IF 0.6 4区化学

Chemija Pub Date : 2022-08-07 DOI: 10.6001/chemija.v33i3.4750

Anastasiia Belikova, Anna Materienko, Ludmila Sidorenko, Olha Chorna, Deividas Burdulis, V. Georgiyants

引用次数: 0

Determination of pyridine and furfuryl alcohol in breath after coffee consumption 饮用咖啡后呼出气体中吡啶和糠醇的测定

IF 0.6 4区化学

Chemija Pub Date : 2022-08-07 DOI: 10.6001/chemija.v33i3.4751

Adrián Vicent Claramunt, Audrius Sadaunykas, Birutė Knašienė, E. Naujalis

{"title":"Determination of pyridine and furfuryl alcohol in breath after coffee consumption","authors":"Adrián Vicent Claramunt, Audrius Sadaunykas, Birutė Knašienė, E. Naujalis","doi":"10.6001/chemija.v33i3.4751","DOIUrl":"https://doi.org/10.6001/chemija.v33i3.4751","url":null,"abstract":"We aimed to demonstrate that breath analysis can be used as a method for the detection of potentially harmful compounds in food after their ingestion. Development of such a method could be adapted as a tool for detection of food intoxication. To achieve this, we compared the levels of pyridine (Py) and furfuryl alcohol (FFA) found in breath with the quantity of these compounds ingested when drinking coffee. Coffee drink beverages were prepared in the laboratory and consumed by volunteers (n = 5). An aliquot of coffee was analysed using high performance liquid chromatography with diode-array detection (HPLC-DAD) to quantify Py and FFA in the beverage. Breath samples were collected several times over a 45 min period after ingestion of coffee and analysed by thermal desorption coupled to gas chromatography/mass spectrometry (TD/GC-MS). The levels of Py and FFA found in coffee ranged from 0.2 to 3 mg/cup of coffee, and from 7 to 30 mg/cup of coffee, respectively. The levels of these compounds detected in breath ranged from 7 to 1200 ng/l breath for Py and from 1 to 760 ng/l breath for FFA. Several parameters can influence the levels of these chemicals in breath, especially the collection time of the breath sample.","PeriodicalId":9720,"journal":{"name":"Chemija","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44949454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Corrosion resistance of AZ31 alloy after treatment with high current density impulse or/and laser irradiation in Hank’s solution AZ31合金在Hank’s溶液中高电流密度脉冲或/和激光辐照后的耐蚀性

IF 0.6 4区化学

Chemija Pub Date : 2022-08-07 DOI: 10.6001/chemija.v33i3.4748

G. Bikulčius, S. Lichušina, V. Pakštas, M. Gedvilas, V. Stankevič, A. Selskienė, A. Grigucevičienė

引用次数: 0

The validated method for the analysis of a mixture of psychotropic medicines olanzapine, clorazepate and escitalopram using a high-performance liquid chromatography method 建立了一种高效液相色谱法分析精神药物奥氮平、氯硝西酯和艾司西酞普兰混合物的方法

IF 0.6 4区化学

Chemija Pub Date : 2022-05-04 DOI: 10.6001/chemija.v33i2.4706

Mamdouh Alasabashi, A. Ževžikovienė, M. Marksa, Laura Rimkiene, A. Ževžikovas

{"title":"The validated method for the analysis of a mixture of psychotropic medicines olanzapine, clorazepate and escitalopram using a high-performance liquid chromatography method","authors":"Mamdouh Alasabashi, A. Ževžikovienė, M. Marksa, Laura Rimkiene, A. Ževžikovas","doi":"10.6001/chemija.v33i2.4706","DOIUrl":"https://doi.org/10.6001/chemija.v33i2.4706","url":null,"abstract":"It was established that self-poisoning with antipsychotics, anti-anxiety drugs and antidepressants is caused by consumption of the drug in higher doses than prescribed. So it is very important to determine fast the materials causing poisoning and use the method which would allow one to identify several substances during only one analysis. Reference and test solutions were prepared in ethanol. A qualitative and quantitative analysis was carried out on a Waters Alliance 2695 liquid chromatograph equipped with a Waters 996 PDA detector and an ACE C18 (250 mm × 4.6 mm × 5 μm) column. The mobile phase consisted of solvent trifluoroacetic acid (0.1 %) and acetonitrile. The linear gradient elution profile was used. For the validation process the following parameters were chosen: specificity, repeatability, precision and limits (LOD and LOQ). According to the study results, it can be concluded that the validated method for the qualitative and quantitative evaluation analysis of olanzapine, clorazepate and escitalopram was developed.","PeriodicalId":9720,"journal":{"name":"Chemija","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44188926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of pyrimidines containing hydroxamic acid, 1,3,4-oxadiazole or 1,2,4-triazole moieties as potential HDAC inhibitors 合成含有羟基肟酸、1,3,4-恶二唑或1,2,4-三唑的嘧啶类潜在HDAC抑制剂

IF 0.6 4区化学

Chemija Pub Date : 2022-05-04 DOI: 10.6001/chemija.v33i2.4708

V. Jakubkienė, Mantas Žvirblis, S. Tumkevičius

{"title":"Synthesis of pyrimidines containing hydroxamic acid, 1,3,4-oxadiazole or 1,2,4-triazole moieties as potential HDAC inhibitors","authors":"V. Jakubkienė, Mantas Žvirblis, S. Tumkevičius","doi":"10.6001/chemija.v33i2.4708","DOIUrl":"https://doi.org/10.6001/chemija.v33i2.4708","url":null,"abstract":"The histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through deacetylation of nuclear histone proteins and are promising therapeutic targets for treatment of various diseases. Therefore, interest to the design and synthesis of novel HDAC inhibitors, among which hydroxamic acids occupy an important place, has been constantly increasing in recent years. Here, synthesis of pyrimidines with 1,3,4-oxadiazole or 1,2,4-triazole and hydroxamic acid moieties as potential HDAC inhibitors is described. The target compounds were obtained by sequential reactions of (O- and N-pyrimidinyl)alkanoates with hydrazine hydrate followed by cyclization reaction of the obtained hydrazides with potassium O-ethyl xanthate and alkylation of the synthesised oxadiazole(triazole)thiones with 2-chloro-N-hydroxyacetamide. One of 1,3,4-oxadiazole-2-thiones under the treatment with hydrazine hydrate underwent the recyclisation reaction to give the corresponding 4-amino-1,2,4-triazole. Investigation of the inhibitory activity of the synthesised compounds against HDAC4 and HDAC8 isoforms revealed that N-hydroxy-2-(5-(4-(6-(6-methyl-2-(methylthio)pyrimidin-4-yloxy) butyl)-1,3,4-oxadiazol-2-ylthio)acetamide exhibited a weak inhibitory activity against HDAC8 isoform (IC50 = 12.7 μM).","PeriodicalId":9720,"journal":{"name":"Chemija","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46266601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The comparative study of redox properties of recombinant human cytosolic and mitochondrial NADPH: thioredoxin reductases 重组人细胞质和线粒体NADPH:硫氧还蛋白还原酶氧化还原特性的比较研究

IF 0.6 4区化学

Chemija Pub Date : 2022-05-04 DOI: 10.6001/chemija.v33i2.4707

Lina Misevičienė, K. Krikštopaitis, N. Čėnas

引用次数: 0

Curing of epoxy resins by bio-based phenalkamines vs low-molecular-weight amines: study by DSC 生物基苯烷胺与低分子量胺固化环氧树脂的DSC研究

IF 0.6 4区化学

Chemija Pub Date : 2022-05-04 DOI: 10.6001/chemija.v33i2.4709

J. Jonikaitė-Švėgždienė, Liepa Pastarnokienė, Virginija Juknevičiūtė, R. Makuška

{"title":"Curing of epoxy resins by bio-based phenalkamines vs low-molecular-weight amines: study by DSC","authors":"J. Jonikaitė-Švėgždienė, Liepa Pastarnokienė, Virginija Juknevičiūtė, R. Makuška","doi":"10.6001/chemija.v33i2.4709","DOIUrl":"https://doi.org/10.6001/chemija.v33i2.4709","url":null,"abstract":"In this study, curing of BPA-based epoxy resins Araldite®GY-2600 and Araldite®GY-240 by low-molecular-weight amines EDA, TETA and Jeffamine D-230, and bio-based phenalkamines Cardolite®NX-6019, Cardolite®Lite-2002 and Cardolite®GX-6004 was studied by differential scanning calorimetry (DSC) and rheology measurements. DSC provided quantitative information on the overall reaction kinetics (the enthalpy of curing reaction, ΔHR; cure degree, α; curing reaction rate, dα/dt) and the glass transition temperature (Tg) of the cured product. It was demonstrated that the DSC curing of epoxy resins by phenalkamines started at lower temperature, and the curing rates were slightly lower compared to those cured by low-molecular-weight amine hardeners. The enthalpy of the curing by phenalkamines was lower, especially in the case of more viscous epoxy resin GY-2600. Tg of the cured epoxy resins varied from 50 to 98°C and was slightly lower when cured with cardanol-based phenalkamines. The results demonstrate that curing of epoxy resins by bio-based phenalkamines proceeds in a similar temperature interval like using low-molecular-weight amines as hardeners but with less exothermic effect, which could be an advantage.","PeriodicalId":9720,"journal":{"name":"Chemija","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48926200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A novel method for the formation of bioceramic nano-calcium hydroxyapatite coatings using sol-gel and dissolution-precipitation processing 溶胶-凝胶-溶解沉淀法制备生物陶瓷纳米钙羟基磷灰石涂层的新方法

IF 0.6 4区化学

Chemija Pub Date : 2022-05-04 DOI: 10.6001/chemija.v33i2.4705

Rasa Karalkevičienė, Greta Briedytė, T. Murauskas, Mantas Norkus, A. Zarkov, J. Yang, A. Kareiva

引用次数: 0

Profiling of volatile organic compounds for environment discrimination in Vilnius City 维尔纽斯市用于环境识别的挥发性有机化合物图谱

IF 0.6 4区化学

Chemija Pub Date : 2022-02-07 DOI: 10.6001/chemija.v33i1.4661

A. V. Claramunt, Audrius Sadaunykas, Simonas Balčiūnas, Birutė Knašienė, Audrius Zolumskis, E. Naujalis

引用次数: 0

Microwave synthesis of silver core-silica decorated nanoparticles 微波合成银芯-二氧化硅修饰纳米粒子