Cardiovascular Research最新文献

{"title":"Testosterone and atrial fibrillation: does the dose make the poison?","authors":"Fleur E Mason, Aiste Liutkute, Niels Voigt","doi":"10.1093/cvr/cvaf113","DOIUrl":"https://doi.org/10.1093/cvr/cvaf113","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting autophagy to treat neointimal hyperplasia in vascular disease.","authors":"Runan Yan, Simon Tual-Chalot, Konstantinos Stellos","doi":"10.1093/cvr/cvaf104","DOIUrl":"https://doi.org/10.1093/cvr/cvaf104","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-fibre diet is associated with high-risk coronary plaque features.","authors":"Ingrid Larsson,Jiangming Sun,Shafqat Ahmad,Göran Bergström,Carl-Johan Carlhäll,Kerstin Cederlund,Isabel Drake,Jan E Engvall,Mats Eriksson,Henrik Hagström,Tomas Jernberg,Tanja Kero,Krister Lindmark,Maria Mannila,Marju Orho-Melander,Araz Rawshani,Ulf Risérus,Annika Rosengren,Mats Ryberg,Caroline Schmidt,Emily Sonestedt,Maria Wennberg,Carl Johan Östgren,Isabel Goncalves","doi":"10.1093/cvr/cvaf088","DOIUrl":"https://doi.org/10.1093/cvr/cvaf088","url":null,"abstract":"AIMSDiet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features.METHODS AND RESULTSThe cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited in 2013 to 2018 who were free of clinical cardiovascular disease. The recruitment and comprehensive examinations were conducted at six locations in Sweden. A dietary index (DI) based on a previously published anti-inflammatory DI including high proportion of plant-based foods, and low in red or processed meat and sugar-sweetened beverages was constructed. The reference group was within lowest DI tertile. Coronary atherosclerosis assessed by coronary computed tomography angiography, including any-, significant-, and adverse or high-risk coronary plaque, which is non-calcified with a significant stenosis ≥50%. Lowest, compared to highest DI tertile was associated with younger age, more often men (62.2% vs. 32.9%), higher high-sensitive C-reactive protein, more cardiometabolic risk and smokers, higher alcohol-, and higher energy-intake. In the highest and lowest tertile, coronary plaques were present in 36.3% and 44.3%, respectively, stenosis ≥ 50% in 3.7% and 6.0%. Non-calcified coronary plaques with stenosis ≥50% were present in 0.9% and 1.5% in highest and lowest tertiles. In multivariable analyses, the lowest tertile of DI was associated with high-risk plaque features after adjusting for age, sex, smoking, with waist circumference, triglycerides (TGs), and hypertension as possible mediators.CONCLUSIONA low-fibre diet with high red meat content was associated with high-risk plaques features, increased coronary calcification and significant stenosis. Waist circumference, TGs, and hypertension emerged as potential mediators of these associations, underscoring the role of metabolic and hemodynamic factors in the dietary impact on coronary atherosclerosis. Our findings strengthen the importance of cardioprotective dietary recommendations.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"38 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An activator of PI3Kα restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance","authors":"Pelin Golforoush, Elias Sulaiman, David He, Derek M Yellon, Sean M Davidson","doi":"10.1093/cvr/cvaf111","DOIUrl":"https://doi.org/10.1093/cvr/cvaf111","url":null,"abstract":"Background In patients with coronary artery disease (CAD), morbidity and mortality from myocardial infarction remain high. Cardioprotective strategies such as Remote Ischaemic Conditioning (RIC) are highly effective in animal models but have disappointed in large clinical trials. One explanation may be that ischaemia and reperfusion (I/R) experiments are typically conducted in mice that lack CAD. Unlike most mouse models, double-knockout Scarb1;Ldlr (DKO) mice do develop CAD when fed a high-fat diet (HFD). The aim of this study was therefore to use these mice to investigate cardioprotection in the setting of CAD. We hypothesized that RIC, which requires cell-surface receptor signalling, would be ineffective in these mice; but that UCL-TRO-1938, a PI3Kalpha activator that bypasses cell-surface receptors, would be cardioprotective. Methods and results After 6-weeks HFD, DKO mice, but not WT or Ldlr KO mice, developed CAD as determined by histology. Anaesthetized mice were subject to 30-min coronary ischaemia and 2-h reperfusion. In line with our hypothesis, RIC did reduce infarct size in WT and Ldlr KO mice, but did not reduce infarct size in DKO mice subject to I/R. We sought to understand the effects of CAD in DKO hearts that might impair RIC, using RNAseq, immunostaining and Western blot analysis. RNAseq revealed significantly altered gene expression in DKO hearts compared to WT and Ldlr KO hearts, primarily in inflammatory pathways; in particular the IL-17 pathway. Coronary endothelial cells were activated, as shown by ICAM-1 expression in DKO but not Ldlr KO or WT. In contrast to RIC, treatment with UCL-TRO-1938 was cardioprotective in DKO mice. Conclusions The DKO mouse may be a more clinically translatable mouse model of I/R and cardioprotection. Furthermore, UCL-TRO-1938 is a promising cardioprotective drug as it remains effective in a mouse model with CAD.","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"37 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing obesity and subsequent cardiovascular risk in primary care: the relevance of high- and low-resource settings.","authors":"Aletta E Schutte","doi":"10.1093/cvr/cvaf094","DOIUrl":"https://doi.org/10.1093/cvr/cvaf094","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":""},"PeriodicalIF":10.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upfront lipid-lowering combination therapy in high cardiovascular risk patients: a route to effective atherosclerotic cardiovascular disease prevention.","authors":"Maciej Banach, Stanisław Surma, Tomasz J Guzik, Peter E Penson, Michael J Blaha, Fausto J Pinto, Laurence S Sperling","doi":"10.1093/cvr/cvaf045","DOIUrl":"10.1093/cvr/cvaf045","url":null,"abstract":"<p><p>Despite three decades of using statin therapy, 20 years of experience with ezetimbe, and availability of innovative non-statin lipid lowering therapies (LLT), there are still about 70% patients over the low-density lipoprotein cholesterol (LDL-C) goal, with every 5th to 6th being over the target from the group of very high and extremely high cardiovascular disease (CVD) risk patients. Adding another even every 5th patient at very high CVD risk without any LLT makes this situation highly frustrating, especially lipid disorders are the most common CVD risk factor with the prevalence of over 60%, with the worst awareness within all cardiovascular risk factors (only about 15% people knows their LDL-C level). To answer this since 2021, there is an approach to apply upfront (immediate) lipid-lowering combination therapy of statin and ezetimibe in very high and extremely high-risk patients to be on the LDL-C target as low as possible, but especially as early as possible, enabling to introduce the third line therapy (i.e. bempedoic acid and/or PCSK9 targeted therapy) already after 4-6 weeks. This review discusses the current stage of knowledge and recent data on the group of patients that might benefit the most from the upfront combination LLT, when it should be optimally implemented, and the recent data on its role on LDL-C reduction, cardiovascular and mortality outcomes as well as safety issues.</p>","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"851-859"},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mediterranean diet displays an immunomodulatory effect that correlates with beneficial changes in carotid atherosclerosis.","authors":"Ana Maria Ruiz-Leon, Miguel Camafort, Aleix Sala-Vila, Rosa Gilabert, Isabel Núñez, Sara Castro-Barquero, Montserrat Fitó, Rosa María Lamuela-Raventós, Xavier Pintó, Ana García-Arellano, Emilio Ros, Ramon Estruch, Rosa Casas","doi":"10.1093/cvr/cvaf027","DOIUrl":"10.1093/cvr/cvaf027","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"847-850"},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTRP7 as a molecular biomarker associating with responsiveness to pulmonary vasodilators: insights from human and animal studies in pulmonary arterial hypertension.","authors":"Kaito Yamada, Taijyu Satoh, Nobuhiro Yaoita, Naoki Chiba, Yusuke Yamada, Kohei Komaru, Sho Onuma, Shigeo Godo, Saori Yamamoto, Haruka Sato, Takashi Nakata, Kotaro Nochioka, Hisashi Oishi, Satoshi Miyata, Yoshinori Okada, Satoshi Yasuda","doi":"10.1093/cvr/cvaf064","DOIUrl":"10.1093/cvr/cvaf064","url":null,"abstract":"<p><strong>Aims: </strong>Pulmonary arterial hypertension (PAH) is a life-threatening condition. Although pulmonary vasodilators have shown promise in managing PAH, the improvement in prognosis is modest, partly because of a lack of biomarkers to guide their selection. Herein, we aimed to identify molecular-based predictors of responsiveness to pulmonary vasodilators using clinical and preclinical investigations.</p><p><strong>Methods and results: </strong>RNA sequencing was conducted on cultured pulmonary artery smooth muscle cells (PASMCs) from patients with and without pulmonary hypertension (PH), identifying variations in 3017 genes. Next, we performed a case-control study (PAH, n = 114; non-PH, n = 70) and examined plasma samples to identify potential clinical biomarkers. PASMCs exhibited elevated expression of C1q/TNF-related protein 7 (CTRP7; log2 fold change 5.37, P < 0.01). Patients with PAH had higher plasma CTRP7 levels [19.7 (9.8-90.5)] than those without PH [11.8 (0.6-61.6) ng/mL; P < 0.01]. Plasma and single-cell assessments revealed a significant correlation between CTRP7 and interleukin (IL)-6 levels (P < 0.001). Chromatin immunoprecipitation demonstrated that IL-6 up-regulated CTRP7 in PASMCs. CTRP7 reduced the expression of prostacyclin analogue receptor (PTGIR) through Rab5a-mediated internalization, resulting in diminished responsiveness to selexipag (prostacyclin analogue). Consistent with human study results, PTGIR expression was reduced in the pulmonary arteries of hypoxic PH mice, correlating with limited responses to selexipag treatment (low cardiac output and persistent pulmonary artery resistance); this effect was mitigated by the IL-6-R neutralizing antibody or adeno-associated virus-mediated silencing of CTRP7 expression in the pulmonary arteries.</p><p><strong>Conclusion: </strong>In patients with PAH, RNA sequencing of PASMCs revealed elevated expression of CTRP7 among candidate biomarkers. Patients with PAH had higher plasma CTRP7 levels than those without PH. Mechanistically, CTRP7 regulated PTGIR internalization via the IL-6-Rab5a axis, influencing responsiveness to selexipag. Herein, CTRP7 emerged as a crucial biomarker associating with responsiveness to prostacyclin analogues, advancing the development of PAH treatment strategies.</p>","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":"121 6","pages":"929-942"},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It takes more than omics to identify a cardioprotective mechanism.","authors":"Gerd Heusch, Petra Kleinbongard","doi":"10.1093/cvr/cvaf052","DOIUrl":"10.1093/cvr/cvaf052","url":null,"abstract":"","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"839-840"},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetraspanin CD37 regulates platelet hyperreactivity and thrombosis.","authors":"Marcin A Sowa, Carmen Hannemann, Ivan Pinos, Elissa Ferreira, Bharti Biwas, Min Dai, Emma M Corr, Macintosh G Cornwell, Kamelia Drenkova, Angela H Lee, Tanya Spruill, Harmony R Reynolds, Judith S Hochman, Kelly V Ruggles, Robert A Campbell, Coen van Solingen, Mark D Wright, Kathryn J Moore, Jeffrey S Berger, Tessa J Barrett","doi":"10.1093/cvr/cvaf051","DOIUrl":"10.1093/cvr/cvaf051","url":null,"abstract":"<p><strong>Aims: </strong>To investigate how psychosocial stress contributes to accelerated thrombosis, focusing on platelet activation and hyperreactivity. The specific objective was to identify novel platelet regulators involved in stress-mediated thrombosis, with a particular emphasis on the tetraspanin CD37.</p><p><strong>Methods and results: </strong>To explore how stress contributes to platelet hyperreactivity, platelets were isolated from (i) mice that experienced chronic variable stress and stress-free controls (n = 8/group) and (ii) human subjects with self-reported high- and no-stress levels (n = 18/group), followed by RNA-sequencing. By comparing mutually expressed transcripts, a subset of genes differentially expressed following psychosocial stress was identified in both human and mouse platelets. In both mice and humans, platelet CD37 positively associates with platelet aggregation responses that underlie thrombosis, with Cd37-/- platelets exhibiting impaired integrin αIIbβ3 signalling, characterized by reduced platelet fibrinogen spreading and decreased agonist-induced αIIbβ3 activation. Consistent with a role for CD37 in regulating platelet activation responses, chimeric mice that received Cd37-/- bone marrow experienced a significantly increased time to vessel occlusion in the carotid artery FeCl3 model compared to mice reconstituted with wild-type bone marrow. CD37 deficiency did not alter haemostasis, as platelet count, coagulation metrics, prothrombin time, and partial thromboplastin time did not differ in Cd37-/- mice relative to wild-type mice. Consistent with this, bleeding time did not differ between wild-type and Cd37-/- mice following tail tip transection.</p><p><strong>Conclusion: </strong>This study provides new insights into the platelet-associated mechanisms underlying stress-mediated thrombosis. Identifying CD37 as a novel regulator of platelet activation responses offers potential therapeutic targets for reducing the thrombotic risk associated with psychosocial stress. The findings also contribute to understanding how psychosocial stress accelerates thrombotic events and underscore the importance of platelet activation in this process.</p><p><strong>Clinical trial registration: </strong>NCT02106429, NCT03022552.</p>","PeriodicalId":9638,"journal":{"name":"Cardiovascular Research","volume":" ","pages":"943-956"},"PeriodicalIF":10.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}