result \u0000s (1)The penile relaxation length in the physical treatment group increased from (25.48±6.13) mm to (30.72±6.49) mm, the length of stretch increased from (34.90±7.71) mm to (41.08±8.43) mm, the transverse diameter of glans increased from (14.81±3.40) mm to (16.57±3.42) mm, and the longitudinal diameter increased from (13.94±3.15) mm to (15.82±3.52) mm, and the differences were statistically significant (all P 0.05). (4) Compared with the control group, the penile relaxation length, the length of stretch, transverse diameter and longitudinal diameters of glans in the physical treatment group increased significantly, and the differences of growth values between the two groups were statistically significant (all P<0.05). (5) Compared with the control group, the penile relaxation length, the length of stretch, transverse diameter and longitudinal diameters of glans in the drug treatment group also increased significantly, and the difference of growth values between the two groups were statistically significant (all P<0.05). (6) The growth of penile relaxation length, the length of stretch and transverse and longitudinal diameters in the drug treatment group were higher than those in the physical treatment group, and the difference of growth values were statistically significant (all P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Both the negative pressure suction method and topical application of Testosterone cream are effective in the treatment of small and short penis after hypospadias surgery.However, Testosterone cream is difficult to obtain, and the treatment of negative pressure suction is simple, noninvasive, painless and free of adverse reactions. \u0000 \u0000 \u0000Key words: \u0000Hypospadias; Small penis; Treatment; Negative pressure suction; Testosterone cream","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"297-301"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44512518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances on mesenchymal stem cells in the treatment of refractory pulmonary diseases","authors":"Z. Fu, Jingyi You, L. Zou","doi":"10.3760/CMA.J.CN101070-20200313-00390","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20200313-00390","url":null,"abstract":"Refractory pulmonary disease is a respiratory disease that seriously threatens the health of patients, and can lead to impaired pulmonary function and even respiratory failure.Currently, conventional drug therapy does not work well, so it is particularly important to find more effective treatments.Mesenchymal stem cells(MSCs) are a kind of multifunctional stem cells, which can promote the repair of damaged cells by regulating inflammatory and immune reactions and boost the regeneration of damaged tissues through paracrine.Therefore, MSCs are expected to provide a possibility for the treatment of refractory lung pulmonary diseases. \u0000 \u0000 \u0000Key words: \u0000Refractory; Pulmonary diseases; Mesenchymal stem cells; Therapy","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"251-254"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43697923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of prealbumin in children with severe Mycoplasma pneumoniae pneumonia","authors":"Chengyi Wang, Guanghua Liu, Shibiao Wang, J. Zhang","doi":"10.3760/CMA.J.CN101070-20190328-00258","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190328-00258","url":null,"abstract":"目的 \u0000分析重症肺炎支原体肺炎(MPP)患儿血浆前清蛋白与临床指标的关系，探讨检测血浆前清蛋白在重症MPP中的临床意义。 \u0000 \u0000 \u0000方法 \u0000选取2015年1月至2018年3月福建省妇幼保健院儿科重症监护病房收治符合重症MPP诊断标准的患儿，收集患儿一般资料和实验室检查指标，进行统计学分析。 \u0000 \u0000 \u0000结果 \u00001．最终符合标准185例患儿，根据三代儿童死亡评分分为低危组(0～ 10 d (62.5%比44.6%)、机械通气(31.3%比12.4%)、小儿危重症评分<80分的比例(21.9%比9.92%)和三代儿童死亡评分预估病死率[8.02%(0.48%～88.12%)比1.81%(0.41%～31.69%)]越高，差异均有统计学意义(P＝0.030、0.003、0.043，P<0.001)。 \u0000 \u0000 \u0000结论 \u0000血浆前清蛋白水平可反映重症MPP的严重程度，提示血浆前清蛋白水平有可能成为预警重症MPP进展的客观指标之一。","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"302-304"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46627010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the incidence of retinopathy of prematurity in premature infants born in the hospital and transported from other hospitals","authors":"Jia-wei Ren, Yumei Yuan, Xiufang Chi, Xianqiong Luo, C. Nie","doi":"10.3760/CMA.J.CN101070-20190704-00596","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190704-00596","url":null,"abstract":"Objective \u0000To explore the incidence, diagnosis and treatment of retinopathy of prematurity(ROP) in preterm infants born in the Guangdong Women and Children′s Hospital and transported from other hospital. \u0000 \u0000 \u0000Method \u0000s Clinical data of 755 premature infants with ROP at Neonatal Intensive Care Unit, Guangdong Women and Children′s Hospital from January 2013 to December 2015 were retrospectively analyzed.There were 239 cases born in the hospital and 516 cases transported from other hospitals.Their gestational age, birth weight, gender, severity of ROP lesion and clinical data were collected and compared. \u0000 \u0000 \u0000Result \u0000s The birth weight in the group of transported from other hospital was lower than that in the group of born in the hospital[(1 290.64±392.87) g vs.(1 586.21±512.74) g], and the difference was statistically significant(P<0.001). The ROP diagnosis of gestational age in the group of transported from other hospital was higher than that in the group of born in the hospital[(35.53±2.81)weeks vs.(34.51±2.17)weeks], and the difference was statistically significant(P<0.001). On the proportion of severe condition [such as lesion area Ⅰ, aggressive posterior retinopathy of prematurity(AP-ROP) and plus combined lesions], in the group of transported from other hospital was higher than that in the group of born in the hospital, and the differences was statistically significant(P<0.001). In the comparison of the proportion of laser photocoagulation, vitreous injection, combination of the two operations and supplementary laser therapy, in the group of transported from other hospital were higher than those in the group of born in the hospital[60.1%(310/516 cases) vs.20.9%(50/239 cases); 10.9%(56/516 cases) vs.2.5%(6/239 cases); 8.1%(42/516 cases) vs.1.7%(4/239 cases); 4.5%(23/516 cases) vs.1.3%(3/239 cases)], and the differences were statistically significant(all P<0.001). \u0000 \u0000 \u0000Conclusions \u0000Premature infants with ROP transported from other hospitals have lower birth weight, severe ROP lesions and high surgical intervention rate.Improving ROP screening level in primary hospitals, timely diagnosis and efficient transportation can help to effectively prevent the deterioration of ROP in premature infants and improve their quality of life. \u0000 \u0000 \u0000Key words: \u0000Retinopathy of prematurity; Infant, preterm; Transport","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"293-296"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42495066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of compound novel heterozygous mutations of TRPM6 gene in hypomagnesaemia with secondary hypocalcaemia","authors":"Wen Li, Jianhua Mao","doi":"10.3760/CMA.J.CN101070-20190123-00052","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190123-00052","url":null,"abstract":"回顾性分析浙江大学医学院附属儿童医院收治的1例原发性低镁血症继发低钙血症患儿的临床资料及随访资料。患儿为8月龄男童，临床表现为婴儿期出现的惊厥、生长发育迟缓、精神发育迟滞。通过补镁等对症治疗后患儿临床症状缓解。最终通过亚全外显子测序，检测到患儿TRPM6基因的复合杂合突变，分别为c.5386A>T(p.K1796X)和c.453_454del(p.M151fs)。提示基因检测是确诊该病的金标准，本研究发现TRPM6基因的2种新的突变。","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"308-309"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42500522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular biological characteristics and antimicrobial resistance of Staphylococcus aureus isolated from children with pneumonia","authors":"Lim-Lim Kong, Xin Yang, S. Qian, F. Dong, Ying-chao Liu, Lijuan Wang, K. Yao, Wenqi Song","doi":"10.3760/CMA.J.CN101070-20190429-00362","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190429-00362","url":null,"abstract":"Objective \u0000To investigate the molecular characteristic and antimicrobial resistance of Staphyloco-ccus aureus (S.aureus) isolated from children with pneumonia, in order to provide the evidence for clinical diagnosis and treatment. \u0000 \u0000 \u0000Method \u0000s The S.aureus strains isolated from children diagnosed as S.aureus pneumonia in the Beijing Children′s Hospital, Capital Medical University, between January 2016 and March 2017 were collected.Methicillin-resistant S.aureus(MRSA)and Methicillin-susceptible S.aureus(MSSA)were identified using the cefoxitin disc method and the detection of the mecA gene.S.aureus isolates were characterized by multilocus sequence typing (MLST) and Staphylococcal protein A (spa) typing, and MRSA strains were characterized by Staphylococcal chromosome cassette (SCCmec) typing.Besides, 21 superantigens (SAgs) genes, panton-valentine leucocidin (PVL) genes, adhesion genes fnbb and cna were detected by PCR; E-test was used to detect in vitro drug sensitivity of 14 antibiotics. \u0000 \u0000 \u0000Result \u0000s A total of 42 S.aureus were collected, and 21 isolates were MSSA, the same to MRSA, while MSSA strains had relatively dispersed typing, with ST25-t078 (14.2%) as the most common one.ST59-SCCmecⅣa-t437 (71.4%) were the most predominant clones of MRSA.Of the 42 isolates, 36 strains (85.7%) had at least 1 superantigen gene, and sek-seq (21.4%) was the main virulence genotype.The ratio of pvl in MRSA strains (52.3%)was significantly higher than that in MSSA strains (14.2%), while the detection rate of fnbB and cna in MRSA(9.5%, 9.5%) was significantly lower than that in MSSA(42.8%, 47.6%), and the differences were statistically significant (all P<0.05). Ninety point four percent (38/42 strains) of the S.aureus isolates were multidrug resistant. \u0000 \u0000 \u0000Conclusions \u0000In children with S.aureus pneumonia, MRSA has a high detection rate, and its dominant clonotype is ST59-SCCmecⅣa-t437.The pre-valence of superantigen genes and the multidrug resistant rate of S.aureus are relatively high.MRSA strains often carry pvl, while MSSA strains usually carry fnbB and cna gene. \u0000 \u0000 \u0000Key words: \u0000Pneumonia; Child; Staphylococcus aureus; Molecular characteristics; Virulence; Antimicrobial susceptibility","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"268-273"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45126364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of multidimensional assessment in refractory asthma of children","authors":"Lei Chi, Yuxia Shan, Ziwei Zhu","doi":"10.3760/CMA.J.CN101070-20200309-00354","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20200309-00354","url":null,"abstract":"Refractory asthma is an inevitable clinical difficulty that is often faced by pediatricians in the promotion of standardized diagnosis and treatment of asthma.In this paper, the important role of multidimensional assessment (MDA) in the diagnosis of refractory asthma is emphasized, and the method of MDA is described in detail at first.Then foreign and domestic research on the internal mechanism of truly refractory asthma in recent years is syste-matically reviewed, which shows the progress of research on the internal phenotypes, biomarkers and targeted treatment of refractory asthma to the readers, with a view to developing the pediatricians′ ideas and further improving the diagnosis and treatment level of asthma by taking precision medical treatment as the goal. \u0000 \u0000 \u0000Key words: \u0000Child; Asthma; Refractory asthma; Assessment; Treatment","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"262-267"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42890297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress in genetic studies of Rolandic epilepsy","authors":"Xiao Li, Li Jiang","doi":"10.3760/CMA.J.CN101070-20190306-00167","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190306-00167","url":null,"abstract":"Rolandic epilepsy (RE), also known as benign epilepsy of childhood with centrotemporal spikes (BECTS), is the most common childhood idiopathic epilepsy syndrome.In the past, RE was often thought to have a good prognosis and usually disappeared spontaneously before puberty.However, Aicardi and Chevrie proposed the concept of RE variant (ARE) in 1982, and claimed that the clinical and electrophysiological manifestations of some RE children patients were in accordance with the characteristics of RE at the early stage of onset, but the clinical and EEG deteriorated during the course of the disease.RE is now considered to be a continuous epileptic-aphasia spectrum (EAS) disorder that causes mild to severe brain damage, often accompanied by varying degrees of cognitive and speech dysfunction.The etiology of RE is complex, and its pathogenesis is still not quite clear.With the development of molecular genetics, a complex interplay between the polygenic inheritance and environment has been found contributed to the etiology of RE.In addition, many striking genes are discovered.In this review, recent gene findings associated with RE were stressed, and the molecular biological characteristics and variants of related genes (GRIN2A, KCNQ2, KCNQ3, DEPDC5, ELP4-PAX6, GABAA-R, RBFOX1/3), clinical-gene correlation and variants-function investigation were described in detail in order to help with interpretation of clinical gene report clinical diagnosis of RE. \u0000 \u0000 \u0000Key words: \u0000Rolandic epilepsy; Epilepsy-aphasia spectrum; Genetics","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"314-317"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46431218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between asthma and attention deficit hyperactivity disorder in children and their risk factors","authors":"Mingxi Zhou, Hao Zhou, Yuxia Cui","doi":"10.3760/CMA.J.CN101070-20190426-00354","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20190426-00354","url":null,"abstract":"In recent years, the relationship between children′s chronic diseases and neuropsychiatric diseases and their pathogenesis have become a hot and difficult issue in pediatric research.Bronchial asthma (asthma) is a co-mmon chronic airway inflammatory disease in children.The latest large-scale population-based reports confirmed the close relationship between asthma and attention deficit hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in children.Therefore, the specific relationship between asthma and ADHD, and the latest research progress of their risk factors were reviewed in this article in order to understand the specific relationship between them and its risk factors, so as to facilitate the long-term clinical management of asthmatic children. \u0000 \u0000 \u0000Key words: \u0000Bronchial asthma; Attention deficit hyperactivity disorder; Risk factor","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"310-313"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43869418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of respiratory interventional therapy in pediatrics","authors":"J. Dai, Yin Zhang","doi":"10.3760/CMA.J.CN101070-20200308-00346","DOIUrl":"https://doi.org/10.3760/CMA.J.CN101070-20200308-00346","url":null,"abstract":"With the development of pediatric bronchoscopy and the accumulation of clinical experience, its indications are expanding, and it plays an increasingly important role in pediatric respiratory diseases.In this paper, by introducing the new techniques applied in clinical practice in recent years, such as bronchoscopic balloon dilatation, bronchoscopic ablation, bronchoscopic stenting, transbronchial lung biopsy and transbronchial needle aspiration, the progress of new techniques of interventional therapy in pediatric respiratory is briefly introduced. \u0000 \u0000 \u0000Key words: \u0000Child; Bronchoscopy; Interventional therapy; Progress","PeriodicalId":9843,"journal":{"name":"中华实用儿科临床杂志","volume":"35 1","pages":"254-258"},"PeriodicalIF":0.0,"publicationDate":"2020-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48943101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}