Case Reports in Dermatological Medicine最新文献_第6页

Drug-Induced Phototoxicity in Vitiligo: The Role of Hydrochlorothiazide in Photosensitivity Dermatitis. 白癜风药物诱导的光毒性：氢氯噻嗪在光敏性皮炎中的作用。

Case Reports in Dermatological Medicine Pub Date : 2025-12-26 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/4302190

Andres D Parga, Celina Dubin, Donald Rudikoff

{"title":"Drug-Induced Phototoxicity in Vitiligo: The Role of Hydrochlorothiazide in Photosensitivity Dermatitis.","authors":"Andres D Parga, Celina Dubin, Donald Rudikoff","doi":"10.1155/crdm/4302190","DOIUrl":"10.1155/crdm/4302190","url":null,"abstract":"Photosensitivity dermatitis is a multifactorial dermatologic condition characterized by an exaggerated cutaneous response to ultraviolet (UV) radiation, often exacerbated by exogenous agents, particularly photosensitizing medications. The pathophysiology involves direct phototoxic or immune-mediated photoallergic mechanisms, leading to inflammatory skin reactions upon UV exposure. In individuals with vitiligo, the absence of melanocytes in depigmented areas significantly diminishes photoprotective mechanisms, rendering these regions highly susceptible to UV-induced damage. Consequently, vitiliginous skin is inherently more vulnerable to photo-induced inflammation and cutaneous injury. We report a 54-year-old man with generalized vitiligo who developed erythematous papules confined to sun-exposed depigmented skin. The clinical course suggested a medication-induced phototoxic reaction, likely potentiated by the patient's underlying lack of cutaneous melanin. This case highlights the need to recognize drug-induced photosensitivity in vitiligo and understand how UV vulnerability and photosensitizing medications interact.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"4302190"},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12741891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon Dioxide Laser Ablation for the Treatment of a Rare Case of Acquired Lymphangioma Circumscriptum of the Vulva in an Adult Patient. 二氧化碳激光消融治疗一例罕见的成人外阴周围获得性淋巴管瘤。

Case Reports in Dermatological Medicine Pub Date : 2025-12-12 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/9927730

Harriet Rothschild, Sara McKinney

引用次数: 0

Disseminated Cutaneous, Osteoarticular, and Tubulointerstitial Sporotrichosis in an Immunosenescent and Diabetic Host: A Case Report. 免疫衰老和糖尿病宿主弥散性皮肤、骨关节和小管间质孢子菌病1例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-11-26 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/7955710

Juan Esteban Velez-Hernandez, Natalia Giraldo, Erika Andrea Sánchez-Cifuentes, María Del Pilar Jiménez-Alzate, Fernando Lopez-Urbano

{"title":"Disseminated Cutaneous, Osteoarticular, and Tubulointerstitial Sporotrichosis in an Immunosenescent and Diabetic Host: A Case Report.","authors":"Juan Esteban Velez-Hernandez, Natalia Giraldo, Erika Andrea Sánchez-Cifuentes, María Del Pilar Jiménez-Alzate, Fernando Lopez-Urbano","doi":"10.1155/crdm/7955710","DOIUrl":"10.1155/crdm/7955710","url":null,"abstract":"Introduction: Disseminated sporotrichosis is an uncommon presentation of this infectious disease, primarily observed in immunocompromised patients. Here, we present a case of disseminated sporotrichosis occurring in an immunosenescent patient.Case presentation: An 81-year-old man presented to our clinic with skin ulcers in the scalp, back, right arm, and both legs, knee arthritis, and acute kidney injury. After skin biopsy and synovial fluid analysis, the diagnosis of disseminated sporotrichosis was made using fungal culture and in-house PCR. The only factor that favored immunocompromise was immunosenescence.Conclusion: This case of disseminated sporotrichosis highlights its rare occurrence in a patient with controlled diabetes and immunosenescence. Advanced diagnostics confirmed Sporothrix schenckii as the causative agent, and itraconazole treatment led to significant improvement.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"7955710"},"PeriodicalIF":0.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronous Macular Amyloidosis and Brachioradialis Pruritus Successfully Treated With Gabapentin. 加巴喷丁治疗同步性黄斑淀粉样变性和肱桡肌瘙痒症成功。

Case Reports in Dermatological Medicine Pub Date : 2025-11-26 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/5909428

Hoda Rahimi, Mehrdad Ashayer, Roya Zeinali, Leila Rezaie Shirmard

引用次数: 0

Correction to "15 Years of Intermittent Therapy With Hydroxychloroquine Without Any Loss of Efficacy in Reticular Erythematous Mucinosis". 更正“15年羟氯喹间歇治疗网状红斑性黏液病无任何疗效损失”。

Case Reports in Dermatological Medicine Pub Date : 2025-11-19 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/9802656

引用次数: 0

Multiple Cutaneous Squamous Cell Carcinomas on Primary Epidermodysplasia Verruciformis in a 19-Year-Old Black Subject. 19岁黑人受试者原发性疣状表皮发育不良多发皮肤鳞状细胞癌。

Case Reports in Dermatological Medicine Pub Date : 2025-11-09 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/9936485

Panawé Kassang, Abas Mouhari-Toure, Toukilnan Djiwa, Sefako Abla Akakpo, Julienne Noudé Teclessou, Bayaki Saka, Palokinam Pitche

{"title":"Multiple Cutaneous Squamous Cell Carcinomas on Primary Epidermodysplasia Verruciformis in a 19-Year-Old Black Subject.","authors":"Panawé Kassang, Abas Mouhari-Toure, Toukilnan Djiwa, Sefako Abla Akakpo, Julienne Noudé Teclessou, Bayaki Saka, Palokinam Pitche","doi":"10.1155/crdm/9936485","DOIUrl":"10.1155/crdm/9936485","url":null,"abstract":"Introduction: Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic human papillomavirus infection of the skin and a risk of carcinomatous degeneration. We report a case of EV complicated by multiple cutaneous carcinomas of the scalp in a 19-year-old subject.Case presentation: A 19-year-old male, phototype VI according to Fitzpatrick's classification, was referred to the dermatology department of CHU Kara with multiple painful tumoral lesions of the scalp that had been evolving for about 1 year. Clinical examination revealed hypochromic macules (Pityriasis versicolor-like), hypochromic verrucous flat papules scattered over the face, scalp, neck, trunk, and upper limbs. These lesions were associated with occasional pruritus. Apart from these lesions, there were three ulcerative-bourgeonous tumors on the scalp. A normal blood count was obtained, and the HIV serological test was negative. Histological examination of lesion biopsies confirmed the diagnosis of squamous cell carcinoma for all three lesions. Patient management was limited by lack of financial resources.Conclusion: As sub-Saharan Africa is characterized by fragile health systems and high solar gradients, particular emphasis must be placed on preventive measures for skin cancers in patients with genodermatoses at risk of degeneration.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"9936485"},"PeriodicalIF":0.0,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12620045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Presentation of Cystic Metastatic Melanoma in the Upper Chest. 罕见的上胸部囊性转移性黑色素瘤。

Case Reports in Dermatological Medicine Pub Date : 2025-10-28 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8706831

Madeline Tchack, Noah Musolff, Sydney Wolfe, Ria Sandeep, Babar Rao

引用次数: 0

Kindler Syndrome in a 24-Year-Old Male: A Clinical Diagnosis in the Absence of Genetic Testing: A Rare Case Report. 金德勒综合征在24岁男性：临床诊断在缺乏基因检测：一个罕见的病例报告。

Case Reports in Dermatological Medicine Pub Date : 2025-10-28 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/9343494

Dyala Sayed Ahmad, Rim Nasser, Alaa Mahmoud, Moatasem Hussein Al-Janabi, Zuheir Al-Shehabi, Fouz Hassan

引用次数: 0

A Case of Navigating Autism and Atypical Rashes in Dermatology Practice. 一例导航自闭症和非典型皮疹在皮肤科实践。

Case Reports in Dermatological Medicine Pub Date : 2025-10-18 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/2338787

Benjamin S Kahn, Kathleen Ward, Nedyalko Ivanov, Marcus B Goodman

{"title":"A Case of Navigating Autism and Atypical Rashes in Dermatology Practice.","authors":"Benjamin S Kahn, Kathleen Ward, Nedyalko Ivanov, Marcus B Goodman","doi":"10.1155/crdm/2338787","DOIUrl":"10.1155/crdm/2338787","url":null,"abstract":"A 4-year-old nonverbal autistic female presented to the clinic with a 3-month history of a persistent, inflamed papular rash, which was violaceous to skin-toned, verrucous, and dome-shaped with crateriform ulcerations on an erythematous base localized in the perianal region. A dermatologic condition with these characteristics, location, and demographic warrants a thorough workup, physical exam, and broad differential diagnosis. The clinical appearance of these lesions can mimic many cutaneous conditions in this age group and requires careful attention for potential signs of abuse. As demonstrated in our case, with a comprehensive patient history, a biopsy, and a culture of the lesions, one can properly direct management of what looked like a broad complex differential to something more benign and underappreciated. When seeing and performing skin check screenings on particular vulnerable patient populations, such as those with autism, educating these patients and their parents is a very important aspect of management. Narrowing the condition down, we reached a diagnosis of pseudoverrucous papules and nodules, a skin rash rarely discovered in children but detected in elderly patients who are debilitated and bedridden with urinary and/or fecal incontinence. This complex case illustrates the importance of proper patient care in patients with autism and considering the entire clinical context before making a diagnosis or conclusion, specifically in vulnerable youth.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"2338787"},"PeriodicalIF":0.0,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12553524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Koebner Phenomenon Induced by Eyeglasses in a Patient With Discoid Lupus Erythematosus. 眼镜致盘状红斑狼疮患者Koebner现象1例。

Case Reports in Dermatological Medicine Pub Date : 2025-10-16 eCollection Date: 2025-01-01 DOI: 10.1155/crdm/8262393

Sam Fathizadeh, Alexander D Woods, Roger Haber

{"title":"Koebner Phenomenon Induced by Eyeglasses in a Patient With Discoid Lupus Erythematosus.","authors":"Sam Fathizadeh, Alexander D Woods, Roger Haber","doi":"10.1155/crdm/8262393","DOIUrl":"10.1155/crdm/8262393","url":null,"abstract":"The Koebner phenomenon, or isomorphic response, refers to the induction of disease-specific lesions on uninvolved skin following trauma. This phenomenon is well-documented across several dermatologic conditions such as psoriasis and vitiligo but is less recognized in discoid lupus erythematosus (DLE). We report a case of a 37-year-old African American woman with DLE, triggered by repeated contact with eyeglass frames, leading to the development of discoid lesions at the points of pressure on her face. This case is a rare occurrence of Koebnerization in DLE, diagnosed through characteristic histopathological findings and supported by serological evidence. Her management included hydroxychloroquine, topical corticosteroids, and methotrexate due to disease flaring. Eventually, she developed systemic lupus erythematosus, complicating her clinical course. This case discusses the need for awareness regarding Koebnerization in DLE and its potential role in indicating active disease or predicting transition to systemic involvement. Further research is necessary to explore the pathogenic mechanisms and implications of Koebnerization in DLE, emphasizing the importance of preventive measures against mechanical trauma in susceptible individuals.","PeriodicalId":9630,"journal":{"name":"Case Reports in Dermatological Medicine","volume":"2025 ","pages":"8262393"},"PeriodicalIF":0.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12549199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0