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Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. RAD52环的小分子破坏作为brca缺陷癌症的精准医疗机制。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.10.003
Gurushankar Chandramouly, Shane McDevitt, K. Sullivan, T. Kent, A. Luz, J. Glickman, M. Andrake, T. Skorski, R. Pomerantz
{"title":"Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.","authors":"Gurushankar Chandramouly, Shane McDevitt, K. Sullivan, T. Kent, A. Luz, J. Glickman, M. Andrake, T. Skorski, R. Pomerantz","doi":"10.1016/j.chembiol.2015.10.003","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.10.003","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"30 1","pages":"1491-1504"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89402490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 76
Profiling of Free Fatty Acids Using Stable Isotope Tagging Uncovers a Role for Saturated Fatty Acids in Neuroexocytosis. 利用稳定同位素标记分析游离脂肪酸揭示了饱和脂肪酸在神经胞吐作用中的作用。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.09.010
V. Narayana, Vanesa M Tomatis, Tong Wang, D. Kvaskoff, F. Meunier
{"title":"Profiling of Free Fatty Acids Using Stable Isotope Tagging Uncovers a Role for Saturated Fatty Acids in Neuroexocytosis.","authors":"V. Narayana, Vanesa M Tomatis, Tong Wang, D. Kvaskoff, F. Meunier","doi":"10.1016/j.chembiol.2015.09.010","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.09.010","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"34 1","pages":"1552-1561"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73460853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Dissecting How Mtb Makes Its Wall, Buffering Endosomal pH, and Discovery of Ribocil. 剖析结核分枝杆菌壁的形成、缓冲内体pH值和发现核糖酸。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.11.003
M. Kostić
{"title":"Dissecting How Mtb Makes Its Wall, Buffering Endosomal pH, and Discovery of Ribocil.","authors":"M. Kostić","doi":"10.1016/j.chembiol.2015.11.003","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.11.003","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"32 1","pages":"1415-1416"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73570805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. 探讨大肠杆菌脂肪酸脱水酶FabA的底物特异性和蛋白-蛋白相互作用。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.09.009
Kara L Finzel, C. Nguyen, D. R. Jackson, Aarushi Gupta, S. Tsai, M. Burkart
{"title":"Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA.","authors":"Kara L Finzel, C. Nguyen, D. R. Jackson, Aarushi Gupta, S. Tsai, M. Burkart","doi":"10.1016/j.chembiol.2015.09.009","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.09.009","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"221 1","pages":"1453-1460"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79579892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Combining Suppression of Stemness with Lineage-Specific Induction Leads to Conversion of Pluripotent Cells into Functional Neurons. 结合抑制干细胞与谱系特异性诱导导致多能细胞转化为功能性神经元。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.10.008
Debasish Halder, Gyeong-Eon Chang, Debojyoti De, Eunji Cheong, K. Kim, I. Shin
{"title":"Combining Suppression of Stemness with Lineage-Specific Induction Leads to Conversion of Pluripotent Cells into Functional Neurons.","authors":"Debasish Halder, Gyeong-Eon Chang, Debojyoti De, Eunji Cheong, K. Kim, I. Shin","doi":"10.1016/j.chembiol.2015.10.008","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.10.008","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"29 1","pages":"1512-1520"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83082429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. 用于大肠杆菌和果蝇中央细胞代谢中蛋白谷胱甘肽化的可点击探针的开发。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.09.012
S. Feng, Yuling Chen, Fan Yang, Lei Zhang, Yiyi Gong, Gulishana Adilijiang, Yan Gao, Haiteng Deng
{"title":"Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila.","authors":"S. Feng, Yuling Chen, Fan Yang, Lei Zhang, Yiyi Gong, Gulishana Adilijiang, Yan Gao, Haiteng Deng","doi":"10.1016/j.chembiol.2015.09.012","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.09.012","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"33 1","pages":"1461-1469"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85477661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation. 艰难梭菌定量脂蛋白组学揭示脂蛋白在产孢过程中的作用。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.10.006
Thomas M. Charlton, A. Kovács-Simon, S. L. Michell, N. Fairweather, E. Tate
{"title":"Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.","authors":"Thomas M. Charlton, A. Kovács-Simon, S. L. Michell, N. Fairweather, E. Tate","doi":"10.1016/j.chembiol.2015.10.006","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.10.006","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"16 1","pages":"1562-1573"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86181969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis. 突变酰基转移酶结构域的底物柔韧性及其对聚酮生物合成的影响。
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.02.008
Kenny Bravo-Rodriguez, Stephan Klopries, K. R. Koopmans, U. Sundermann, S. Yahiaoui, Julia Arens, S. Kushnir, F. Schulz, E. Sánchez-García
{"title":"Substrate Flexibility of a Mutated Acyltransferase Domain and Implications for Polyketide Biosynthesis.","authors":"Kenny Bravo-Rodriguez, Stephan Klopries, K. R. Koopmans, U. Sundermann, S. Yahiaoui, Julia Arens, S. Kushnir, F. Schulz, E. Sánchez-García","doi":"10.1016/j.chembiol.2015.02.008","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.02.008","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"69 1","pages":"1425-1430"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75141041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs. 利用适应性BimKARs可视化区隔化激酶活性动态。
Chemistry & biology Pub Date : 2015-11-19 Epub Date: 2015-11-05 DOI: 10.1016/j.chembiol.2015.10.004
Charlene Depry, Sohum Mehta, Ruojing Li, Jin Zhang
{"title":"Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs.","authors":"Charlene Depry, Sohum Mehta, Ruojing Li, Jin Zhang","doi":"10.1016/j.chembiol.2015.10.004","DOIUrl":"10.1016/j.chembiol.2015.10.004","url":null,"abstract":"<p><p>The ability to monitor kinase activity dynamics in live cells greatly aids the study of how signaling events are spatiotemporally regulated. Here, we report on the adaptability of bimolecular kinase activity reporters (bimKARs) as molecular tools to enhance the real-time visualization of kinase activity. We demonstrate that the bimKAR design is truly versatile and can be used to monitor a variety of kinases, including JNK, ERK, and AMPK. Furthermore, bimKARs can have significantly enhanced dynamic ranges over their unimolecular counterparts, allowing the elucidation of previously undetectable kinase activity dynamics. Using these newly designed bimKARs, we investigate the regulation of AMPK by protein kinase A (PKA) in the plasma membrane, and demonstrate that PKA can both negatively and positively regulate AMPK activity in the same cell. </p>","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"43 1","pages":"1470-1479"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86040848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus. 具有挑战性靶标的工程双工rna: ALS/FTD C9orf72位点GGGGCC/CCCCGG重复序列的识别
Chemistry & biology Pub Date : 2015-11-19 DOI: 10.1016/j.chembiol.2015.09.016
Jiaxin Hu, Jing Liu, Liande Li, Keith T. Gagnon, D. Corey
{"title":"Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus.","authors":"Jiaxin Hu, Jing Liu, Liande Li, Keith T. Gagnon, D. Corey","doi":"10.1016/j.chembiol.2015.09.016","DOIUrl":"https://doi.org/10.1016/j.chembiol.2015.09.016","url":null,"abstract":"","PeriodicalId":9772,"journal":{"name":"Chemistry & biology","volume":"133 1","pages":"1505-1511"},"PeriodicalIF":0.0,"publicationDate":"2015-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87617881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
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