Cephalalgia Reports最新文献_第8页

Sumatriptan as abortive treatment in cyclic vomiting syndrome: A cross-sectional study 舒马曲坦作为周期性呕吐综合征的流产治疗:一项横断面研究

Cephalalgia Reports Pub Date : 2020-10-12 DOI: 10.1177/2515816320958174

Bixuan Lin, Zhipeng Zhou, T. Venkatesan

{"title":"Sumatriptan as abortive treatment in cyclic vomiting syndrome: A cross-sectional study","authors":"Bixuan Lin, Zhipeng Zhou, T. Venkatesan","doi":"10.1177/2515816320958174","DOIUrl":"https://doi.org/10.1177/2515816320958174","url":null,"abstract":"Cyclic vomiting syndrome (CVS) is characterized by episodic vomiting and shares similarities with migraine headache. Guidelines recommend using triptans as abortive therapy in CVS, but there are limited data on its efficacy. Methods: We thus sought to characterize sumatriptan use and performed a cross-sectional study of adults with CVS episodes within the previous 6 months. Questionnaires about demographics, clinical characteristics, and response to sumatriptan (defined as >50% reduction in symptoms) were administered via e-mail. We investigated differences between responders and nonresponders, using χ 2 and Student’s t test. Results: Of 101 participants (age 41 ± 15 years, 74% female, 83% Caucasian), 39 (38%) used sumatriptan during their last CVS attack. Most reported an improvement in nausea (55%), vomiting (59%), and abdominal pain (43%) within 2 h and at 24 h (67%, 73%, and 67%) respectively. Eighteen (46%) reported that sumatriptan helped them avoid emergency department visits and 20 (51%) avoided being hospitalized. Nonresponse to sumatriptan was associated with depression (p = 0.01), current cannabis use (p = 0.02), use of benzodiazepines (p = 0.04), and opioids (0.02) during an episode. No serious side effects were noted. Conclusions: Sumatriptan use reduced symptoms of CVS but did not abort them. Prospective studies to determine its independent effects are needed.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320958174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47463845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Orofacial pain resembling hypnic headache: A case report 类似于炒作性头痛的口齿面部疼痛1例报告

Cephalalgia Reports Pub Date : 2020-10-08 DOI: 10.1177/2515816320962783

N. Imai, Asami Moriya, E. Kitamura

引用次数: 0

Clinical and vascular responses to propranolol and candesartan in migraine patients: A randomized controlled clinical trial 普萘洛尔和坎地沙坦对偏头痛患者的临床和血管反应：一项随机对照临床试验

Cephalalgia Reports Pub Date : 2020-10-07 DOI: 10.1177/2515816320946491

Aros Dlawer Barzenje, K. Gjesdal, B. Winsvold, M. Småstuen, L. Stovner, G. Gravdahl, K. Nilsen

{"title":"Clinical and vascular responses to propranolol and candesartan in migraine patients: A randomized controlled clinical trial","authors":"Aros Dlawer Barzenje, K. Gjesdal, B. Winsvold, M. Småstuen, L. Stovner, G. Gravdahl, K. Nilsen","doi":"10.1177/2515816320946491","DOIUrl":"https://doi.org/10.1177/2515816320946491","url":null,"abstract":"Background: Both propranolol and candesartan are prophylactic drugs for migraine, but with unknown mechanisms of action. The objectives of the present study were to investigate these drugs’ effects on arterial wall dynamics and the potential relation between their vascular and clinical effect. Methods: The study was based on data from a previously published randomized, placebo-controlled, triple-blinded, double crossover clinical trial comparing the prophylactic effects of candesartan and propranolol in 72 patients. Finapres noninvasive blood pressure curves were analyzed. On the descending limb of the pulse curve, a notch is produced by pulse wave reflection, and its relative height compared to the top of the curve (the notch ratio) was used as a marker of arterial wall stiffness. Results: Candesartan decreased the notch ratio from baseline (p = 0.005), reflecting more compliant arteries and vasodilation, whereas propranolol increased the notch ratio (p = 0.005), reflecting less compliant arteries and vasoconstriction. There was no difference in baseline notch ratio between clinical responders and nonresponders. Conclusion: The drugs are both efficient prophylactic medications, yet they have opposite effects on arterial wall dynamics. This suggests that drug effects other than those on arterial compliance must be responsible for their prophylactic effect in migraine.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320946491","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47797752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epicrania fugax: Report of eight cases with some novel features 富氏腺鼠疫:附8例新特征报告

Cephalalgia Reports Pub Date : 2020-10-07 DOI: 10.1177/2515816320946492

D. Chowdhury, T. Chawla, A. Duggal

{"title":"Epicrania fugax: Report of eight cases with some novel features","authors":"D. Chowdhury, T. Chawla, A. Duggal","doi":"10.1177/2515816320946492","DOIUrl":"https://doi.org/10.1177/2515816320946492","url":null,"abstract":"Introduction: Epicrania fugax (EF) is an epicranial headache syndrome characterized by short lasting headache paroxysms which spread in a typical linear/zigzag pattern. The definition of EF has evolved over time, and new phenotypes have been observed in various studies. Aim: We present eight cases diagnosed as EF according to the International Classification of Headaches Disorders, 3rd edition criteria and highlight certain novel characteristics which will help in the further categorization of this disorder. Methods: We prospectively studied eight cases of EF who presented to our headache clinic from January 2016 to September 2020. Demographic and detailed clinical data were collected and analyzed. Results: The mean age of onset of the cohort was 42 ± 10.47 years with a median duration of symptoms being 1 year. There were 5 male and 3 female patients. The mean visual analog scale score was 5.25 ± 1.83. Headache frequency had high intra and interindividual variability. Four patients had a typical spread of pain along the distribution of greater occipital, and supraorbital, nerves. Four patients had an atypical presentation with midline headache, transverse occipital, and bilateral simultaneous hemicranium involvement. Headache paroxysm was followed by a prolonged fixed pain in the same linear distribution in three patients. One patient had ipsilateral redness in the eye. All eight patients required medical intervention with amitriptyline or neuromodulators, five of whom reported a significant reduction in their headache symptoms. Conclusion: Our case series highlights a few interesting features which need further exploration with larger studies. Firstly, the atypical distribution of the pain trajectory forces us to dig deeper into the pathogenesis of the disorder. Secondly, our data also suggest a possibility of EF triggered “linear headaches.” EF is a relatively uncommon headache disorder that can be managed easily with neuromodulators but the lack of awareness of the condition often leads to delayed diagnosis.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320946492","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46726486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translation and validation of an extended German version of ID Migraine™ as a migraine screening tool 翻译和验证扩展的德语版本ID偏头痛™作为偏头痛筛查工具

Cephalalgia Reports Pub Date : 2020-10-01 DOI: 10.1177/2515816320962773

A. Thiele, S. Strauss, A. Angermaier, M. Kronenbuerger, R. Fleischmann

{"title":"Translation and validation of an extended German version of ID Migraine™ as a migraine screening tool","authors":"A. Thiele, S. Strauss, A. Angermaier, M. Kronenbuerger, R. Fleischmann","doi":"10.1177/2515816320962773","DOIUrl":"https://doi.org/10.1177/2515816320962773","url":null,"abstract":"Background and purpose: Diagnosing a patient with headache as a migraineur is critical for state-of-the-art migraine management. Screening tools are imperative means to improve the diagnostic yield in the primary care settings and specialized clinics. This study aims to translate and assess the diagnostic accuracy of a German version of the ID Migraine™ as a widely used and efficient screening instrument. Methods: The Functional Assessment of Chronic Illness Therapy translation methodology was used to translate the original three-item ID Migraine™, including a fourth question for aura, from the English language into the German language. Diagnostic accuracy of the German ID Migraine™ and predictors of false screening results were assessed among patients presenting to a headache outpatient clinic of a tertiary care center in Germany over a 6-month period. Results: The translation procedure yielded a harmonized German ID Migraine™ and its diagnostic accuracy was assessed in 105 patients (80 female, 46.5 ± 17.2 years of age), including 79 patients (75.2%) with migraine. The three-item German ID Migraine™ provides a sensitivity of 99%, specificity of 68%, and positive and negative predictive values of 90% and 95%, respectively, using a cutoff of ≥2. Positive and negative predictive values in a general headache population are estimated to be 74% and 98%, respectively. The aura question identified 18 out of 20 migraineurs with aura. Conclusions: The German ID Migraine™ is an accurate screening tool for migraine even in a challenging population of a specialized outpatient clinic. Its diagnostic accuracy indicates a potential utility for screening in primary health care.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320962773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44179249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Vestibular migraine presenting with acute peripheral vestibulopathy: Clinical, oculographic and vestibular test profiles 前庭偏头痛表现为急性外周前庭病变:临床、眼科和前庭试验资料

Cephalalgia Reports Pub Date : 2020-09-14 DOI: 10.1177/2515816320958175

Z. Calic, B. Nham, Rachael L. Taylor, A. Young, A. Bradshaw, L. McGarvie, J. Colebatch, D. Cordato, C. Cappelen-Smith, M. Welgampola

{"title":"Vestibular migraine presenting with acute peripheral vestibulopathy: Clinical, oculographic and vestibular test profiles","authors":"Z. Calic, B. Nham, Rachael L. Taylor, A. Young, A. Bradshaw, L. McGarvie, J. Colebatch, D. Cordato, C. Cappelen-Smith, M. Welgampola","doi":"10.1177/2515816320958175","DOIUrl":"https://doi.org/10.1177/2515816320958175","url":null,"abstract":"To describe clinical, oculographic and vestibular test profiles in patients with vestibular migraine (VM) who presented with acute peripheral vestibulopathy. VM was diagnosed according to Bárány Society or Neuhauser criteria. Neuro-otological examination, video-head impulse tests (v-HIT), cervical and ocular vestibular-evoked myogenic potentials (cVEMP/oVEMP), subjective visual horizontal (SVH) and audiometry were undertaken. Ten patients presented with prolonged vertigo. All had primary position unidirectional horizontal spontaneous nystagmus (mean slow-phase velocity 9.6 ± 7.0°). Horizontal canal vestibulo-ocular reflex was reduced in all (mean gain 0.54 ± 0.2) with refixation saccades (cumulative amplitude 6.4 ± 3.2°). Abnormality rates for cVEMP, oVEMP and SVH were 30%, 80%, 78%, respectively. Magnetic resonance imaging brain was normal in all patients. Patients were followed up over 6 months to 8 years with no change in the final diagnosis. VM can rarely present as an acute peripheral vestibulopathy with findings that mimic vestibular neuritis and should be considered in the differential diagnosis of acute prolonged vertigo.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320958175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42747418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Long-term safety and efficacy of lasmiditan for acute treatment of migraine: Final results of the GLADIATOR study 利西他坦治疗偏头痛急性期的长期安全性和有效性：GLADIATOR研究的最终结果

Cephalalgia Reports Pub Date : 2020-09-14 DOI: 10.1177/2515816320958176

J. Brandes, S. Klise, J. Krege, M. Case, R. Khanna, Raghavendra Vasudeva, J. Raskin, D. Kudrow

{"title":"Long-term safety and efficacy of lasmiditan for acute treatment of migraine: Final results of the GLADIATOR study","authors":"J. Brandes, S. Klise, J. Krege, M. Case, R. Khanna, Raghavendra Vasudeva, J. Raskin, D. Kudrow","doi":"10.1177/2515816320958176","DOIUrl":"https://doi.org/10.1177/2515816320958176","url":null,"abstract":"GLADIATOR was a prospective, randomized, open-label, phase 3 study of lasmiditan 100 mg or 200 mg dosed intermittently for up to 1 year in patients with episodic migraine. Most patients had completed one of two single-attack studies before participation. A total of 2030 patients received ≥1 lasmiditan dose and 19,879 migraine attacks were treated. Safety results were similar to the previously reported interim analysis. The most frequently reported treatment-emergent adverse events (TEAEs) included dizziness (18.5%), somnolence (8.5%), and paresthesia (6.8%), with frequency of adverse events appearing to decrease with subsequently treated attacks. At 2 h post-dose, 26.7% and 32.2% of all attacks treated with lasmiditan 100 mg and 200 mg, respectively, were pain free. This pattern was generally consistent across study quarters and treated attacks. In conclusion, during a 1-year treatment period, intermittent lasmiditan for episodic migraine treatment was associated with generally decreasing TEAEs and consistent efficacy.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320958176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42639137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sensory hypersensitivities in those with persistent post-traumatic headache versus migraine 持续性创伤后头痛患者与偏头痛患者的感觉超敏反应

Cephalalgia Reports Pub Date : 2020-09-08 DOI: 10.1177/2515816320942191

Jeffery J. Hanna, C. Chong, Gina M. Dumkrieger, Katherine B Ross, T. Schwedt

{"title":"Sensory hypersensitivities in those with persistent post-traumatic headache versus migraine","authors":"Jeffery J. Hanna, C. Chong, Gina M. Dumkrieger, Katherine B Ross, T. Schwedt","doi":"10.1177/2515816320942191","DOIUrl":"https://doi.org/10.1177/2515816320942191","url":null,"abstract":"Background and Objective: Symptoms of persistent post-traumatic headache (PPTH) most often resemble those of migraine, including the presence of photo-, phono-, and cutaneous hypersensitivities. The severity of these hypersensitivity symptoms in those with PPTH compared to those with migraine has yet to be fully elucidated. The objective of this study was to compare symptoms of sensory hypersensitivities between PPTH, migraine, and healthy controls (HCs). Further defining characteristics of PPTH and its similarities to migraine might assist with developing future diagnostic criteria for PPTH and provide insights into PPTH mechanisms. Methods: This analysis included 56 individuals with PPTH attributed to mild traumatic brain injury, 30 with migraine, and 36 HCs. To assess sensory hypersensitivities, all subjects completed the Allodynia Symptom Checklist-12, the Photosensitivity Assessment Questionnaire, and the Hyperacusis Questionnaire. Differences among groups were assessed using Fisher’s exact test, Kruskal–Wallis, or Mann–Whitney U test. Results: PPTH and migraine groups had greater severity of cutaneous, photo-, and phono-hypersensitivity symptoms compared to HCs. There were no statistically significant differences between the PPTH and migraine groups for cutaneous allodynia (median [first quartile, third quartile]; PPTH: 4.0 [2.0, 7.0]; migraine: 5.0 [3.0, 8.0]; p = 0.54) or photosensitivity severity (PPTH: 5.0 [2.0, 7.0]; migraine: 5.0 [2.0, 6.0]; p = 0.53). Those with PPTH had higher hyperacusis scores compared to those with migraine (PPTH: 23.0 [17.0, 31.0]; migraine: 13.5 [9.0, 24.0]; p = 0.001). Conclusion: Sensory hypersensitivity symptoms among individuals with PPTH are at least as severe as those experienced by people with migraine. Results further confirm symptom similarities between PPTH and migraine and could suggest that PPTH and migraine have a partially shared underlying pathophysiology.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320942191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41451064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Erenumab for chronic cluster headache: A case report Erenumab治疗慢性丛集性头痛1例

Cephalalgia Reports Pub Date : 2020-08-31 DOI: 10.1177/2515816320947713

F. Riederer, A. Wenner

引用次数: 3

Failure to identify underlying autoimmunity and primary headache disorder might be the reasons for refractoriness of trochlear headaches 未能识别潜在的自身免疫和原发性头痛障碍可能是滑车头痛顽固性的原因

Cephalalgia Reports Pub Date : 2020-08-28 DOI: 10.1177/2515816320951770

P. Ojha, V. Aglave, Suranjana Basak, J. Yadav

{"title":"Failure to identify underlying autoimmunity and primary headache disorder might be the reasons for refractoriness of trochlear headaches","authors":"P. Ojha, V. Aglave, Suranjana Basak, J. Yadav","doi":"10.1177/2515816320951770","DOIUrl":"https://doi.org/10.1177/2515816320951770","url":null,"abstract":"Introduction: A better understanding of etiology might improve poor outcomes of trochlear headaches (TRHs). Aims: To study clinical spectrum, etiology, and therapeutic response of TRH. Methods: Fifty-three TRH patients seen in a single center between 2015 and 2020 were included, excluding Trigeminal Autonomic Cephalalgia (TAC). Results: Mean age was 36.45 years (range 11–85 years), with 77.35% being females. Twenty-five patients had continuous trochlear headache (CTRH) and 28 episodic trochlear headache (ETRH). Tension-type headache (TTH) occurred in 9 ETRH patients and 24 of 25 CTRH patients, and migraine-like headaches occurred in 19 ETRH patients and 8 CTRH (trochlear migraine) patients. Prior history of headaches was noted in 22 of 28 ETRH and 11 of 25 CTRH patients. Twenty-eight responded to migraine/TTH prophylaxis, 25 being nonresponders (partial/no response). Fourteen of 25 nonresponders, 4 of 28 responders (4 of 4 secondary and 5 of 9 idiopathic trochleitis (IT), 3 of 9 primary TRH (PTRH), and 6 of 28 ETRH) had autoantibodies, that is, 11 antinuclear antibodies (ANAs) and 7 antithyroid antibodies. Ten of 14 (71.42%) antibody-positive nonresponders improved with immunosuppressants including steroids/hydroxychloroquine and only 11 required local injections. Finally, 38 patients had good response, 13 partial, and 2 no response. The etiology and refractoriness of IT can be attributed to underlying autoimmunity and a minor contribution by primary headaches, vice versa being the case for PTRH and ETRH. Refractory TRHs should be evaluated for underlying autoimmunity and primary headaches. Conclusion: Identification and treatment of underlying autoimmunity and primary headaches can help improve outcome of TRH.","PeriodicalId":9702,"journal":{"name":"Cephalalgia Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515816320951770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48239193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1