Central European Journal of Immunology最新文献_第9页

HMBOX1, a member of the homeobox family: current research progress. homeobox家族成员HMBOX1:研究进展。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.126615

Yu Jiang, Hongli Mu, Hengli Zhao

{"title":"HMBOX1, a member of the homeobox family: current research progress.","authors":"Yu Jiang, Hongli Mu, Hengli Zhao","doi":"10.5114/ceji.2023.126615","DOIUrl":"https://doi.org/10.5114/ceji.2023.126615","url":null,"abstract":"Homeobox containing 1 (HMBOX1) is a transcription factor that was identified in 2006 from a cDNA library of the human pancreas. It belongs to the HNF gene class of the homeobox family. HMBOX1 is widely expressed in normal human tissues; however, its expression level is rather uneven. Homeobox members have been widely reported to participate in embryonic development and differentiation as well as in pathological and physiological processes. Although research on the role of HMBOX1 is still in its infancy, many reports have revealed its regulatory role in cell differentiation, immune regulation, inflammation, and tumor progression. HMBOX1 plays an important role in promoting the differentiation of bone marrow stromal stem cells (BMSCs) into endothelial cells and contributes to their physiological functions. As an immunoregulatory factor, HMBOX1 can significantly inhibit the inflammatory response in hepatocytes and NK cells and impede the infiltration of peripheral immune cells to the liver. In tumor development, HMBOX1 exerts diametrically opposite biological functions, inhibiting or promoting the process. HMBOX1 possesses complex and diverse biological functions. In this review, we provide a brief overview of the research on HMBOX1.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"63-69"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/9b/CEJI-48-50543.PMC10189581.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9758302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation. 角膜缘干细胞免疫学：干细胞移植的最新方法。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132033

Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński

{"title":"The immunology of corneal limbal stem cells: the up-to-date approach to stem cell transplantation.","authors":"Katarzyna Samelska, Magdalena Kupis, Katarzyna Szymanek, Justyna Izdebska, Anna Zaleska-Żmijewska, Piotr Skopiński","doi":"10.5114/ceji.2023.132033","DOIUrl":"https://doi.org/10.5114/ceji.2023.132033","url":null,"abstract":"Limbal epithelial stem cells (LSC, LESC) are multipotent cells used as regenerative treatment of the cornea in patients with limbal epithelial stem cell deficiency (LSCD, LESCD). There are different types of stem cell grafting including cultivated limbal epithelial transplantation (CET) and simple limbal epithelial transplantation (SLET). The outcomes of the techniques have been assessed as similar, with differences in the sample size required during the procedures. The most important culture components for stem cell cultivation include 3T3 murine fibroblasts, human amniotic membrane (HAM), fibrin gel, and culture medium. The culture medium may be enriched with serum or not; however, xenobiotic-free materials are preferred because of the low risk of pathogen transmission. Multiple studies have defined molecules important for maintaining the function of LSC including C/EBP δ, Bmi-1, p63 α, interleukins (IL-6), epithelial structural proteins - keratins, and antibodies against epidermal growth factor receptor (EGFR). The cell phenotype of LSC has been described with factors of transplantation success rate such as a high percentage of p63 positive cells. The article emphasizes the role of recipient tissue preparation, modern cultivation techniques and pathophysiological processes in LSC transplantation effectiveness.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"245-250"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The persistence of SARS-CoV-2 neutralizing antibodies after COVID-19: A one-year observation. Is a SARS-CoV-2 vaccination booster dose necessary? COVID-19后SARS-CoV-2中和抗体的持久性:一年观察是否有必要接种SARS-CoV-2强化疫苗?

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.126206

Adam Tworek, Krzysztof Jaroń, Małgorzata Cicha, Andrzej Rydzewski, Waldemar Wierzba, Artur Zaczyński, Zbigniew Król, Grażyna Rydzewska

{"title":"The persistence of SARS-CoV-2 neutralizing antibodies after COVID-19: A one-year observation. Is a SARS-CoV-2 vaccination booster dose necessary?","authors":"Adam Tworek, Krzysztof Jaroń, Małgorzata Cicha, Andrzej Rydzewski, Waldemar Wierzba, Artur Zaczyński, Zbigniew Król, Grażyna Rydzewska","doi":"10.5114/ceji.2023.126206","DOIUrl":"https://doi.org/10.5114/ceji.2023.126206","url":null,"abstract":"Introduction: The aim of this study was to investigate the persistence of SARS-CoV-2 neutralizing antibodies (NAbs) one year after contracting COVID-19.Material and methods: The study included 38 patients - 34 men and 4 women - suffering from COVID-19 between March 15 and May 26, 2020. The median age in the group was 31 years, ranging from 22 to 67 years. The levels of neutralizing antibodies were measured at three time-points - baseline, 6 months, and 12 months. The primary endpoint was a post-infection positive result for NAbs (> 15 AU/ml; Liaison SARS-CoV-2 S1/S2 IgG quantitative test) 12 months after infection.Results: The median level of NAbs after 12 months was 26.5 AU/ml. At the end of observation (12 months), 21 of the 38 patients had a NAb level of >15 AU/ml (positive). The median antibody half-life was 5.8 months.Conclusions: A high percentage of the patients maintained positive levels of antibodies 6 and 12 months after COVID-19 infection. The dynamics of the antibody level decline suggests the need for booster vaccination at least once a year.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"92-96"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/7d/CEJI-48-50430.PMC10485689.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological mechanisms of arterial damage in pediatric patients with primary hypertension. 原发性高血压患儿动脉损伤的免疫学机制。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.127542

Adam Bujanowicz, Piotr Skrzypczyk

{"title":"Immunological mechanisms of arterial damage in pediatric patients with primary hypertension.","authors":"Adam Bujanowicz, Piotr Skrzypczyk","doi":"10.5114/ceji.2023.127542","DOIUrl":"https://doi.org/10.5114/ceji.2023.127542","url":null,"abstract":"Primary hypertension is a disease that is being diagnosed with increasing frequency in pediatric patients, and many of them are found to have hypertension-mediated organ damage (HMOD), including arterial damage. The pathophysiology of primary hypertension and the formation of HMOD is multifactorial. One mechanism studied in recent years is the subclinical inflammation accompanying the elevation of blood pressure. Experimental studies, studies in adults and children, revealed the involvement of immune mechanisms in the formation of vascular lesions in the course of primary hypertension. The paper summarizes the current knowledge on this subject and points to possible therapeutic targets. Particular emphasis is placed on data from pediatric patients with primary hypertension, as a relation between arterial damage (early vascular aging) and immune system activation had already been found in children. The correct identification of immunological mechanisms may not only broaden our understanding of primary hypertension as a disease but also, more importantly, lead to the most effective methods of its treatment.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"150-157"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/49/CEJI-48-50699.PMC10485694.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Downregulation of HMGB1 in thymoma cells affects T cell differentiation. 胸腺瘤细胞中HMGB1的下调影响T细胞的分化。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132198

Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang

{"title":"Downregulation of HMGB1 in thymoma cells affects T cell differentiation.","authors":"Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang","doi":"10.5114/ceji.2023.132198","DOIUrl":"https://doi.org/10.5114/ceji.2023.132198","url":null,"abstract":"Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma tissues and peripheral blood. High mobility group box 1 (HMGB1) is an inflammatory mediator and participates in the pathogenesis of various autoimmune diseases. However, its function in thymoma is still unclear. Material and methods: We first analyzed immune indices in peripheral blood of patients with MG-associated thymoma and patients with thymoma alone. Next, we explored the expression of HMGB1 in MG-associated thymoma and thymoma alone tissues. Furthermore, we transfected si-HMGB1 in thymoma cell line Thy0517 and co-cultured Thy0517 with peripheral blood mononuclear cells (PBMC).Results: In this study, the levels of IgG, C3, C4, CRP and globulins in peripheral blood of patients with MG-associated thymoma were different from those of patients with thymoma alone (p < 0.05). The expression of HMGB1 in MG-associated thymoma tissues was higher than thymoma alone. Co-culture of Thy0517 and PBMC showed that the percentage of Th17 cells in PBMC was lower than that in the control group, and the percentage of Treg cells was higher than that in the control group.Conclusions: These findings demonstrate that HMGB1 is involved in the mechanism of abnormal Th17/Treg cell differentiation in thymoma and affects the occurrence of immune abnormalities in MG-associated thymoma.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"237-244"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer. 光动力疗法增强奥沙利铂诱导的大肠癌癌症免疫原性细胞死亡。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-29 DOI: 10.5114/ceji.2023.132053

Xiaobo Wang, Lei Ren, Linhan Ye, Jing Cao

{"title":"Photodynamic therapy augments oxaliplatin-induced immunogenic cell death in colorectal cancer.","authors":"Xiaobo Wang, Lei Ren, Linhan Ye, Jing Cao","doi":"10.5114/ceji.2023.132053","DOIUrl":"https://doi.org/10.5114/ceji.2023.132053","url":null,"abstract":"Colorectal cancer is one of the most frequently diagnosed cancers. Immunotherapy has been proven to be a potential treatment option for colorectal cancer. Colorectal cancer maintains immune escape by expressing low immunogenicity and following the tolerogenic cell death pathway. There is also emerging evidence that oxaliplatin and photodynamic therapy (PDT) can promote anti-tumor immunity. However, the effect of PDT combined with oxaliplatin on colorectal cancer remains elusive. Here, we analyzed the viability of HCT116 and DLD-1 cell lines after treatment with the combination of PDT and oxaliplatin. We found that the viability decreased significantly after the combination treatment. Meanwhile, we also detected that sinoporphyrin sodium (DVDMS)-derived PDT could amplify oxaliplatin-induced immunogenic cell death (ICD) in different colorectal cancer cell lines. More importantly, the combination of DVDMS-derived PDT and oxaliplatin presented strong immunogenic potential in immunocompetent BALB/c mice in the vaccination assay. Taken together, our data demonstrated that the combination of DVDMS-derived PDT and oxaliplatin is a potential novel therapy for colorectal cancer.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"189-202"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual cause of rapidly progressive glomerulonephritis associated with ANCA vasculitis and ovarian malignancy - a relapse 39 years after initial treatment. 与ANCA血管炎和卵巢恶性肿瘤相关的快速进展性肾小球肾炎的不寻常原因-在初始治疗后39年复发。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.127744

Nikola Simovic, Petar Djuric, Jelena Stojsic, Nada Dimkovic, Radomir Naumovic

{"title":"An unusual cause of rapidly progressive glomerulonephritis associated with ANCA vasculitis and ovarian malignancy - a relapse 39 years after initial treatment.","authors":"Nikola Simovic, Petar Djuric, Jelena Stojsic, Nada Dimkovic, Radomir Naumovic","doi":"10.5114/ceji.2023.127744","DOIUrl":"https://doi.org/10.5114/ceji.2023.127744","url":null,"abstract":"A 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly progressive renal failure. She was admitted to the nephrology department due to severe deterioration of renal function with complaints of malaise, fever, dry cough and occasional epistaxis that appeared 2 months prior to admission. Histopathologic examination of a specimen from kidney biopsy and immunologic findings revealed ANCA positive pauci-immune crescentic glomerulonephritis. The patient had a history of ovarian granulosa cell tumor and lung metastases that were treated surgically with postoperative radiotherapy and chemotherapy. Thoracic computed tomography showed tissue neoplasm in the right lung and ultrasound-guided percutaneous transthoracic biopsy confirmed granulosa cell tumor. That was a relapse, thirty-nine years after initial treatment of malignant disease and twenty-four years after surgical resection of metastases from both lungs. Although the association between malignancy and vasculitis has been well known for decades, this is the first described case of ANCA vasculitis associated with any type of gynecological malignancy and glomerulonephritis.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 2","pages":"163-166"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/25/CEJI-48-50761.PMC10485690.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome. 常染色体显性高IgE综合征患者口腔颌面部异常。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-05 DOI: 10.5114/ceji.2023.130874

Ildikó Tar, Márta Szegedi, Ewa Krasuska-Sławińska, Edyta Heropolitańska-Pliszka, Ewa A Bernatowska, Elif Öncü, Sevgi Keles, Sukru N Guner, Ismail Reisli, Nevena Gesheva, Elissaveta Naumova, Lydie Izakovicova-Holla, Jiri Litzman, Igor Savchak, Larysa Kostyuchenko, Melinda Erdõs

{"title":"Intraoral and maxillofacial abnormalities in patients with autosomal dominant hyper-IgE syndrome.","authors":"Ildikó Tar, Márta Szegedi, Ewa Krasuska-Sławińska, Edyta Heropolitańska-Pliszka, Ewa A Bernatowska, Elif Öncü, Sevgi Keles, Sukru N Guner, Ismail Reisli, Nevena Gesheva, Elissaveta Naumova, Lydie Izakovicova-Holla, Jiri Litzman, Igor Savchak, Larysa Kostyuchenko, Melinda Erdõs","doi":"10.5114/ceji.2023.130874","DOIUrl":"10.5114/ceji.2023.130874","url":null,"abstract":"Autosomal dominant hyper-IgE syndrome (AD-HIES) is an inborn error of immunity (IEI) caused by a dominant-negative mutation in the signal transducer and activator of transcription 3 (STAT 3). This disease is characterized by chronic eczematoid dermatitis, recurrent staphylococcal skin abscesses, pneumonia, pneumatoceles, and extremely high serum IgE levels. Loss-of-function STAT3 mutations may also result in distinct non-immunologic features such as dental, facial, skeletal, and vascular abnormalities, central nervous system malformations and an increased risk for bone fractures. Prophylactic treatment of Candida infections and prophylactic antimicrobial therapy for staphylococcal skin infections and sinopulmonary infections are essential. An awareness of the oral and maxillofacial features of HIES may facilitate early diagnosis with genetic counselling and may improve future patient care. This study describes oral, dental, and maxillofacial manifestations in 14 patients with genetically defined AD-HIES. We also review the literature and propose recommendations for the complex care of patients with this rare primary immunodeficiency.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"1 1","pages":"228-236"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71071975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure duration of ambient fine particulate matter determines the polarization of macrophages. 环境细颗粒物的暴露时间决定了巨噬细胞的极化。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 Epub Date: 2023-09-19 DOI: 10.5114/ceji.2023.130978

Xiangru Li, Hongyan Cai, Wei Wu, Shaoyan Si, Minli Zhu

{"title":"Exposure duration of ambient fine particulate matter determines the polarization of macrophages.","authors":"Xiangru Li, Hongyan Cai, Wei Wu, Shaoyan Si, Minli Zhu","doi":"10.5114/ceji.2023.130978","DOIUrl":"https://doi.org/10.5114/ceji.2023.130978","url":null,"abstract":"Ambient fine particulate matter (FPM) promotes airway inflammation and aggravates respiratory and cardiovascular diseases. Macrophage polarization plays an essential role in FPM-induced inflammation and tissue repair. The balance of pro-inflammatory M1-type and anti-inflammatory M2-type macrophages determines the fate of tissues and is involved in the pathogenesis of various FPM-induced diseases. The mechanism of macrophage polarization induced by FPM is still not fully understood. Here, we explored the effect of ambient FPM exposure duration on the polarization of peritoneal macrophages. Mice were exposed to concentrated ambient FPM for different duration. Markers of M1-type macrophage and M2-type macrophage in peritoneal macrophages were detected. We found that macrophage polarization was affected by FPM both in vitro and in vivo. Acute FPM stimulation in vitro and short-term concentrated ambient FPM exposure in vivo promoted the expression of NLRP3 and NOS2 and inhibited the expression of ARG1 and CD206. With the extension of concentrated ambient FPM exposure time, ARG1 was gradually up-regulated, and NLRP3 was gradually down-regulated. These results indicate that FPM exposure duration interferes with macrophage polarization. This may provide new insight into the treatment of patients exposed to FPM.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 3","pages":"219-227"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10604645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy - one-center preliminary study. 在儿童狼疮肾病肾活检超微结构研究中存在小管网状包裹体-单中心初步研究。

IF 1.3 4区医学

Central European Journal of Immunology Pub Date : 2023-01-01 DOI: 10.5114/ceji.2023.125237

Tomasz Koszutski, Łukasz Mielańczyk, Grażyna Kucharska, Natalia Matysiak, Agnieszka Wiernik, Grzegorz Kudela, Lidia Hyla-Klekot

{"title":"Presence of tubuloreticular inclusions in ultrastructural studies of renal biopsies in children with lupus nephropathy - one-center preliminary study.","authors":"Tomasz Koszutski, Łukasz Mielańczyk, Grażyna Kucharska, Natalia Matysiak, Agnieszka Wiernik, Grzegorz Kudela, Lidia Hyla-Klekot","doi":"10.5114/ceji.2023.125237","DOIUrl":"https://doi.org/10.5114/ceji.2023.125237","url":null,"abstract":"Introduction: Juvenile systemic lupus erythematosus (jSLE) is an autoimmune disease that develops as a result of multi-level immune dysregulation, including the interferon pathway. Nephropathy develops at an early stage and eventually affects 90% of patients. A renal biopsy allows one to classify lupus nephritis and determine the proper treatment. Biopsy assessment should be done not only in a light microscope but also in a transmission electron microscope (TEM). Its usage may reveal the presence of intracellular tubuloreticular inclusions (TRIs), considered as a morphological marker of interferon hyperactivity.Material and methods: Renal biopsies of 10 children with jSLE and nephropathy were analyzed in TEM. The location, structure, and size of TRIs were assessed. Demographic data, nephropathy manifestation, non-renal symptoms, and serological activity of lupus were analyzed.Results: All the patients were female with an average onset at 12.7 years of age and met SLE criteria. Nephropathy manifested with proteinuria (n = 10) and hematuria (n = 6). Glomerular filtration rate (GFR) was normal in all patients. In three children with early disease onset, it manifested with hematological disorders. TRIs were revealed in 7 biopsies, with the highest expression in the youngest children, with peripheral cytopenia, membranous glomerulonephritis, and lupus nephritis.Conclusions: Demonstration of TRIs in renal biopsies of children with juvenile systemic lupus may confirm the diagnosis of lupus nephritis and is a sign of involvement of the interferon pathway at the early stage of the disease.","PeriodicalId":9694,"journal":{"name":"Central European Journal of Immunology","volume":"48 1","pages":"26-34"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/5c/CEJI-48-50170.PMC10189577.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0