Cancer Cell最新文献_第3页

Targeting brain macrophages: NF-κB as a therapeutic gateway in melanoma brain metastasis

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.020

Martina Molgora, Marco Colonna

引用次数: 0

A CDK4-selective inhibitor puts the brakes on cancer cells

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.007

Chang-Ching Lin, Ariella B. Hanker

引用次数: 0

Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.011

Mao Yang, Yuhao Zhao, Chen Li, Xiaoling Weng, Zhizhen Li, Wu Guo, Wenning Jia, Feiling Feng, Jiaming Hu, Haonan Sun, Bo Wang, Huaifeng Li, Ming Li, Ting Wang, Wei Zhang, Xiaoqing Jiang, Zongli Zhang, Fubao Liu, Hai Hu, Xiangsong Wu, Yingbin Liu

{"title":"Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders","authors":"Mao Yang, Yuhao Zhao, Chen Li, Xiaoling Weng, Zhizhen Li, Wu Guo, Wenning Jia, Feiling Feng, Jiaming Hu, Haonan Sun, Bo Wang, Huaifeng Li, Ming Li, Ting Wang, Wei Zhang, Xiaoqing Jiang, Zongli Zhang, Fubao Liu, Hai Hu, Xiangsong Wu, Yingbin Liu","doi":"10.1016/j.ccell.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.02.011","url":null,"abstract":"Gallbladder cancer (GBC) frequently mimics gallbladder benign lesions (GBBLs) in radiological images, leading to preoperative misdiagnoses. To address this challenge, we initiated a prospective, multicenter clinical trial (ChicCTR2100049249) and proposed a multimodal, non-invasive diagnostic model to distinguish GBC from GBBLs. A total of 301 patients diagnosed with gallbladder-occupying lesions (GBOLs) from 11 medical centers across 7 provinces in China were enrolled and divided into a discovery cohort and an independent external validation cohort. An artificial intelligence (AI)-based integrated model, GBCseeker, is created using cell-free DNA (cfDNA) genetic signatures, radiomic features, and clinical information. It achieves high accuracy in distinguishing GBC from GBBL patients (93.33% in the discovery cohort and 87.76% in the external validation cohort), reduces surgeons’ diagnostic errors by 56.24%, and reclassifies GBOL patients into three categories to guide surgical options. Overall, our study establishes a tool for the preoperative diagnosis of GBC, facilitating surgical decision-making.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"21 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic enhancement of adoptive T cell immunotherapy

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.022

Zhenyu Dai, Melody Smith

引用次数: 0

Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.023

Xueliang Wang, Yi Fang, Wei Liang, Chi Chun Wong, Huanlong Qin, Yaohui Gao, Meinong Liang, Lei Song, Yongxin Zhang, Miao Fan, Chuanfa Liu, Harry Cheuk-Hay Lau, Lixia Xu, Xiaoxing Li, Wu Song, Junlin Wang, Na Wang, Tao Yang, Mengmiao Mo, Xiang Zhang, Jun Yu

引用次数: 0

An innovative ALA-CART platform exhibits high efficacy against cancers

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.021

Jiasheng Wang, Xin Lin

引用次数: 0

Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.008

Catherine Pham-Danis, Amanda J. Novak, Etienne Danis, Samantha M. McClellan, Lillie Leach, Michael C. Yarnell, Christopher C. Ebmeier, Sarah K. Tasian, M. Eric Kohler

{"title":"Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemia","authors":"Catherine Pham-Danis, Amanda J. Novak, Etienne Danis, Samantha M. McClellan, Lillie Leach, Michael C. Yarnell, Christopher C. Ebmeier, Sarah K. Tasian, M. Eric Kohler","doi":"10.1016/j.ccell.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.02.008","url":null,"abstract":"Chimeric antigen receptor (CAR) T cells induce responses in patients with relapsed/refractory leukemia; however, long-term efficacy is frequently limited by relapse. The inability to target antigen-low cells is an intrinsic vulnerability of second-generation CAR T cells and underlies most relapses following CD22BBz CAR T cell therapy. Here, we interrogate CD22BBz CAR signaling in response to low antigen and find inefficient phosphorylation of the linker for activation of T cells (LAT) limiting downstream signaling. To overcome this, we designed the adjunctive LAT-activating CAR T cell (ALA-CART) platform, pairing a second-generation CAR with a LAT-CAR incorporating the intracellular domain of LAT. ALA-CART cells demonstrate reduced differentiation during manufacturing and increased LAT phosphorylation, MAPK signaling, and AP-1 activity. ALA-CART cells show improved cytotoxicity, proliferation, persistence, and efficacy against antigen-low leukemias that were refractory to clinically active CD22BBz CAR T cells. Restoration of LAT signaling through the ALA-CART platform represents a promising strategy for overcoming multiple mechanisms of CAR T cell failure.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"59 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.012

Mathieu Desaunay, Poulikos I. Poulikakos

引用次数: 0

Exploring the “chemo” in chemoimmunotherapy for triple-negative breast cancer

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.016

Ting Liu, Leif W. Ellisen

引用次数: 0

Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

IF 50.3 1区医学

Cancer Cell Pub Date : 2025-03-10 DOI: 10.1016/j.ccell.2025.02.009

Jiang Chang, Junting Lu, Qingyi Liu, Tao Xiang, Shaosen Zhang, Yonglin Yi, Dongxu Li, Tianyuan Liu, Zeyuan Liu, Xinjie Chen, Zhenghao Dong, Cainan Li, HanZhang Yi, Siqi Yu, Luwei Huang, Fangfei Qu, Mengdi Wang, Dehe Wang, Hao Dong, Guoyu Cheng, Chen Wu

{"title":"Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis","authors":"Jiang Chang, Junting Lu, Qingyi Liu, Tao Xiang, Shaosen Zhang, Yonglin Yi, Dongxu Li, Tianyuan Liu, Zeyuan Liu, Xinjie Chen, Zhenghao Dong, Cainan Li, HanZhang Yi, Siqi Yu, Luwei Huang, Fangfei Qu, Mengdi Wang, Dehe Wang, Hao Dong, Guoyu Cheng, Chen Wu","doi":"10.1016/j.ccell.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.ccell.2025.02.009","url":null,"abstract":"Cancer development involves the co-evolution of cancer cells and their surrounding microenvironment, yet the dynamics of this interaction within the physical architecture remains poorly understood. Here, we present a spatial transcriptomic map at single-cell resolution, encompassing 127 multi-stage fields of view from 43 patients, to chart the evolutionary trajectories of human esophageal squamous cell carcinoma (ESCC). By analyzing 6.4 million cells, we reveal that ESCC progression is driven by a proliferative epithelial cell subpopulation that acquires dedifferentiated and invasive characteristics. At the late precancerous stage, these cells disrupt the epithelial-stromal interface and recruit normal fibroblasts via JAG1-NOTCH1 signaling, transforming them into cancer-associated fibroblasts (CAFs). This interaction leads to the formation of a “CAF-Epi” (CAF and epithelial cell) niche at the tumor edge that shields the tumor from immune surveillance. The CAF-Epi niche formation is a key indicator of progression in ESCC and other squamous cell carcinomas and patient outcomes.","PeriodicalId":9670,"journal":{"name":"Cancer Cell","volume":"62 1","pages":""},"PeriodicalIF":50.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0