Chemistry of Heterocyclic Compounds最新文献_第6页

A novel approach to obtain 3-amino-1-benzothiophene-2-carbonitriles 获得 3-氨基-1-苯并噻吩-2-甲腈的新方法

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-04-05 DOI: 10.1007/s10593-024-03299-y

Dmitry S. Ivanov, Anatolii I. Sokolov, Alexander Yu. Smirnov, Mikhail S. Baranov

引用次数: 0

Comparison of the fecal microbiota with high- and low performance race horses. 高水平和低水平赛马粪便微生物群的比较。

IF 2.3 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-03-01 Epub Date: 2024-03-31 DOI: 10.5187/jast.2023.e45

Taemook Park, Jungho Yoon, YoungMin Yun, Tatsuya Unno

{"title":"Comparison of the fecal microbiota with high- and low performance race horses.","authors":"Taemook Park, Jungho Yoon, YoungMin Yun, Tatsuya Unno","doi":"10.5187/jast.2023.e45","DOIUrl":"10.5187/jast.2023.e45","url":null,"abstract":"Exercise plays an important role in regulating energy homeostasis, which affects the diversity of the intestinal microbial community in humans and animals. To the best of the authors' knowledge, few studies have reported the associations between horse gut microbiota along with their predicted metabolic activities and the athletic ability of Jeju horses and Thoroughbreds living in Korea. This study was conducted to investigate the association between the gut microbiota and athletic performance in horses. This study sequenced the V3 and V4 hypervariable regions of the partial 16S rRNA genes obtained from racehorse fecal samples and compared the fecal microbiota between high- and low-performance Jeju horses and Thoroughbreds. Forty-nine fecal samples were divided into four groups: high-performance Jeju horses (HJ, n = 13), low-performance Jeju horses (LJ, n = 17), high-performance Thoroughbreds (HT, n = 9), and low-performance Thoroughbreds (LT, n = 10). The high-performance horse groups had a higher diversity of the bacterial community than the low-performance horse groups. Two common functional metabolic activities of the hindgut microbiota (i.e., tryptophan and succinate syntheses) were observed between the low-performance horse groups, indicating dysbiosis of gut microbiota and fatigue from exercise. On the other hand, high-performance horse groups showed enriched production of polyamines, butyrate, and vitamin K. The racing performance may be associated with the composition of the intestinal microbiota of Jeju horses and Thoroughbreds in Korea.","PeriodicalId":9770,"journal":{"name":"Chemistry of Heterocyclic Compounds","volume":"30 1","pages":"425-437"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73011919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of chromeno[2,3-c]pyrrol-9(2H)-ones (microreview) 铬并[2,3-c]吡咯-9(2H)-酮的合成（微型综述）

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-15 DOI: 10.1007/s10593-024-03264-9

Viktoriia S. Moskvina, Volodymir P. Khilya

引用次数: 0

The synthesis of indolizin-1-ylphosphonates via the reaction of ethynylphosphonates with pyridinium methylides 通过乙炔基膦酸盐与吡啶鎓甲酯反应合成吲哚利嗪-1-基膦酸盐

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-13 DOI: 10.1007/s10593-024-03272-9

引用次数: 0

Contemporary approaches to the synthesis of cyclic sulfonates (microreview) 合成环状磺酸盐的当代方法（微型综述）

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-13 DOI: 10.1007/s10593-024-03265-8

引用次数: 0

Synthesis and antiproliferative activity of new oxazole-steroid glycoconjugates 新型噁唑-类固醇糖轭化合物的合成与抗增殖活性

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-13 DOI: 10.1007/s10593-024-03277-4

Luis A. Méndez-Delgado, Alma Fuentes-Aguilar, Socorro Meza-Reyes, Sara Montiel-Smith, José Luis Vega-Baez, José M. Padrón, Penélope Merino-Montiel, Sylvain Bernès

引用次数: 0

Highly diastereoselective synthesis of pyridinium-substituted piperidin-2-ones from pyridinium ylides, aldehydes, Michael acceptors, and ammonium acetate 由吡啶鎓酰化物、醛、迈克尔受体和乙酸铵高非对映选择性合成吡啶鎓取代的哌啶-2-酮

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-13 DOI: 10.1007/s10593-024-03271-w

Andrey D. Vinokurov, Taygib M. Iliyasov, Kirill A. Karpenko, Radmir N. Akchurin, Yana V. Derkach, Anatoly N. Vereshchagin

{"title":"Highly diastereoselective synthesis of pyridinium-substituted piperidin-2-ones from pyridinium ylides, aldehydes, Michael acceptors, and ammonium acetate","authors":"Andrey D. Vinokurov, Taygib M. Iliyasov, Kirill A. Karpenko, Radmir N. Akchurin, Yana V. Derkach, Anatoly N. Vereshchagin","doi":"10.1007/s10593-024-03271-w","DOIUrl":"https://doi.org/10.1007/s10593-024-03271-w","url":null,"abstract":"A novel four-component diastereoselective synthesis of piperidin-2-one salts containing a quaternized pyridine unit is reported. The Michael–Mannich cascade was conducted using Michael acceptors, pyridinium ylides, aromatic aldehydes, and ammonium acetate in methanol. It is a convenient approach to the synthesis of 1-((3SR,4RS,6SR)-4,6-diaryl-5,5-dicyano-2-oxopiperidin-3-yl)pyridin-1-ium halides with three stereocenters in 48–84% yield or 1-[(3SR,4RS,5RS,6SR)-4,6-diaryl-5-cyano-5-(methoxycarbonyl)-2-oxopiperidin-3-yl]-pyridin-1-ium halides with four stereocenters in 44–74%. This reaction is highly stereoselective. Only one diastereomer was formed. Ammonium acetate plays a dual role, acting as a base and as a nitrogen source. Structures of the synthesized compounds were confirmed by 1H, 13C NMR, IR, and mass spectra. The formation of a single diastereomer was confirmed by singe crystal X-ray diffraction studies. Products were obtained by simple filtration, and other purification methods as column chromatography were not necessary.","PeriodicalId":9770,"journal":{"name":"Chemistry of Heterocyclic Compounds","volume":"9 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139463372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A one-pot thiomethylation of pyrrole and indoles 吡咯和吲哚的一锅硫代甲基化反应

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-12 DOI: 10.1007/s10593-024-03278-3

Vnira R. Akhmetova, Danil V. Leont’ev, El’mira M. Galimova, Ekaterina S. Mescheryakova

引用次数: 0

Ring-chain isomerism of aldehyde 2-alkylsemicarbazones: experimental and theoretical studies. Novel semicarbazone-based synthesis of 2-alkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones 醛类 2-烷基半咔唑酮的环链异构：实验和理论研究。基于半咔唑酮合成 2-烷基-2,4-二氢-3H-1,2,4-三唑-3-酮的新方法

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-11 DOI: 10.1007/s10593-024-03269-4

{"title":"Ring-chain isomerism of aldehyde 2-alkylsemicarbazones: experimental and theoretical studies. Novel semicarbazone-based synthesis of 2-alkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones","authors":"","doi":"10.1007/s10593-024-03269-4","DOIUrl":"https://doi.org/10.1007/s10593-024-03269-4","url":null,"abstract":" <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/10593_2024_3269_Figa_HTML.png\"/> Ring-chain isomerism of aldehyde semicarbazones/1,2,4-triazolidin-3-ones was first studied in detail. Aliphatic aldehyde semicarbazones completely cyclized under the action of very strong Brønsted acids (TfOH, HCl) in aprotic solvents at room temperature to give the corresponding salts of the N1-protonated 1,2,4-triazolidin-3-ones. Both the obtained salts and their free bases are unstable in the presence of air oxygen and undergo slow oxidative aromatization. A novel synthesis of 2-alkyl-2,4-dihydro-3H-1,2,4-triazol-3-ones via the TfOH-promoted cyclization of aliphatic aldehyde semicarbazones followed by aromatization of the isolated crude 1,2,4-triazolidin-3-ones or their hydrotriflates with m-CPBA was developed. In contrast to aliphatic aldehyde semicarbazones, the cyclization of benzaldehyde semicarbazones does not proceed in the presence of strong Brønsted acids. Thermodynamic and kinetic characteristics of the aldehyde semicarbazone ring-chain isomerism are discussed based on the DFT B3LYP/6-311++G(d,p) calculations.","PeriodicalId":9770,"journal":{"name":"Chemistry of Heterocyclic Compounds","volume":"180 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139421514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in the synthesis of nitroisoxazoles and their hydrogenated analogs via [3+2] cycloaddition reactions (microreview) 通过[3+2]环加成反应合成硝基异噁唑及其氢化类似物的最新进展（微综述）

IF 1.5 4区化学

Chemistry of Heterocyclic Compounds Pub Date : 2024-01-10 DOI: 10.1007/s10593-024-03262-x

引用次数: 0